Anti-Obesity and Anti-Dyslipidemic Effects of Oil Palm Phenolics in Preventing Atherosclerosis and Cardiovascular Disease

Abstract

A composition comprising extracts containing oil palm phenolics in an amount effective for use in a method of reducing cholesterol biosynthesis and thus preventing obesity. The composition up regulates fatty acid beta oxidation and down regulates cholesterol biosynthesis in livers. The composition is useful for prevention of obesity associated diseases. The composition delays the onset of obesity and attenuates the inflammatory response of atherogenic diet, whereby the composition aids to suppress the inflammatory response thereby ameliorating artherosclerosis. The composition delays weight gain or obesity thereby preventing the effects of dyslipidemia.

1 . A composition useful for providing anti-obesity or anti-dyslipidemics properties, wherein said composition comprising oil palm phenolics. 
     
     
         2 . A composition useful for providing anti-obesity or anti-dyslipidemics properties, wherein said composition comprising extracts from oil palm. 
     
     
         3 . The composition as claimed in  claim 2  wherein the extracts comprise oil palm phenolics. 
     
     
         4 . The composition as claimed in  claim 1  wherein the composition is useful for prevention of artherosclerosis and cardiovascular diseases and diseases related thereto. 
     
     
         5 . The composition as claimed in  claim 1  wherein composition is useful for reducing the inflammatory effects of an atherogenic diet. 
     
     
         6 . The composition as claimed in  claims 1  to  5  wherein the composition prevents oxidative stress caused by the atherogenic diet. 
     
     
         7 . The composition as claimed in anyone of  claims 1  to  5  wherein the composition delays the onset of obesity and attenuates the inflammatory response of atherogenic diet, whereby the composition aids to suppress the inflammatory response thereby ameliorating artherosclerosis. 
     
     
         8 . The composition as claimed in  claim 1  wherein the composition delays weight gain or obesity thereby preventing the effects of dyslipidemia. 
     
     
         9 . The composition as claimed in  claim 1  wherein the composition is further useful to induce reduction of cholesterol biosynthesis. 
     
     
         10 . The composition as claimed in  claim 1  wherein the composition is further useful in up-regulating fatty acid beta oxidation. 
     
     
         11 . The composition as claimed in  claim 1  wherein the composition is further useful in suppression of liver fat and visceral fat accumulation by way of up-regulating the fatty acid beta oxidation. 
     
     
         12 . The composition as claimed in  claim 1  wherein the composition is further useful in preventing diabetes. 
     
     
         13 . The composition as claimed in  claim 1  wherein the composition is further useful in preventing alcohol-induced liver damage. 
     
     
         14 . The composition as claimed in  claim 1  wherein the composition is further useful in up-regulating unfolded protein response, thus eliminating the proteins that cannot be re-folded. 
     
     
         15 . The composition as claimed in  claim 1  wherein composition is further useful in down-regulating antigen presentation. 
     
     
         16 . The composition as claimed in  claim 1  wherein the composition is further useful in reducing damaged proteins caused by artherogenic diet. 
     
     
         17 . The composition as claimed in  claim 1  wherein the extract is obtained from any part of palm oil. 
     
     
         18 . The composition as claimed in  claim 1  wherein the extract is obtained from palm oil mill vegetation liquor. 
     
     
         19 . Use of a pharmaceutically acceptable amount of a composition comprising an extract containing oil palm phenolics in the preparation of a medicament for the treatment and prevention of atherosclerosis and cardiovascular diseases related thereto in a patient in need thereof. 
     
     
         20 . The composition as claimed in  claim 19  wherein the composition is provided in solid dosage form. 
     
     
         21 . The composition as claimed in  claim 19  wherein the composition is provided in liquid dosage form. 
     
     
         22 . The composition as claimed in  claim 19  wherein the composition is provided in solution form. 
     
     
         23 . The composition as claimed in  claim 19  wherein the composition is provided in a pharmaceutically effective form. 
     
     
         24 . The composition as claimed in  claim 19  wherein the composition is provided in nutraceutical form. 
     
     
         25 . The composition as claimed in  claim 19  wherein the composition is in nutritional supplementary form. 
     
     
         26 . The composition as claimed in  claim 19  wherein the composition is provided in a form suitable for oral administration.