Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors

Abstract

The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are defined in the application. The compounds according to the invention are positive allosteric modulators of metabotropic receptors—subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

1 . A compound according to general Formula (I), 
       
         
           
           
               
               
           
         
         a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof and an N-oxide form thereof, wherein: 
         R 1  is not hydrogen and is a radical —V 1 -M 1 ; 
         V 1  is a covalent bond or a radical selected from the group consisting of —(C 1 -C 6 )alkyl- optionally substituted with halo(C 1 -C 6 )alkyl; —(C 2 -C 6 )alkynyl-; —(C 2 -C 6 )alkenyl-; —(C 1 -C 6 )alkyl-C(═O)—(C 0 -C 6 )alkyl-; —(C 1 -C 6 )alkyl-C(═O)NR 7 —(C 0 -C 6 )alkyl- wherein R 7  is hydrogen or —(C 1 -C 6 )alkyl; and —(C 1 -C 6 )alkyl-O—(C 0 -C 6 )alkyl; 
         R 2  is hydrogen; 
         R 3  is a —V 2 -M 2  radical; 
         R 4  is hydrogen; 
         R 5  is hydrogen; 
         V 2  is a covalent bond or a radical selected from the group consisting of —O—; —C(═O)—; —NR 10 —; and a radical selected from the group consisting of ethyl; n-propyl; i-propyl; n-butyl; i-butyl; s-butyl; t-butyl; n-pentyl; i-pentyl; t-pentyl; neopentyl; n-hexyl; i-hexyl; t-hexyl; —(C 1 -C 6 )alkyl- substituted with hydroxyl; —(C 2 -C 6 )alkynyl-; —(C 0 -C 6 )alkyl-O—(C 1 -C 6 )alkyl-; and —(C 0 -C 6 )alkyl-NR 10 —(C 1 -C 6 )alkyl-; 
         R 10  is hydrogen or an (C 1 -C 6 )alkyl radical; 
         (R 2  and R 3 ) or (R 4  and R 5 ) taken together with the carbon atoms to which they are respectively attached may form an optionally substituted phenyl ring optionally substituted with a radical selected from the group consisting of methoxy, 4-methoxyphenyl-ethylamino, 4-hydroxyphenyl-ethylamino or 4-methoxyphenyl-ethyloxy; 
         M 1  and M 2  are each independently selected from the group consisting of hydrogen, and an optionally substituted radical selected from the group consisting of cycloalkyl, and an optionally substituted up to 10 membered ring system selected from the group consisting of aryl and heteroaryl; 
         wherein the cycloalkyl radical is cyclopropyl, cyclopentyl or cyclohexyl; 
         the aryl radical is phenyl and naphthyl; 
         the heteroaryl radical is pyridyl, indolyl, pyrrolyl, pyrazolyl, furyl, thienyl, pyrimidinyl, quinolinyl, quinoxalinyl, isoxazolyl, oxadiazolyl, benzoxazolyl, thiazolyl, benzothiazolyl, benzofuranyl, benzodioxolyl, pyrazinyl and benzothiophenyl; 
         and 
         wherein any of the optionally substituted aforementioned rings may carry at least one substituent selected from the group consisting of (C 1 -C 6 )alkyl; (C 1 -C 6 )alkyloxy; hydroxy(C 1 -C 6 )alkyloxy; (C 1 -C 6 )alkyloxy(C 1 -C 6 )alkyl; (C 1 -C 6 )alkyloxy(C 1 -C 6 )alkyloxy; (C 1 -C 6 )alkyloxycarbonyl; (C 1 -C 6 )-alkyloxycarbonyl(C 1 -C 6 )alkyl; (C 1 -C 6 )alkyloxycarbonyloxy; (C 1 -C 6 )-alkyloxycarbonyl(C 1 -C 6 )alkyloxy; (C 1 -C 6 )alkylcarbonyl; (C 1 -C 6 )-alkylcarbonyl(C 1 -C 6 )alkyloxy; (C 1 -C 6 )alkylthieno; (C 1 -C 6 )alkylsulfonyl; morpholinylsulfonyl; pyrrolidinylsulfonyl; (C 1 -C 6 )alkylsulfonylamino; (C 2 -C 6 )alkenyl; phenyl; fluoro; chloro; hydroxy; hydroxy(C 1 -C 6 )alkyl; cyano; cyano(C 1 -C 6 )alkyloxy; trifluoro(C 1 -C 6 )alkyl; trifluoro(C 1 -C 6 )alkyloxy; amino; amino(C 1 -C 6 )alkyloxy; mono- and di((C 1 -C 6 )alkyl)amino; mono- and di((C 1 -C 6 )alkylcarbonyl)amino; mono- and di((C 1 -C 6 )alkyloxycarbonyl)amino; mono- and di((C 1 -C 6 )alkylcarbonyl)amino(C 1 -C 6 )alkyl; mono- and di((C 1 -C 6 )-alkylsulfonyl)amino(C 1 -C 6 )alkyloxy; mono- and di((C 1 -C 6 )alkyl)amino(C 1 -C 6 )-alkyloxy; mono- and di((C 1 -C 6 )alkylcarbonyl)amino(C 1 -C 6 )alkyloxy; mono- and di((C 1 -C 6 )alkyl)aminocarbonyl; mono- and di((C 1 -C 6 )alkyl)aminocarbonyl(C 1 -C 6 )alkyl; mono- and di((C 1 -C 6 )alkyl)aminocarbonyl(C 1 -C 6 )alkyloxy; mono- and di((C 1 -C 6 )alkyl)amino(C 1 -C 6 )alkylamino; nitro; tri(C 1 -C 6 )alkylsilyl; morpholinyl; heterocyclic-(C 1 -C 6 )alkyloxy selected from pyridinyl-(C 1 -C 6 )alkyloxy, morpholinyl-(C 1 -C 6 )alkyloxy, pyrrolidinyl-(C 1 -C 6 )alkyloxy optionally substituted with oxo, isoxazolyl-(C 1 -C 6 )alkyloxy, imidazolyl-(C 1 -C 6 )alkyloxy, tetrazolyl-(C 1 -C 6 )alkyloxy and thiazolyl-(C 1 -C 6 )alkyloxy, wherein the isoxazolyl, imidazolyl, tetrazolyl or thiazolyl rings may be optionally substituted with methyl, 
         wherein the compound is not 
       
       
         
           
           
               
               
           
         
       
     
     
         2 . A compound according to  claim 1  having the general Formula (I), 
       
         
           
           
               
               
           
         
         a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof and an N-oxide form thereof, wherein: 
         R 1  is not hydrogen and is a radical —V 1 -M 1 ; 
         V 1  is —CH 2 —; 
         R 2  is hydrogen; 
         R 3  is a —V 2 -M 2  radical; 
         R 4  is hydrogen; 
         R 5  is hydrogen; 
         V 2  is a covalent bond; 
         M 1  is a phenyl group having at least one halo group; and 
         M 2  is a phenyl group substituted with at least one substituent selected from the group consisting of (C 1 -C 6 )alkyloxy, pyridinyl-(C 1 -C 6 )alkyloxy, morpholinyl-(C 1 -C 6 )alkyloxy, pyrrolidinyl-(C 1 -C 6 )alkyloxy optionally substituted with oxo, isoxazolyl-(C 1 -C 6 )alkyloxy, imidazolyl-(C 1 -C 6 )alkyloxy, tetrazolyl-(C 1 -C 6 )alkyloxy and thiazolyl-(C 1 -C 6 )alkyloxy, wherein the isoxazolyl, imidazolyl, tetrazolyl or thiazolyl rings may be optionally substituted with methyl. 
       
