US2013089545A1PendingUtilityA1
Novel compounds and their effects on feeding behaviour
Est. expiryDec 13, 2026(~0.4 yrs left)· nominal 20-yr term from priority
Inventors:Stephen Robert Bloom
A61P 43/00A61P 3/10A61P 3/04C07K 14/605A61K 8/64C07K 14/5759A61K 38/00A61K 45/06A61K 38/26A61Q 19/06A61K 38/02C07K 14/575
50
PatentIndex Score
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Claims
Abstract
The invention provides a peptide comprising the amino acid sequence given below, together with uses of the peptide and methods associated therewith. The peptide finds particular use as an appetite suppressant and in the treatment of obesity. Xaa1 Xaa2 Xaa3 Gly4 Thr5 Phe6 Thr7 Ser8 Asp9 Tyr10 Ser11 Lys12 Tyr13 Leu14 Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 Trp25 Leu26 Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 Lys33 Asn34 Asn35 Ile36 Ala37; wherein: Xaa1 is His1 or D-His1, Xaa2 is Ser2 or Ala2, Xaa3 is Gln3 or Asp3; Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 is: Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24, Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24, Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24, Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24, Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24, Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24, Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24, Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24, Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24, Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24, Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24, Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24, Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24, Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24, Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24, Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24, or Asp15 Ser16 Arg17 Arg18 Ala19 Gln20 Asp21 Phe22 Val23 Gln24; Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 is: Met27 Asn28 Thr29 Lys30 Arg31 Asn32, Lys27 Asn28 Ala29 Gly30 Pro31 Ser32, or Lys27 Asn28 Gly29 Gly30 Pro31 Ser32 or a peptide as set out above in which residue Asn34 is replaced with Asp34; or a peptide as set out above in which Xaa3 is Glu3; with the proviso that if Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 is Asp15 Ser16 Arg17 Arg18 Ala19 Gln20 Asp21 Phe22 Val23 Gln24, then Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 is not Met27 Asn28 Thr29 Lys30 Arg31 Asn32.
Claims
exact text as granted — not AI-modified1 - 25 . (canceled)
26 . A pharmaceutical composition comprising a first peptide and a second peptide, and one or more pharmaceutically acceptable carriers, wherein the first peptide is a peptide comprising the amino acid sequence:
(SEQ ID NO: 356)
Xaa1 Xaa2 Xaa3 Gly4 Thr5 Phe6 Thr7 Ser8 Asp9 Tyr10
Ser11 Lys12 Tyr13 Leu14 Xaa15 Xaa16 Xaa17 Xaa18
Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 Trp25 Leu26
Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 Lys33 Xaa34
Asn35 Ile36 Ala37;
wherein:
Xaa1 is His1 or D-His1,
Xaa2 is Ser2 or Ala2,
Xaa3 is Gln3 or Asp3;
Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 is selected from the group consisting of:
Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24 (SEQ ID NO:362),
Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24 (SEQ ID NO:363),
Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24 (SEQ ID NO:364),
Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24 (SEQ ID NO:365),
Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24 (SEQ ID NO:366),
Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24 (SEQ ID NO:367),
Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24 (SEQ ID NO:368),
Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24 (SEQ ID NO:370),
Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24 (SEQ ID NO:371),
Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24 (SEQ ID NO:372),
Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24 (SEQ ID NO:373),
Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24 (SEQ ID NO:374),
Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24 (SEQ ID NO:375),
Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24 (SEQ ID NO:376),
and Asp15 Ser16 Arg17 Arg18 Ala19 Gln20 Asp21 Phe22 Val23 Gln24 (SEQ ID NO:378);
Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 is:
Met27 Asn28 Thr29 Lys30 Arg31 Asn32 (SEQ ID NO:379),
Lys27 Asn28 Ala29 Gly30 Pro31 Ser32 (SEQ ID NO:380),
or Lys27 Asn28 Gly29 Gly30 Pro31 Ser32 (SEQ ID NO:381); and
Xaa34 is Asn34 or Asp34;
wherein the peptide optionally comprises a fusion partner;
or a peptide as set out above in which Xaa3 is Glu3;
with the proviso that if
Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 is
Asp15 Ser16 Arg17 Arg18 Ala19 Gln20 Asp21 Phe22 Val23 Gln24 (SEQ ID NO:378),
then Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 is not
Met27 Asn28 Thr29 Lys30 Arg31 Asn32 (SEQ ID NO:379), and
wherein the second agent is selected from the group consisting of an additional appetite suppressant, a food intake-reducing agent, a dipeptidyl peptidase-IV (DPP-IV) inhibiting agent, a plasma glucose-lowering agent, and a plasma lipid-altering agent.
