US2013184835A1PendingUtilityA1

Biodegradable scaffolds

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Assignee: FERRARI MAUROPriority: Jul 9, 2010Filed: Mar 24, 2011Published: Jul 18, 2013
Est. expiryJul 9, 2030(~4 yrs left)· nominal 20-yr term from priority
Inventors:Mauro FerrariRachel BuchananChristine SmidEnnio Tasciotti
A61L 2300/44A61L 2300/41A61L 2300/406A61L 2300/252A61L 27/58A61L 27/18A61L 2300/64A61L 27/20A61L 2430/02A61L 27/16A61L 27/3847A61L 27/54A61L 27/446A61L 27/3834A61L 27/56
46
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Claims

Abstract

In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects. Further embodiments of the present invention pertain to methods of making the compositions of the present invention.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A composition comprising:
 a biodegradable polymer matrix; and   at least one biodegradable reinforcing particle dispersed in the matrix,
 wherein the at least one biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. 
   
     
     
         2 . The composition of  claim 1 , wherein the polymer matrix comprises an unsaturated biodegradable polymer. 
     
     
         3 . The composition of  claim 2 , wherein the unsaturated biodegradable polymer is poly(propylene fumarate) (PPF). 
     
     
         4 . The composition of  claim 1 , further comprising porogen particles dispersed in the matrix. 
     
     
         5 . The composition of  claim 4 , wherein the porogen particles comprise hydrogel porogen particles. 
     
     
         6 . The composition of  claim 4 , wherein the porogen particles comprise at least one natural or synthetic biodegradable particle. 
     
     
         7 . The composition of  claim 4 , wherein the porogen particles comprise poly(lactic-co-glycolic acid) (PLGA). 
     
     
         8 . The composition of  claim 5 , wherein the hydrogel porogen particles comprise at least one of alginates, fibrins, and gelatins. 
     
     
         9 . The composition of  claim 4 , wherein the porogen particles comprise at least one biocompatible vesicle. 
     
     
         10 . The composition of  claim 9 , wherein the biocompatible vesicle comprises at least one of a liposome or a micelle. 
     
     
         11 . The composition of  claim 4 , wherein the porogen particles comprise at least one active agent. 
     
     
         12 . The composition of  claim 11 , wherein the at least one active agent is selected from the group consisting of therapeutics, imaging agents, anti-inflammatory agents, antibiotics, proteins, platelet rich plasma, cells, degradation inducers of porous particles, and combinations thereof. 
     
     
         13 . The composition of  claim 11 , wherein the active agent comprises stem cells. 
     
     
         14 . The composition of  claim 11 , wherein the active agent comprises mesenchymal stem cells. 
     
     
         15 . The composition of  claim 4 , wherein the porogen particles contain at least one biodegradable porous particle within the porogen particles. 
     
     
         16 . The composition of  claim 15 , wherein the at least one biodegradable porous particle comprises a silicon porous particle. 
     
     
         17 . The composition of  claim 16 , wherein the at least one biodegradable porous particle comprises at least one active agent. 
     
     
         18 . The composition of  claim 17 , wherein the at least one active agent is selected from the group consisting of therapeutics, imaging agents, anti-inflammatory agents, antibiotics, proteins, platelet rich plasma, cells, degradation inducers of porous particles, and combinations thereof. 
     
     
         19 . The composition of  claim 15 , wherein a surface of the biodegradable porous particle is modified with a biodegradable polymer. 
     
     
         20 . The composition of  claim 19 , wherein the biodegradable polymer is agarose. 
     
     
         21 . The composition of  claim 19 , wherein the biodegradable polymer is poly(lactic-co-glycolic acid) (PLGA). 
     
     
         22 . The composition of any one of  claims 15 - 21 , wherein the biodegradable porous particle facilitates or controls at least one of intracellular delivery of an active agent, bio-distribution of an active agent, stability of an active agent, and internalization of the porous particle by cells or organelles. 
     
     
         23 . The composition of  claim 4 , wherein the biodegradable reinforcing particle comprises a degradation inducer of the porogen particles. 
     
     
         24 . The composition of  claim 23 , wherein the porogen particles comprise alginate, and wherein the degradation inducer comprises sodium citrate. 
     
     
         25 . The composition of  claim 1 , wherein the at least one biodegradable reinforcing particle comprises a mesoporous silica particle. 
     
     
         26 . The composition of  claim 25 , wherein at least one imaging agent is embedded into a matrix of the mesoporous silica particles. 
     
     
         27 . The composition of  claim 26 , wherein the at least one imaging agent comprises barium sulfate. 
     
