US2013142817A1PendingUtilityA1
Microbial delivery system
Est. expiryApr 6, 2020(expired)· nominal 20-yr term from priority
A61P 37/08A61P 11/06A61K 2039/523A61K 39/35A61K 2039/5256A61K 2039/5156
58
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Claims
Abstract
The present invention provides methods and compositions for treating or preventing allergic responses, particularly anaphylactic allergic responses, in subjects who are allergic to allergens or susceptible to allergies. Methods of the present invention utilize administration of microorganisms to subjects, where the microorganisms produce allergens and protect the subjects from exposure to the allergens until phagocytosed by antigen-presenting cells. Particularly preferred microorganisms are gram-negative bacteria, gram-positive bacteria, and yeast. Particularly preferred allergens are proteins found in foods, venoms, drugs and latex that elicit allergic reactions and anaphylactic allergic reactions in individuals who are allergic to the proteins or are susceptible to allergies to the proteins. The proteins may also be modified to reduce the ability of the proteins to bind and crosslink IgE antibodies and thereby reduce the risk of eliciting anaphylaxis without affecting T-cell mediated Th1-type immunity.
Claims
exact text as granted — not AI-modifiedWe claim:
1 - 45 . (canceled)
46 . A method of manufacturing a composition comprising steps of:
(a) providing dead E. coli cells having expressed and encapsulated therein a non-secreted, recombinant version of a protein allergen; and (b) formulating the dead E. coli into a pharmaceutical composition by combination with a pharmaceutically acceptable carrier.
47 . The method of claim 46 , wherein the step of formulating comprises formulating for delivery by rectal, vaginal, nasal, oral, buccal, or mucosal delivery.
48 . A method comprising steps of:
killing E. coli cells that have expressed a non-secreted, recombinant version of a protein allergen, such that the allergen is encapsulated within the killed E. coli, the recombinant protein allergen being selected from the group consisting of:
Acarus siro (mite) fatty acid-binding protein (Aca s 13);
Actinidia chinensis (kiwi) cysteine protease (Act c 1);
Aedes aegyptii (mosquito) antigen (Aed a 2);
Aedes aegyptii (mosquito) antigen (Aed a 2);
Aedes aegyptii (mosquito) apyrase (Aed a 1);
Aedes aegyptii (mosquito) apyrase (Aed a 1);
Alnus glutinosa (alder) antigen (Aln g 1);
Alternaria alternate (fungus) acid. ribosomal protein P1 (Alt a 12);
Alternaria alternata (fungus) aldehyde dehydrogenase (Alt a 10);
Alternaria alternata (fungus) antigen (Alt a 1);
Alternaria alternata (fungus) antigen (Alt a 2);
Alternaria alternata (fungus) enloase (Alt a 11);
Alternaria alternata (fungus) heat shock protein (Alt a 3);
Alternaria alternata (fungus) ribosomal protein (Alt a 6);
Alternaria alternata (fungus) YCP4 protein (Alt a 7);
Ambrosia artemisiifolia (short ragweed) antigen E (Amb a 1);
Ambrosia artemisiifolia (short ragweed) antigen K (Amb a 2);
Ambrosia artemisiifolia (short ragweed) Ra3 antigen (Amb a 3);
Ambrosia artemisiifolia (short ragweed) Ra5 antigen (Amb a 5);
Ambrosia artemisiifolia (short ragweed) Ra6 antigen (Amb a 6);
Ambrosia artemisiifolia (short ragweed) Ra7 antigen (Amb a 7);
Ambrosia trifida (giant ragweed) Ra5G antigen (Amb t 5);
Anisakis simplex (nematode) antigen (Ani s 1);
Anisakis simplex (nematode) paramyosin (Ani s 2);
Apis mellifera (honey bee) antigen (Api m 6);
Apis mellifera (honey bee) hyaluronidase (Api m 2);
Apis mellifera (honey bee) melittin (Api m 4);
Apis mellifera (honey bee) phospholipase A2 (Api m 1);
Apium graveolens (celery) antigen (Api g 5);
Apium graveolens (celery) Bet v 1 homologue (Api g 1);
Apium graveolens (celery) profilin (Api g 4);
Arachis hypogaea (peanut) (conglutin Ar a h 2);
Arachis hypogaea (peanut) (profilin Ar a h 5);
Arachis hypogaea (peanut) conglutin homologue (Ar a h 6);
Arachis hypogaea (peanut) conglutin homologue (Ar a h 7);
Arachis hypogaea (peanut) glycinin (Ar a h 3);
Arachis hypogaea (peanut) glycinin (Ar a h 4);
Arachis hypogaea (peanut) vicilin (Ar a h 1);
Artemisia vulgaris (mugwort) antigen (Art v 1);
Artemisia vulgaris (mugwort) antigen (Art v 2);
Ascaris suum (worm) antigen (Asc s 1);
Aspergillus flavus (fungus) alkaline serine proteinase (Asp fl 13);
Aspergillus Fumigatus (fungus) alkaline serine proteinase (Asp f 13);
Aspergillus Fumigatus (fungus) antigen (Asp f 1);
Aspergillus Fumigatus (fungus) antigen (Asp f 15);
Aspergillus Fumigatus (fungus) antigen (Asp f 16);
Aspergillus Fumigatus (fungus) antigen (Asp f 17);
Aspergillus Fumigatus (fungus) antigen (Asp f 2);
Aspergillus Fumigatus (fungus) antigen (Asp f 4);
Aspergillus Fumigatus (fungus) antigen (Asp f 7);