     
     
         3 . The compound of  claim 2 , wherein M 1  is a phenyl group having at least one fluoro or chloro group. 
     
     
         4 . The compound of  claim 2 , wherein M 1  is a phenyl group having one fluoro group and one chloro group. 
     
     
         5 . The compound of  claim 2 , wherein M 1  is 
       
         
           
           
               
               
           
         
       
     
     
         6 . The compound of  claim 2 , wherein M 2  is a phenyl group substituted with at least one (C 1 -C 6 )alkyloxy. 
     
     
         7 . The compound of  claim 2 , wherein M 2  is a phenyl group substituted with a methoxy group. 
     
     
         8 . The compound of  claim 2 , wherein M 2  is a phenyl group substituted with at least one tetrazolyl-(C 1 -C 6 )alkyloxy. 
     
     
         9 . The compound of  claim 2 , wherein M 2  is a phenyl group substituted with 
       
         
           
           
               
               
           
         
       
     
     
         10 . A compound according to  claim 1 , or a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof and an N-oxide form thereof, wherein said compound is:
 1-(2,4-difluorobenzyl)-5-(benzofuran-2-yl)pyridin-2(1H)-one;   1-benzyl-5-(4-fluorophenyl)pyridin-2(1H)-one;   1-(2,4-difluorobenzyl)-5-(4-fluorophenyl)pyridin-2(1H)-one;   1-(3-chlorobenzyl)-5-(4-fluorophenyl)pyridin-2(1H)-one;   1-benzyl-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(3-(trifluoromethyl)benzyl)-5-phenylpyridin-2(1H)-one;   1-(4-methylbenzyl)-5-phenylpyridin-2(1H)-one;   1-(2,4-difluorobenzyl)-5-(thiophen-2-yl)pyridin-2(1H)-one;   1-benzyl-5-(4-chlorophenyl)pyridin-2(1H)-one;   1-(3-(trifluoromethyl)benzyl)-5-(4-chlorophenyl)pyridin-2(1H)-one;   1-(2,4-difluorobenzyl)-5-(4-chlorophenyl)pyridin-2(1H)-one;   1-(2,4-dichlorobenzyl)-5-(4-methoxyphenyl)pyrimidin-2(1H)-one;   1-(3-chlorobenzyl)-5-phenylpyridin-2(1H)-one;   1-(3-chlorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-phenylpyridin-2(1H)-one;   1-(2,4-difluorobenzyl)-5-phenylpyridin-2(1H)-one;   1-Benzyl-5-(3-methoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(3-chlorophenyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-cyanophenyl)pyridin-2(1H)-one;   1-Benzyl-5-(3-nitrophenyl)pyridin-2(1H)-one;   1-Benzyl-5-(2-fluorophenyl)pyridin-2(1H)-one;   1-Benzyl-5-(3,4-dimethoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(naphthalen-2-yl)pyridin-2(1H)-one;   1-Benzyl-5-(2-methoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-m-tolylpyridin-2(1H)-one;   1-Benzyl-5-(3-chloro-4-isopropoxyphenyl)pyridin-2(1H)-one;   Ethyl-4-(1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)benzoate;   1-Benzyl-5-(2-fluoro-5-methoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-tolyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-(trifluoromethoxy)phenyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-acetylphenyl)pyridin-2(1H)-one;   2-(4-Fluorobenzyl)isoquinolin-1(2H)-one;   1-(2-Fluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Fluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Nitrobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(3,4-Dichlorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(3-Nitrobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(3-Methoxybenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(Benzo[d]thiazol-2-ylmethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-isobutoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(2-phenylethynyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-hydroxyphenyl)pyridin-2(1H)-one;   1-(4-Methoxybenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   3-((5-(4-Methoxyphenyl)-2-oxopyridin-1(2H)-yl)methyl)benzonitrile;   1-(3-Fluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-(1-phenylethyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-(pyridin-3-ylmethyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-ethylphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(2,3-dihydro-1-benzofuran-5-yl)pyridin-2(1H)-one;   1-Benzyl-5-(4-(dimethylamino)phenyl)pyridin-2(1H)-one;   1-Benzyl-5-(3,4-dimethylphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(3,4-dichlorophenyl)pyridin-2(1H)-one;   1-((3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-tert-butylphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(indol-5-yl)pyridin-2(1H)-one;   1-Benzyl-5-(4-propoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-(trimethylsilyl)phenyl)pyridin-2(1H)-one;   1-Benzyl-5-(3,5-difluorophenyl)pyridin-2(1H)-one;   N-(4-Fluorobenzyl)-2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-methylacetamide;   1-((5-Fluorobenzo[d]oxazol-2-yl)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(6-methoxypyridin-3-yl)pyridin-2(1H)-one;   1-Benzyl-5-(4-methoxyphenyl)-3-nitropyridin-2(1H)-one;   1-(4-Methylbenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(3,4-Difluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-(Trifluoromethyl)benzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(3-Fluoro-4-methylbenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   Methyl 4-((5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)methyl)benzoate;   4-((5-(4-Methoxyphenyl)-2-oxopyridin-1(2H)-yl)methyl)benzonitrile; -(4-Methoxyphenyl)-1-(naphthalen-2-ylmethyl)pyridin-2(1H)-one;   1-(3-Fluoro-4-(trifluoromethyl)benzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(3-Chloro-4-fluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chloro-3-(trifluoromethyl)benzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(2-Fluoro-4-(trifluoromethyl)benzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(2-Fluoro-4-chlorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)quinolin-2(1H)-one;   1-Benzyl-5-phenethylpyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-((5-methylisoxazol-3-yl)methyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(2,5-difluorophenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(3-fluoro-4-methylphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(2-ethoxyphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(quinolin-3-yl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-tolyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(2-fluorophenyl)pyridin-2(1H)-one;   Methyl-3-(4-(1-(4-chlorobenzyl)-1,6-dihydro-6-oxopyridin-3-yl)phenyl) propanoate;   1-(4-Chlorobenzyl)-5-(4-isobutylphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-sec-butylphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-vinylphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(3-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(2,3-dihydrobenzofuran-5-yl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-acetylphenyl)pyridin-2(1H)-one;   Methyl 3-(3-(1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)propanoate;   1-(4-Chlorobenzyl)-5-(4-(ethylthio)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(3-ethoxyphenyl)pyridin-2(1H)-one;   N-(3-(1-(4-Chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)methane sulfonamide;   1-(4-Chlorobenzyl)-5-(6-methoxypyridin-3-yl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(methoxymethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-((3-methoxymethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(furan-3-yl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(1-benzyl-1H-pyrazol-4-yl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(methylthio)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(1-methyl-1H-indol-5-yl)pyridin-2(1H)-one;   tert-Butyl 