Anti-angiogenic composition containing macrolactin a and a derivative thereof as active ingredients

Abstract

The present invention relates to an anti-angiogenic composition containing macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A, and 7-O-succinyl macrolactin A as active ingredients. The macrolactin compounds according to the present invention strongly suppress angiogenesis in in vivo experiments and can be used as a pharmaceutical composition for preventing or treating diseases caused by angiogenesis.

1 . An anti-angiogenic composition comprising at least one of macrolactin A, 7-O-malonyl macrolactin A and 7-O-succinyl macrolactin A as an active ingredient. 
     
     
         2 . The composition according to  claim 1 , which comprises macrolactin A as the active ingredient. 
     
     
         3 . The composition according to  claim 1 , which comprises 7-O-malonyl macrolactin A as the active ingredient. 
     
     
         4 . The composition according to  claim 1 , which comprises 7-O-succinyl macrolactin A as the active ingredient. 
     
     
         5 . The composition according to  claim 1 , wherein the diseases caused by angiogenesis are at least one selected from the group consisting of rheumatoid arthritis, osteoarthritis, septic arthritis, psoriasis, corneal ulcer, age-related macular degeneration, diabetic retinopathy, proliferative vitreoretinopathy, immature retinopathy, ophthalmic inflammation, conical cornea, Sjogren's syndrome, myopia ophthalmic tumor, rejection of corneal transplantation, abnormal cut conglutination, bone disease, proteinuria, disorders of abdominal aneurysm, cartilage loss resulting from traumatic joint damage, neurologic demyelination, cirrhosis, glomerular diseases, immature rupture of embryo-fetal membrane, inflammatory bowel diseases, periodontal diseases, arteriosclerosis, restenosis, inflammatory diseases of the central nervous system, Alzheimer's disease, skin aging, and infiltration and metastasis of cancer.