Aspergillus Fumigatus (fungus) antigen (Asp f 9);
Aspergillus Fumigatus (fungus) aspartis protease (Asp f 10);
Aspergillus Fumigatus (fungus) heat shock protein P70 (Asp f 12);
Aspergillus Fumigatus (fungus) metalloprotease (Asp f 5);
Aspergillus Fumigatus (fungus) Mn superoxide dismutase (Asp f 6);
Aspergillus Fumigatus (fungus) peptidyl-prolyl isomerase (Asp f 11);
Aspergillus Fumigatus (fungus) peroxisomal protein (Asp f 3);
Aspergillus Fumigatus (fungus) ribosomal protein P2 (Asp f 8);
Aspergillus Fumigatus (fungus) vacuolar serine (Asp f 18);
Aspergillus niger (fungus) antigen (Asp n 18);
Aspergillus niger (fungus) beta-xylosidase (Asp n 14);
Aspergillus niger (fungus) vacuolar serine proteinase;
Aspergillus oryzae (fungus) alkaline serine proteinase (Asp o 13);
Aspergillus oryzae (fungus) TAKA-amylase A (Asp o 2);
Bertholletia excelsa (Brazil nut) 2S albumin (Ber e 1);
Betula verrucosa (birch) antigen (Bet v 1);
Betula verrucosa (birch) antigen (Bet v 3);
Betula verrucosa (birch) antigen (Bet v 4);
Betula verrucosa (birch) cyclophilin (Bet v 7);
Betula verrucosa (birch) isoflavone reductase homologue (Bet v 5);
Betula verrucosa (birch) profilin (Bet v 2);
Blattella germanica (German cockroach) aspartic protease (Bla g 2);
Blattella germanica (German cockroach) Bd90k (Bla g 1);
Blattella germanica (German cockroach) calycin (Bla g 4);
Blattella germanica (German cockroach) glutathione transferase (Bla g 5);
Blattella germanica (German cockroach) troponin C (Bla g 6);
Blomia tropicalis (mite) antigen (Blo t 5);
Blomia tropicalis (mite) Bt11a antigen (Blo t 12);
Blomia tropicalis (mite) Bt6 fatty acid-binding protein (Blo t);
Bombus pennsylvanicus (bumble bee) phospholipase (Bom p 1);
Bombus pennsylvanicus (bumble bee) protease (Bom p 4);
Bos domesticus (cow) Ag3, lipocalin (Bos d 2);
Bos domesticus (cow) alpha-lactalbumin (Bos d 4);
Bos domesticus (cow) beta-lactalbumin (Bos d 5);
Bos domesticus (cow) casein (Bos d 8);
Bos domesticus (cow) immunoglobulin (Bos d 7);
Bos domesticus (cow) serum albumin (Bos d 6);
Brassica juncea (oriental mustard) 2S albumin (Bra j 1);
Brassica rapa (turnip) prohevein-like protein (Bar r 2);
Candida albicans (fungus) antigen (Cand a 1);
Candida boidinii (fungus) antigen (Cand b 2);
Canis familiaris (dog) albumin (Can f ?);
Canis familiaris (dog) antigen (Can f 1);
Canis familiaris (dog) antigen (Can f 2);
Carpinus betulus (hornbeam) antigen (Car b 1);
Castanea sativa (chestnut) Bet v 1 homologue (Cas s 1);
Castanea sativa (chestnut) chitinase (Cas s 5);
Chironomus thummi thummi (midge) component I (Chi t 2.0101);
Chironomus thummi thummi (midge) component IA (Chi t 2.0102);
Chironomus thummi thummi (midge) component II-beta (Chi t 3);
Chironomus thummi thummi (midge) component III (Chi t 1.01);
Chironomus thummi thummi (midge) component IIIA (Chi t 4);
Chironomus thummi thummi (midge) component IV (Chi t 1.02);
Chironomus thummi thummi (midge) component IX (Chi t 6.02);
Chironomus thummi thummi (midge) component VI (Chi t 5);
Chironomus thummi thummi (midge) component VIIA (Chi t 6.01);
Chironomus thummi thummi (midge) component VIIB (Chi t 7);
Chironomus thummi thummi (midge) component VIII (Chi t 8);
Chironomus thummi thummi (midge) component X (Chi t 9);
Chironomus thummi thummi (midge) hemoglobin (Chi t 1-9);
Cladosporium herbarum (fungus) acid. ribosomal protein P1 (Cla h 12);
Cladosporium herbarum (fungus) aldehyde dehydrogenase (Cla h 3);
Cladosporium herbarum (fungus) antigen (Cla h 1);
Cladosporium herbarum (fungus) antigen (Cla h 2);
Cladosporium herbarum (fungus) enolase (Cla h 6);
Cladosporium herbarum (fungus) ribosomal protein);
Cladosporium herbarum (fungus) YCP4 protein (Cla h 5);
Coprinus comatus (shaggy cap) antigen (Cop c 1);
Coprinus comatus (shaggy cap) antigen (Cop c 2);
Coprinus comatus (shaggy cap) antigen (Cop c 3);
Coprinus comatus (shaggy cap) antigen (Cop c 5);
Coprinus comatus (shaggy cap) antigen (Cop c 7);
Corylus avelana (hazel) antigen (Cor a 1);
Corylus avellana (hazelnut) Bet v 1 homologue (Cor a 1.0401);
Cryptomeria japonica (sugi) antigen (Cry j 1);
Cryptomeria japonica (sugi) antigen (Cry j 2);
Ctenocephalides felis felis (cat flea) antigen (Cte f 1);
Cynodon dactylon (Bermuda grass) antigen (Cyn d 1);
Cynodon dactylon (Bermuda grass) antigen (Cyn d 7);
Cynodon dactylon (Bermuda grass) profilin (Cyn d 12);
Dactylis glomerata (orchard grass) AgDg1 antigen (Dac g 1);
Dactylis glomerata (orchard grass) antigen (Dac g 2);
Dactylis glomerata (orchard grass) antigen (Dac g 3);
Dactylis glomerata (orchard grass) antigen (Dac g 5);
Dermatophagoides farinae (mite) antigen (Der f 1);
Dermatophagoides farinae (mite) antigen (Der f 2);
Dermatophagoides farinae (mite) antigen (Der f 3);
