Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors

Abstract

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where V, W, R 1 , R 2 , R 3 and R 4 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

1 .- 24 . (canceled) 
     
     
         25 . A method of inhibiting human stearoyl-CoA desaturase (hSCD) activity comprising contacting a source of hSCD with a compound of formula (I): 
       
         
           
           
               
               
           
         
         wherein: 
         W is selected from —O—, —OC(O)—, —OC(O)N(R 5 )—, —OS(O) 2 N(R 5 )—, —C(O)—, —C(O)O—, —C(O)N(R 5 )—, —N(R 5 )—, —N(R 5 )C(O)—, —N(R 5 )C(O)O—, —N(R 5 )C(O)N(R 5 )—, —N(R 5 )S(O) 2 —, —S(O) t — (where t is 0, 1 or 2), or —S(O) 2 N(R 5 )—; 
         V is selected from —C(O)—, —C(O)N(R 5 )—, —C(O)O—, —S(O) t — (where t is 1 or 2) or a direct bond; 
         R 1  is selected from alkyl, alkenyl, —R 6 —OR 7 , hydroxyalkenyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; 
         or R 1  is a multi-ring structure having 2 to 4 rings wherein the rings are independently selected from cycloalkyl, heterocyclyl, aryl or heteroaryl and where some or all of the rings may be fused to each other; 
         R 2  is selected from alkyl, alkenyl, —R 6 —OR 7 , hydroxyalkenyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl; 
         or R 2  is a multi-ring structure having 2 to 4 rings wherein the rings are independently selected from cycloalkyl, heterocyclyl, aryl or heteroaryl and where some or all of the rings may be fused to each other; 
         R 3  is selected from hydrogen, alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, aryl, aralkyl, heteroaryl, fluoro, chloro, bromo, trihaloalkyl, trihaloalkoxy, cyano, nitro, —OR 4 , —OC(O)R 2 , —OC(O)N(R 4 )(R 5 ), —OS(O) 2 N(R 4 )(R 5 ), —S(O) t R 2  (where t is 0, 1 or 2), —S(O) t N(R 4 )(R 5 ) (where t is 1 or 2), —C(O)R 2 , —C(O)OR 2 , —C(O)N(R 4 )(R 5 ), —N(R 4 )(R 5 ), —N(R 5 )C(O)R 5 , —N(R 5 )C(O)OR 5 , —N(R 5 )C(O)N(R 4 )(R 5 ) or —N(R 5 )S(O) 2 R 2 ; and 
         each R 4  and R 5  is independently selected from —R 6 —N(R 7 ) 2 , —R 6 —OR 7 , —R 6 —C(O)OR 7 , hydrogen, alkyl, cycloalkylalkyl or aralkyl; 
         each R 6  is a straight or branched alkylene chain; and 
         each R 7  is hydrogen, alkyl, aryl or aralkyl; 
         or a stereoisomer, enantiomer or tautomer thereof, or a racemic or non-racemic mixture thereof, 
         or a pharmaceutically acceptable salt or prodrug thereof. 
       
     
     
         26 . A method of treating a disease or condition mediated by stearoyl-CoA desaturase in a mammal, wherein the method comprises administering to the mammal in need thereof a therapeutically effective amount of a compound of formula (I): 
       
         
           
           
               
               
           
         
         wherein: 
         W is selected from —O—, —OC(O)—, —OC(O)N(R 5 )—, —OS(O) 2 N(R 5 )—, —C(O)—, —C(O)O—, —C(O)N(R 5 )—, —N(R 5 )—, —N(R 5 )C(O)—, —N(R 5 )C(O)O—, —N(R 5 )C(O)N(R 5 )—, —N(R 5 )S(O) 2 —, —S(O) t — (where t is 0, 1 or 2) or —S(O) 2 N(R 5 )—; 
         V is selected from —C(O)—, —C(O)N(R 5 )—, —C(O)O—, —S(O) t — (where t is 1 or 2) or a direct bond; 
         R 1  is selected from alkyl, alkenyl, —R 6 —OR 7 , hydroxyalkenyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl; 
         or R 1  is a multi-ring structure having 2 to 4 rings wherein the rings are independently selected from cycloalkyl, heterocyclyl, aryl or heteroaryl and where some or all of the rings may be fused to each other; 
         R 2  is selected from alkyl, alkenyl, —R 6 —OR 7 , hydroxyalkenyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl; 
         or R 2  is a multi-ring structure having 2 to 4 rings wherein the rings are independently selected from cycloalkyl, heterocyclyl, aryl or heteroaryl and where some or all of the rings may be fused to each other; 
         R 3  is selected from hydrogen, alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, aryl, aralkyl, heteroaryl, fluoro, chloro, bromo, trihaloalkyl, trihaloalkoxy, cyano, nitro, —OR 4 , —OC(O)R 2 , —OC(O)N(R 4 )(R 5 ), —OS(O) 2 N(R 4 )(R 5 ), —S(O) t R 2  (where t is 0, 1 or 2), —S(O) t N(R 4 )(R 5 ) (where t is 1 or 2), —C(O)R 2 , —C(O)OR 2 , —C(O)N(R 4 )(R 5 ), —N(R 4 )(R 5 ), —N(R 5 )C(O)R 5 , —N(R 5 )C(O)OR 5 , —N(R 5 )C(O)N(R 4 )(R 5 ) or —N(R 5 )S(O) 2 R 2 ; 
         each R 4  and R 5  is independently selected from —R 6 —N(R 7 ) 2 , —R 6 —OR 7 , —R 6 —C(O)OR 7 , hydrogen, alkyl, cycloalkylalkyl or aralkyl; 
         each R 6  is a straight or branched alkylene chain; and 
         each R 7  is hydrogen, alkyl, aryl or aralkyl; 
         or a stereoisomer, enantiomer or tautomer thereof, or a racemic or non-racemic mixture thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof; 
         wherein the disease or condition is a body weight disorder, metabolic syndrome, fatty liver, non-alcoholic steatohepatitis or a skin disorder. 
       