2-(1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrrole-1-carboxylate;   1-(3-Fluorobenzyl)-5-p-tolylpyridin-2(1H)-one;   5-(4-((2H-Tetrazol-5-yl)methyl)phenyl)-1-(4-chlorobenzyl)pyridin-2(1H)-one;   1-(3-Fluorobenzyl)-5-(2-(3-methoxyphenyl)ethynyl)pyridine-2(1H)-one;   1-(3-Fluorobenzyl)-5-(2-(pyridin-3-yl)ethynyl)pyridin-2(1H)-one hydrochloride;   1-(4-Chlorobenzyl)-5-(4-(methylsulfonyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(1H-indol-5-yl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-methoxyphenyl)-6-methylpyridin-2(1H)-one;   1-((6-Chloropyridin-3-yl)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chloro-3-fluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(3,4-Difluorobenzyl)-5-(4-(methoxymethyl)phenyl)pyridin-2(1H)-one;   1-(3,4-Difluorobenzyl)-5-(4-acetylphenyl)pyridin-2(1H)-one;   1-(3,4-Difluorobenzyl)-5-(2,3-dihydrobenzofuran-5-yl)pyridin-2(1H)-one;   1-(4-Methyl-benzyl)-2-oxo-4-thiophen-2-yl-1,2-dihydro-pyridine-3-carbonitrile;   1-(3,4-Difluorobenzyl)-5-(3-methoxyphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-(3-phenylpropyl)pyridin-2(1H)-one;   1-(4-Fluorophenethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-(4-phenylbutyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-hydroxyphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-((methyl(phenyl)amino)methyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-((benzyl(methyl)amino)methyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-((phenylamino)methyl)pyridin-2(1H)-one;   (Z)-5-(3-Methoxystyryl)-1-(4-chlorobenzyl)pyridin-2(1H)-one;   (E)-5-(3-Methoxystyryl)-1-(4-chlorobenzyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-isopropoxyphenyl)pyridin-2(1H)-one;   Ethyl 2-(4-(1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)acetate;   1-(4-Chlorobenzyl)-5-((4-fluorophenyl)(hydroxy)methyl)pyridine-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-fluorobenzyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(hydroxy(3-methoxyphenyl)methyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-(2-oxo-2-phenylethyl)-1H-pyridin-2-one;   1-((4-Chlorophenoxy)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-(2-phenoxyethyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-sec-butoxyphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(3-methoxybenzoyl)pyridin-2(1H)-one;   5-(3-Methoxyphenethyl)-1-(4-chloro-3-fluorobenzyl)pyridin-2(1H)-one;   1-(3,4-Difluorobenzyl)-5-(3-methoxyphenethyl)pyridine-2(1H)-one;   5-(3-Methoxybenzyl)-1-(4-chlorobenzyl)pyridin-2(1H)-one;   1-(4-Chloro-3-fluorobenzyl)-5-(4-methoxyphenethyl)pyridine-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-methoxyphenyl)-4-methylpyridin-2(1H)-one;   1-(4-Chloro-3-fluorobenzyl)-5-(benzo[d]thiazol-2-yl)pyridin-2(1H)-one;   1-(3,4-Difluorobenzyl)-5-(phenoxymethyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-((4-methoxyphenoxy)methyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-((4-fluorophenyl)(methyl)amino)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(phenoxymethyl)pyridin-2(1H)-one;   1-(3,4-Difluorobenzyl)-5-(thiophen-2-yl)pyridin-2(1H)-one;   4-(1-(3,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile;   N-(4-(1-(3,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)methanesulfonamide;   N-(3-Chlorobenzyl)-2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-methylacetamide;   N-Benzyl-2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-methylacetamide;   N-(3-Methoxybenzyl)-2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-methylacetamide;   1-(3,4-Difluorobenzyl)-5-(6-methoxypyridin-3-yl)pyridine-2(1H)-one;   1-(3,4-Difluorobenzyl)-5-(benzo[d][1,3]dioxol-5-yl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(trifluoromethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(3-fluoro-4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-(Trifluoromethoxy)benzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(2,4-Difluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(2-Methylphenylmethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(2,3-Difluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   N-(4-Nitrobenzyl)-2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-methylacetamide;   N-(4-Methylbenzyl)-2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-methylacetamide;   N-(4-(Trifluoromethyl)benzyl)-2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-methylacetamide;   1-(4-Chlorobenzyl)-5-phenylpyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(benzo[b]thiophen-5-yl)pyridin-2(1H)-one;   1-(2,4,6-Trifluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(2-Chlorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2(1H)-one hydrochloride;   4-(1-(4-Methoxybenzyl)-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile;   1-(4-Methoxybenzyl)-5-(4-acetylphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-((6-methoxypyridin-3-yl)methyl)pyridin-2(1H)-one hydrochloride;   1-(4-Chloro-2-fluorobenzyl)-5-(3,4-dimethoxyphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-((5-phenyl-1,2,4-oxadiazol-3-yl)methyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-hydroxyphenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(pyrrolidin-1-ylsulfonyl)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(morpholinosulfonyl)phenyl)pyridin-2(1H)-one;   1-((4-Fluorobenzo[d]thiazol-2-yl)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(2-methoxyethoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-bromopyridin-2(1H)-one;   1-(4-Chlorobenzyl)-3-(hydroxymethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(2-morpholinoethoxy)phenyl)pyridin-2(1H)-one;   1-(Benzo[d]thiazol-2-ylmethyl)-5-phenylpyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(2-(dimethylamino)ethoxy)phenyl)pyridin-2(1H)-one;   2-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)acetonitrile;   5-(4-((2H-Tetrazol-5-yl)methoxy)phenyl)-1-(4-chloro-2-fluorobenzyl)pyridin-2(1H)-one;   1-Butyl-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(3-morpholinopropoxy)phenyl)pyridin-2(1H)-one hydrochloride;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(3-(dimethylamino)propoxy)phenyl)pyridin-2(1H)-one;   4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl methyl carbonate;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(2-oxopropoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-isobutoxyphenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-methoxy-3-methylphenyl)pyridin-2(1H)-one;   Methyl 2-(4-(1-(4-chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)acetate;   5-(4-(1H-Tetrazol-5-yl)phenyl)-1-(4-chloro-2-fluorobenzyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-aminophenyl)pyridin-2(1H)-one hydrochloride;   1-(4-Chloro-2-fluorobenzyl)-5-(3-aminophenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(hydroxymethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-methoxy-3,5-dimethylphenyl)pyridin-2(1H)-one;   1-Isobutyl-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-Isopentyl-5-(4-methoxyphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-(pent-4-ynyl)pyridin-2(1H)-one;   1-(Cyclohexylmethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   N-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)acetamide;   1-(4-Chloro-2-fluorobenzyl)-5-(4-((2-methylthiazol-4-yl)methoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-((1-methyl-1H-imidazol-2-yl)methoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(2-aminoethoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-((5-methylisoxazol-3-yl)methoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-propoxyphenyl)pyridin-2(1H)-one;   