US2013158055A1PendingUtilityA1

Prevention Of Pancreatic Beta Cell Degeneration

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Assignee: REAUME ANDREW GPriority: May 28, 2010Filed: May 27, 2011Published: Jun 20, 2013
Est. expiryMay 28, 2030(~3.9 yrs left)· nominal 20-yr term from priority
Inventors:Andrew G. ReaumeMichael S. SaporitoAlexander R. Ochman
A61K 31/513A61P 3/10
47
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Claims

Abstract

The present invention relates to compounds and pharmaceutically acceptable salts thereof and formulations comprising the compounds or a pharmaceutically acceptable salts thereof that are useful in methods of preventing pancreatic beta cell degeneration or methods of treating a disorder associated with pancreatic beta cell degeneration, such as type I diabetes.

Claims

exact text as granted — not AI-modified
1 - 9 . (canceled) 
     
     
         10 . A method of preventing pancreatic beta cell degeneration, treating a disorder associated with pancreatic beta cell degeneration, or treating or preventing type I diabetes in a mammal comprising administering to the mammal in need thereof an effective amount of a composition comprising a compound of formula: 
       
         
           
           
               
               
           
         
         wherein R 1  is an alkyl group; X is a halogen; n is an integer from 0 to 5 and m is 0 or 1, wherein m+n is less than or equal to 5. 
       
     
     
         11 . The method of  claim 10 , wherein the alkyl group is methyl and n is 1. 
     
     
         12 . The method of  claim 10 , wherein the halogen is chlorine and m is 1. 
     
     
         13 . The method of  claim 10 , wherein R 1  is methyl, n is 1, and m is 0. 
     
     
         14 . The method of  claim 11 , wherein R 1  is in the meta position. 
     
     
         15 . The method of  claim 10 , wherein X is chlorine, n is 0, and m is 1. 
     
     
         16 . The method of  claim 15 , wherein X is in the meta position. 
     
     
         17 . A method of preventing pancreatic beta cell degeneration, treating a disorder associated with pancreatic beta cell degeneration, or treating or preventing type I diabetes in a mammal comprising administering to the mammal in need thereof an effective amount of a composition comprising a compound of formula: 
       
         
           
           
               
               
           
         
         wherein R 1  is an alkyl group and n is an integer from 0 to 5. 
       
     
     
         18 . The method of  claim 17 , wherein R 1  is methyl, n is 1. 
     
     
         19 . The method of  claim 17 , wherein R 1  is in the meta position. 
     
     
         20 - 91 . (canceled)

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