Dermatophagoides farinae (mite) Mag 3, apolipophorin (Der f 14);
Dermatophagoides farinae (mite) paramyosin (Der f 11);
Dermatophagoides farinae (mite) tropomyosin (Der f 10);
Dermatophagoides microceras (mite) antigen (Der m 1);
Dermatophagoides pteronyssinus (mite) amylase (Der p 4);
Dermatophagoides pteronyssinus (mite) antigen (Der p 2);
Dermatophagoides pteronyssinus (mite) antigen (Der p 5);
Dermatophagoides pteronyssinus (mite) antigen (Der p 7);
Dermatophagoides pteronyssinus (mite) antigen P1 (Der p 1);
Dermatophagoides pteronyssinus (mite) apolipophorin like p (Der p 14);
Dermatophagoides pteronyssinus (mite) chymotrypsin (Der p 6);
Dermatophagoides pteronyssinus (mite) collagenolytic serine prot. (Der p 9);
Dermatophagoides pteronyssinus (mite) glutathione transferase (Der p 8);
Dermatophagoides pteronyssinus (mite) tropomyosin (Der p 10);
Dermatophagoides pteronyssinus (mite) trypsin (Der p 3);
Dolichovespula arenaria (yellow hornet) antigen 5 (Dol a 5);
Dolichovespula maculata (white face hornet) antigen 5 (Dol m 5);
Dolichovespula maculata (white face hornet) phospholipase (Dol m 1);
Dolichovespula maculata (white face hornet) hyaluronidase (Dol m 2);
Equus caballus (horse) lipocalin (Equ c 1);
Equus caballus (horse) lipocalin (Equ c 2);
Euroglyphus maynei (mite) apolipophorin (Eur m 14);
Felis domesticus (cat) cat-1 antigen (Fel d 1);
Fraxinus excelsior (ash) antigen (Fra e 1);
Gadus callarias (cod) allergen M (Gad c 1);
Gallus domesticus (chicken) conalbumin; A22 (Gal d 3);
Gallus domesticus (chicken) lysozyme (Gal d 4);
Gallus domesticus (chicken) ovalbumin (Gal d 2);
Gallus domesticus (chicken) ovomucoid (Gal d 1);
Gallus domesticus (chicken) serum albumin (Gal d 5);
Glycine max (soybean) antigen (Gly m 2);
Glycine max (soybean) HPS (Gly m 1.0101);
Glycine max (soybean) HPS (Gly m 1.0102);
Glycine max (soybean) profilin (Gly m 3);
Haliotis Midae (abalone) antigen (Hal m 1);
Helianthus annuus (sunflower) antigen (Hel a 1);
Helianthus annuus (sunflower) profilin (Hel a 2);
Hevea brasiliensis (rubber) 1,3-glucanase (Hey b 2);
Hevea brasiliensis (rubber) antigen (Hey b 3);
Hevea brasiliensis (rubber) antigen (Hey b 5);
Hevea brasiliensis (rubber) component of microhelix protein complex (Hey b 4);
Hevea brasiliensis (rubber) C-terminal fragment antigen (Hey b 6.03);
Hevea brasiliensis (rubber) elongation factor (Hey b 1);
Hevea brasiliensis (rubber) enolase (Hey b 9);
Hevea brasiliensis (rubber) hevein (Hey b 6.02);
Hevea brasiliensis (rubber) hevein precursor (Hey b 6.01);
Hevea brasiliensis (rubber) Mn-superoxide dismut (Hey b 10);
Hevea brasiliensis (rubber) patatin homologue (Hey b 7);
Hevea brasiliensis (rubber) profilin (Hey b 8);
Holcus lanatus (velvet grass) antigen (Hol l 1);
Homo sapiens (human autoallergen) antigen (Hom s 1);
Homo sapiens (human autoallergen) antigen (Hom s 2);
Homo sapiens (human autoallergen) antigen (Hom s 3);
Homo sapiens (human autoallergen) antigen (Hom s 4);
Homo sapiens (human autoallergen) antigen (Hom s 5).
Hordeum vulgare (barley) BMAI-1 (Hor v 1);
Juglans regia (English walnut) 2S albumin (Jug r 1);
Juglans regia (English walnut) vicilin (Jug r 2);
Juniperus ashei (mountain cedar) antigen (Jun a 1);
Juniperus ashei (mountain cedar) antigen (Jun a 3);
Juniperus oxycedrus (prickly juniper) calmodulin-like antigen (Jun o 2);
Juniperus sabinoides (mountain cedar) antigen (Jun s 1);
Juniperus virginiana (eastern red cedar) antigen (Jun v 1);
Lepidoglyphus destructor (storage mite) antigen (Lep d 2.0101);
Lepidoglyphus destructor (storage mite) antigen (Lep d 2.0102);
Ligustrum vulgare (privet) antigen (Lig v 1);
Lolium perenne (rye grass) antigen (Lol p Ib);
Lolium perenne (rye grass) group I antigen (Lol p 1);
Lolium perenne (rye grass) group II antigen (Lol p 2);
Lolium perenne (rye grass) group III antigen (Lol p 3);
Lolium perenne (rye grass) group IX antigen (Lol p 5);
Lolium perenne (rye grass) trypsin (Lol p 11);
Malassezia furfur (fungus) antigen (Mal f 1);
Malassezia furfur (fungus) antigen (Mal f 4);
Malassezia furfur (fungus) antigen (Mal f 5);
Malassezia furfur (fungus) cyclophilin homologue (Mal f 6);
Malassezia furfur (fungus) MF1 peroxisomal membrane protein (Mal f 2);
Malassezia furfur (fungus) MF2 peroxisomal membrane protein (Mal f 3);
Malus domestica (apple) Bet v 1 homologue (Mal d 1);
Malus domestica (apple) lipid transfer protein (Mal d 3);
Mercurialis annua (annual mercury) profilin (Mer a 1);
Metapenaeus ensis (shrimp) tropomyosin (Met e 1);
Mus musculus (mouse) MUP antigen (Mus m 1);
Myrmecia pilosula (Australian jumper ant) antigen (Myr p 1);
Myrmecia pilosula (Australian jumper ant) antigen (Myr p 2);
Olea europea (olive) antigen (Ole e 1);
Olea europea (olive) antigen (Ole e 3);
Olea europea (olive) antigen (Ole e 4);