N-(3-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)acetamide;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(aminomethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(3-hydroxyphenyl)pyridin-2(1H)-one;   N-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)benzyl)acetamide;   N-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)benzyl)methanesulfonamide;   N-(3-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)benzyl)acetamide;   5-(4-Methoxyphenyl)-1-((5-(trifluoromethyl)furan-2-yl)methyl)pyridin-2(1H)-one;   1-(4-(Methoxymethyl)benzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   2-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)-N-methylacetamide;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(3-aminopropoxy)phenyl)pyridin-2(1H)-one;   1-(4-(Ethoxymethyl)benzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-chlorobenzyl)-5-(4-(ethoxymethyl)phenyl)pyridin-2(1H)-one;   N-(2-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)ethyl)acetamide;   N-Acetyl-N-(2-(4-(1-(4-chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)ethyl)acetamide;   N-(2-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)ethyl)methanesulfonamide;   N-(3-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)propyl)methanesulfonamide;   N-Acetyl-N-(3-(4-(1-(4-chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)propyl)acetamide;   N-(3-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)propyl)acetamide;   1-(4-Chloro-2-fluorobenzyl)-5-isopropylpyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(6-(dimethylamino)pyridin-3-yl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(3-amino-4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-morpholinophenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(5-methylthiophen-2-yl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(6-morpholinopyridin-3-yl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(6-methoxypyridin-3-yl)pyridin-2(1H)-one;   5-(6-Methoxypyridin-3-yl)-1-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(ethoxymethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(benzyloxymethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(hydroxymethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(dimethylamino)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(quinoxalin-6-yl)pyridin-2(1H)-one;   Methyl 4-(1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)benzoate;   1-(4-Chlorobenzyl)-5-(4-(3-hydroxypropyl)phenyl)pyridin-2(1H)-one;   4-(1-Isopentyl-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile;   N-(3-(1-Isopentyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)methanesulfonamide;   3-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile;   1-(4-Chlorobenzyl)-5-(6-chloropyridin-3-yl)pyridin-2(1H)-one;   N-(5-(1-(4-Chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methoxyphenyl)methanesulfonamide;   5-(4-Methoxyphenyl)-1-pentylpyridin-2(1H)-one;   1-(Cyclopropylmethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(Cyclopentylmethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   Methyl 2-(4-(1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)acetate;   1-(4-Chlorobenzyl)-5-cyclohexylpyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(quinolin-7-yl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(furan-2-ylmethoxy)phenyl)pyridin-2(1H)-one;   5-(3-(2H-Tetrazol-5-yl)phenyl)-1-(4-chloro-2-fluorobenzyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(2-hydroxypropan-2-yl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(isobutoxymethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-((2-(dimethylamino)ethoxy)methyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-((2-morpholinoethoxy)methyl)phenyl)pyridin-2(1H)-one;   4-(1-(4-Chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-N,N-dimethylbenzamide;   2-(4-(1-(4-Chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-N,N-dimethylacetamide;   N-(2-(4-(1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)benzyloxy)ethyl)acetamide;   1-(4-Chlorobenzyl)-5-(4-((2-methoxyethoxy)methyl)phenyl)pyridin-2(1H)-one;   2-(4-(1-(4-Chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-N-methylacetamide;   3-(4-(1-(4-Chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-N-methylpropanamide;   3-(4-(1-(4-Chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-N,N-dimethylpropanamide;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(2-hydroxypropoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(3-phenylpropyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(3-methoxyphenyl)butyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-phenylbutyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-butylpyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-methoxyphenyl)pyrimidin-2(1H)-one;   1-Benzyl-5-(4-methoxyphenyl)pyrimidin-2(1H)-one;   1-Isopentyl-5-(4-methoxyphenyl)pyrazin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(2-(dimethylamino)ethylamino)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(2-methoxyethylamino)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(propylamino)phenyl)pyridin-2(1H)-one;   1-(3,3-Dimethylbutyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(pyridin-3-ylmethoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(4-methoxyphenyl)butyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-methoxybenzyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(3-phenoxypropyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-methoxyphenoxy)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-propoxypyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(cyclohexylmethoxy)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-fluorobenzyloxy)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-methoxybenzyloxy)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-phenethoxypyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-fluorophenoxy)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(2-methoxyethoxy)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(5-methylpyridin-2-yl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(pyridin-2-ylmethoxy)phenyl)pyridin-2(1H)-one;   5-(2-Methoxybenzyl)-1-(4-chloro-2-fluorobenzyl)pyridin-2(1H)-one;   5-(4-Methoxyphenethylamino)-2-propylisoquinolin-1(2H)-one;   5-(4-Hydroxyphenethylamino)-2-propylisoquinolin-1(2H)-one;   5-(4-Methoxyphenyl)-1-((6-(4-methoxyphenyl)pyridin-3-yl)methyl)pyridin-2(1H)-one;   1-((6-Ethynylpyridin-3-yl)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-((6-Ethylpyridin-3-yl)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-((2-methylthiazol-5-yl)methyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-((5-methylpyrazin-2-yl)methyl)pyridin-2(1H)-one;   5-(Phenoxymethyl)-1-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2(1H)-one; mixture of isomers of 1-(4-chloro-2-fluorobenzyl)-5-(4-((2-methyl-2H-tetrazol-5-yl)methoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-fluorophenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-(pentan-2-yl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-((4-methylcyclohexyl)methyl)pyridin-2(H)-one;   1-(4-Ethoxybenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-Isopentyl-5-(4-methoxyphenyl)pyrimidin-2(1H)-one;   1-Isopentyl-5-((4-methoxyphenoxy)methyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-((3-methoxyphenoxy)methyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(2-fluoro-4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(2-methoxypyrimidin-5-yl)pyridin-2(1H)-one;   5-(4-Methoxyphenethoxy)-2-propylisoquinolin-1(2H)-one.   
     