27 . The pharmaceutical composition of claim 26 , further comprising administering a therapeutically effective amount of a second agent, wherein the second agent is selected from the group consisting of GLP-1 or an analogue thereof, exenatide, pramlintide, amfepramone, phentermine, mazindol, phenylpropanolamine, fenfluramine, dexfenfluramine, sibutramine, rimonabant, fluoxetine, sitagliptin phosphate, and vildagliptin.
28 . The pharmaceutical composition of claim 26 , wherein the peptide and the second agent are administered simultaneously or sequentially.
29 . The pharmaceutical composition of claim 26 , wherein the peptide and the second agent are formulated and administered as a single dose.
30 . The pharmaceutical composition of claim 26 , wherein the subject is overweight, obese or diabetic.
31 . The pharmaceutical composition as claimed in claim 26 which is for peripheral administration.
32 . The pharmaceutical composition as claimed in claim 26 which is for administration subcutaneously, intravenously, intramuscularly, intranasally, transdermally, transmucosally, orally, bucally, sublingually or via the lungs.
33 . The pharmaceutical composition of claim 26 , wherein the peptide comprises a fusion partner, which is an antibody or fragment thereof.
34 . The pharmaceutical composition of claim 26 , wherein
Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 is selected from the group consisting of: Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24 (SEQ ID NO:362), Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24 (SEQ ID NO:363), Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24 (SEQ ID NO:364), Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24 (SEQ ID NO:365), Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24 (SEQ ID NO:366), Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24 (SEQ ID NO:367), Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24 (SEQ ID NO:368), Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24 (SEQ ID NO:370), Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24 (SEQ ID NO:371), Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24 (SEQ ID NO:372), Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24 (SEQ ID NO:373), Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24 (SEQ ID NO:374), Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24 (SEQ ID NO:375), Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24 (SEQ ID NO:376),
and Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24 (SEQ ID NO:377).
35 . The pharmaceutical composition of claim 26 , wherein the peptide comprises an amino acid sequence selected from the group consisting of:
(SEQ ID NO: 1)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 2)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 3)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 4)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 5)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 6)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 7)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 8)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 9
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 10)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 11)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 12)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 13)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 14)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 15)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 16)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 17)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 18)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 19)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 20)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 21)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 25)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 26)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 27)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 28)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 29)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 30)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 31)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 32)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 33)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 34)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 35)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 36)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 37)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 38)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 39)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 40)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 41)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 42)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 43)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 44)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 45)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 49)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 50)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 51)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 52)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 53)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 54)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 55)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 56)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 57)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 58)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 59
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 60
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 61
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 62)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 63)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 64)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 65)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 66)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 67)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 68)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 69)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 73)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 74)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 75)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 76)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 77)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 78)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 79)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 80)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 81)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 82)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 83)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 84)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 85)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 86)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 87)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 88)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 89)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 90)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 91)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 92)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 93)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 97)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 98)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 99)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 100)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 101)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 102)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 103)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 104)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 105)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 106)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 107)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 108)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 109)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 110)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 111)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 112)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 113)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 114)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 115)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 116)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 117)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 121)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 122)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 123)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 124)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 125)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 126)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 127)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 128)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 129)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 130)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 131)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 132)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 133)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 134)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 135)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 136)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 137)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 138)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 139)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 140)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 141)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 145)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 146)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 147)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 148)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 149)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 