Linear cyclodextrin copolymers

Abstract

Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.

1 - 45 . (canceled) 
     
     
         46 . A method of preparing a β-cyclodextrin-PEG copolymer, comprising:
 a. providing a salt of 6 A ,6 D -diamino-6 A ,6 D -deoxy-β-cyclodextrin in a suspension; 
 b. treating the suspension with a polyethylene glycol diacid chloride; 
 c. allowing the treated suspension to become a homogeneous solution; 
 d. removing solvent from the homogeneous solution to generate a residue; 
 e. subjecting the residue to gel permeation chromatography; and 
 f. recovering the copolymer. 
 
     
     
         47 . The method of  claim 46 , wherein the polyethylene glycol diacid chloride is polyethylene glycol 600 diacid chloride. 
     
     
         48 . The method of  claim 46 , wherein the suspension further comprises triethylamine and anhydrous N,N-dimethylacetamide.