     
         11 . A compound according to  claim 1 , wherein said compound exists as optical isomers, wherein said compound is either the racemic mixture or the individual optical isomer. 
     
     
         12 . A pharmaceutical composition comprising a therapeutically effective amount of a compound according to  claim 1  and a pharmaceutically acceptable carrier and/or excipient. 
     
     
         13 . A method for (a) treating or preventing a condition in a mammal affected or facilitated by the neuromodulatory effect of mGluR2 positive allosteric modulators or (b) treating, or preventing, ameliorating, controlling or reducing the risk of various neurological and psychiatric disorders associated with glutamate dysfunction in a mammal affected or facilitated by the neuromodulatory effect of mGluR2 positive allosteric modulators comprising administering to a patient in need thereof a compound according to the general Formula (I), 
       
         
           
           
               
               
           
         
         a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof and an N-oxide form thereof, wherein: 
         R 1  is not hydrogen and is a radical —V 1 -M 1 ; 
         V 1  is a covalent bond or a radical selected from the group consisting of —(C 1 -C 6 )alkyl- optionally substituted with halo(C 1 -C 6 )alkyl; —(C 2 -C 6 )alkynyl-; —(C 2 -C 6 )alkenyl-; —(C 1 -C 6 )alkyl-C(═O)—(C 0 -C 6 )alkyl-; —(C 1 -C 6 )alkyl-C(═O)NR 7 —(C 0 -C 6 )alkyl- wherein R 7  is hydrogen or —(C 1 -C 6 )alkyl; and —(C 1 -C 6 )alkyl-O—(C 0 -C 6 )alkyl; 
         R 2  is hydrogen; 
         R 3  is a —V 2 -M 2  radical; 
         R 4  is hydrogen; 
         R 5  is hydrogen; 
         V 2  is a covalent bond or a radical selected from the group consisting of —O—; —C(═O)—; —NR 10 —; and a radical selected from the group consisting of ethyl; n-propyl; i-propyl; n-butyl; i-butyl; s-butyl; t-butyl; n-pentyl; i-pentyl; t-pentyl; neopentyl; n-hexyl; i-hexyl; t-hexyl; —(C 1 -C 6 )alkyl- substituted with hydroxyl; —(C 2 -C 6 )alkynyl-; —(C 0 -C 6 )alkyl-O—(C 1 -C 6 )alkyl-; and —(C 0 -C 6 )alkyl-NR 10 —(C 1 -C 6 )alkyl-; 
         R 10  is hydrogen or an (C 1 -C 6 )alkyl radical; 
         (R 2  and R 3 ) or (R 4  and R 5 ) taken together with the carbon atoms to which they are respectively attached may form an optionally substituted phenyl ring optionally substituted with a radical selected from the group consisting of methoxy, 4-methoxyphenyl-ethylamino, 4-hydroxyphenyl-ethylamino or 4-methoxyphenyl-ethyloxy; 
         M 1  and M 2  are each independently selected from the group consisting of hydrogen, and an optionally substituted radical selected from the group consisting of cycloalkyl, and an optionally substituted up to 10 membered ring system selected from the group of aryl and heteroaryl; 
         wherein the cycloalkyl radical is cyclopropyl, cyclopentyl or cyclohexyl; 
         the aryl radical is phenyl and naphthyl; 
         the heteroaryl radical is pyridyl, indolyl, pyrrolyl, pyrazolyl, furyl, thienyl, pyrimidinyl, quinolinyl, quinoxalinyl, isoxazolyl, oxadiazolyl, benzoxazolyl, thiazolyl, benzothiazolyl, benzofuranyl, benzodioxolyl, pyrazinyl and benzothiophenyl; 
         and 
         wherein any of the optionally substituted aforementioned rings may carry at least one substituent selected from the group consisting of (C 1 -C 6 )alkyl; (C 1 -C 6 )alkyloxy; hydroxy(C 1 -C 6 )alkyloxy; (C 1 -C 6 )alkyloxy(C 1 -C 6 )alkyl; (C 1 -C 6 )alkyloxy(C 1 -C 6 )alkyloxy; (C 1 -C 6 )alkyloxycarbonyl; (C 1 -C 6 )-alkyloxycarbonyl(C 1 -C 6 )alkyl; (C 1 -C 6 )alkyloxycarbonyloxy; (C 1 -C 6 )-alkyloxycarbonyl(C 1 -C 6 )alkyloxy; (C 1 -C 6 )alkylcarbonyl; (C 1 -C 6 )-alkylcarbonyl(C 1 -C 6 )alkyloxy; (C 1 -C 6 )alkylthieno; (C 1 -C 6 )alkylsulfonyl; morpholinylsulfonyl; pyrrolidinylsulfonyl; (C 1 -C 6 )alkylsulfonylamino; (C 2 -C 6 )alkenyl; phenyl; fluoro; chloro; hydroxy; hydroxy(C 1 -C 6 )alkyl; cyano; cyano(C 1 -C 6 )alkyloxy; trifluoro(C 1 -C 6 )alkyl; trifluoro(C 1 -C 6 )alkyloxy; amino; amino(C 1 -C 6 )alkyloxy; mono- and di((C 1 -C 6 )alkyl)amino; mono- and di((C 1 -C 6 )alkylcarbonyl)amino; mono- and di((C 1 -C 6 )alkyloxycarbonyl)amino; mono- and di((C 1 -C 6 )alkylcarbonyl)amino(C 1 -C 6 )alkyl; mono- and di((C 1 -C 6 )-alkylsulfonyl)amino(C 1 -C 6 )alkyloxy; mono- and di((C 1 -C 6 )alkyl)amino(C 1 -C 6 )-alkyloxy; mono- and di((C 1 -C 6 )alkylcarbonyl)amino(C 1 -C 6 )alkyloxy; mono- and di((C 1 -C 6 )alkyl)aminocarbonyl; mono- and di((C 1 -C 6 )alkyl)aminocarbonyl(C 1 -C 6 )alkyl; mono- and di((C 1 -C 6 )alkyl)aminocarbonyl(C 1 -C 6 )alkyloxy; mono- and di((C 1 -C 6 )alkyl)amino(C 1 -C 6 )alkylamino; nitro; tri(C 1 -C 6 )alkylsilyl; morpholinyl; heterocyclic-(C 1 -C 6 )alkyloxy selected from pyridinyl-(C 1 -C 6 )alkyloxy, morpholinyl-(C 1 -C 6 )alkyloxy, pyrrolidinyl-(C 1 -C 6 )alkyloxy optionally substituted with oxo, isoxazolyl-(C 1 -C 6 )alkyloxy, imidazolyl-(C 1 -C 6 )alkyloxy, tetrazolyl-(C 1 -C 6 )alkyloxy and thiazolyl-(C 1 -C 6 )alkyloxy, wherein the isoxazolyl, imidazolyl, tetrazolyl or thiazolyl rings may be optionally substituted with methyl, 
         wherein the compound is not 
       
       
         
           
           
               
               
           
         
       
       and
 wherein the condition or disorder is a central nervous system disorder selected from the group consisting of anxiety disorders, psychotic disorders, personality disorders, substance-related disorders, eating disorders, mood disorders, migraine, epilepsy or convulsive disorders, childhood disorders, cognitive disorders, neurodegeneration, neurotoxicity and ischemia. 
 
     
     
         14 . A method according to  claim 13 , wherein said compound has the general Formula (I), 
       
         
           
           
               
               
           
         
         a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof and an N-oxide form thereof, wherein: 
         R 1  is not hydrogen and is a radical —V 1 -M 1 ; 
         V 1  is —CH 2 —; 
         R 2  is hydrogen; 
         R 3  is a —V 2 -M 2  radical; 
         R 4  is hydrogen; 
         R 5  is hydrogen; 
         V 2  is a covalent bond; 
         M 1  is a phenyl group having at least one halo group; and 
         M 2  is a phenyl group substituted with at least one substituent selected from the group consisting of (C 1 -C 6 )alkyloxy, pyridinyl-(C 1 -C 6 )alkyloxy, morpholinyl-(C 1 -C 6 )alkyloxy, pyrrolidinyl-(C 1 -C 6 )alkyloxy optionally substituted with oxo, isoxazolyl-(C 1 -C 6 )alkyloxy, imidazolyl-(C 1 -C 6 )alkyloxy, tetrazolyl-(C 1 -C 6 )alkyloxy or thiazolyl-(C 1 -C 6 )alkyloxy, wherein the isoxazolyl, imidazolyl, tetrazolyl and thiazolyl rings may be optionally substituted with methyl. 
       
     
     
         15 . The method of  claim 14 , wherein M 1  is a phenyl group having at least one fluoro or chloro group. 
     
     
         16 . The method of  claim 14 , wherein M 1  is a phenyl group having one fluoro group and one chloro group. 
     
     
         17 . The method of  claim 14 , wherein M 1  is 
       
         
           
           
               
               
           
         
       
     
     
         18 . The method of  claim 14 , wherein M 2  is a phenyl group substituted with at least one (C 1 -C 6 )alkyloxy. 
     
     
         19 . The compound of  claim 14 , wherein M 2  is a phenyl group substituted with a methoxy group. 
     
     
         20 . The compound of  claim 14 , wherein M 2  is a phenyl group substituted with at least one tetrazolyl-(C 1 -C 6 )alkyloxy. 
     