     
     
         27 . The method of  claim 26  wherein the body weight disorder is obesity, overweight, cachexia or anorexia. 
     
     
         28 . The method according to  claim 26 , wherein the metabolic syndrome is dyslipidemia, obesity, insulin resistance, hypertension, microalbuminemia, hyperuricaemia or hypercoagulability. 
     
     
         29 . The method according to  claim 26  wherein the skin disorder is eczema, acne, psoriasis or keyloid scar formation. 
     
     
         30 . The method according to any one of  claims 25 - 29  wherein the compound of formula (I) is selected from:
 2-(4-Bromobenzoylamino)-4-methylthiazole-5-carboxylic acid o-tolylamide; 
 2-(4-Bromobenzoylamino)-4-methylthiazole-5-carboxylic acid (2-chlorophenyl)amide; 
 2-(4-Bromobenzoylamino)-4-methylthiazole-5-carboxylic acid (3-methoxyphenyl)amide; 
 4-Methyl-2-(3,4,5-trimethoxybenzoylamino)thiazole-5-carboxylic acid phenylamide; 
 4-Methyl-2-(4-methylbenzoylamino)thiazole-5-carboxylic acid (4-methoxyphenyl)amide; 
 4-Methyl-2-[(thiophene-2-carbonyl)amino]thiazole-5-carboxylic acid (4-chlorophenyl)amide; 
 2-(Cyclohexanecarbonylamino)-4-methylthiazole-5-carboxylic acid (2,3-dihydro-benzo[1,4]dioxin-6-yl)amide, 
 2-(4-Methoxybenzoylamino)-4-methylthiazole-5-carboxylic acid pyridin-3-ylamide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid (5-methyl[1,3,4]thiadiazol-2-yl)amide; 
 2-[(Furan-2-carbonyl)amino]-4-methylthiazole-5-carboxylic acid o-tolylamide; 
 2-[(Furan-2-carbonyl)amino]-4-methylthiazole-5-carboxylic acid (4-bromophenyl)amide; 
 2-(3-Methoxybenzoylamino)-4-methylthiazole-5-carboxylic acid (4-bromophenyl)amide; 
 2-[(Furan-2-carbonyl)amino]-4-methylthiazole-5-carboxylic acid (4-chlorophenyl)amide; 
 2-[(Furan-2-carbonyl)amino]-4-methylthiazole-5-carboxylic acid (3-methoxyphenyl)amide; 
 2-[(Furan-2-carbonyl)amino]-4-methylthiazole-5-carboxylic acid (4-methoxyphenyl)amide; 
 4-Methyl-2-(2-phenoxyacetylamino)thiazole-5-carboxylic acid phenylamide; 
 4-Methyl-2-(2-phenoxyacetylamino)thiazole-5-carboxylic acid benzylamide; 
 2-Chloro-N-[4-methyl-5-(morpholine-4-carbonyl)thiazol-2-yl]benzamide; 
 2-(3-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid (4-bromophenyl)amide; 
 2-(2-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid (4-bromophenyl)amide; 
 2-Acetylamino-4-methylthiazole-5-carboxylic acid indan-5-ylamide; 
 2-Acetylamino-4-methylthiazole-5-carboxylic acid cyclohexylamide; 
 2-(4-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid (4-bromophenyl)amide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid phenylamide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid (3-methoxyphenyl)amide; 
 2-(4-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid (4-methoxyphenyl)amide; 
 4-Methyl-2-propionylaminothiazole-5-carboxylic acid indan-5-ylamide; 
 2-(Cyclopropanecarbonylamino)-4-methylthiazole-5-carboxylic acid phenylamide; 
 2-(Cyclopropanecarbonylamino)-4-methylthiazole-5-carboxylic acid (4-chlorophenyl)amide; 
 2-(4-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid phenylamide; 
 2-(4-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid o-tolylamide; 
 2-(4-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid (4-chlorophenyl)amide; 
 2-(4-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid (2-chlorophenyl)amide; 
 2-(4-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid (3-methoxyphenyl)amide; 
 N-[4-Methyl-5-(piperidine-1-carbonyl)-thiazol-2-yl]benzamide; 
 2-(Cyclopropanecarbonylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(Cyclopropanecarbonylamino)-4-methylthiazole-5-carboxylic acid indan-5-ylamide; 
 4-Methyl-2-(4-methylbenzoylamino)thiazole-5-carboxylic acid pyridin-3-ylamide; 
 4-Methyl-2-propionylaminothiazole-5-carboxylic acid benzylamide; 
 [(2-Benzoylamino-4-methylthiazole-5-carbonyl)amino]acetic acid ethyl ester; 
 N-[4-Methyl-5-(morpholine-4-carbonyl)thiazol-2-yl]propionamide; 
 N-(5-Benzylcarbamoyl-4-methylthiazol-2-yl)isonicotinamide; 
 N-[5-(3-Chlorophenylcarbamoyl)-4-methylthiazol-2-yl]isonicotinamide; 
 N-[5-(2-Chlorophenylcarbamoyl)-4-methylthiazol-2-yl]isonicotinamide; 
 N-(4-Oxo-5,6,7,8-tetrahydro-4H-thiazolo[5,4-c]azepin-2-yl)acetamide; 
 N-(7,7-Dimethyl-4-oxo-5,6,7,8-tetrahydro-4H-thiazolo[5,4-c]azepin-2-yl)acetamide; 
 2-(3-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid phenylamide; 
 4-Methyl-2-(4-methylbenzoylamino)thiazole-5-carboxylic acid o-tolylamide; 
 2-(2-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid o-tolylamide; 