Olea europea (olive) antigen (Ole e 6);
Olea europea (olive) profilin (Ole e 2);
Olea europea (olive) superoxide dismutase (Ole e 5);
Oryza sativa (rice) antigen (Ory s 1);
Penaeus aztecus (shrimp) tropomyosin (Pen a 1);
Penaeus indicus (shrimp) tropomyosin (Pen i 1);
Penicillium brevicompactum (fungus) alkaline serine proteinase (Pen b 13);
Penicillium citrinum (fungus) alkaline serine proteinase (Pen c 13);
Penicillium citrinum (fungus) heat shock protein P70 (Pen c 1);
Penicillium citrinum (fungus) peroxisomal membrane protein (Pen c 3);
Penicillium notatum (fungus) alkaline serine proteinase (Pen n 13);
Penicillium notatum (fungus) N-acetyl glucosaminidase (Pen n 1);
Penicillium notatum (fungus) vacuolar serine proteinase (Pen n 18);
Penicillium oxalicum (fungus) vacuolar serine proteinase (Pen o 18);
Periplaneta americana (American cockroach) Cr-PI (Per a 3);
Periplaneta americana (American cockroach) Cr-PII (Per a 1);
Periplaneta americana (American cockroach) tropomyosin (Per a 7);
Persea americana (avocado) endochitinase (Pers a 1);
Phalaris aquatica (canary grass) antigen (Pha a 1);
Phleum pratense (timothy grass) antigen (Phl p 1);
Phleum pratense (timothy grass) antigen (Phl p 2);
Phleum pratense (timothy grass) antigen (Phl p 4);
Phleum pratense (timothy grass) antigen (Phl p 6);
Phleum pratense (timothy grass) antigen Ag 25 (Phl p 5);
Phleum pratense (timothy grass) polygalacturonase (Phl p 13);
Phleum pratense (timothy grass) profilin (Phl p 12);
Poa pratensis (Kentucky blue grass) antigen (Poa p 5);
Poa pratensis (Kentucky blue grass) group I antigen (Poa p 1);
Polistes annularies (wasp) antigen 5 (Pol a 5);
Polistes annularies (wasp) hyaluronidase (Pol a 2);
Polistes annularies (wasp) phospholipase A1 (Pol a 1);
Polistes dominulus (Mediterranean paper wasp) antigen (Pol d 1);
Polistes dominulus (Mediterranean paper wasp) antigen (Pol d 5);
Polistes dominulus (Mediterranean paper wasp) serine protease (Pol d 4);
Polistes exclamans (wasp) antigen 5 (Pol e 5);
Polistes exclamans (wasp) phospholipase A1 (Pol e 1);
Polistes fuscatus (wasp) antigen 5 (Pol f 5);
Polistes metricus (wasp) antigen 5 (Pol m 5);
Prunus armeniaca (apricot) Bet v 1 homologue (Pru ar 1);
Prunus armeniaca (apricot) lipid transfer protein (Pru ar 3);
Prunus avium (sweet cherry) Bet v 1 homologue (Pru av 1);
Prunus avium (sweet cherry) profilin (Pru av 4);
Prunus avium (sweet cherry) thaumatin homologue (Pru av 2);
Prunus persica (peach) lipid transfer protein (Pru p 3);
Psilocybe cubensis (fungus) antigen (Psi c 1);
Psilocybe cubensis (fungus) cyclophilin (Psi c 2);
Pyrus communis (pear) Bet v 1 homologue (Pyr c 1);
Pyrus communis (pear) isoflavone reductase homologue (Pyr c 5);
Pyrus communis (pear) profilin (Pyr c 4);
Quercus alba (white oak) antigen (Que a 1);
Rattus norvegius (rat) antigen (Rat n 1);
Ricinus communis (castor bean) 2S albumin (R1c c 1);
Salmo salar (Atlantic salmon) parvalbumin (Sal s 1);
Sinapis alba (yellow mustard) 2S albumin (Sin a 1);
Solanum tuberosum (potato) patatin (Sol t 1);
Solenopsis geminata (tropical fire ant) antigen (Sol g 2);
Solenopsis geminata (tropical fire ant) antigen (Sol g 4);
Solenopsis invicta (fire ant) antigen (Sol i 2);
Solenopsis invicta (fire ant) antigen (Sol i 3);
Solenopsis invicta (fire ant) antigen (Sol i 4);
Solenopsis saevissima (Brazilian fire ant) antigen (Sol s 2);
Sorghum halepense (Johnson grass) antigen (Sor h 1);
Syringa vulgaris (lilac) antigen (Syr v 1);
Todarodes pacificus (squid) tropomyosin (Tod p 1);
Trichophyton rubrum (fungus) antigen (Tri r 2);
Trichophyton rubrum (fungus) serine protease (Tri r 4);
Trichophyton tonsurans (fungus) antigen (Tri t 1);
Trichophyton tonsurans (fungus) serine protease (Tri t 4);
Vespa crabo (European hornet) antigen 5 (Vesp c 5.0101);
Vespa crabo (European hornet) antigen 5 (Vesp c 5.0102);
Vespa crabo (European hornet) phospholipase (Vesp c 1);
Vespa mandarina (giant Asian hornet) antigen (Vesp m 1.01);
Vespa mandarina (giant Asian hornet) antigen (Vesp m 1.02);
Vespa mandarina (giant Asian hornet) antigen (Vesp m 5);
Vespula flavopilosa (yellowjacket) antigen 5 (Ves f 5);
Vespula germanica (yellowjacket) antigen 5 (Ves g 5);
Vespula maculifrons (yellowjacket) antigen 5 (Ves m 5);
Vespula maculifrons (yellowjacket) hyaluronidase (Ves m 2);
Vespula maculifrons (yellowjacket) phospholipase A1 (Ves m 1);
Vespula pennsylvanica (yellowjacket) (antigen 5Ves p 5);
Vespula squamosa (yellowjacket) antigen 5 (Ves s 5);
Vespula vidua (wasp) antigen (Ves vi 5);
Vespula vulgaris (yellowjacket) antigen 5 (Ves v 5);
Vespula vulgaris (yellowjacket) hyaluronidase (Ves v 2);
Vespula vulgaris (yellowjacket) phospholipase A1 (Ves v 1); and
Zea mays (maize, corn) lipid transfer protein (Zea m 14).