150)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 151)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 152)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 153)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 154)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 155)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 156)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 157)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 158)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 159)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 160)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 161)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 162)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 163)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 164)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 165)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 169)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 170)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 171)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 172)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 173)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 174)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 175)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 176)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 177)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 178)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 179)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 180)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 181)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 182)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 183)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 184)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 185)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 186)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 187)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 188)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 189)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala;
(SEQ ID NO: 215)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 216)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 217)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 218)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 220)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 221)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 222)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 223)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 225)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 226)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 227)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 228)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 229)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 231)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 232)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 233)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 234)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 236)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 237)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 238)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 239)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 240)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 244)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 245)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 246)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-
myristoyl
(SEQ ID NO: 247)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-
palmitoyl
(SEQ ID NO: 248)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-
stearoyl
(SEQ ID NO: 249)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-
arachidoyl
(SEQ ID NO: 250)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys
(SEQ ID NO: 251)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-
myristoyl
(SEQ ID NO: 252)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-
palmitoyl
(SEQ ID NO: 253)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-
arachidoyl
(SEQ ID NO: 254)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 255)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 256)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 257)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 259)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 260)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 261)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 262)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 264)
L-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 265)
L-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 266)
L-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 267)
L-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 268)
L-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 270)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 271)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 272)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 273)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 275)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 276)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 277)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 278)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 279)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 283)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 284)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 285)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala
Lys-myristoyl
(SEQ ID NO: 286)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-
palmitoyl
(SEQ ID NO: 287)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-
stearoyl
(SEQ ID NO: 288)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-
arachidoyl
(SEQ ID NO: 289)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys
(SEQ ID NO: 290)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-
myristoyl
(SEQ ID NO: 291)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-
palmitoyl
(SEQ ID NO: 292)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-
arachidoyl
(SEQ ID NO: 293)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 294)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 295)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 297)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 298)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 299)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 301)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 302)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 303)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 304)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 305)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 307)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 308)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 309)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 310)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 314)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 315)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 316)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala
Lys-myristoyl
(SEQ ID NO: 317)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-
palmitoyl
(SEQ ID NO: 318)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-
stearoyl
(SEQ ID NO: 319)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-
arachidoyl
(SEQ ID NO: 320)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys
(SEQ ID NO: 321)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-
myristoyl
(SEQ ID NO: 322)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-
palmitoyl
(SEQ ID NO: 323)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-
arachidoyl
(SEQ ID NO: 324)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 325)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 326)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 328)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 329)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 330)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 332)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 333)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 334)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 335)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 336)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 338)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 339)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 340)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 341)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 345)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 346)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 347)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-
myristoyl
(SEQ ID NO: 348)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-
palmitoyl
(SEQ ID NO: 349)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-
stearoyl
(SEQ ID NO: 350)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-
arachidoyl
(SEQ ID NO: 351)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys
(SEQ ID NO: 352)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-
myristoyl
(SEQ ID NO: 353)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-
palmitoyl;
and
(SEQ ID NO: 354)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-
arachidoyl.
36 . The pharmaceutical composition of claim 26 , wherein the peptide is a peptide conjugate comprising an additional extension moiety of sequence -A-B-C, wherein:
A is absent or 1, 2, 3 or 4 Ala residues or 1, 2, 3 or 4 Glu residues B is absent or 1, 2, 3 or 4 Ala residues or 1, 2, 3 or 4 Glu residues
provided that A and B do not both comprise Ala residues, and that A and B do not both comprise Glu residues; and
C is Lys, or Lys with an acid selected from capric acid, lauric acid, myristic acid, palmitic acid, stearic acid and arachidic acid, attached via its —COOH group to the —NH 2 group of the Lys side chain by means of a peptide bond.
