Extract of aerial parts of maca rich in polyphenols and composition comprising same

Abstract

The invention relates to an extract of aerial parts of Maca rich in polyphenols, and also to a composition comprising such an extract and, where appropriate, a suitable excipient. The invention also relates to a process for extracting an extract of aerial parts of Maca rich in polyphenols, and also to the extract that can be obtained by means of said process. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths and/or for use thereof in preventing and/or treating vascular disorders. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which comprises the administration of such a composition or of such an extract.

1 . Extract of aerial parts of Maca containing at least 1%, advantageously at least 3%, more advantageously at least 5% by weight of polyphenols, expressed in gallic acid equivalents, with respect to the weight of the dry extract, said polyphenols being advantageously flavonoids, typically having a flavonoid content greater than 0.2%, advantageously greater than 0.5%, more advantageously greater than 1% and even more advantageously greater than 2%, expressed in rutin equivalents, with respect to the total weight of the dry extract. 
     
     
         2 . Extract according to  claim 1 , characterised in that the flavonoids contain quercetin, kaempferol, derivatives thereof or mixtures thereof, advantageously at a concentration of at least 30%, typically at least 50%, by weight, expressed in gallic acid equivalents, with respect to the total weight of the flavonoids. 
     
     
         3 . Extract according to  claim 1  or  2 , characterised in that aerial parts are Maca leaves. 
     
     
         4 . Extract according to any of the above claims, characterised in that it is obtained by means of solid-liquid extraction of the aerial parts of Maca in a solvent chosen from the group consisting of water, alcohols, glycerols, glycols, or mixtures thereof. 
     
     
         5 . Extract according to  claim 4 , characterised in that it is obtained by means of solid-liquid extraction of the aerial parts of Maca in a solvent chosen from the group consisting of hydro-alcoholic, hydro-glycerolic and/or hydro-glycolic solvents or mixtures therefore, advantageously binary mixtures, and preferentially in a proportion between 30 and 90% alcohol, glycerol, and/or glycol in water. 
     
     
         6 . Composition comprising as an active compound an extract according to any of the above claims and advantageously a suitable excipient, characterised in that it consists of a cosmetic, pharmaceutical, dermatological or nutraceutical composition. 
     
     
         7 . Composition according to  claim 6 , further comprising at least one further active compound in addition to the extract of aerial parts of Maca particularly chosen from the group consisting of emollients, moisturising agents, keratoregulators, keratolytics, skin barrier healing and/or remodelling agents, PPAR, RXR or LXR agonists, sebo-regulating agents, anti-irritant and/or anti-inflammatory and/or soothing agents, anti-oxidant agents, anti-ageing agents, depigmenting or hypopigmenting agents, pigmenting agents, lipolytic agents or lipogenesis inhibitors or anti-cellulite or slimming agents, mineral or organic sun filters and screens, antifungal compounds, preservatives, antibacterial agents, pre and probiotics, antibiotics and immunomodulators. 
     
     
         8 . Composition according to  claim 7 , characterised in that the further active compound is chosen from:
 skin barrier healing and/or remodelling agents, preferably panthenol, arabinogalactan and zinc oxide,   sebo-regulating agents, preferably chosen from the group consisting of 5-alpha reductase inhibitors, zinc derivatives, spironolactone, and linoleic acid,   anti-inflammatory and/or anti-irritant and/or soothing agents, preferably arabinogalactan,   hypopigmenting or depigmenting agents, preferably N-undecylenoyl-L-phenylalanine,   mineral and/or organic sun screens or filters, preferably UVB and/or UVA sun filters or screens, and   preservatives preferably chosen from capryloyl glycine, glyceryl caprylate, hexanediol, sodium levulinate, zinc and copper derivatives.   
     
     
         9 . Composition according to any of  claims 6  to  8 , further comprising at least one further active substance chosen from the group consisting of:
 plant oils, preferably soybean oil, rapeseed oil, avocado oil, lupin oil and advantageously sweet white lupin oil, or a mixture of these oils. 
 the oleodistillates or concentrates of plant or animal oils, preferably sunflower, avocado, rapeseed, corn and palm oil, advantageously concentrated in unsaponifiables, 
 plant or plant oil unsaponifiables, preferably avocado unsaponifiables, soybean unsaponifiables, or a mixture thereof, advantageously avocado furans, and particularly a mixture of furan avocado unsaponifiables and soybean unsaponifiables in a respective ratio of approximately 1:3-2:3, sterol unsaponifiables, plant sterols, sterol esters and vitamin derivatives, 
 plant peptides or amino acid complexes, preferably avocado peptides, lupin peptides, quinoa peptides, Maca peptides, optionally fermented soybean peptides, rice peptides, 
 plant sugars, preferably avocado sugars, 
 butyl avocadate, 
 extracts rich in polyphenols, preferably avocado extracts and extracts of aerial parts of  Gynandropsis gynandra,    
 lupeol, 
 lupin total extract, 
 Cupuaçu butter, 
 an  Acacia macrostachya  seed extract,  Schizandra sphenanthera  seed extract and  Vigna unguiculata  seed extract, 
 oxazolines, preferably 2-undecyl-4-hydroxymethyl-4-methyl-1,3-oxazoline, 2-undecyl-4,4-dimethyl-1,3-oxazoline, (E)-4,4-dimethyl-2-heptadec-8-enyl-1,3-oxazoline, 4-hydroxymethyl-4-methyl-2-heptadecyl-1,3-oxazoline, (E)-4-hydroxymethyl-4-methyl-2-heptadec-8-enyl-1,3-oxazoline, 2-undecyl-4-ethyl-4-hydroxymethyl-1,3-oxazoline and 2-undecyl-4,4-dimethyl-1,3-oxazoline, and 
 
       mixtures thereof. 
     
     
         10 . Composition according to any of  claims 6  to  9 , characterised in that it is formulated for topical or oral administration. 
     
     
         11 . Composition according to any of  claims 6  to  10  or extract as defined in any of  claims 1  to  5  for use for preventing and/or treating disorders or pathologies of the skin and/or mucous membranes and/or superficial body growths. 
     
     
         12 . Composition according to any of  claims 6  to  10  or extract as defined in any of  claims 1  to  5  for use for preventing and/or treating vascular disorders, and more particularly for strengthening vessel walls and tonicity. 
     
     
         13 . Composition according to any of  claims 6  to  10  or extract as defined in any of  claims 1  to  5  for use for preventing and/or treating allergic, inflammatory, irritant reactions or pathologies, or barrier or homeostasis disorders of immature, normal or mature/aged skin, superficial body growths and/or mucous membranes. 
     
     
         14 . Composition according to any of  claims 6  to  10  or extract as defined in any of  claims 1  to  5  for use for preventing and/or treating adipose tissue alterations, and more particularly treating adipose tissue regulations. 
     
     
         15 . Cosmetic care process for the skin and/or superficial body growths and/or mucous membranes, with a view to improving the condition and/or appearance thereof, advantageously with a view to enhancing the firmness, elasticity or tonicity of the skin, and for combating the accumulation of adipose tissue and skin with cellulite, or for preventing and/or treating dermal tissue alterations, or for preventing and/or treating blood circulation disorders and increasing vessel tonicity, or for preventing and/or treating ageing, comprising the administration of a cosmetic composition as defined according to any of  claims 6  to  10  or an extract as defined according to any of  claims 1  to  5 .