49 . A method comprising steps of:
expressing in E. coli cells a recombinant allergen selected from
Acarus siro (mite) fatty acid-binding protein (Aca s 13);
Actinidia chinensis (kiwi) cysteine protease (Act c 1);
Aedes aegyptii (mosquito) antigen (Aed a 2);
Aedes aegyptii (mosquito) antigen (Aed a 2);
Aedes aegyptii (mosquito) apyrase (Aed a 1);
Aedes aegyptii (mosquito) apyrase (Aed a 1);
Alnus glutinosa (alder) antigen (Aln g 1);
Alternaria alternata (fungus) acid. ribosomal protein P1 (Alt a 12);
Alternaria alternata (fungus) aldehyde dehydrogenase (Alt a 10);
Alternaria alternata (fungus) antigen (Alt a 1);
Alternaria alternata (fungus) antigen (Alt a 2);
Alternaria alternata (fungus) enloase (Alt a 11);
Alternaria alternata (fungus) heat shock protein (Alt a 3);
Alternaria alternata (fungus) ribosomal protein (Alt a 6);
Alternaria alternata (fungus) YCP4 protein (Alt a 7);
Ambrosia artemisiifolia (short ragweed) antigen E (Amb a 1);
Ambrosia artemisiifolia (short ragweed) antigen K (Amb a 2);
Ambrosia artemisiifolia (short ragweed) Ra3 antigen (Amb a 3);
Ambrosia artemisiifolia (short ragweed) Ra5 antigen (Amb a 5);
Ambrosia artemisiifolia (short ragweed) Ra6 antigen (Amb a 6);
Ambrosia artemisiifolia (short ragweed) Ra7 antigen (Amb a 7);
Ambrosia trifida (giant ragweed) Ra5G antigen (Amb t 5);
Anisakis simplex (nematode) antigen (Ani s 1);
Anisakis simplex (nematode) paramyosin (Ani s 2);
Apis mellifera (honey bee) antigen (Api m 6);
Apis mellifera (honey bee) hyaluronidase (Api m 2);
Apis mellifera (honey bee) melittin (Api m 4);
Apis mellifera (honey bee) phospholipase A2 (Api m 1);
Apium graveolens (celery) antigen (Api g 5);
Apium graveolens (celery) Bet v 1 homologue (Api g 1);
Apium graveolens (celery) profilin (Api g 4);
Arachis hypogaea (peanut) (conglutin Ar a h 2);
Arachis hypogaea (peanut) (profilin Ar a h 5);
Arachis hypogaea (peanut) conglutin homologue (Ar a h 6);
Arachis hypogaea (peanut) conglutin homologue (Ar a h 7);
Arachis hypogaea (peanut) glycinin (Ar a h 3);
Arachis hypogaea (peanut) glycinin (Ar a h 4);
Arachis hypogaea (peanut) vicilin (Ar a h 1);
Artemisia vulgaris (mugwort) antigen (Art v 1);
Artemisia vulgaris (mugwort) antigen (Art v 2);
Ascaris suum (worm) antigen (Asc s 1);
Aspergillus flavus (fungus) alkaline serine proteinase (Asp fl 13);
Aspergillus Fumigatus (fungus) alkaline serine proteinase (Asp f 13);
Aspergillus Fumigatus (fungus) antigen (Asp f 1);
Aspergillus Fumigatus (fungus) antigen (Asp f 15);
Aspergillus Fumigatus (fungus) antigen (Asp f 16);
Aspergillus Fumigatus (fungus) antigen (Asp f 17);
Aspergillus Fumigatus (fungus) antigen (Asp f 2);
Aspergillus Fumigatus (fungus) antigen (Asp f 4);
Aspergillus Fumigatus (fungus) antigen (Asp f 7);
Aspergillus Fumigatus (fungus) antigen (Asp f 9);
Aspergillus Fumigatus (fungus) aspartis protease (Asp f 10);
Aspergillus Fumigatus (fungus) heat shock protein P70 (Asp f 12);
Aspergillus Fumigatus (fungus) metalloprotease (Asp f 5);
Aspergillus Fumigatus (fungus) Mn superoxide dismutase (Asp f 6);
Aspergillus Fumigatus (fungus) peptidyl-prolyl isomerase (Asp f 11);
Aspergillus Fumigatus (fungus) peroxisomal protein (Asp f 3);
Aspergillus Fumigatus (fungus) ribosomal protein P2 (Asp f 8);
Aspergillus Fumigatus (fungus) vacuolar serine (Asp f 18);
Aspergillus niger (fungus) antigen (Asp n 18);
Aspergillus niger (fungus) beta-xylosidase (Asp n 14);
Aspergillus niger (fungus) vacuolar serine proteinase;
Aspergillus oryzae (fungus) alkaline serine proteinase (Asp o 13);
Aspergillus oryzae (fungus) TAKA-amylase A (Asp o 2);
Bertholletia excelsa (Brazil nut) 2S albumin (Ber e 1);
Betula verrucosa (birch) antigen (Bet v 1);
Betula verrucosa (birch) antigen (Bet v 3);
Betula verrucosa (birch) antigen (Bet v 4);
Betula verrucosa (birch) cyclophilin (Bet v 7);
Betula verrucosa (birch) isoflavone reductase homologue (Bet v 5);
Betula verrucosa (birch) profilin (Bet v 2);
Blattella germanica (German cockroach) aspartic protease (Bla g 2);
Blattella germanica (German cockroach) Bd90k (Bla g 1);
Blattella germanica (German cockroach) calycin (Bla g 4);
Blattella germanica (German cockroach) glutathione transferase (Bla g 5);
Blattella germanica (German cockroach) troponin C (Bla g 6);
Blomia tropicalis (mite) antigen (Blo t 5);
Blomia tropicalis (mite) Bt11a antigen (Blo t 12);