 2-(4-Bromobenzoylamino)-4-methylthiazole-5-carboxylic acid (4-chlorophenyl)amide; 
 4-Methyl-2-(3,4,5-trimethoxybenzoylamino)thiazole-5-carboxylic acid (4-chlorophenyl)amide; 
 2-(4-Bromobenzoylamino)-4-methylthiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 4-Methyl-2-(3-methylbenzoylamino)thiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 2-(3-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 4-Methyl-2-(2-methylbenzoylamino)thiazole-5-carboxylic acid (2-chlorophenyl)amide; 
 4-Methyl-2-(3,4,5-trimethoxybenzoylamino)thiazole-5-carboxylic acid (2-chlorophenyl)amide; 
 4-Methyl-2-(3-methylbenzoylamino)thiazole-5-carboxylic acid (2-chlorophenyl)amide; 
 2-(3-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid (2-chlorophenyl)amide; 
 2-(4-Bromobenzoylamino)-4-methylthiazole-5-carboxylic acid (2,3-dihydro-benzo[1,4]dioxin-6-yl)amide; 
 2-(4-Methoxybenzoylamino)-4-methylthiazole-5-carboxylic acid (2,3-dihydro-benzo[1,4]dioxin-6-yl)amide; 
 4-Methyl-2-(3-methylbenzoylamino)thiazole-5-carboxylic acid (2,3-dihydrobenzo[1,4]dioxin-6-yl)amide; 
 2-(4-Bromobenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(4-Bromobenzoylamino)-4-methylthiazole-5-carboxylic acid indan-5-ylamide; 
 4-Methyl-2-(3-methylbenzoylamino)thiazole-5-carboxylic acid indan-5-ylamide; 
 4-Methyl-2-(3,4,5-trimethoxybenzoylamino)thiazole-5-carboxylic acid cyclohexylamide; 
 2-Fluoro-N-[4-methyl-5-(piperidine-1-carbonyl)thiazol-2-yl]benzamide; 
 4-Bromo-N-[4-methyl-5-(morpholine-4-carbonyl)thiazol-2-yl]benzamide; 
 4-Methoxy-N-[4-methyl-5-(morpholine-4-carbonyl)thiazol-2-yl]benzamide; 
 2-(Cyclohexanecarbonylamino)-4-methylthiazole-5-carboxylic acid (4-methoxyphenyl)amide; 
 4-Methyl-2-(3,4,5-trimethoxybenzoylamino)thiazole-5-carboxylic acid o-tolylamide; 
 4-Methyl-2-(3,4,5-trimethoxybenzoylamino)thiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 2-(4-Methoxybenzoylamino)-4-methylthiazole-5-carboxylic acid (3-methoxyphenyl)amide; 
 4-Methyl-2-(4-methylbenzoylamino)thiazole-5-carboxylic acid (2,3-dihydrobenzo[1,4]dioxin-6-yl)amide; 
 4-Methyl-2-(3,4,5-trimethoxybenzoylamino)thiazole-5-carboxylic acid (2,3-dihydro-benzo[1,4]dioxin-6-yl)amide; 
 4-Methyl-2-(4-methylbenzoylamino)thiazole-5-carboxylic acid benzylamide; 
 4-Methyl-2-(4-methylbenzoylamino)thiazole-5-carboxylic acid indan-5-ylamide; 
 4-Methyl-2-(4-methylbenzoylamino)thiazole-5-carboxylic acid (4-chlorophenyl)amide; 
 4-Methyl-2-(4-methylbenzoylamino)thiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 4-Methyl-2-(4-methylbenzoylamino)thiazole-5-carboxylic acid (2-chlorophenyl)amide; 
 4-Methyl-2-(4-methylbenzoylamino)thiazole-5-carboxylic acid (3-methoxyphenyl)amide; 
 4-Methyl-2-(4-methylbenzoylamino)thiazole-5-carboxylic acid phenylamide; 
 2-(Cyclohexanecarbonylamino)-4-methylthiazole-5-carboxylic acid (4-chlorophenyl)amide; 
 2-(Cyclohexanecarbonylamino)-4-methylthiazole-5-carboxylic acid (2-chlorophenyl)amide; 
 3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [5-(2-chloro-phenylcarbamoyl)-4-methylthiazol-2-yl]amide; 
 2-(Cyclohexanecarbonylamino)-4-methylthiazole-5-carboxylic acid indan-5-ylamide; 
 {[2-(4-Methoxy-benzoylamino)-4-methylthiazole-5-carbonyl]amino}acetic acid ethyl ester; 
 3-Fluoro-N-[4-methyl-5-(morpholine-4-carbonyl)thiazol-2-yl]benzamide; 
 2-[(5-Chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)amino]-4-methylthiazole-5-carboxylic acid cyclohexylamide; 
 4-Methyl-2-(3-phenylacryloylamino)thiazole-5-carboxylic acid (2-dimethylaminoethyl)amide; 
 2-[(Furan-2-carbonyl)amino]-4-methylthiazole-5-carboxylic acid phenylamide; 
 2-[(Adamantane-1-carbonyl)amino]-4-methylthiazole-5-carboxylic acid phenylamide; 
 2-[(Adamantane-1-carbonyl)amino]-4-methylthiazole-5-carboxylic acid (4-bromophenyl)amide; 
 2-(3-Methoxybenzoylamino)-4-methylthiazole-5-carboxylic acid (4-chlorophenyl)amide; 
 2-[(Furan-2-carbonyl)amino]-4-methylthiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 2-(3-Methoxybenzoylamino)-4-methylthiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 2-(3-Methoxybenzoylamino)-4-methylthiazole-5-carboxylic acid (2-chlorophenyl)amide; 
 2-(3-Methoxybenzoylamino)-4-methylthiazole-5-carboxylic acid (2,3-dihydro-benzo[1,4]dioxin-6-yl)amide; 
 2-(3-Methoxybenzoylamino)-4-methylthiazole-5-carboxylic acid indan-5-ylamide; 
 {[2-(3-Methoxybenzoylamino)-4-methylthiazole-5-carbonyl]amino}acetic acid ethyl ester; 
 2-(4-Bromobenzoylamino)-4-methylthiazole-5-carboxylic acid (5-methyl[1,3,4]thiadiazol-2-yl)amide; 
 2-(3-Methoxy-benzoylamino)-4-methylthiazole-5-carboxylic acid (4-methoxyphenyl)amide; 
