Perfluorocarbon gel formulations

Abstract

A perfluorocarbon gel composition is disclosed with numerous uses including topical medical and cosmetic uses.

What is claimed is: 
     
         1 . A perfluorocarbon gel composition comprising 10-90 wt % perfluorocarbon and 8-70 wt % water relative to the total weight of the gel, wherein the perfluorocarbon is perfluoro(tert-butylcyclohexane). 
     
     
         2 . (canceled) 
     
     
         3 . The perfluorocarbon gel composition of  claim 1 , wherein the composition further comprises 1-5 wt % surfactants. 
     
     
         4 . The perfluorocarbon gel composition of  claim 3 , wherein the surfactants include polyoxyethylene-polyoxypropylene block copolymers. 
     
     
         5 . The perfluorocarbon gel composition of  claim 4 , wherein the polyoxyethylene-polyoxypropylene block copolymers include Poloxamer 105 and/or Poloxamer 188. 
     
     
         6 . The perfluorocarbon gel composition of  claim 1 , wherein the composition further comprises 0.01-10 wt % Vitamin E. 
     
     
         7 . The perfluorocarbon gel composition of  claim 6 , wherein the composition comprises 0.03 wt % Vitamin E. 
     
     
         8 . The perfluorocarbon gel composition of  claim 1 , wherein the composition further comprises 0.02-3.20 wt % preservatives. 
     
     
         9 . The perfluorocarbon gel composition of  claim 8 , wherein the preservatives include poly(diallyldimethylammonium chloride), poly(acrylamide-co-diallyldimethylammonium chloride) and/or ethylene diamine tetraacetic acid. 
     
     
         10 . (canceled) 
     
     
         11 . The perfluorocarbon gel composition of  claim 3 , wherein the composition comprises 30-50 wt % perfluorocarbon, 48-70 wt % water, and 2 wt % surfactants. 
     
     
         12 . (canceled) 
     
     
         13 . (canceled) 
     
     
         14 . The perfluorocarbon gel composition of  claim 8 , wherein the preservatives include 0-0.40 wt % poly(diallyldimethylammonium chloride), 0.01-0.80 wt % poly(acrylamide-co-diallyldimethylammonium chloride) and 0.01-2.00 wt % ethylene diamine tetraacetic acid. 
     
     
         15 . The perfluorocarbon gel composition of  claim 14 , wherein the composition comprises 84-88 wt % perfluoro(tert-butylcyclohexane), 9-11 wt % water, 2-3 wt % Poloxamer 105, 0.01-1 wt % Poloxamer 188, 0-0.40 wt % poly(diallyldimethylammonium chloride), 0.01-0.80 wt % poly(acrylamide-co-diallyldimethylammonium chloride) and 0.01-2.00 wt % ethylene diamine tetraacetic acid. 
     
     
         16 . The perfluorocarbon gel composition of  claim 15 , wherein the composition comprises 85.98 wt % perfluoro(tert-butylcyclohexane), 10.28 wt % water, 2.45 wt % Poloxamer 105, 0.31 wt % Poloxamer 188, 0.74 wt % poly(acrylamide-co-diallyldimethylammonium chloride) and 0.25 wt % ethylene diamine tetraacetic acid. 
     
     
         17 . The perfluorocarbon gel composition of  claim 15 , wherein the composition comprises 86.73 wt % perfluoro(tert-butylcyclohexane), 10.37 wt % water, 2.47 wt % Poloxamer 105, 0.31 wt % Poloxamer 188, 0.10 wt % poly(acrylamide-co-diallyldimethylammonium chloride) and 0.03 wt % ethylene diamine tetraacetic acid. 
     
     
         18 . The perfluorocarbon gel composition of  claim 15 , wherein the composition comprises 85.98 wt % perfluoro(tert-butylcyclohexane), 10.28 wt % water, 2.45 wt % Poloxamer 105, 0.31 wt % Poloxamer 188, 0.25 wt % poly(diallyldimethylammonium chloride), 0.50 wt % poly(acrylamide-co-diallyldimethylammonium chloride) and 0.25 wt % ethylene diamine tetraacetic acid. 
     
     
         19 . The perfluorocarbon gel composition of  claim 15 , wherein the composition comprises 86.73 wt % perfluoro(tert-butylcyclohexane), 10.37 wt % water, 2.47 wt % Poloxamer 105, 0.31 wt % Poloxamer 188, 0.03 wt % poly(diallyldimethylammonium chloride), 0.07 wt % poly(acrylamide-co-diallyldimethylammonium chloride) and 0.03 wt % ethylene diamine tetraacetic acid. 
     
     
         20 . (canceled) 
     
     
         21 . (canceled) 
     
     
         22 . The perfluorocarbon gel composition of  claim 1 , characterized by that it continuously delivers oxygen to a tissue at a rate of 0.2 cc/hour-20.0 cc/hour for up to 24 hours. 
     
     
         23 . The perfluorocarbon gel composition of  claim 22 , wherein the composition continuously delivers oxygen to the tissue at a rate of 2.0 cc/hour for 24 hours. 
     
     
         24 . The perfluorocarbon gel composition of  claim 1 , further comprising urea hydrogen peroxide. 
     
     
         25 . A method of continuously delivering oxygen to a tissue at a rate of 0.2 cc/hour-20.0 cc/hour for up to 24 hours by contacting the tissue with the perfluorocarbon gel composition of  claim 1 . 
     
     
         26 . A method of treating a wound, a burn injury, acne or rosacea in a subject suffering therefrom comprising topically administering to the skin of the subject the perfluorocarbon gel composition of  claim 1  effective to treat the subject's wound, burn injury, acne or rosacea. 
     
     
         27 . A method of increasing the firmness of the skin or reducing the appearance of fine lines, wrinkles or scars in a subject comprising topically administering to the skin of the subject the perfluorocarbon gel composition of  claim 1  effective to increase the firmness of the subject's skin or reduce the appearance of fine lines, wrinkles or scars on the subject's skin. 
     
     
         28 . A process of manufacturing a perfluorocarbon gel composition comprising the steps:
 i) mixing aqueous phase components in a vessel;   ii) homogenizing the mixture;   iii) adding perfluorocarbon to the mixture over time during high speed homogenization; and   iv) obtaining the gel.   
     
     
         29 - 36 . (canceled)