Blomia tropicalis (mite) Bt6 fatty acid-binding protein (Blo t);
Bombus pennsylvanicus (bumble bee) phospholipase (Bom p 1);
Bombus pennsylvanicus (bumble bee) protease (Bom p 4);
Bos domesticus (cow) Ag3, lipocalin (Bos d 2);
Bos domesticus (cow) alpha-lactalbumin (Bos d 4);
Bos domesticus (cow) beta-lactalbumin (Bos d 5);
Bos domesticus (cow) casein (Bos d 8);
Bos domesticus (cow) immunoglobulin (Bos d 7);
Bos domesticus (cow) serum albumin (Bos d 6);
Brassica juncea (oriental mustard) 2S albumin (Bra j 1);
Brassica rapa (turnip) prohevein-like protein (Bar r 2);
Candida albicans (fungus) antigen (Cand a 1);
Candida boidinii (fungus) antigen (Cand b 2);
Canis familiaris (dog) albumin (Can f ?);
Canis familiaris (dog) antigen (Can f 1);
Canis familiaris (dog) antigen (Can f 2);
Carpinus betulus (hornbeam) antigen (Car b 1);
Castanea sativa (chestnut) Bet v 1 homologue (Cas s 1);
Castanea sativa (chestnut) chitinase (Cas s 5);
Chironomus thummi thummi (midge) component I (Chi t 2.0101);
Chironomus thummi thummi (midge) component IA (Chi t 2.0102);
Chironomus thummi thummi (midge) component II-beta (Chi t 3);
Chironomus thummi thummi (midge) component III (Chi t 1.01);
Chironomus thummi thummi (midge) component IIIA (Chi t 4);
Chironomus thummi thummi (midge) component IV (Chi t 1.02);
Chironomus thummi thummi (midge) component IX (Chi t 6.02);
Chironomus thummi thummi (midge) component VI (Chi t 5);
Chironomus thummi thummi (midge) component VIIA (Chi t 6.01);
Chironomus thummi thummi (midge) component VIIB (Chi t 7);
Chironomus thummi thummi (midge) component VIII (Chi t 8);
Chironomus thummi thummi (midge) component X (Chi t 9);
Chironomus thummi thummi (midge) hemoglobin (Chi t 1-9);
Cladosporium herbarum (fungus) acid. ribosomal protein P1 (Cla h 12);
Cladosporium herbarum (fungus) aldehyde dehydrogenase (Cla h 3);
Cladosporium herbarum (fungus) antigen (Cla h 1);
Cladosporium herbarum (fungus) antigen (Cla h 2);
Cladosporium herbarum (fungus) enolase (Cla h 6);
Cladosporium herbarum (fungus) ribosomal protein);
Cladosporium herbarum (fungus) YCP4 protein (Cla h 5);
Coprinus comatus (shaggy cap) antigen (Cop c 1);
Coprinus comatus (shaggy cap) antigen (Cop c 2);
Coprinus comatus (shaggy cap) antigen (Cop c 3);
Coprinus comatus (shaggy cap) antigen (Cop c 5);
Coprinus comatus (shaggy cap) antigen (Cop c 7);
Corylus avelana (hazel) antigen (Cor a 1);
Corylus avellana (hazelnut) Bet v 1 homologue (Cor a 1.0401);
Cryptomeria japonica (sugi) antigen (Cry j 1);
Cryptomeria japonica (sugi) antigen (Cry j 2);
Ctenocephalides felis felis (cat flea) antigen (Cte f 1);
Cynodon dactylon (Bermuda grass) antigen (Cyn d 1);
Cynodon dactylon (Bermuda grass) antigen (Cyn d 7);
Cynodon dactylon (Bermuda grass) profilin (Cyn d 12);
Dactylis glomerata (orchard grass) AgDg1 antigen (Dac g 1);
Dactylis glomerata (orchard grass) antigen (Dac g 2);
Dactylis glomerata (orchard grass) antigen (Dac g 3);
Dactylis glomerata (orchard grass) antigen (Dac g 5);
Dermatophagoides farinae (mite) antigen (Der f 1);
Dermatophagoides farinae (mite) antigen (Der f 2);
Dermatophagoides farinae (mite) antigen (Der f 3);
Dermatophagoides farinae (mite) Mag 3, apolipophorin (Der f 14);
Dermatophagoides farinae (mite) paramyosin (Der f 11);
Dermatophagoides farinae (mite) tropomyosin (Der f 10);
Dermatophagoides microceras (mite) antigen (Der m 1);
Dermatophagoides pteronyssinus (mite) amylase (Der p 4);
Dermatophagoides pteronyssinus (mite) antigen (Der p 2);
Dermatophagoides pteronyssinus (mite) antigen (Der p 5);
Dermatophagoides pteronyssinus (mite) antigen (Der p 7);
Dermatophagoides pteronyssinus (mite) antigen P1 (Der p 1);
Dermatophagoides pteronyssinus (mite) apolipophorin like p (Der p 14);
Dermatophagoides pteronyssinus (mite) chymotrypsin (Der p 6);
Dermatophagoides pteronyssinus (mite) collagenolytic serine prot. (Der p 9);
Dermatophagoides pteronyssinus (mite) glutathione transferase (Der p 8);
Dermatophagoides pteronyssinus (mite) tropomyosin (Der p 10);
Dermatophagoides pteronyssinus (mite) trypsin (Der p 3);
Dolichovespula arenaria (yellow hornet) antigen 5 (Dol a 5);
Dolichovespula maculata (white face hornet) antigen 5 (Dol m 5);
Dolichovespula maculata (white face hornet) phospholipase (Dol m 1);