 2-[(Adamantane-1-carbonyl)amino]-4-methylthiazole-5-carboxylic acid (4-methoxyphenyl)amide; 
 3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (4-methyl-5-phenylcarbamoyl-thiazol-2-yl)amide; 
 3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (4-methyl-5-o-tolylcarbamoyl-thiazol-2-yl)amide; 
 2-[(5-Chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)amino]-4-methylthiazole-5-carboxylic acid (4-bromophenyl)amide; 
 2-[(5-Chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)amino]-4-methylthiazole-5-carboxylic acid (2-chlorophenyl)amide; 
 3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [5-(2,3-dihydro-benzo[1,4]dioxin-6-ylcarbamoyl)-4-methylthiazol-2-yl]amide; 
 3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [5-(indan-5-ylcarbamoyl)-4-methylthiazol-2-yl]amide; 
 3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [4-methyl-5-(5-methyl-[1,3,4]thiadiazol-2-ylcarbamoyl)thiazol-2-yl]amide; 
 3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [4-methyl-5-(piperidine-1-carbonyl)thiazol-2-yl]amide; 
 3-Methyl-N-[4-methyl-5-(piperidine-1-carbonyl)thiazol-2-yl]benzamide; 
 3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [5-(4-methoxy-phenylcarbamoyl)-4-methylthiazol-2-yl]amide; 
 4-Methyl-2-(4-methylbenzoylamino)thiazole-5-carboxylic acid cyclohexylamide; 
 2-(Cyclohexanecarbonylamino)-4-methylthiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 4-Methyl-2-[(thiophene-2-carbonyl)amino]thiazole-5-carboxylic acid (2,3-dihydro-benzo[1,4]dioxin-6-yl)amide; 
 2-[(Adamantane-1-carbonyl)amino]-4-methylthiazole-5-carboxylic acid benzylamide; 
 4-Methyl-2-(4-methylbenzoylamino)thiazole-5-carboxylic acid (4-bromophenyl)amide; 
 2-(Cyclohexanecarbonylamino)-4-methylthiazole-5-carboxylic acid (4-bromophenyl)amide; 
 4-Methyl-2-(3-methylbenzoylamino)thiazole-5-carboxylic acid (4-bromophenyl)amide; 
 2-(2-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid (4-chlorophenyl)amide; 
 2-(2-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid (2-chlorophenyl)amide; 
 2-(3-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid indan-5-ylamide; 
 3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [5-(4-chloro-phenylcarbamoyl)-4-methylthiazol-2-yl]amide; 
 4-Methyl-2-(3-phenylacryloylamino)thiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 2-Acetylamino-4-methylthiazole-5-carboxylic acid (3-methoxyphenyl)amide; 
 4-Methyl-2-(4-nitrobenzoylamino)thiazole-5-carboxylic acid (4-methoxyphenyl)amide; 
 2-Acetylamino-4-methylthiazole-5-carboxylic acid (4-chlorophenyl)amide; 
 2-Acetylamino-4-methylthiazole-5-carboxylic acid (4-methoxyphenyl)amide; 
 4-Methyl-2-(4-methylbenzoylamino)thiazole-5-carboxylic acid (5-methyl[1,3,4]thiadiazol-2-yl)amide; 
 2-(4-Bromobenzoylamino)-4-methylthiazole-5-carboxylic acid phenylamide; 
 4-Methyl-2-(3-phenylacryloylamino)thiazole-5-carboxylic acid (4-methoxyphenyl)amide; 
 4-Methyl-2-propionylaminothiazole-5-carboxylic acid (4-methoxyphenyl)amide; 
 2-(Cyclopropanecarbonylamino)-4-methylthiazole-5-carboxylic acid (4-methoxyphenyl)amide; 
 4-Methyl-2-propionylamino-thiazole-5-carboxylic acid (4-bromophenyl)amide; 
 4-Methyl-2-(4-nitrobenzoylamino)thiazole-5-carboxylic acid (2-chlorophenyl)amide; 
 {[2-(4-Fluorobenzoylamino)-4-methylthiazole-5-carbonyl]amino}acetic acid ethyl ester; 
 {[2-(3-Fluorobenzoylamino)-4-methylthiazole-5-carbonyl]amino}acetic acid ethyl ester; 
 2-(2-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid (4-methoxyphenyl)amide; 
 N-[4-Methyl-5-(piperidine-1-carbonyl)thiazol-2-yl]-2-phenoxyacetamide; 
 2-(4-tert-Butylbenzoylamino)-4-methylthiazole-5-carboxylic acid (4-bromophenyl)amide; 
 4-Methyl-2-(3-phenylacryloylamino)thiazole-5-carboxylic acid (4-bromophenyl)amide; 
 4-Methyl-2-(3-phenylacryloylamino)thiazole-5-carboxylic acid (4-chlorophenyl)amide; 
 2-(4-tert-Butylbenzoylamino)-4-methylthiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 2-(4-tert-Butylbenzoylamino)-4-methylthiazole-5-carboxylic acid (2-chlorophenyl)amide; 
 4-Methyl-2-(3-phenylacryloylamino)thiazole-5-carboxylic acid benzylamide; 
 2-(4-tert-Butylbenzoylamino)-4-methylthiazole-5-carboxylic acid cyclohexylamide; 
 2-(4-Methoxybenzoylamino)-4-methylthiazole-5-carboxylic acid (5-methyl[1,3,4]thiadiazol-2-yl)amide; 
 4-Methyl-2-(4-nitro-benzoylamino)thiazole-5-carboxylic acid o-tolylamide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid (4-bromophenyl)amide; 
 4-Methyl-2-(2-methylbenzoylamino)thiazole-5-carboxylic acid (4-bromophenyl)amide; 
 4-Methyl-2-(2-phenoxyacetylamino)thiazole-5-carboxylic acid (4-bromophenyl)amide; 
