Device for intranasal administration of ketorolac

Abstract

Disclosed herein are vials and devices containing a ketorolac solution for intranasal administration and a head space comprising no more than about 10% v/v oxygen and which vials and devices are stored in an oxygen-impermeable pouch. Also disclosed are processes for preparing the vials and devices.

1 . A vial having a cap, wherein the cap comprises a spray system and wherein the vial has a volume of no more than about 10 mL, the vial comprising: a solution comprising ketorolac, a concave or V-shaped inner bottom, and a dip tube attached to the spray system and dipping into the solution and ending proximate the bottom of the inner bottom. 
     
     
         2 . The vial of  claim 1 , wherein the vial is intended for multiple deliveries of the solution. 
     
     
         3 - 5 . (canceled) 
     
     
         6 . The vial of  claim 1 , wherein the solution comprises from about 12.5% w/v to about 38% w/v of ketorolac tromethamine. 
     
     
         7 . The vial of  claim 1 , wherein the solution comprises about 15% w/v of ketorolac tromethamine. 
     
     
         8 . The vial of  claim 1 , wherein the ketorolac solution comprises about 30% w/v of ketorolac tromethamine. 
     
     
         9 .- 11 . (canceled) 
     
     
         12 . The vial of  claim 1 , further comprising a notched dip tube. 
     
     
         13 - 29 . (canceled) 
     
     
         30 . A method for delivering a ketorolac solution for intranasal administration comprising spraying the ketorolac solution from a vial of  claim 1 .