Dolichovespula maculata (white face hornet) hyaluronidase (Dol m 2);
Equus caballus (horse) lipocalin (Equ c 1);
Equus caballus (horse) lipocalin (Equ c 2);
Euroglyphus maynei (mite) apolipophorin (Eur m 14);
Felis domesticus (cat) cat-1 antigen (Fel d 1);
Fraxinus excelsior (ash) antigen (Fra e 1);
Gadus callarias (cod) allergen M (Gad c 1);
Gallus domesticus (chicken) conalbumin; A22 (Gal d 3);
Gallus domesticus (chicken) lysozyme (Gal d 4);
Gallus domesticus (chicken) ovalbumin (Gal d 2);
Gallus domesticus (chicken) ovomucoid (Gal d 1);
Gallus domesticus (chicken) serum albumin (Gal d 5);
Glycine max (soybean) antigen (Gly m 2);
Glycine max (soybean) HPS (Gly m 1.0101);
Glycine max (soybean) HPS (Gly m 1.0102);
Glycine max (soybean) profilin (Gly m 3);
Haliotis Midae (abalone) antigen (Hal m 1);
Helianthus annuus (sunflower) antigen (Hel a 1);
Helianthus annuus (sunflower) profilin (Hel a 2);
Hevea brasiliensis (rubber) 1,3-glucanase (Hey b 2);
Hevea brasiliensis (rubber) antigen (Hey b 3);
Hevea brasiliensis (rubber) antigen (Hey b 5);
Hevea brasiliensis (rubber) component of microhelix protein complex (Hey b 4);
Hevea brasiliensis (rubber) C-terminal fragment antigen (Hey b 6.03);
Hevea brasiliensis (rubber) elongation factor (Hey b 1);
Hevea brasiliensis (rubber) enolase (Hey b 9);
Hevea brasiliensis (rubber) hevein (Hey b 6.02);
Hevea brasiliensis (rubber) hevein precursor (Hey b 6.01);
Hevea brasiliensis (rubber) Mn-superoxide dismut (Hey b 10);
Hevea brasiliensis (rubber) patatin homologue (Hey b 7);
Hevea brasiliensis (rubber) profilin (Hey b 8);
Holcus lanatus (velvet grass) antigen (Hol l 1);
Homo sapiens (human autoallergen) antigen (Hom s 1);
Homo sapiens (human autoallergen) antigen (Hom s 2);
Homo sapiens (human autoallergen) antigen (Hom s 3);
Homo sapiens (human autoallergen) antigen (Hom s 4);
Homo sapiens (human autoallergen) antigen (Hom s 5).
Hordeum vulgare (barley) BMAI-1 (Hor v 1);
Juglans regia (English walnut) 2S albumin (Jug r 1);
Juglans regia (English walnut) vicilin (Jug r 2);
Juniperus ashei (mountain cedar) antigen (Jun a 1);
Juniperus ashei (mountain cedar) antigen (Jun a 3);
Juniperus oxycedrus (prickly juniper) calmodulin-like antigen (Jun o 2);
Juniperus sabinoides (mountain cedar) antigen (Jun s 1);
Juniperus virginiana (eastern red cedar) antigen (Jun v 1);
Lepidoglyphus destructor (storage mite) antigen (Lep d 2.0101);
Lepidoglyphus destructor (storage mite) antigen (Lep d 2.0102);
Ligustrum vulgare (privet) antigen (Lig v 1);
Lolium perenne (rye grass) antigen (Lol p Ib);
Lolium perenne (rye grass) group I antigen (Lol p 1);
Lolium perenne (rye grass) group II antigen (Lol p 2);
Lolium perenne (rye grass) group III antigen (Lol p 3);
Lolium perenne (rye grass) group IX antigen (Lol p 5);
Lolium perenne (rye grass) trypsin (Lol p 11);
Malassezia furfur (fungus) antigen (Mal f 1);
Malassezia furfur (fungus) antigen (Mal f 4);
Malassezia furfur (fungus) antigen (Mal f 5);
Malassezia furfur (fungus) cyclophilin homologue (Mal f 6);
Malassezia furfur (fungus) MF1 peroxisomal membrane protein (Mal f 2);
Malassezia furfur (fungus) MF2 peroxisomal membrane protein (Mal f 3);
Malus domestica (apple) Bet v 1 homologue (Mal d 1);
Malus domestica (apple) lipid transfer protein (Mal d 3);
Mercurialis annua (annual mercury) profilin (Mer a 1);
Metapenaeus ensis (shrimp) tropomyosin (Met e 1);
Mus musculus (mouse) MUP antigen (Mus m 1);
Myrmecia pilosula (Australian jumper ant) antigen (Myr p 1);
Myrmecia pilosula (Australian jumper ant) antigen (Myr p 2);
Olea europea (olive) antigen (Ole e 1);
Olea europea (olive) antigen (Ole e 3);
Olea europea (olive) antigen (Ole e 4);
Olea europea (olive) antigen (Ole e 6);
Olea europea (olive) profilin (Ole e 2);
Olea europea (olive) superoxide dismutase (Ole e 5);
Oryza sativa (rice) antigen (Ory s 1);
Penaeus aztecus (shrimp) tropomyosin (Pen a 1);
Penaeus indicus (shrimp) tropomyosin (Pen i 1);
Penicillium brevicompactum (fungus) alkaline serine proteinase (Pen b 13);
Penicillium citrinum (fungus) alkaline serine proteinase (Pen c 13);
Penicillium citrinum (fungus) heat shock protein P70 (Pen c 1);
Penicillium citrinum (fungus) peroxisomal membrane protein (Pen c 3);
Penicillium notatum (fungus) alkaline serine proteinase (Pen n 13);
Penicillium notatum (fungus) N-acetyl glucosaminidase (Pen n 1);