     
         21 . The compound of  claim 14 , wherein M 2  is a phenyl group substituted with 
       
         
           
           
               
               
           
         
       
     
     
         22 . A method according to  claim 13 , wherein said compound is:
 1-(2,4-difluorobenzyl)-5-(benzofuran-2-yl)pyridin-2(1H)-one;   1-benzyl-5-(4-fluorophenyl)pyridin-2(1H)-one;   1-(2,4-difluorobenzyl)-5-(4-fluorophenyl)pyridin-2(1H)-one;   1-(3-chlorobenzyl)-5-(4-fluorophenyl)pyridin-2(1H)-one;   1-benzyl-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(3-(trifluoromethyl)benzyl)-5-phenylpyridin-2(1H)-one;   1-(4-methylbenzyl)-5-phenylpyridin-2(1H)-one;   1-(2,4-difluorobenzyl)-5-(thiophen-2-yl)pyridin-2(1H)-one;   1-benzyl-5-(4-chlorophenyl)pyridin-2(1H)-one;   1-(3-(trifluoromethyl)benzyl)-5-(4-chlorophenyl)pyridin-2(1H)-one;   1-(2,4-difluorobenzyl)-5-(4-chlorophenyl)pyridin-2(1H)-one;   1-(2,4-dichlorobenzyl)-5-(4-methoxyphenyl)pyrimidin-2(1H)-one;   1-(3-chlorobenzyl)-5-phenylpyridin-2(1H)-one;   1-(3-chlorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-phenylpyridin-2(1H)-one;   1-(2,4-difluorobenzyl)-5-phenylpyridin-2(1H)-one;   1-Benzyl-5-(3-methoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(3-chlorophenyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-cyanophenyl)pyridin-2(1H)-one;   1-Benzyl-5-(3-nitrophenyl)pyridin-2(1H)-one;   1-Benzyl-5-(2-fluorophenyl)pyridin-2(1H)-one;   1-Benzyl-5-(3,4-dimethoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(naphthalen-2-yl)pyridin-2(1H)-one;   1-Benzyl-5-(2-methoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-m-tolylpyridin-2(1H)-one;   1-Benzyl-5-(3-chloro-4-isopropoxyphenyl)pyridin-2(1H)-one;   Ethyl-4-(1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)benzoate;   1-Benzyl-5-(2-fluoro-5-methoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-tolyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-(trifluoromethoxy)phenyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-acetylphenyl)pyridin-2(1H)-one;   2-(4-Fluorobenzyl)isoquinolin-1(2H)-one;   1-(2-Fluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Fluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Nitrobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(3,4-Dichlorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(3-Nitrobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(3-Methoxybenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(Benzo[d]thiazol-2-ylmethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-isobutoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(2-phenylethynyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-hydroxyphenyl)pyridin-2(1H)-one;   1-(4-Methoxybenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   3-((5-(4-Methoxyphenyl)-2-oxopyridin-1(2H)-yl)methyl)benzonitrile;   1-(3-Fluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-(1-phenylethyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-(pyridin-3-ylmethyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-ethylphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(2,3-dihydro-1-benzofuran-5-yl)pyridin-2(1H)-one;   1-Benzyl-5-(4-(dimethylamino)phenyl)pyridin-2(1H)-one;   1-Benzyl-5-(3,4-dimethylphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(3,4-dichorophenyl)pyridin-2(1H)-one;   1-((3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl)methyl)-5-(4-methoxyphenyl)pyridin-2 (1H)-one;   1-Benzyl-5-(4-tert-butylphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(indol-5-yl)pyridin-2(1H)-one;   1-Benzyl-5-(4-propoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(4-(trimethylsilyl)phenyl)pyridin-2(1H)-one;   1-Benzyl-5-(3,5-difluorophenyl)pyridin-2(1H)-one;   N-(4-Fluorobenzyl)-2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-methylacetamide;   1-((5-Fluorobenzo[d]oxazol-2-yl)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-Benzyl-5-(6-methoxypyridin-3-yl)pyridin-2(1H)-one;   1-Benzyl-5-(4-methoxyphenyl)-3-nitropyridin-2(1H)-one;   1-(4-Methylbenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(3,4-Difluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-(Trifluoromethyl)benzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(3-Fluoro-4-methylbenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   Methyl 4-((5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)methyl)benzoate;   4-((5-(4-Methoxyphenyl)-2-oxopyridin-1(2H)-yl)methyl)benzonitrile;   5-(4-Methoxyphenyl)-1-(naphthalen-2-ylmethyl)pyridin-2(1H)-one;   1-(3-Fluoro-4-(trifluoromethyl)benzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(3-Chloro-4-fluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chloro-3-(trifluoromethyl)benzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(2-Fluoro-4-(trifluoromethyl)benzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(2-Fluoro-4-chlorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)quinolin-2(1H)-one;   1-Benzyl-5-phenethylpyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-((5-methylisoxazol-3-yl)methyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(2,5-difluorophenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(3-fluoro-4-methylphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(2-ethoxyphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(quinolin-3-yl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-tolyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(2-fluorophenyl)pyridin-2(1H)-one;   Methyl-3-(4-(1-(4-chlorobenzyl)-1,6-dihydro-6-oxopyridin-3-yl)phenyl) propanoate;   1-(4-Chlorobenzyl)-5-(4-isobutylphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-sec-butylphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-vinylphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(3-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(2,3-dihydrobenzofuran-5-yl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-acetylphenyl)pyridin-2(1H)-one;   Methyl 3-(3-(1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)propanoate;   1-(4-Chlorobenzyl)-5-(4-(ethylthio)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(3-ethoxyphenyl)pyridin-2(1H)-one;   N-(3-(1-(4-Chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)methanesulfonamide;   1-(4-Chlorobenzyl)-5-(6-methoxypyridin-3-yl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(methoxymethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-((3-methoxymethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(furan-3-yl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(1-benzyl-1H-pyrazol-4-yl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(methylthio)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(1-methyl-1H-indol-5-yl)pyridin-2(1H)-one; tert-Butyl 2-(1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrrole-1-carboxylate;   1-(3-Fluorobenzyl)-5-p-tolylpyridin-2(1H)-one;   5-(4-((2H-Tetrazol-5-yl)methyl)phenyl)-1-(4-chlorobenzyl)pyridin-2(1H)-one;   1-(3-Fluorobenzyl)-5-(2-(3-methoxyphenyl)ethynyl)pyridine-2(1H)-one;   1-(3-Fluorobenzyl)-5-(2-(pyridin-3-yl)ethynyl)pyridin-2(1H)-one hydrochloride;   1-(4-Chlorobenzyl)-5-(4-(methylsulfonyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(1H-indol-5-yl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-methoxyphenyl)-6-methylpyridin-2(1H)-one;   1-((6-Chloropyridin-3-yl)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chloro-3-fluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(3,4-Difluorobenzyl)-5-(4-(methoxymethyl)phenyl)pyridin-2(1H)-one;   1-(3,4-Difluorobenzyl)-5-(4-acetylphenyl)pyridin-2(1H)-one;   1-(3,4-Difluorobenzyl)-5-(2,3-dihydrobenzofuran-5-yl)pyridin-2(1H)-one;   1-(4-Methyl-benzyl)-2-oxo-4-thiophen-2-yl-1,2-dihydro-pyridine-3-carbonitrile;   1-(3,4-Difluorobenzyl)-5-(3-methoxyphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-(3-phenylpropyl)pyridin-2(1H)-one;   1-(4-Fluorophenethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-(4-phenylbutyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-hydroxyphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-((methyl(phenyl)amino)methyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-((benzyl(methyl)amino)methyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-((phenylamino)methyl)pyridin-2(1H)-one;   (Z)-5-(3-Methoxystyryl)-1-(4-chlorobenzyl)pyridin-2(1H)-one;   (E)-5-(3-Methoxystyryl)-1-(4-chlorobenzyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-isopropoxyphenyl)pyridin-2(1H)-one;   Ethyl 2-(4-(1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)acetate;   1-(4-Chlorobenzyl)-5-((4-fluorophenyl)(hydroxy)methyl)pyridine-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-fluorobenzyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(hydroxy(3-methoxyphenyl)methyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-(2-oxo-2-phenylethyl)-1H-pyridin-2-one;   1-((4-Chlorophenoxy)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-(2-phenoxyethyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-sec-butoxyphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(3-methoxybenzoyl)pyridin-2(1H)-one;   5-(3-Methoxyphenethyl)-1-(4-chloro-3-fluorobenzyl)pyridin-2(1H)-one;   1-(3,4-Difluorobenzyl)-5-(3-methoxyphenethyl)pyridine-2(1H)-one;   5-(3-Methoxybenzyl)-1-(4-chlorobenzyl)pyridin-2(1H)-one;   1-(4-Chloro-3-fluorobenzyl)-5-(4-methoxyphenethyl)pyridine-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-methoxyphenyl)-4-methylpyridin-2(1H)-one;   1-(4-Chloro-3-fluorobenzyl)-5-(benzo[d]thiazol-2-yl)pyridin-2(1H)-one;   1-(3,4-Difluorobenzyl)-5-(phenoxymethyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-((4-methoxyphenoxy)methyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-((4-fluorophenyl)(methyl)amino)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(phenoxymethyl)pyridin-2(1H)-one;   1-(3,4-Difluorobenzyl)-5-(thiophen-2-yl)pyridin-2(1H)-one;   4-(1-(3,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile;   N-(4-(1-(3,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)methane sulfonamide;   N-(3-Chlorobenzyl)-2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-methylacetamide;   N-Benzyl-2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-methylacetamide;   N-(3-Methoxybenzyl)-2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-methylacetamide;   1-(3,4-Difluorobenzyl)-5-(6-methoxypyridin-3-yl)pyridine-2(1H)-one;   1-(3,4-Difluorobenzyl)-5-(benzo[d][1,3]dioxol-5-yl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(trifluoromethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(3-fluoro-4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-(Trifluoromethoxy)benzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(2,4-Difluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(2-Methylphenylmethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(2,3-Difluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   N-(4-Nitrobenzyl)-2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-methylacetamide;   N-(4-Methylbenzyl)-2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-methylacetamide;   