Methods of treatment using arylcyclopropylamine compounds

Abstract

Described herein are methods of treating Parkinson's disease using arylcyclopropylamine compounds.

1 . A method of treating Parkinson's disease in a subject in need of treatment, comprising administering to the subject an effective amount of a compound of formula (I): 
       
         
           
           
               
               
           
         
         wherein R 1 , R 2 , R 3 , R 4  and R 5  are independently selected from hydrogen, C 1-7  alkyl, C 3-20  heterocyclyl, C 5-20  aryl, C 1-7  alkoxy, C 1-7  haloalkyl, halo, amino, cyano, nitro, ether and thioether, or any two of R 1 , R 2 , R 3 , R 4  and R 5  may be taken together with the carbon atoms to which they are attached to form an optionally substituted ring; and 
         R 6  is selected from hydrogen and optionally substituted C 5-20  aryl; 
         or an isomer, prodrug or pharmaceutically acceptable salt thereof. 
       
     
     
         2 . The method of  claim 1 , wherein R 1 , R 2 , R 4  and R 5  are hydrogen. 
     
     
         3 . The method of  claim 1 , wherein R 3  is selected from C 1-7  haloalkyl, halo, C 1-7  alkoxy, and C 5-20  aryloxy. 
     
     
         4 . The method of  claim 1 , wherein R 2  and R 3  are taken together with the carbon atoms to which they are attached to form a C 3-20  heterocyclyl ring. 
     
     
         5 . The method of  claim 4 , wherein R 2  and R 3  are taken together to form a five-membered heterocyclyl ring. 
     
     
         6 . The method of  claim 1 , wherein R 6  is hydrogen. 
     
     
         7 . The method of  claim 1 , wherein the compound of formula (I) is selected from the group consisting of: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         8 .- 18 . (canceled) 
     
     
         19 . A method of treating Parkinson's disease in a subject in need of treatment, comprising administering to the subject an effective amount of a compound of formula (IX): 
       
         
           
           
               
               
           
         
         wherein: 
         A is a C 5 -C 6  aryl, cycloalkenyl or heterocyclyl ring; 
         or an isomer, prodrug or pharmaceutically acceptable salt thereof. 
       
     
     
         20 . The method of  claim 19 , wherein A is a heterocyclyl ring. 
     
     
         21 . The method of  claim 19 , wherein A is a bicyclic heterocyclyl ring. 
     
     
         22 . The method of  claim 19 , wherein the compound is of formula (X): 
       
         
           
           
               
               
           
         
         wherein X 1  is selected from CH 2 , O, S, and NH; and 
         - - - represents the presence or absence of a bond. 
       
     
     
         23 . The method of  claim 19 , wherein the compound is of formula (XI): 
       
         
           
           
               
               
           
         
         wherein X 1  is selected from CH 2 , O, S, and NH; and 
         - - - represents the presence or absence of a bond. 
       
     
     
         24 . The method of  claim 19 , wherein the compound is of formula (XII): 
       
         
           
           
               
               
           
         
         wherein X 1  is selected from CH 2 , O, S, and NH; 
         n is 1 or 2; and 
         - - - represents the presence or absence of a bond. 
       
     
     
         25 . The method of  claim 19 , wherein the compound is of formula (XIII): 
       
         
           
           
               
               
           
         
         wherein X 2 , X 3 , X 4  and X 5  are independently selected from CH and N. 
       
     
     
         26 . The method of  claim 19 , wherein the compound is of formula (XIV): 
       
         
           
           
               
               
           
         
         wherein X 1  and X 2  are independently selected from O and S; and 
         n is 1 or 2. 
       
     
     
         27 . The method of  claim 26 , wherein X 1  and X 2  are O. 
     
     
         28 . The method of  claim 26 , wherein n is 1. 
     
     
         29 .- 39 . (canceled) 
     
     
         40 . A pharmaceutical composition comprising a compound having the following formula: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.