 3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [5-(4-bromo-phenylcarbamoyl)-4-methylthiazol-2-yl]amide; 
 4-Methyl-2-(4-nitrobenzoylamino)thiazole-5-carboxylic acid (4-chlorophenyl)amide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 4-Methyl-2-(2-phenoxyacetylamino)thiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [5-(3-chloro-phenylcarbamoyl)-4-methylthiazol-2-yl]amide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid o-tolylamide; 
 4-Methyl-2-(2-phenoxy-acetylamino)thiazole-5-carboxylic acid (3-methoxyphenyl)amide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid (2,3-dihydrobenzo[1,4]dioxin-6-yl)amide; 
 3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (5-benzylcarbamoyl-4-methylthiazol-2-yl)amide; 
 4-Methyl-2-propionylaminothiazole-5-carboxylic acid (3-methoxyphenyl)amide; 
 3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid [5-(3-methoxy-phenylcarbamoyl)-4-methylthiazol-2-yl]amide; 
 4-Methyl-2-(2-methylbenzoylamino)thiazole-5-carboxylic acid indan-5-ylamide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid (4-methoxyphenyl)amide; 
 4-Methyl-2-(2-phenoxyacetylamino)thiazole-5-carboxylic acid (4-methoxyphenyl)amide; 
 4-Methyl-2-(3,4,5-trimethoxybenzoylamino)thiazole-5-carboxylic acid (4-methoxyphenyl)amide; 
 2-(Cyclopropanecarbonylamino)-4-methylthiazole-5-carboxylic acid o-tolylamide; 
 4-Methyl-2-propionylaminothiazole-5-carboxylic acid (4-chlorophenyl)amide; 
 4-Methyl-2-propionylaminothiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 4-Methyl-2-propionylaminothiazole-5-carboxylic acid (2-chlorophenyl)amide; 
 4-Methyl-2-(4-nitrobenzoylamino)thiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 2-(4-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid (2,3-dihydrobenzo[1,4]dioxin-6-yl)amide; 
 2-(4-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid indan-5-ylamide; 
 4-Fluoro-N-[4-methyl-5-(piperidine-1-carbonyl)thiazol-2-yl]benzamide; 
 2-(4-tert-Butylbenzoylamino)-4-methylthiazole-5-carboxylic acid indan-5-ylamide; 
 4-Methyl-2-propionylaminothiazole-5-carboxylic acid cyclohexylamide; 
 N-[4-Methyl-5-(piperidine-1-carbonyl)thiazol-2-yl]propionamide; 
 2-(Cyclopropanecarbonylamino)-4-methylthiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 2-(3-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid (3-methoxyphenyl)amide; 
 2-(Cyclopropanecarbonylamino)-4-methylthiazole-5-carboxylic acid (2-chlorophenyl)amide; 
 4-Methyl-2-(4-nitrobenzoylamino)thiazole-5-carboxylic acid phenylamide; 
 2-(Cyclopropanecarbonylamino)-4-methylthiazole-5-carboxylic acid cyclohexylamide; 
 4-Methyl-2-(4-nitrobenzoylamino)thiazole-5-carboxylic acid (2,3-dihydrobenzo[1,4]dioxin-6-yl)amide; 
 2-(4-tert-Butylbenzoylamino)-4-methylthiazole-5-carboxylic acid phenylamide; 
 4-Methyl-2-(3-phenylacryloylamino)thiazole-5-carboxylic acid phenylamide; 
 4-Methyl-2-(3-phenylacryloylamino)thiazole-5-carboxylic acid o-tolylamide; 
 4-Methyl-2-[(thiophene-2-carbonyl)amino]thiazole-5-carboxylic acid (5-methyl-[1,3,4]thiadiazol-2-yl)amide; 
 4-Methyl-2-(3-phenylacryloylamino)thiazole-5-carboxylic acid (2-chlorophenyl)amide; 
 4-Methyl-2-(4-nitrobenzoylamino)thiazole-5-carboxylic acid (4-bromophenyl)amide; 
 4-Methyl-2-(3-phenylacryloylamino)thiazole-5-carboxylic acid indan-5-ylamide; 
 4-Methyl-2-(3-phenylacryloylamino)thiazole-5-carboxylic acid (2-hydroxy-ethyl)amide; 
 3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (5-cyclohexylcarbamoyl-4-methylthiazol-2-yl)amide; 
 {[2-(2-Fluorobenzoylamino)-4-methylthiazole-5-carbonyl]amino}acetic acid ethyl ester; 
 4-Methyl-2-(3,4,5-trimethoxybenzoylamino)thiazole-5-carboxylic acid (4-bromophenyl)amide; 
 2-(Cyclohexanecarbonylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 N-[4-Methyl-5-(morpholine-4-carbonyl)thiazol-2-yl]-3-phenylacrylamide; 
 N-[4-Methyl-5-(morpholine-4-carbonyl)thiazol-2-yl]-4-nitrobenzamide; 
 {[4-Methyl-2-(3-phenylacryloylamino)thiazole-5-carbonyl]amino}acetic acid ethyl ester; 
 4-Methyl-2-(3-phenylacryloylamino)thiazole-5-carboxylic acid (2,3-dihydrobenzo[1,4]dioxin-6-yl)amide; 
 4-Methyl-2-(3-phenylacryloylamino)thiazole-5-carboxylic acid pyridin-3-ylamide; 
 N-[4-Methyl-5-(piperidine-1-carbonyl)thiazol-2-yl]-3-phenylacrylamide; 
 4-Methyl-2-(3-phenylacryloylamino)thiazole-5-carboxylic acid cyclohexylamide; 
 4-Methyl-2-(3,4,5-trimethoxybenzoylamino)thiazole-5-carboxylic acid (5-methyl-[1,3,4]thiadiazol-2-yl)amide; 
 4-Methyl-2-propionylaminothiazole-5-carboxylic acid o-tolylamide; 
 Cyclopropanecarboxylic acid [4-methyl-5-(piperidine-1-carbonyl)thiazol-2-yl]amide; 
