Composition comprising coumestrol or a bean extract containing coumestrol

Abstract

The present invention relates to a composition for activating mitochondria comprising coumestrol or a bean extract containing coumestrol.

1 . A method for activating mitochondria comprising
 administering coumestrol or a bean extract comprising coumestrol to a subject in such need in an amount effective to activate mitochondria.   
     
     
         2 . The method according to  claim 1 , wherein the coumestrol or bean extract comprising coumestrol promotes energy metabolism. 
     
     
         3 . The method according to  claim 2 , wherein the coumestrol or bean extract comprising coumestrol relieves fatigue, improves endurance, improves muscular strength or improves motor function. 
     
     
         4 . The method according to  claim 2 , wherein the coumestrol or bean extract comprising coumestrol prevents or improves obesity, hyperlipidemia or hypertension by reducing body fat. 
     
     
         5 . The method according to  claim 1 , wherein the coumestrol or bean extract comprising coumestrol prevents or improves mitochondrial disease. 
     
     
         6 . The method according to  claim 5 , wherein the mitochondrial disease comprises one or more of a neuropsychiatric disease, a cardiovascular disease, a visceral disease, an endocrine disease, a sensory system disease, a joint disease and a muscular disease caused by decreased mitochondrial activity. 
     
     
         7 . The method according to  claim 6 , wherein the neuropsychiatric disease comprises one or more of dementia, Parkinson's disease, stroke, neuropsychiatric disorder, autism, mental retardation, seizure, stroke-like seizure, migraine and nerve pain. 
     
     
         8 . The method according to  claim 6 , wherein the cardiovascular disease comprises one or more of cardiac dysfunction, heart failure, cardiomyopathy, tachycardia, sideroblastic anemia, Pearson syndrome, refractory anemia and hypotension. 
     
     
         9 . The method according to  claim 6 , wherein the visceral disease comprises one or more of liver failure, intestinal pseudoobstruction, irritable bowel syndrome, gastroesophageal reflux disease, constipation, diarrhea, renal tubular acidosis and Fanconi syndrome. 
     
     
         10 . The method according to  claim 6 , wherein the endocrine disease comprises one or more of exocrine pancreatic insufficiency, hypothyroidism, hypoparathyroidism, hypogonadism, developmental delay, type 2 diabetes and hypoglycemia. 
     
     
         11 . The method according to  claim 6 , wherein the sensory system disease comprises one or more of optic atrophy, strabismus, retinitis pigmentosa, blindness and hearing loss. 
     
     
         12 . The method according to  claim 6 , wherein the joint disease comprises one or more of degenerative arthritis, rheumatoid arthritis and osteoarthritis. 
     
     
         13 . The method according to  claim 6 , wherein the muscular disease comprises one or more of ataxia, dysarthria, dysphagia, spasticity, encephalomyopathy, muscular pain, muscular dystrophy, muscle spasm, ptosis, ophthalmoplegia, progressive external ophthalmoplegia, Leber's hereditary optic neuropathy, breathing disorder, declined reflex and autonomic imbalance. 
     
     
         14 - 15 . (canceled)