37 . The pharmaceutical composition as claimed in claim 36 , wherein the peptide has a sequence selected from the group consisting of:
(SEQ ID NO: 204)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Ile Gln
Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile
Ala Lys
(SEQ ID NO: 205)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Gln Glu Leu Val Lys Tyr Phe Ile Gln
Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile
Ala Lys
(SEQ ID NO: 206)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Ile Gln
Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile
Ala Ala Ala Lys-myristoyl
(SEQ ID NO: 207)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Ile Gln
Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile
Ala Ala Ala Lys-palmitoyl
(SEQ ID NO: 208)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Ile Gln
Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile
Ala Ala Ala Lys-stearoyl
(SEQ ID NO: 209)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Ile Gln
Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile
Ala Ala Ala Lys-arachidoyl
(SEQ ID NO: 210)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Leu
Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn
Asn Ile Ala Glu Ala Lys
(SEQ ID NO: 211)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Leu Gln
Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile
Ala Glu Ala Lys-myristoyl
(SEQ ID NO: 212)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Leu Gln
Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile
Ala Glu Ala Lys-myristoyl
(SEQ ID NO: 213)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Leu Gln
Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile
Ala Glu Ala Lys-palmitoyl
(SEQ ID NO: 214)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Leu Gln
Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile
Ala Glu Ala Lys-arachidoyl
38 . A method of preventing obesity, treating or preventing diabetes or a co-morbidity of obesity, reducing food intake, reducing caloric intake, reducing body weight, reducing body weight gain, increasing energy expenditure, causing weight loss or preventing weight gain for cosmetic purposes in a subject in need thereof comprising administering to the subject a peptide comprising the amino acid sequence:
(SEQ ID NO: 356)
Xaa1 Xaa2 Xaa3 Gly4 Thr5 Phe6 Thr7 Ser8 Asp9 Tyr10
Ser11 Lys12 Tyr13 Leu14 Xaa15 Xaa16 Xaa17 Xaa18
Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 Trp25 Leu26
Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 Lys33 Xaa34
Asn35 Ile36 Ala37;
wherein:
Xaa1 is His1 or D-His1,
Xaa2 is Ser2 or Ala2,
Xaa3 is Gln3 or Asp3;
Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 is selected from the group consisting of:
Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24 (SEQ ID NO:362),
Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24 (SEQ ID NO:363),
Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24 (SEQ ID NO:364),
Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24 (SEQ ID NO:365),
Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24 (SEQ ID NO:366),
Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24 (SEQ ID NO:367),
Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24 (SEQ ID NO:368),
Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24 (SEQ ID NO:370),
Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24 (SEQ ID NO:371),
Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24 (SEQ ID NO:372),
Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24 (SEQ ID NO:373),
Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24 (SEQ ID NO:374),
Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24 (SEQ ID NO:375),
Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24 (SEQ ID NO:376),
and Asp15 Ser16 Arg17 Arg18 Ala19 Gln20 Asp21 Phe22 Val23 Gln24 (SEQ ID NO:378);
Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 is:
Met27 Asn28 Thr29 Lys30 Arg31 Asn32 (SEQ ID NO:379),
Lys27 Asn28 Ala29 Gly30 Pro31 Ser32 (SEQ ID NO:380),
or Lys27 Asn28 Gly29 Gly30 Pro31 Ser32 (SEQ ID NO:381); and
Xaa34 is Asn34 or Asp34;
wherein the peptide optionally comprises a fusion partner;
or a peptide as set out above in which Xaa3 is Glu3;
with the proviso that if
Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 is
Asp15 Ser16 Arg17 Arg18 Ala19 Gln20 Asp21 Phe22 Val23 Gln24 (SEQ ID NO:378),
then Xaa27 Xaa28 Xaa29 Xaa30 Xaa31 Xaa32 is not
Met27 Asn28 Thr29 Lys30 Arg31 Asn32 (SEQ ID NO:379).
