Novel Use of Cryptotanshinone

Abstract

Provided are a composition for stimulating differentiation of MSCs into osteoblasts, which includes cryptotanshinone, and an osteogenesis stimulator including cryptotanshinone and MSCs. When the cryptotanshinone is treated to the MSCs, the differentiation into osteoblasts is stimulated, and thus osteogenesis of a patient may be stimulated by directly transplanting the differentiation-induced MSCs to the patient. Accordingly, the composition or osteogenesis stimulator may be used to treat patients having disability requiring stimulation of osteogenesis such as osteoporosis, bone fracture, bone grafting including alveolar bone grafting for implant placement, or other bone defects.

What is claimed is: 
     
         1 . A composition for stimulating differentiation of mesenchymal stem cells (MSCs) into osteoblasts, comprising cryptotanshinone. 
     
     
         2 . The composition according to  claim 1 , wherein the cryptotanshinone is included at a concentration of 1 to 50 μM. 
     
     
         3 . An osteogenesis stimulator, comprising cryptotanshinone and MSCs. 
     
     
         4 . The stimulator according to  claim 3 , which is to be grafted to patients having osteoporosis, bone fracture or bone defects, or requiring bone grafting. 
     
     
         5 . The stimulator according to  claim 3 , wherein the MSCs are obtained from tissue, bone marrow, cord blood, blood, or body fluid. 
     
     
         6 . The stimulator according to  claim 4 , wherein the tissue is an adipose tissue. 
     
     
         7 . The stimulator according to  claim 3 , which is administrated by being contained in a carrier. 
     
     
         8 . The stimulator according to  claim 3 , wherein the cryptotanshinone is included at a concentration of 1 to 100 μM. 
     
     
         9 . The stimulator according to  claim 3 , wherein an effective amount of the MSCs is 1×10 4  to 1×10 6  cells/kg.