Penicillium notatum (fungus) vacuolar serine proteinase (Pen n 18);
Penicillium oxalicum (fungus) vacuolar serine proteinase (Pen o 18);
Periplaneta americana (American cockroach) Cr-PI (Per a 3);
Periplaneta americana (American cockroach) Cr-PII (Per a 1);
Periplaneta americana (American cockroach) tropomyosin (Per a 7);
Persea americana (avocado) endochitinase (Pers a 1);
Phalaris aquatica (canary grass) antigen (Pha a 1);
Phleum pratense (timothy grass) antigen (Phl p 1);
Phleum pratense (timothy grass) antigen (Phl p 2);
Phleum pratense (timothy grass) antigen (Phl p 4);
Phleum pratense (timothy grass) antigen (Phl p 6);
Phleum pratense (timothy grass) antigen Ag 25 (Phl p 5);
Phleum pratense (timothy grass) polygalacturonase (Phl p 13);
Phleum pratense (timothy grass) profilin (Phl p 12);
Poa pratensis (Kentucky blue grass) antigen (Poa p 5);
Poa pratensis (Kentucky blue grass) group I antigen (Poa p 1);
Polistes annularies (wasp) antigen 5 (Pol a 5);
Polistes annularies (wasp) hyaluronidase (Pol a 2);
Polistes annularies (wasp) phospholipase A1 (Pol a 1);
Polistes dominulus (Mediterranean paper wasp) antigen (Pol d 1);
Polistes dominulus (Mediterranean paper wasp) antigen (Pol d 5);
Polistes dominulus (Mediterranean paper wasp) serine protease (Pol d 4);
Polistes exclamans (wasp) antigen 5 (Pol e 5);
Polistes exclamans (wasp) phospholipase A1 (Pol e 1);
Polistes fuscatus (wasp) antigen 5 (Pol f 5);
Polistes metricus (wasp) antigen 5 (Pol m 5);
Prunus armeniaca (apricot) Bet v 1 homologue (Pru ar 1);
Prunus armeniaca (apricot) lipid transfer protein (Pru ar 3);
Prunus avium (sweet cherry) Bet v 1 homologue (Pru av 1);
Prunus avium (sweet cherry) profilin (Pru av 4);
Prunus avium (sweet cherry) thaumatin homologue (Pru av 2);
Prunus persica (peach) lipid transfer protein (Pru p 3);
Psilocybe cubensis (fungus) antigen (Psi c 1);
Psilocybe cubensis (fungus) cyclophilin (Psi c 2);
Pyrus communis (pear) Bet v 1 homologue (Pyr c 1);
Pyrus communis (pear) isoflavone reductase homologue (Pyr c 5);
Pyrus communis (pear) profilin (Pyr c 4);
Quercus alba (white oak) antigen (Que a 1);
Rattus norvegius (rat) antigen (Rat n 1);
Ricinus communis (castor bean) 2S albumin (Ric c 1);
Salmo salar (Atlantic salmon) parvalbumin (Sal s 1);
Sinapis alba (yellow mustard) 2S albumin (Sin a 1);
Solanum tuberosum (potato) patatin (Sol t 1);
Solenopsis geminata (tropical fire ant) antigen (Sol g 2);
Solenopsis geminata (tropical fire ant) antigen (Sol g 4);
Solenopsis invicta (fire ant) antigen (Sol i 2);
Solenopsis invicta (fire ant) antigen (Sol i 3);
Solenopsis invicta (fire ant) antigen (Sol i 4);
Solenopsis saevissima (Brazilian fire ant) antigen (Sol s 2);
Sorghum halepense (Johnson grass) antigen (Sor h 1);
Syringa vulgaris (lilac) antigen (Syr v 1);
Todarodes pacificus (squid) tropomyosin (Tod p 1);
Trichophyton rubrum (fungus) antigen (Tri r 2);
Trichophyton rubrum (fungus) serine protease (Tri r 4);
Trichophyton tonsurans (fungus) antigen (Tri t 1);
Trichophyton tonsurans (fungus) serine protease (Tri t 4);
Vespa crabo (European hornet) antigen 5 (Vesp c 5.0101);
Vespa crabo (European hornet) antigen 5 (Vesp c 5.0102);
Vespa crabo (European hornet) phospholipase (Vesp c 1);
Vespa mandarina (giant Asian hornet) antigen (Vesp m 1.01);
Vespa mandarina (giant Asian hornet) antigen (Vesp m 1.02);
Vespa mandarina (giant Asian hornet) antigen (Vesp m 5);
Vespula flavopilosa (yellowjacket) antigen 5 (Ves f 5);
Vespula germanica (yellowjacket) antigen 5 (Ves g 5);
Vespula maculifrons (yellowjacket) antigen 5 (Ves m 5);
Vespula maculifrons (yellowjacket) hyaluronidase (Ves m 2);
Vespula maculifrons (yellowjacket) phospholipase A1 (Ves m 1);
Vespula pennsylvanica (yellowjacket) (antigen 5Ves p 5);
Vespula squamosa (yellowjacket) antigen 5 (Ves s 5);
Vespula vidua (wasp) antigen (Ves vi 5);
Vespula vulgaris (yellowjacket) antigen 5 (Ves v 5);
Vespula vulgaris (yellowjacket) hyaluronidase (Ves v 2);
Vespula vulgaris (yellowjacket) phospholipase A1 (Ves v 1); and
Zea mays (maize, corn) lipid transfer protein (Zea m 14); and
killing the E. coli cells, so a composition is produced in which the expressed recombinant allergen is encapsulated within the killed E. coli cells.Join the waitlist — get patent alerts
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