Metal coordinated compositions

Abstract

A metal coordination complex of a biologically active moiety and a metal is disclosed. The complex confers to the biologically active moiety an improved performance which can include potency, stability, absorbability, targeted delivery, and combinations thereof.

1 - 47 . (canceled) 
     
     
         48 . A metal coordination complex of a biologically active moiety and a metal, wherein the biologically active moiety is selected from the group consisting of: metformin, omeprazole, famotidine, rabeprazole, theophylline, hydrochlorothiazide, alendronate, mitoxantrone, adefovir, acyclovir, clonidine, dipyramidole, atovaquone, idarubicin, etidronate, valganciclovir, saquinavir, fosamprenavir, retinoic acid, minoxidil, cyclosporine, fosphenyloin, atrial natriuretic peptide, abarelix, and heparin and their derivatives. 
     
     
         49 . The metal coordination complex of claim  1 , wherein the metal is selected from the group consisting of: aluminum, bismuth, calcium, iron, magnesium, silicon, and zinc. 
     
     
         50 . A metal coordination complex of a biologically active moiety and a metal, wherein the biologically active moiety contains a β-diketone, ketophenol or β-ketoalcohol, functional group. 
     
     
         51 . The metal coordination complex of claim  3 , wherein the metal is selected from the group consisting of: aluminum, bismuth, calcium, iron, magnesium, silicon, and zinc. 
     
     
         52 . A metal coordination complex of a biologically active moiety and a metal, wherein the biologically active moiety contains an alcohol and an azole functional group. 
     
     
         53 . The metal coordination complex of claim  5 , wherein the metal is selected from the group consisting of: aluminum, bismuth, calcium, iron, magnesium, silicon, and zinc.