Linear polyol stabilized polyfluoroacrylate compositions

Abstract

The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.

What is claimed is: 
     
         1 . A process for preparing a crosslinked cation exchange polymer salt, the process comprising mixing the crosslinked cation exchange polymer salt with a solution of a linear sugar alcohol, the crosslinked cation exchange polymer comprising structural units corresponding to Formulae 1 and 2, Formulae 1 and 3, or Formulae 1, 2, and 3, wherein
 Formula 1, Formula 2, and Formula 3 are represented by the following structures:   
       
         
           
           
               
               
           
         
       
       wherein
 R 1  and R 2  are each independently hydrogen, alkyl, cycloalkyl, or aryl; 
 A 1  is carboxylic, phosphonic, or phosphoric; 
 X 1  is arylene; and 
 X 2  is alkylene, an ether moiety, or an amide moiety. 
 
     
     
         2 . The process of  claim 1  wherein the structural units represented by Formulae 1, 2, and 3 are represented by the following structures: 
       
         
           
           
               
               
           
         
       
     
     
         3 . The process of  claim 1  wherein the polymer comprises structural units corresponding to Formulae 1, 2 and 3. 
     
     
         4 . The process of  claim 1  wherein the polymer comprises structural units corresponding to Formulae 1 and 2. 
     
     
         5 . The process of  claim 1  wherein the polymer comprises structural units corresponding to Formulae 1 and 3. 
     
     
         6 . The process of  claim 1  wherein the cation of the salt is calcium, sodium, or a combination thereof. 
     
     
         7 . The process of  claim 1  wherein the cation of the salt comprises calcium. 
     
     
         8 . The process of  claim 1  wherein the linear sugar alcohol is selected from the group consisting of arabitol, erythritol, glycerol, maltitol, mannitol, ribitol, sorbitol, xylitol, threitol, galactitol, isomalt, iditol, lactitol and combinations thereof. 
     
     
         9 . The process of  claim 1  wherein the linear sugar alcohol is sorbitol, xylitol, or a combination thereof. 
     
     
         10 . The process of  claim 8  wherein the cation of the salt is calcium, sodium, or a combination thereof. 
     
     
         11 . The process of  claim 9  wherein the cation of the salt comprises calcium. 
     
     
         12 . The process of  claim 2  wherein the polymer comprises structural units corresponding to Formulae 1, 2 and 3, the cation of the salt comprises calcium and the linear sugar alcohol comprises sorbitol. 
     
     
         13 . A process for preparing a crosslinked cation exchange polymer salt, the process comprising mixing the crosslinked cation exchange polymer salt with a solution of a linear sugar alcohol, the crosslinked cation exchange polymer being a reaction product of a polymerization mixture comprising monomers of either (i) Formulae 11 and 22, (ii) Formulae 11 and 33, or (iii) Formulae 11, 22, and 33, wherein
 Formula 11, Formula 22, and Formula 33 are represented by the following structures:   
       
         
           
           
               
               
           
         
       
       and wherein
 R 1  and R 2  are each independently hydrogen, alkyl, cycloalkyl, or aryl; 
 A 11  is an optionally protected carboxylic, phosphonic, or phosphoric; 
 X 1  is arylene; and 
 X 2  is alkylene, an ether moiety, or an amide moiety. 
 
     
     
         14 . The process of  claim 13  wherein A 11  is a protected carboxylic, phosphonic, or phosphoric. 
     
     
         15 . The process of  claim 13  wherein Formulae 11, 22, and 33 are represented by the following structures: 
       
         
           
           
               
               
           
         
       
     
     
         16 . The process of  claim 13  wherein the polymer comprises structural units corresponding to Formulae 11, 22, and 33. 
     
     
         17 . The process of  claim 13  wherein the cation of the salt is calcium, sodium, or a combination thereof. 
     
     
         18 . The process of  claim 13  wherein the linear sugar alcohol is selected from the group consisting of arabitol, erythritol, glycerol, maltitol, mannitol, ribitol, sorbitol, xylitol, threitol, galactitol, isomalt, iditol, lactitol and combinations thereof. 
     
     
         19 . The process of  claim 13  wherein the linear sugar alcohol is sorbitol, xylitol, or a combination thereof. 
     
     
         20 . The process of  claim 15  further comprising hydrolysis of the protected carboxylic acid group, wherein the polymer comprises structural units corresponding to Formulae 11, 22, and 33, the cation of the salt comprises calcium, and the linear sugar alcohol comprises sorbitol. 
     
     
         21 . A crosslinked cation exchange polymer salt loaded with a stabilizing amount of a linear sugar alcohol, the polymer salt being prepared by the process of  claim 1 . 
     
     
         22 . A crosslinked cation exchange polymer salt loaded with a stabilizing amount of a linear sugar alcohol, the polymer salt being prepared by the process of  claim 13 .