N-(4-(Trifluoromethyl)benzyl)-2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-methylacetamide;   1-(4-Chlorobenzyl)-5-phenylpyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(benzo[b]thiophen-5-yl)pyridin-2(1H)-one;   1-(2,4,6-Trifluorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(2-Chlorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2(1H)-one hydrochloride;   4-(1-(4-Methoxybenzyl)-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile;   1-(4-Methoxybenzyl)-5-(4-acetylphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-((6-methoxypyridin-3-yl)methyl)pyridin-2(1H)-one hydrochloride;   1-(4-Chloro-2-fluorobenzyl)-5-(3,4-dimethoxyphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-((5-phenyl-1,2,4-oxadiazol-3-yl)methyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-hydroxyphenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(pyrrolidin-1-ylsulfonyl)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(morpholinosulfonyl)phenyl)pyridin-2(1H)-one;   1-((4-Fluorobenzo[d]thiazol-2-yl)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(2-methoxyethoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-bromopyridin-2(1H)-one;   1-(4-Chlorobenzyl)-3-(hydroxymethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(2-morpholinoethoxy)phenyl)pyridin-2(1H)-one;   1-(Benzo[d]thiazol-2-ylmethyl)-5-phenylpyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(2-(dimethylamino)ethoxy)phenyl)pyridin-2(1H)-one;   2-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)acetonitrile;   5-(4-((2H-Tetrazol-5-yl)methoxy)phenyl)-1-(4-chloro-2-fluorobenzyl)pyridin-2(1H)-one;   1-Butyl-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(3-morpholinopropoxy)phenyl)pyridin-2(1H)-one hydrochloride;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(3-(dimethylamino)propoxy)phenyl)pyridin-2(1H)-one;   4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl methyl carbonate;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(2-oxopropoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-isobutoxyphenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-methoxy-3-methylphenyl)pyridin-2(1H)-one;   Methyl 2-(4-(1-(4-chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)acetate;   5-(4-(1H-Tetrazol-5-yl)phenyl)-1-(4-chloro-2-fluorobenzyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-aminophenyl)pyridin-2(1H)-one hydrochloride;   1-(4-Chloro-2-fluorobenzyl)-5-(3-aminophenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(hydroxymethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-methoxy-3,5-dimethylphenyl)pyridin-2(1H)-one;   1-Isobutyl-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-Isopentyl-5-(4-methoxyphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-(pent-4-ynyl)pyridin-2(1H)-one;   1-(Cyclohexylmethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   N-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)acetamide;   1-(4-Chloro-2-fluorobenzyl)-5-(4-((2-methylthiazol-4-yl)methoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-((1-methyl-1H-imidazol-2-yl)methoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(2-aminoethoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-((5-methylisoxazol-3-yl)methoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-propoxyphenyl)pyridin-2(1H)-one;   N-(3-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)acetamide;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(aminomethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(3-hydroxyphenyl)pyridin-2(1H)-one;   N-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)benzyl)acetamide;   N-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)benzyl)methanesulfonamide;   N-(3-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)benzyl)acetamide;   5-(4-Methoxyphenyl)-1-((5-(trifluoromethyl)furan-2-yl)methyl)pyridin-2(1H)-one;   1-(4-(Methoxymethyl)benzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   2-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)-N-methylacetamide;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(3-aminopropoxy)phenyl)pyridin-2(1H)-one;   1-(4-(Ethoxymethyl)benzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-chlorobenzyl)-5-(4-(ethoxymethyl)phenyl)pyridin-2(1H)-one;   N-(2-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)ethyl)acetamide;   N-Acetyl-N-(2-(4-[1-(4-chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl]phenoxy)ethyl)acetamide;   N-(2-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)ethyl)methanesulfonamide;   N-(3-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)propyl)methane sulfonamide;   N-Acetyl-N-(3-(4-(1-(4-chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)propyl)acetamide;   N-(3-(4-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)propyl)acetamide;   1-(4-Chloro-2-fluorobenzyl)-5-isopropylpyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(6-(dimethylamino)pyridin-3-yl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(3-amino-4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-morpholinophenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(5-methylthiophen-2-yl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(6-morpholinopyridin-3-yl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(6-methoxypyridin-3-yl)pyridin-2(1H)-one;   5-(6-Methoxypyridin-3-yl)-1-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(ethoxymethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(benzyloxymethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(hydroxymethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(dimethylamino)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(quinoxalin-6-yl)pyridin-2(1H)-one;   Methyl 4-(1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)benzoate;   1-(4-Chlorobenzyl)-5-(4-(3-hydroxypropyl)phenyl)pyridin-2(1H)-one;   4-(1-Isopentyl-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile;   N-(3-(1-Isopentyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)methanesulfonamide;   3-(1-(4-Chloro-2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile;   1-(4-Chlorobenzyl)-5-(6-chloropyridin-3-yl)pyridin-2(1H)-one;   N-(5-(1-(4-Chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methoxyphenyl)methanesulfonamide;   5-(4-Methoxyphenyl)-1-pentylpyridin-2(1H)-one;   1-(Cyclopropylmethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(Cyclopentylmethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   Methyl 2-(4-(1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)acetate;   1-(4-Chlorobenzyl)-5-cyclohexylpyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(quinolin-7-yl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(furan-2-ylmethoxy)phenyl)pyridin-2(1H)-one;   5-(3-(2H-Tetrazol-5-yl)phenyl)-1-(4-chloro-2-fluorobenzyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(2-hydroxypropan-2-yl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(isobutoxymethyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-((2-(dimethylamino)ethoxy)methyl)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-((2-morpholinoethoxy)methyl)phenyl)pyridin-2(1H)-one;   4-(1-(4-Chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-N,N-dimethylbenzamide;   2-(4-(1-(4-Chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-N,N-dimethylacetamide;   N-(2-(4-(1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)benzyloxy)ethyl)acetamide;   1-(4-Chlorobenzyl)-5-(4-((2-methoxyethoxy)methyl)phenyl)pyridin-2(1H)-one;   2-(4-(1-(4-Chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-N-methylacetamide;   3-(4-(1-(4-Chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-N-methylpropanamide;   3-(4-(1-(4-Chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-N,N-dimethylpropanamide;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(2-hydroxypropoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(3-phenylpropyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(3-methoxyphenyl)butyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-phenylbutyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-butylpyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-methoxyphenyl)pyrimidin-2(1H)-one;   1-Benzyl-5-(4-methoxyphenyl)pyrimidin-2(1H)-one;   1-Isopentyl-5-(4-methoxyphenyl)pyrazin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(2-(dimethylamino)ethylamino)phenyl)pyridin-2(1H)— one;   1-(4-Chlorobenzyl)-5-(4-(2-methoxyethylamino)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-(propylamino)phenyl)pyridin-2(1H)-one;   1-(3,3-Dimethylbutyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(pyridin-3-ylmethoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(4-methoxyphenyl)butyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-methoxybenzyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(3-phenoxypropyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-methoxyphenoxy)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-propoxypyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(cyclohexylmethoxy)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-fluorobenzyloxy)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-methoxybenzyloxy)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-phenethoxypyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-fluorophenoxy)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(2-methoxyethoxy)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(5-methylpyridin-2-yl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-(4-(pyridin-2-ylmethoxy)phenyl)pyridin-2(1H)-one;   5-(2-Methoxybenzyl)-1-(4-chloro-2-fluorobenzyl)pyridin-2(1H)-one;   5-(4-Methoxyphenethylamino)-2-propylisoquinolin-1(2H)-one;   5-(4-Hydroxyphenethylamino)-2-propylisoquinolin-1(2H)-one;   5-(4-Methoxyphenyl)-1-((6-(4-methoxyphenyl)pyridin-3-yl)methyl)pyridin-2(1H)-one;   1-((6-Ethynylpyridin-3-yl)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-((6-Ethylpyridin-3-yl)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-((2-methylthiazol-5-yl)methyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-((5-methylpyrazin-2-yl)methyl)pyridin-2(1H)-one;   5-(Phenoxymethyl)-1-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2(1H)-one;   mixture of isomers of 1-(4-chloro-2-fluorobenzyl)-5-(4-((2-methyl-2H-tetrazol-5-yl)methoxy)phenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(4-fluorophenyl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-(pentan-2-yl)pyridin-2(1H)-one;   5-(4-Methoxyphenyl)-1-((4-methylcyclohexyl)methyl)pyridin-2(1H)-one;   1-(4-Ethoxybenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;   1-Isopentyl-5-(4-methoxyphenyl)pyrimidin-2(1H)-one;   1-Isopentyl-5-((4-methoxyphenoxy)methyl)pyridin-2(1H)-one;   1-(4-Chloro-2-fluorobenzyl)-5-((3-methoxyphenoxy)methyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(2-fluoro-4-methoxyphenyl)pyridin-2(1H)-one;   1-(4-Chlorobenzyl)-5-(2-methoxypyrimidin-5-yl)pyridin-2(1H)-one; and   5-(4-Methoxyphenethoxy)-2-propylisoquinolin-1(2H)-one.   
     