     
         28 . The composition of  claim 1 , wherein the at least one biodegradable reinforcing particle comprises elongated, rod-like microparticles or nanoparticles. 
     
     
         29 . The composition of  claim 1 , wherein the at least one biodegradable reinforcing particle is covalently bound to the polymer matrix. 
     
     
         30 . The composition of  claim 29 , wherein the reinforcing particle is bound to the polymer matrix through an acrylate moiety on a surface of the reinforcing particle. 
     
     
         31 . The composition of  claim 30 , wherein the reinforcing particle is conjugated with the acrylate moiety. 
     
     
         32 . The composition of  claim 1 , wherein the biodegradable reinforcing particle comprises at least one active agent. 
     
     
         33 . The composition of  claim 32 , wherein the at least one active agent is selected from the group consisting of therapeutics, imaging agents, anti-inflammatory agents, antibiotics, proteins, platelet rich plasma, cells, degradation inducers of porous particles, and combinations thereof. 
     
     
         34 . The composition of  claim 32 , wherein the at least one active agent comprises at least one imaging agent. 
     
     
         35 . The composition of  claim 34 , wherein the at least one imaging agent comprises barium sulfate. 
     
     
         36 . The composition of  claim 32 , wherein the at least one active agent comprises at least a cell viability enhancing agent. 
     
     
         37 . The composition of  claim 36 , wherein the at least one cell viability enhancing agent comprises glucose. 
     
     
         38 . The composition of  claim 1 , wherein the composition is a scaffold. 
     
     
         39 . The composition of  claim 38 , wherein the scaffold is utilized to treat a bone defect in a subject. 
     
     
         40 . The composition of  claim 39 , wherein the bone defect comprises a bone fracture. 
     
     
         41 . The composition of  claim 38 , wherein the scaffold is utilized to treat a tissue injury in a subject. 
     
     
         42 . A method of treating a bone defect in a subject, wherein the method comprises:
 applying to an area of the bone defect in the subject a scaffold, wherein the scaffold comprises:
 a biodegradable polymer matrix, and 
 at least one biodegradable reinforcing particle dispersed in the matrix, wherein the at least one biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. 
   
     
     
         43 . The method of  claim 42 , wherein the scaffold further comprises porogen particles dispersed in the matrix. 
     
     
         44 . The method of  claim 43 , wherein the porogen particles comprise hydrogel porogen particles. 
     
     
         45 . The method of  claim 43 , wherein the porogen particles comprise at least one active agent. 
     
     
         46 . The method of  claim 45 , wherein the at least one active agent is selected from the group consisting of therapeutics, imaging agents, anti-inflammatory agents, antibiotics, proteins, platelet rich plasma, cells, degradation inducers of porous particles, and combinations thereof. 
     
     
         47 . The method of  claim 43 , wherein the porogen particles contain at least one biodegradable porous particle within the porogen particles. 
     
     
         48 . The method of  claim 47 , wherein the biodegradable porous particle facilitates or controls at least one of intracellular delivery of an active agent, bio-distribution of an active agent, stability of an active agent, and internalization of the porous particle by cells or organelles. 
     
     
         49 . The method of  claim 42 , wherein the applying step comprises injecting the subject with a composition comprising the biodegradable polymer matrix and the at least one biodegradable reinforcing particle,
 wherein the scaffold is formed from the composition in the body of the subject after the injecting.   
     
     
         50 . The method of  claim 42 , wherein the bone defect comprises a bone fracture. 
     
     
         51 . The method of  claim 42 , wherein the subject is a human being. 
     
     
         52 . A method of making a biodegradable composition comprising:
 dispersing in a biodegradable polymer matrix at least one biodegradable reinforcing particle selected from the group consisting of porous oxide particles and porous semiconductor particles.   
     
     
         53 . The method of  claim 52 , further comprising dispersing in the biodegradable polymer matrix porogen particles. 
     
     
         54 . The method of  claim 53 , wherein the porogen particles comprise hydrogel porogen particles. 
     
     
         55 . The method of  claim 53 , wherein the porogen particles comprise at least one active agent. 
     
     
         56 . The method of  claim 55 , wherein the at least one active agent is selected from the group consisting of therapeutics, imaging agents, anti-inflammatory agents, antibiotics, proteins, platelet rich plasma, cells, degradation inducers of porous particles, and combinations thereof. 
     
     
         57 . The method of  claim 52 , wherein the composition is utilized to treat a bone defect in a subject. 
     
     
         58 . The method of  claim 57 , wherein the bone defect comprises a bone fracture. 
     
     
         59 . The method of  claim 52 , wherein the composition is utilized to treat a tissue injury in a subject.

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