 4-Methyl-2-(2-phenoxyacetylamino)thiazole-5-carboxylic acid o-tolylamide; 
 4-Methyl-2-(2-phenoxyacetylamino)thiazole-5-carboxylic acid (2,3-dihydrobenzo[1,4]dioxin-6-yl)amide; 
 2-(Cyclopropanecarbonylamino)-4-methylthiazole-5-carboxylic acid (4-bromophenyl)amide; 
 4-Methyl-2-(3,4,5-trimethoxybenzoylamino)thiazole-5-carboxylic acid indan-5-ylamide; 
 2-[(Adamantane-1-carbonyl)amino]-4-methylthiazole-5-carboxylic acid cyclohexylamide; 
 2-(3-Chlorobenzoylamino)-4-methylthiazole-5-carboxylic acid pyridin-3-ylamide; 
 2-(3-Chlorobenzoylamino)-4-methylthiazole-5-carboxylic acid cyclohexylamide; 
 {[4-Methyl-2-(3,4,5-trimethoxybenzoylamino)thiazole-5-carbonyl]amino}acetic acid ethyl ester; 
 4-Methyl-2-(2-methylbenzoylamino)thiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 2-(4-Chlorobenzoylamino)-4-methylthiazole-5-carboxylic acid cyclohexylamide; 
 4-Methyl-2-(4-methylbenzoylamino)thiazole-5-carboxylic acid (2-dimethylaminoethyl)amide; 
 5-tert-Butyl-2-methyl-2H-pyrazole-3-carboxylic acid (7,7-dimethyl-4-oxo-5,6,7,8-tetrahydro-4H-thiazolo[5,4-c]azepin-2-yl)amide; 
 2-[(5-Chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)amino]-4-methylthiazole-5-carboxylic acid indan-5-ylamide; 
 4-Methyl-2-(4-nitrobenzoylamino)thiazole-5-carboxylic acid indan-5-ylamide; 
 2-Acetylamino-4-methylthiazole-5-carboxylic acid (5-methyl[1,3,4]thiadiazol-2-yl)amide; 
 2-Chloro-N-(7,7-dimethyl-4-oxo-5,6,7,8-tetrahydro-4H-thiazolo[5,4-c]azepin-2-yl)-benzamide; 
 N-(7,7-Dimethyl-4-oxo-5,6,7,8-tetrahydro-4H-thiazolo[5,4-c]azepin-2-yl)benzamide; 
 N-(4-Oxo-5,6,7,8-tetrahydro-4H-thiazolo[5,4-c]azepin-2-yl)benzamide; 
 2-Chloro-N-(4-oxo-5,6,7,8-tetrahydro-4H-thiazolo[5,4-c]azepin-2-yl)benzamide; 
 2-(3,4-Dimethoxybenzoylamino)-4-methylthiazole-5-carboxylic acid dimethylamide; 
 4-Methyl-2-(2-phenyl-propionylamino)thiazole-5-carboxylic acid dimethylamide; 
 2-(2,6-Difluorobenzoylamino)-4-methylthiazole-5-carboxylic acid dimethylamide; 
 3-Chloro-N-[4-methyl-5-(piperidine-1-carbonyl)thiazol-2-yl]benzamide; 
 2-[2-(4-Chloro-2-methylphenoxy)propionylamino]-4-methylthiazole-5-carboxylic acid dimethylamide; 
 6,8-Dimethyl-2-pyridin-4-ylquinoline-4-carboxylic acid (5-dimethylcarbamoyl-4-methylthiazol-2-yl)amide; 
 4-Methyl-2-[(3-methylbenzofuran-2-carbonyl)amino]thiazole-5-carboxylic acid dimethylamide; 
 2-Acetylamino-4-methylthiazole-5-carboxylic acid (3-chlorophenyl)amide; 
 4-Methyl-2-(2-phenoxyacetylamino)thiazole-5-carboxylic acid indan-5-ylamide; 
 5-(7,7-Dimethyl-4-oxo-5,6,7,8-tetrahydro-4H-thiazolo[5,4-c]azepin-2-ylcarbamoyl)-thiophene-2-carboxylic acid methyl ester; 
 4-Methyl-2-(3-methylbenzoylamino)thiazole-5-carboxylic acid cyclohexylamide; 
 4-Methyl-2-(3-phenylacryloylamino)thiazole-5-carboxylic acid (3-methoxyphenyl)amide; 
 4-Methyl-2-(4-nitrobenzoylamino)thiazole-5-carboxylic acid (3-methoxyphenyl)amide; 
 2-[(Adamantane-1-carbonyl)amino]-4-methylthiazole-5-carboxylic acid (3-methoxyphenyl)amide; 
 N-[5-(2-Cyclopropylethylcarbamoyl)-4-methylthiazol-2-yl]isonicotinamide; 
 N-(4-Methyl-5-phenethylcarbamoylthiazol-2-yl)isonicotinamide; 
 N-[4-Methyl-5-(3-phenylpropylcarbamoyl)thiazol-2-yl]isonicotinamide; 
 N-[5-(4-Chlorobenzylcarbamoyl)-4-methylthiazol-2-yl]isonicotinamide; 
 2-(Cyclopropanecarbonylamino)-4-methylthiazole-5-carboxylic acid 4-chloro-benzylamide; 
 2-(2,5-Difluorobenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(Cyclobutanecarbonylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 4-Methyl-2-[(2-phenylcyclopropanecarbonyl)amino]thiazole-5-carboxylic acid benzylamide; 
 2-(2-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(2,2-Dimethylpropionylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid benzylamide; 
 4-Methyl-2-(2-trifluoromethylbenzoylamino)thiazole-5-carboxylic acid benzylamide; 
 2-(4-Chlorobenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(4-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 4-Methyl-2-(4-trifluoromethylbenzoylamino)thiazole-5-carboxylic acid benzylamide; 
 2-(2-Chlorobenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(2,4-Dichlorobenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(Cyclopentanecarbonylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(2-Chloro-4-fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(3-Chlorobenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 4-Methyl-2-(2-trifluoromethoxybenzoylamino)thiazole-5-carboxylic acid benzylamide; 
