Avocado flesh and/or skin extract rich in polyphenols and cosmetic, dermatological and nutraceutical compositions comprising same

Abstract

The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative to the dry extract obtained, wherein said polyphenols contain procyanidins, cafeic acid and cafeic acid derivatives, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalent relative to the total polyphenol content by weight. The invention also relates to a composition comprising an extract according to the invention as active agent and a suitable excipient. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which consists in administering such a composition or such an extract.

1 . A polyphenol-rich extract of avocado fruit, containing at least 10% by weight of polyphenols and advantageously between 10 and 30% by weight of polyphenols, expressed in gallic acid equivalents in relation to the dry extract obtained, said polyphenols advantageously containing procyanidins, caffeic acid and derivatives of caffeic acid, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalents in relation to the total polyphenols content by weight. 
     
     
         2 . The extract of  claim 1 , characterized in that the proportions of procyanidins, advantageously selected from the group comprised of B-type procyanidin dimers, A- and B-type procyanidin trimers and A- and B-type procyanidin tetramers, of caffeic acid and of derivatives of caffeic acid in said polyphenols are at least 80% by weight, expressed in gallic acid equivalents in relation to the total polyphenols content by weight. 
     
     
         3 . The extract of  claim 1  or  claim 2 , characterized in that the polyphenols contained in this extract contain at least 30% of procyanidins, expressed in gallic acid equivalents in relation to the total polyphenols content by weight. 
     
     
         4 . The extract of any one of the preceding claims, characterized in that the polyphenols contained in this extract contain caffeic acid and derivatives thereof in a proportion of at least 30% by weight, expressed in gallic acid equivalents in relation to the total polyphenols content by weight. 
     
     
         5 . The extract of any one of the preceding claims, characterized in that it further includes at least 10%, advantageously from 10 to 60% avocado sugars, said sugars containing at least D-mannoheptulose and/or perseitol, with percentages being expressed by weight in relation to the weight of the dry extract. 
     
     
         6 . The extract of any one of the preceding claims, characterized in that it is obtained by extraction of the avocado fruit, advantageously by extraction of avocado fruits that first have been dried, under gentle conditions, and then delipidated. 
     
     
         7 . The extract of any one of  claims 1  to  6 , characterized in that it is obtained by solid-liquid extraction of a portion of the avocado fruit in an aqueous and/or alcoholic and/or glycolic and/or glycerolic solvent. 
     
     
         8 . The extract of  claim 7 , characterized in that the solvent is selected from the group composed of water, ethanol, glycerol or a glycol such as propanediol, or mixtures thereof, advantageously binary mixtures, in proportions between 0 and 100% of water in relation to other solvents. 
     
     
         9 . A composition including as active agent an extract as defined in any one of  claims 1  to  8  and a suitable carrier, characterized in that it is a cosmetic, pharmaceutical, dermatological or nutraceutical composition. 
     
     
         10 . The composition of  claim 9 , further including another active agent, in particular selected from the group composed of emollients, moisturizing active agents, keratoregulators, keratolytics, healing agents and/or agents that restructure the cutaneous barrier, PPAR, RXR or LXR agonists, sebum-regulating agents, anti-irritation and/or anti-inflammatory and/or soothing agents, antioxidant agents, anti-aging agents, depigmenting or hypopigmenting agents, pigmenting agents, lipolytic or lipogenesis inhibitor agents or anti-cellulitis or slimming agents, organic or mineral sun screens and filters (pigmentary or ultrafine), antifungal compounds, preservatives, antibacterial agents, prebiotics and probiotics, antibiotics, and immunomodulators. 
     
     
         11 . The composition of  claim 9  or  claim 10 , characterized in that the other active agent is selected from:
 healing agents and/or agents that restructure the cutaneous barrier, preferably panthenol, arabinogalactan, zinc oxide, ceramides, cholesterol, squalane and phospholipids, 
 sebum-regulating agents, preferably selected from 5-alpha reductase inhibitors and zinc derivatives, 
 anti-inflammatory and/or anti-irritation and/or soothing agents, preferably arabinogalactan, 
 hypopigmenting or depigmenting agents, preferably N-undecylenoyl-L-phenylalanine, 
 organic or mineral sun screens and filters, preferably UVB and/or UVA sun screens and filters, and 
 preservatives preferably selected from capryloyl glycine, glyceryl caprylate and hexanediol. 
 
     
     
         12 . The composition of any one of  claims 9  to  11 , further including at least one other active agent selected from the group composed of:
 plant oils, preferably soy oil, rapeseed oil, avocado oil, lupin oil, and advantageously sweet white lupin oil, or a mixture of these oils, 
 oleodistillates or concentrates of plant or animal oil, preferably of sunflower, avocado, rapeseed, corn and palm and advantageously concentrated in unsaponifiables, 
 unsaponifiables of plants or plant oil, preferably avocado unsaponifiables, soy unsaponifiables or mixtures thereof, advantageously of avocado furans, and in particular, a mixture of avocado furanic unsaponifiables and soy unsaponifiables in a respective ratio of approximately 1/3-2/3, sterolic unsaponifiables, phytosterols, esters of sterols and vitamin derivatives, 
 peptides or complexes of plant amino acids, preferably avocado peptides, lupin peptides, quinoa peptides, maca peptides, fermented or non-fermented soy peptides, rice peptides, 
 plant sugars, preferably avocado sugars, 
 butyl avocadate, 
 polyphenol-rich extracts, preferably extracts of the above-ground parts of  Gynandropsis gynandra  and extracts of maca leaves, 
 lupeol, 
 total lupin extract, 
 extract of  Acacia macrostachya  seeds, extract of maca leaves, an extract of  Schisandra sphenanthera  and an extract of  Vigna unguiculata  seeds, 
 oxazolines, preferably 2-undecyl-4-hydroxymethyl-4-methyl-1,3-oxazoline, 2-undecyl-4,4-dimethyl-1,3-oxazoline, (E)-4,4-dimethyl-2-heptadec-8-enyl-1,3-oxazoline, 4-hydroxymethyl-4-methyl-2-heptadecyl-1,3-oxazoline, (E)-4-hydroxymethyl-4-methyl-2-heptadec-8-enyl-1,3-oxazoline, 2-undecyl-4-ethyl-4-hydroxymethyl-1,3-oxazoline and 2-undecyl-4,4-dimethyl-1,3-oxazoline, and 
 
       mixtures thereof. 
     
     
         13 . The composition of any one of  claims 9  to  12 , characterized in that it is formulated to be administered by topical or oral route. 
     
     
         14 . The composition of any one of  claims 9  to  13  or extract as defined in any one of  claims 1  to  8  to be used in the prevention and/or treatment of disorders or pathologies of the skin and/or mucous membranes and/or appendages, advantageously allergic, inflammatory or irritative reactions or pathologies or disorders of the barrier or homeostasis of the skin, or vascular disorders or as depigmenting and healing agent. 
     
     
         15 . A cosmetic care method for the skin and/or appendages and/or mucous membranes, advantageously for sensitive skin, with a view to improving the condition and/or appearance thereof, in particular in order to promote the hydration thereof, or to improve the firmness, elasticity or tonicity of the skin and to prevent the accumulation of adipose tissue and skin with cellulitis, or to reduce pigmentation spots, or to prevent and/or treat aging, comprising the administration of a cosmetic composition according to any one of  claims 9  to  13  or an extract as defined in any one of  claims 1  to  8 .