Gel useful for the delivery of ophthalmic drugs

Abstract

The present invention relates to a solid powder composed of a mixture of a natural or a synthetic polymer which forms a gel, a buffer, such as an hydroxyacid or a dicarboxyacid, a saccharide, one or more drugs useful for the treatment of diseases of the eyes and optionally one or more excipients and/or regulators of the osmotic pressure ophthalmologically acceptable.

1 . A solid powder comprising:
 a carboxy vinyl polymer;   a buffer;   a saccharide; and   L-carnitine and/or one or more alkanoyl L-carnitine,   said solid powder providing a gel suitable for ophthalmic use when reconstituted in water.   
     
     
         2 . The solid powder of  claim 1 , wherein the carboxy vinyl polymer is carbopol. 
     
     
         3 . The solid powder of  claim 1 , wherein the buffer is a hydroxyacid or a dicarboxylic acid selected from the group consisting of phosphate, boric acetate, citrate, lactate, tartrate, maleate, succinate and fumarate buffer. 
     
     
         4 . The solid powder of  claim 1 , wherein the saccharide is selected from the group consisting of glucose, fructose, mannitol, sorbitol, lactose, trehalose and maltose. 
     
     
         5 . The solid powder of  claim 1 , further comprising an excipient, a diluent or a regulator of the osmotic pressure ophthalmologically acceptable. 
     
     
         6 . Physiological supplement comprising the solid powder of  claim 1  and further comprising: 
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                   L-carnitine 
                      1%; 
                 
                     
                   taurine 
                    0.5%; 
                 
                     
                   sodium hyaluronate 
                    0.2%; 
                 
                     
                   vitamin E 
                    0.2%; 
                 
                     
                   manganese 
                   0.051%; 
                 
                     
                   zinc 
                    1.02%; 
                 
                     
                   sodium 
                   30 mg/L; 
                 
                     
                   potassium 
                    9 mg/L. 
                 
                     
                     
                 
             
                
               
               
                
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         7 . Physiological supplement comprising the solid powder of  claim 1  and further comprising: 
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                   L-carnitine 
                    10%; 
                 
                     
                   taurine 
                     2%; 
                 
                     
                   sodium hyaluronate 
                   0.2%; 
                 
                     
                   vitamin E 
                   0.2%; 
                 
                     
                   zinc 
                    1.02 mg/L; 
                 
                     
                   manganese 
                   0.051 mg/L; 
                 
                     
                   sodium 
                     30 mg/L; 
                 
                     
                   potassium 
                      9 mg/L. 
                 
                     
                     
                 
             
                
               
               
                
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         8 . Physiological supplement comprising the solid powder of  claim 1  and further comprising: 
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                   L-carnitine 
                     5%; 
                 
                     
                   3-Hydroxykynurenine O-P-DL-glucoside 
                    0.1 mg/mL; 
                 
                     
                   taurine 
                     2%; 
                 
                     
                   resveratrol 
                    0.3 mg/mL; 
                 
                     
                   sodium jaluronate 
                   0.2%; 
                 
                     
                   vitamin E 
                   0.2%; 
                 
                     
                   zinc 
                    1.02 mg/L; 
                 
                     
                   manganese 
                   0.051 mg/L; 
                 
                     
                   sodium 
                     30 mg/L; 
                 
                     
                   potassium 
                      9 mg/L. 
                 
                     
                     
                 
             
                
               
               
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         9 . Physiological supplement comprising the solid powder of  claim 1  and further comprising: 
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                   acetyl L-carnitine 
                   20%; 
                 
                     
                   3-Hydroxykynurenine O-β-DL-glucoside 
                   0.1 mg/mL; 
                 
                     
                   vitamin E 
                    1%; 
                 
                     
                   vitamin A 
                   25000 UI. 
                 
                     
                     
                 
             
                
               
               
                
                
                
                
                
               
            
           
         
       
     
     
         10 . Kit comprising the solid powder of  claim 1  and water or a liquid solution. 
     
     
         11 . Kit of  claim 10 , in which each component is packaged in the same vial or in two different vials. 
     
     
         12 . Kit comprising:
 a) the powder of  claim 1 , without L-carnitine and/or one or more alkanoyl L-carnitine;   b) L-carnitine and/or one or more alkanoyl L-carnitine in the form of liquid, solid, cream, gel or powder; and   c) water or a liquid solution.   
     
     
         13 . Kit of  claim 12 , wherein each component is packaged in a separate form in the same vial or in different vials.