 2-(3,5-Dichlorobenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(3-Cyanobenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(5-Chloro-2-fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(3-Fluorobenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 4-Methyl-2-(4-trifluoromethoxybenzoylamino)thiazole-5-carboxylic acid benzylamide; 
 4-Methyl-2-(3-trifluoromethylbenzoylamino)thiazole-5-carboxylic acid benzylamide; 
 2-(3-Methoxybenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 4-Methyl-2-[(naphthalene-1-carbonyl)amino]thiazole-5-carboxylic acid benzylamide; 
 2-(4-Cyanobenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(3,5-Difluorobenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 4-Methyl-2-(3-trifluoromethoxybenzoylamino)thiazole-5-carboxylic acid benzylamide; 
 2-(4-Methoxybenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(3-Methanesulfonylbenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(2-Methanesulfonylbenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-Benzoylamino-4-trifluoromethylthiazole-5-carboxylic acid benzylamide; 
 N-(5-Benzylcarbamoyl-4-methylthiazol-2-yl)nicotinamide; 
 2-(3,4-Dichlorobenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(4-Methanesulfonylbenzoylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 4-Methyl-2-(3-phenylpropionylamino)thiazole-5-carboxylic acid benzylamide; 
 2-Benzylamino-4-methylthiazole-5-carboxylic acid benzylamide; 
 4-Methyl-2-phenylacetylaminothiazole-5-carboxylic acid benzylamide; 
 2-Benzoylamino-4-phenylthiazole-5-carboxylic acid benzylamide; 
 4-Methyl-2-(3-phenylureido)thiazole-5-carboxylic acid benzylamide; 
 2-[3-(4-Fluorophenyl)ureido]-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-[3-(4-Chlorophenyl)ureido]-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-(2-Cyclopropylacetylamino)-4-methylthiazole-5-carboxylic acid benzylamide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid 2-trifluoromethylbenzylamide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid 3-chlorobenzylamide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid cyclopropylmethyl-amide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid 3-fluorobenzylamide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid 2-chlorobenzylamide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid 2-fluorobenzylamide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid 4-fluorobenzylamide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid benzylmethylamide; 
 2-Benzoylamino-4-chlorothiazole-5-carboxylic acid benzylamide; 
 2-[(4-Pentylbenzoyl)amino]-N-(phenylmethyl)-4-(trifluoromethyl)-5-thiazolecarboxamide; 
 2-Benzoylamino-4-methylthiazole-5-carboxylic acid (1-phenylpropyl)amide; 
 4-Methyl-2-(toluene-4-sulfonylamino)thiazole-5-carboxylic acid benzylamide; 
 4-Methyl-2-[4-(2H-tetrazol-5-yl)benzoylamino]thiazole-5-carboxylic acid benzylamide; 
 2-Benzoylamino-thiazole-5-carboxylic acid benzylamide; 
 4-Amino-2-benzoylaminothiazole-5-carboxylic acid benzylamide; 
 N-[5-(N-Benzoylhydrazinocarbonyl)-4-methylthiazol-2-yl]benzamide; 
 N-[5-(Imidazole-1-carbonyl)-4-methylthiazol-2-yl]benzamide; 
 4-Methyl-2-(4-phenylbutyrylamino)thiazole-5-carboxylic acid benzylamide; 
 4-Methyl-2-(5-phenylpentanoylamino)thiazole-5-carboxylic acid benzylamide; 
 4-Methyl-2-[4-(2-oxo-2H-pyridin-1-yl)benzoylamino]thiazole-5-carboxylic acid benzylamide; 
 2-[(5-Benzylcarbamoyl-4-methyl-thiazol-2-ylcarbamoyl)methyl]benzoic acid; 
 N-(5-Benzylcarbamoyl-4-methylthiazol-2-yl)-2-methoxyisonicotinamide; 
 2-Oxo-1,2-dihydropyridine-4-carboxylic acid (5-benzylcarbamoyl-4-methylthiazol-2-yl)amide; 
 2-Oxo-1-phenyl-1,2-dihydropyridine-4-carboxylic acid (5-benzylcarbamoyl-4-methyl-thiazol-2-yl)amide; 
 N,4-Dibenzyl-2-(3-phenylpropanamido)thiazole-5-carboxamide; 
 2-Benzamido-N,4-dibenzylthiazole-5-carboxamide, 
 2-(4-Bromo-2-hydroxymethylbenzoylamino)-4-methyl-thiazole-5-carboxylic acid benzylamide; 
 N-benzyl-4-methyl-2-(N-methylbenzamido)thiazole-5-carboxamide; 
 N-benzyl-N,4-dimethyl-2-(N-methylbenzamido)thiazole-5-carboxamide; 
 2-(4-((1H-pyrazol-1-yl)methyl)benzamido)-N-benzyl-4-methylthiazole-5-carboxamide; 
 N-Benzyl-4-(morpholinomethyl)-2-(3-phenylpropanamido)thiazole-5-carboxamide; 
 N-benzyl-2-(4-benzylbenzamido)-4-methylthiazole-5-carboxamide; 
 2-(4-Benzylbenzoylamino)-4-diethylaminomethylthiazole-5-carboxylic acid benzylamide; 
 2-Benzamido-N-benzyl-4-((diethylamino)methyl)thiazole-5-carboxamide; 
 2-(4-Benzylbenzamido)-N-(2-cyanoethyl)-4-methylthiazole-5-carboxamide; 
 2-(4-Benzylbenzamido)-N-ethyl-4-methylthiazole-5-carboxamide; or 
 N-Benzyl-2-(4-benzylbenzamido)-4-((methylamino)methyl)thiazole-5-carboxamide. 
 