39 . The method as claimed in claim 38 , wherein the peptide comprises an amino acid sequence selected from the group consisting of:
(SEQ ID NO: 1)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 2)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 3)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 4)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 5)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 6)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 7)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 8)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 9
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 10)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 11)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 12)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 13)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 14)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 15)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 16)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 17)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 18)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 19)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 20)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 21)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 25)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 26)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 27)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 28)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 29)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 30)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 31)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 32)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 33)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 34)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 35)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 36)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys Tyr
Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 37)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 38)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 39)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 40)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 41)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 42)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 43)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 44)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 45)
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys Tyr
Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 49)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 50)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 51)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 52)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 53)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 54)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 55)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 56)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 57)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 58)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 59
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 60
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 61
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 62)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 63)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 64)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 65)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 66)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 67)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 68)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 69)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 73)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 74)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 75)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 76)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 77)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 78)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 79)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 80)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 81)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 82)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 83)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 84)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 85)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 86)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 87)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 88)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 89)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 90)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 91)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 92)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 93)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 97)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 98)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 99)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 100)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 101)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 102)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 103)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 104)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 105)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 106)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 107)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 108)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 109)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 110)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 111)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 112)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 113)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 114)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 115)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 116)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 117)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 121)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 122)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 123)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 124)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 125)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 126)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 127)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 128)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 129)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 130)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 131)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 132)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 133)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 134)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 135)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 136)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 137)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 138)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 139)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 140)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 141)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 145)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 146)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 147)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 148)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 149)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 150)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 151)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 152)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 153)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 154)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 155)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 156)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 157)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 158)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 159)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 160)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 161)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 162)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 163)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 164)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 165)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 169)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 170)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 171)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 172)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 173)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 174)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 175)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 176)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 177)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 178)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 179)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 180)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 181)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 182)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 183)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 184)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 185)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 186)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 187)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 188)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 189)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala;
(SEQ ID NO: 215)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 216)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 217)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 218)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 220)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 221)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 222)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 223)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 225)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 226)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 227)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 228)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 229)
