Fluro substituted Omega-Carboxyaryl Diphenyl Urea for the Treatment and Prevention of Diseases and Conditions

Abstract

A compound of Formula (I): salts thereof, prodrugs thereof, metabolites thereof, pharmaceutical compositions containing such a compound, and use of such compound and compositions to treat diseases mediated by raf, VEGFR, PDGFR, p38 and flt-3.

1 - 54 . (canceled) 
     
     
         55 . A compound which is a derivative of a compound of Formula I where the methylamide group is oxidized 
       
         
           
           
               
               
           
         
       
     
     
         56 . A compound claim  2  where the methylamide group is substituted with a hydroxyl group. 
     
     
         57 . A pharmaceutical composition comprising a compound of claim  1  and a physiologically acceptable carrier. 
     
     
         58 . A pharmaceutical composition for the treatment of a cancerous cell growth comprising a compound of claim  1  and a physiologically acceptable carrier for treating cancer. 
     
     
         59 . A compound which is a derivative of a compound of Formula I where one of the two urea nitrogen atoms is oxidized 
       
         
           
           
               
               
           
         
       
     
     
         60 . A compound claim  5  where either urea nitrogen atom of the compound of formula I is substituted with a hydroxyl group. 
     
     
         61 . A compound which is a derivative of a compound of Formula I where the pyridine nitrogen atom and the methylamide functionality are oxidized 
       
         
           
           
               
               
           
         
       
     
     
         62 . A compound claim  7  where the pyridine nitrogen atom is in the n-oxide form and the methylamide functionality is substituted with a hydroxyl group.