     
     
         31 . A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a therapeutically effective amount of a compound of formula (I): 
       
         
           
           
               
               
           
         
         wherein: 
         W is selected from —O—, —OC(O)—, —OC(O)N(R 5 )—, —OS(O) 2 N(R 5 )—, —C(O)—, —C(O)O—, —C(O)N(R 5 )—, —N(R 5 )—, —N(R 5 )C(O)—, —N(R 5 )C(O)O—, —N(R 5 )C(O)N(R 5 )—, —N(R 5 )S(O) 2 —, —S(O) t — (where t is 0, 1 or 2), or —S(O) 2 N(R 5 )—; 
         V is selected from —C(O)—, —C(O)N(R 5 )—, —C(O)O—, —S(O) t — (where t is 1 or 2) or a direct bond; 
         R 1  is selected from alkyl, alkenyl, —R 6 —OR 7 , hydroxyalkenyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; 
         or R 1  is a multi-ring structure having 2 to 4 rings wherein the rings are independently selected from cycloalkyl, heterocyclyl, aryl or heteroaryl and where some or all of the rings may be fused to each other; 
         R 2  is selected from alkyl, alkenyl, —R 6 —OR 7 , hydroxyalkenyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl; 
         or R 2  is a multi-ring structure having 2 to 4 rings wherein the rings are independently selected from cycloalkyl, heterocyclyl, aryl or heteroaryl and where some or all of the rings may be fused to each other; 
         R 3  is selected from hydrogen, alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, aryl, aralkyl, heteroaryl, fluoro, chloro, bromo, trihaloalkyl, trihaloalkoxy, cyano, nitro, —OR 4 , —OC(O)R 2 , —OC(O)N(R 4 )(R 5 ), —OS(O) 2 N(R 4 )(R 5 ), —S(O) t R 2  (where t is 0, 1 or 2), —S(O) t N(R 4 )(R 5 ) (where t is 1 or 2), —C(O)R 2 , —C(O)OR 2 , —C(O)N(R 4 )(R 5 ), —N(R 4 )(R 5 ), —N(R 5 )C(O)R 5 , —N(R 5 )C(O)OR 5 , —N(R 5 )C(O)N(R 4 )(R 5 ) or —N(R 5 )S(O) 2 R 2 ; 
         each R 4  and R 5  is independently selected from —R 6 —N(R 7 ) 2 , —R 6 —OR 7 , —R 6 —C(O)OR 7 , hydrogen, alkyl, cycloalkylalkyl or aralkyl; 
         each R 6  is a straight or branched alkylene chain; and 
         each R 7  is hydrogen, alkyl, aryl or aralkyl; 
         or a stereoisomer, enantiomer or tautomer thereof, or a racemic or non-racemic mixture thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof. 
       
     
     
         32 . A pharmaceutical composition comprising a pharmaceutically acceptable excipient; a therapeutically effective amount of a compound of formula (I): 
       
         
           
           
               
               
           
         
         wherein: 
         W is selected from —O—, —OC(O)—, —OC(O)N(R 5 )—, —OS(O) 2 N(R 5 )—, —C(O)—, —C(O)O—, —C(O)N(R 5 )—, —N(R 5 )—, —N(R 5 )C(O)—, —N(R 5 )C(O)O—, —N(R 5 )C(O)N(R 5 )—, —N(R 5 )S(O) 2 —, —S(O) t — (where t is 0, 1 or 2), or —S(O) 2 N(R 5 )—; 
         V is selected from —C(O)—, —C(O)N(R 5 )—, —C(O)O—, —S(O) t — (where t is 1 or 2) or a direct bond; 
         R 1  is selected from alkyl, alkenyl, —R 6 —OR 7 , hydroxyalkenyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; 
         or R 1  is a multi-ring structure having 2 to 4 rings wherein the rings are independently selected from cycloalkyl, heterocyclyl, aryl or heteroaryl and where some or all of the rings may be fused to each other; 
         R 2  is selected from alkyl, alkenyl, —R 6 —OR 7 , hydroxyalkenyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl; 
         or R 2  is a multi-ring structure having 2 to 4 rings wherein the rings are independently selected from cycloalkyl, heterocyclyl, aryl or heteroaryl and where some or all of the rings may be fused to each other; 
         R 3  is selected from hydrogen, alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, aryl, aralkyl, heteroaryl, fluoro, chloro, bromo, trihaloalkyl, trihaloalkoxy, cyano, nitro, —OR 4 , —OC(O)R 2 , —OC(O)N(R 4 )(R 5 ), —OS(O) 2 N(R 4 )(R 5 ), —S(O) t R 2  (where t is 0, 1 or 2), —S(O) t N(R 4 )(R 5 ) (where t is 1 or 2), —C(O)R 2 , —C(O)OR 2 , —C(O)N(R 4 )(R 5 ), —N(R 4 )(R 5 ), —N(R 5 )C(O)R 5 , —N(R 5 )C(O)OR 5 , —N(R 5 )C(O)N(R 4 )(R 5 ) or —N(R 5 )S(O) 2 R 2 ; 
         each R 4  and R 5  is independently selected from —R 6 —N(R 7 ) 2 , —R 6 —OR 7 , —R 6 —C(O)OR 7 , hydrogen, alkyl, cycloalkylalkyl or aralkyl; 
         each R 6  is a straight or branched alkylene chain; and 
         each R 7  is hydrogen, alkyl, aryl or aralkyl; 
         or a stereoisomer, enantiomer or tautomer thereof, or a racemic or non-racemic mixture thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof; and 
         a therapeutically effective amount of insulin, insulin derivative, insulin mimetic, insulin secretagogue, insulinotropic sulfonylurea receptor ligand, PPAR ligand, insulin sensitizer, biguanide, alpha-glucosidase inhibitors, GLP-1, GLP-1 analog, GLP-1 mimetic, DPPIV inhibitor, HMG-CoA reductase inhibitor, squalene synthase inhibitor, FXR ligand, LXR ligand, cholestyramine, fibrates, nicotinic acid or aspirin.