US2013096081A1PendingUtilityA1

Dermal filler compositions

54
Individually held — no corporate assignee on recordPriority: Jun 3, 2011Filed: Dec 5, 2012Published: Apr 18, 2013
Est. expiryJun 3, 2031(~4.9 yrs left)· nominal 20-yr term from priority
Inventors:Gabriel N. NjikangXiaojie YuFutian LiuNicholas J. Manesis
A61K 8/042A61Q 19/08A61L 27/52A61K 2800/91A61L 2430/34A61L 2400/06A61L 27/20A61K 8/735A61Q 19/00C08B 37/0072
54
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method of making an injectable dermal filler composition for treating wrinkles in skin, the method comprising the steps of crosslinking hyaluronic acid (HA) with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent. 
     
     
         2 . The method of  claim 1  wherein the crosslinker is a linear di-amine crosslinker. 
     
     
         3 . The method of  claim 2  wherein the crosslinker is hexamethylene di-amine (HMDA). 
     
     
         4 . The method of  claim 1  wherein the crosslinker is 3-[3-(3-amino propoxy)-2,2-bis(3-amino-propoxymethyl)-propoxy]-propylamine (4 AA). 
     
     
         5 . The method of  claim 1  wherein the crosslinker is made up of at least three polyethylene glycol (PEG) chains and no more than eight PEG chains emanating from a central point. 
     
     
         6 . The method of  claim 1  wherein the crosslinker is made up of at least three polyethylene glycol (PEG) chains and no more than eight PEG chains emanating from a central point, each chain having a terminal amine group. 
     
     
         7 . The method of  claim 1  wherein the crosslinker contains polyethylene glycol (PEG) chains having a least one ethylene glycol unit and not more than 55 ethylene glycol units. 
     
     
         8 . The method of  claim 1  wherein the crosslinker is lysine methyl ester. 
     
     
         9 . The method of  claim 1  wherein the coupling agent is 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC). 
     
     
         10 . The method of  claim 1  wherein the crosslinking takes place in the presence of 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC). 
     
     
         11 . The method of  claim 10  wherein the crosslinking takes place in the presence of N-hydroxysuccinimide (NHS) or N-hydroxysulfosuccinimide (sulfoNHS). 
     
     
         12 . A dermal filler composition for treatment of superficial wrinkles in skin, the composition comprising:
 a hyaluronic acid component crosslinked with a di-amine or multiamine crosslinker; and   a carbodiimide coupling agent;
 the composition being substantially optically transparent; and 
 the composition exhibiting reduced or no perceptible blue discoloration when administered into a dermal region of a patient. 
   
     
     
         13 . The composition of  claim 12  wherein the dermal region is a tear trough region, a glabellar line, a periorbital region or a forehead region. 
     
     
         14 . The composition of  claim 12  which exhibits reduced or no perceptible blue discoloration when administered at a depth of no greater than about 1.0 mm into the dermal region. 
     
     
         15 . The composition of  claim 12  which exhibits reduced or no perceptible blue discoloration when administered at a depth of no greater than about 0.8 mm into the dermal region. 
     
     
         16 . The composition of  claim 12  which exhibits reduced or no perceptible blue discoloration when administered at a depth of no greater than about 0.6 mm into the dermal region. 
     
     
         17 . The composition of  claim 12  wherein the crosslinker is a linear di-amine crosslinker. 
     
     
         18 . The composition of  claim 12  wherein the crosslinker is hexamethylene di-amine (HMDA). 
     
     
         19 . The composition of  claim 12  wherein the crosslinker is 3-[3-(3-amino propoxy)-2,2-bis(3-amino-propoxymethyl)-propoxy]-propylamine (4 AA). 
     
     
         20 . The composition of  claim 12  wherein the crosslinker is present in the composition at a concentration between about 10 μM to about 50 μM. 
     
     
         21 . The composition of  claim 12  wherein the crosslinker is made up of at least three polyethylene glycol (PEG) chains and no more than eight PEG chains. 
     
     
         22 . The composition of  claim 12  wherein the crosslinker is made up of at least three polyethylene glycol (PEG) chains and no more than eight PEG chains emanating from a central point. 
     
     
         23 . The composition of  claim 12  wherein the crosslinker is made up of at least three polyethylene glycol (PEG) chains and no more than eight PEG chains emanating from a central point, each chain having a terminal amine group. 
     
     
         24 . The composition of  claim 12  wherein the crosslinker contains polyethylene glycol (PEG) chains having a least one ethylene glycol unit and not more than 55 ethylene glycol units. 
     
     
         25 . The composition of  claim 12  wherein the crosslinker is lysine methyl ester. 
     
     
         26 . The composition of  claim 12  wherein the coupling agent is a water soluble carbodiimide. 
     
     
         27 . The composition of  claim 12  wherein the coupling agent is 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC). 
     
     
         28 . The composition of  claim 12  wherein the coupling agent is present in the composition at a concentration between about 20 μM to 100 μM. 
     
     
         29 . A method of treating fine lines in skin comprising administering a dermal filler composition made by a method of  claim 12  into a dermal region of a patient.

Join the waitlist — get patent alerts

Track US2013096081A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.