Pharmaceutical composition for the prevention or treatment of inflammatory diseases or immune diseases containing ramalin

Abstract

The present invention relates to the novel use (anti-inflammatory activity) of Ramalin isolated from the Antarctic lichen Ramalina terebrata , and more specifically to a pharmaceutical composition containing Ramalin as an active ingredient. Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. In addition, it inhibits the activation of the inflammatory mediator NF-κB, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. Thus, the composition containing Ramalin can be effectively used to fundamentally treat or prevent inflammatory diseases or immune diseases and to relieve or alleviate the symptoms of the diseases.

1 . A pharmaceutical composition for preventing or treating inflammatory disease or immune disease, which contains, as an active ingredient, Ramalin having a structure of the following formula 1 or a pharmaceutically acceptable salt thereof: 
       
         
           
           
               
               
           
         
       
     
     
         2 . The pharmaceutical composition of  claim 1 , wherein the inflammatory disease or immune disease is atopic dermatitis, arthritis, urethritis, cystitis, arteriosclerosis, allergic disease, nasitis, asthma, acute pain, chronic pain, paradentitis, gingivitis, inflammatory bowel disease, gout, myocardial infarction, congestive heart failure, hypertension, angina pectoris, stomach ulcer, cerebral infarction, Down's syndrome, multiple sclerosis, obesity, diabetes, dementia, depression, schizophrenia, tuberculosis, sleep disorder, sepsis, a burn, pancreatitis, Parkinson's disease, stroke, brain damage caused by seizure, or autoimmune disease. 
     
     
         3 . The pharmaceutical composition of  claim 1 , which further contains a suitable carrier, excipient or diluent which is commonly used in preparation of pharmaceutical compositions. 
     
     
         4 . The pharmaceutical composition of  claim 1 , which is formulated or used in combination with one or more agents selected from the group consisting of anti-histamine agents, anti-inflammatory agents, anticancer agents and antibiotics. 
     
     
         5 . A functional food for preventing or improving inflammatory disease or immune disease, which contains, as an active ingredient, Ramalin having a structure of the following formula 1: 
       
         
           
           
               
               
           
         
       
     
     
         6 . The functional food of  claim 5 , wherein the inflammatory disease or immune disease is atopic dermatitis, arthritis, urethritis, cystitis, arteriosclerosis, allergic disease, nasitis, asthma, acute pain, chronic pain, paradentitis, gingivitis, inflammatory bowel disease, gout, myocardial infarction, congestive heart failure, hypertension, angina pectoris, stomach ulcer, cerebral infarction, Down's syndrome, multiple sclerosis, obesity, diabetes, dementia, depression, schizophrenia, tuberculosis, sleep disorder, sepsis, a burn, pancreatitis, Parkinson's disease, stroke, brain damage caused by seizure, or autoimmune disease. 
     
     
         7 . A functional cosmetic product which contains, as an active ingredient, Ramalin having a structure of the following formula 1: 
       
         
           
           
               
               
           
         
       
     
     
         8 . The functional cosmetic product of  claim 7 , which is used to improve inflammatory disease. 
     
     
         9 . The functional cosmetic product of  claim 8 , wherein the inflammatory disease is atopic dermatitis or a burn.