     
         23 . A method according to  claim 13 , wherein said compound exists as optical isomers, wherein said compound is either the racemic mixture or the individual optical isomer. 
     
     
         24 . A method according to  claim 13 , wherein the central nervous system disorder is an anxiety disorder, selected from the group consisting of agoraphobia, generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD), panic disorder, posttraumatic stress disorder (PTSD), social phobia and other phobias. 
     
     
         25 . A method according to  claim 13 , wherein the central nervous system disorder is a psychotic disorder selected from the group consisting of schizophrenia, delusional disorder, schizoaffective disorder, schizophreniform disorder and substance-induced psychotic disorder. 
     
     
         26 . A method according to  claim 13 , wherein the central nervous system disorder is a personality disorder selected from the group consisting of obsessive-compulsive personality disorder and schizoid, and schizotypal disorder. 
     
     
         27 . A method according to  claim 13 , wherein the central nervous system disorder is a substance-related disorder selected from the group consisting of alcohol abuse, alcohol dependence, alcohol withdrawal, alcohol withdrawal delirium, alcohol-induced psychotic disorder, amphetamine dependence, amphetamine withdrawal, cocaine dependence, cocaine withdrawal, nicotine dependence, nicotine withdrawal, opioid dependence and opioid withdrawal. 
     
     
         28 . A method according to  claim 13 , wherein the central nervous system disorder is an eating disorder selected from the group consisting of anorexia nervosa and bulimia nervosa. 
     
     
         29 . A method according to  claim 13 , wherein the central nervous system disorder is a mood disorder selected from the group consisting of bipolar disorders (I & II), cyclothymic disorder, depression, dysthymic disorder, major depressive disorder and substance-induced mood disorder. 
     
     
         30 . A method according to  claim 13 , wherein the central nervous system disorder is a migraine. 
     
     
         31 . A method according to  claim 13 , wherein the central nervous system disorder is epilepsy or a convulsive disorder selected from the group consisting of generalized nonconvulsive epilepsy, generalized convulsive epilepsy, petit mal status epilepticus, grand mal status epilepticus, partial epilepsy with or without impairment of consciousness, infantile spasms, epilepsy partialis continua, and other forms of epilepsy. 
     
     
         32 . A method according to  claim 13 , wherein the childhood disorder is attention-deficit/hyperactivity disorder. 
     
     
         33 . A method according to  claim 13 , wherein the central nervous system disorder is a cognitive disorder selected from the group consisting of delirium, substance-induced persisting delirium, dementia, dementia due to HIV disease, dementia due to Huntington's disease, dementia due to Parkinson's disease, dementia of the Alzheimer's type, substance-induced persisting dementia and mild cognitive impairment. 
     
     
         34 . A method according to  claim 13 , wherein the central nervous system disorder is selected from the group consisting of anxiety, schizophrenia, migraine, depression, and epilepsy. 
     
     
         35 . A method according to  claim 13 , wherein the mGluR2 positive allosteric modulator has an ED 50  of about 1 μM or less.