D-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 231)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 232)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 233)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 234)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 236)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 237)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 238)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 239)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 240)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 244)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 245)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 246)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-
myristoyl
(SEQ ID NO: 247)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-
palmitoyl
(SEQ ID NO: 248)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-
stearoyl
(SEQ ID NO: 249)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-
arachidoyl
(SEQ ID NO: 250)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys
(SEQ ID NO: 251)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-
myristoyl
(SEQ ID NO: 252)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-
palmitoyl
(SEQ ID NO: 253)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-
arachidoyl
(SEQ ID NO: 254)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 255)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 256)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 257)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 259)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 260)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 261)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 262)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 264)
L-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 265)
L-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 266)
L-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 267)
L-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 268)
L-His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 270)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 271)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Glu Trp Leu Met Asn Thr Lys Arg Asn Lys Asp Asn Ile Ala
(SEQ ID NO: 272)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 273)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 275)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 276)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 277)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 278)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 279)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala
(SEQ ID NO: 283)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 284)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Lys
(SEQ ID NO: 285)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala
Lys-myristoyl
(SEQ ID NO: 286)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-
palmitoyl
(SEQ ID NO: 287)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-
stearoyl
(SEQ ID NO: 288)
L-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asp Asn Ile Ala Ala Ala Lys-
arachidoyl
(SEQ ID NO: 289)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys
(SEQ ID NO: 290)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-
myristoyl
(SEQ ID NO: 291)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-
palmitoyl
(SEQ ID NO: 292)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asp Asn Ile Ala Glu Ala Lys-
arachidoyl
(SEQ ID NO: 293)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 294)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 295)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 297)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 298)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 299)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 301)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 302)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 303)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 304)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 305)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 307)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 308)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 309)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 310)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 314)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 315)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 316)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala
Lys-myristoyl
(SEQ ID NO: 317)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-
palmitoyl
(SEQ ID NO: 318)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-
stearoyl
(SEQ ID NO: 319)
D-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-
arachidoyl
(SEQ ID NO: 320)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys
(SEQ ID NO: 321)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-
myristoyl
(SEQ ID NO: 322)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-
palmitoyl
(SEQ ID NO: 323)
D-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-
arachidoyl
(SEQ ID NO: 324)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Ile Val Lys
Tyr Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 325)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 326)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 328)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 329)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 330)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 332)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 333)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Met Asn Thr Lys Arg Asn Lys Asn Asn Ile Ala
(SEQ ID NO: 334)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 335)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 336)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Ile Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 338)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 339)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 340)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 341)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala
(SEQ ID NO: 345)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 346)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Gln Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Lys
(SEQ ID NO: 347)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-
myristoyl
(SEQ ID NO: 348)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-
palmitoyl
(SEQ ID NO: 349)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-
stearoyl
(SEQ ID NO: 350)
L-His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Ile Gln Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala Ala Ala Lys-
arachidoyl
(SEQ ID NO: 351)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys
(SEQ ID NO: 352)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-
myristoyl
(SEQ ID NO: 353)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-
palmitoyl;
and
(SEQ ID NO: 354)
L-His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys
Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala Glu Ala Lys-
arachidoyl.
40 . The method as claimed in claim 38 , wherein the peptide is a peptide conjugate comprising an additional extension moiety of sequence -A-B-C, wherein:
A is absent or 1, 2, 3 or 4 Ala residues or 1, 2, 3 or 4 Glu residues B is absent or 1, 2, 3 or 4 Ala residues or 1, 2, 3 or 4 Glu residues
provided that A and B do not both comprise Ala residues, and that A and B do not both comprise Glu residues; and
C is Lys, or Lys with an acid selected from capric acid, lauric acid, myristic acid, palmitic acid, stearic acid and arachidic acid, attached via its —COOH group to the —NH 2 group of the Lys side chain by means of a peptide bond.
41 . The method as claimed in claim 40 , wherein the peptide has a sequence selected from the group consisting of:
(SEQ ID NO: 204)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Ile Gln
Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile
Ala Lys
(SEQ ID NO: 205)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Gln Glu Leu Val Lys Tyr Phe Ile Gln
Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile
Ala Lys
(SEQ ID NO: 206)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Ile Gln
Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile
Ala Ala Ala Lys-myristoyl
(SEQ ID NO: 207)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Ile Gln
Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile
Ala Ala Ala Lys-palmitoyl
(SEQ ID NO: 208)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Ile Gln
Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile
Ala Ala Ala Lys-stearoyl
(SEQ ID NO: 209)
D-His Ala Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Ile Gln
Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile
Ala Ala Ala Lys-arachidoyl
(SEQ ID NO: 210)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Leu Gln
Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile
Ala Glu Ala Lys
(SEQ ID NO: 211)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Leu Gln
Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile
Ala Glu Ala Lys-myristoyl
(SEQ ID NO: 212)
L-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Leu Gln
Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile
Ala Glu Ala Lys-myristoyl
(SEQ ID NO: 213)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Leu Gln
Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile
Ala Glu Ala Lys-palmitoyl
(SEQ ID NO: 214)
D-His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys
Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Leu Gln
Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile
Ala Glu Ala Lys-arachidoyl
42 . The method of claim 38 , further comprising administering a therapeutically effective amount of a second agent, wherein the second agent is selected from the group consisting of an additional appetite suppressant, a food intake-reducing agent, a dipeptidyl peptidase-IV (DPP-IV) inhibiting agent, a plasma glucose-lowering agent, and a plasma lipid-altering agent.
43 . The method of claim 42 , wherein the peptide and the second agent are administered simultaneously or sequentially.
44 . The method of claim 38 , wherein the peptide is administered peripherally.
45 . The method of claim 38 , wherein the peptide further comprises a fusion partner.Cited by (0)
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