Foamable Composition

Abstract

A foamable composition, includes (1) about 6% to about 70% by weight of at least one organic carrier; (2) about 0.1% to about 5% by weight of at least one surface-active agent; (3) about 0.01% to about 5% by weight of at least one film forming agent; (4) water; and (5) about 3% to about 25% by weight of the total composition of at least one liquefied or compressed gas propellant. The composition is substantially alcohol free and is used in treating, alleviating or preventing a disorder.

What is claimed is: 
     
         1 . A foamable composition comprising a carrier composition and a propellant, the carrier composition comprising:
 a) about 6% to about 70% by weight of the carrier composition of an organic carrier selected from the group consisting of a hydrophobic organic carrier, an emollient, a polar solvent, and mixtures of any two or more thereof;   b) about 0.1% to about 5% by weight of the carrier composition of a surface-active agent, wherein the surface-active agent present is a non-ionic surface-active agent or a mixture of a non-ionic surface-active agent and an ionic surface-active agent in a ratio of 6:1 or greater than about 6:1 by weight;   c) an active agent; and   d) water;   wherein the propellant comprises about 3% to about 25% by weight of the carrier composition of a liquefied or compressed gas propellant; and   wherein upon release from a container, the foamable composition forms a breakable foam.   
     
     
         2 . The foamable composition of  claim 1 , wherein the carrier composition further comprises about 0.01% to about 5% by weight of the carrier composition of a polymeric additive selected from the group consisting of a gelling agent, a bioadhesive agent, a phase change agent, and mixtures of any two or more thereof. 
     
     
         3 . The foamable composition of  claim 1 , wherein the carrier composition further comprises about 0.01% to about 5% by weight of the carrier composition of a film forming agent. 
     
     
         4 . The foamable composition of  claim 1 , wherein the carrier composition further comprises about 0.1% to about 5% by weight of the carrier composition of a foam adjuvant selected from the group consisting of a fatty alcohol, a fatty acid, and mixtures thereof. 
     
     
         5 . The foamable composition of  claim 1 , wherein the organic carrier comprises a hydrophobic organic carrier and an emollient in a ratio of 2:8 to 8:2 by weight. 
     
     
         6 . The foamable composition of  claim 2 , wherein the active agent is selected from the group consisting of a cosmetic active agent, an anti-infective, an antibiotic, an antibacterial agent, a disinfectant, an antifungal agent, an antiviral agent, an antiparasitic agent, an anti-inflammatory agent, an anti-allergic agent, a steroid, a steroidal anti-inflammatory agent, a nonsteroidal anti-inflammatory drug, an immunosuppressive agent, an immunomodulator, an immunoregulating agent, a hormone, a keratolytically active agent, an alpha hydroxyl acid, a beta-hydroxy acid, vitamin A, a vitamin A derivative, a retinoid, vitamin B, a vitamin B derivative, vitamin C, a vitamin C derivative, vitamin D, a vitamin D derivative, vitamin E, a vitamin E derivative, vitamin F, a vitamin F derivative, vitamin K, a vitamin K derivative, a wound healing agent, a burn healing agent, an anesthetic, a protein, a peptide, a neuropeptide, a allergen, an immunogenic substance, a haptene, an oxidizing agent, an antioxidant, a dicarboxylic acid, an antiproliferative agent, an anticancer agent, a photodynamic therapy agent, a sunscreen agent, an anti-wrinkle agent, a radical scavenger, a metal oxide, an anti wrinkle agent, an anti-acne agent, a skin whitening agent, a self tanning agent, an anti-cellulite agent, a skin protective agent, a masking agent, an anti-wart agent, a refatting agent, a lubricating agent, and mixtures of any two or more thereof. 
     
     
         7 . The foamable composition of  claim 1 , wherein the surface-active agent is selected from the group consisting of a polysorbate, a polyoxyethylene fatty acid ester, a polyoxyethylene alkyl ether, a sucrose ester, a partial ester of sorbitol, a partial ester of sorbitol anhydride, sodium methyl cocoyl taurate, sodium methyl oleoyl taurate, sodium lauryl sulfate, triethanolamine lauryl sulfate, a betaine, a mono-, di- or tri-ester of sucrose with fatty acids, a monoglyceride, a diglyceride, polyoxyethylene (20) sorbitan monostearate, polyoxyethylene (20) sorbitan monooleate, polyoxyethylene (8) Stearate, polyoxyethylene (20) stearate, polyoxyethylene (100) stearate, a polyoxyethylene cetyl ether, polyoxyethylene (2) cetyl ether, polyoxyethylene (10) cetyl ether, sorbitan monolaurate, isoceteth-20, cocamidopropyl betaine, polyoxyethylene 40 stearate, and mixtures of any two or more thereof. 
     
     
         8 . The foamable composition of  claim 1 , wherein the surface-active agent is a non ionic surface-active agent. 
     
     
         9 . The foamable composition of  claim 8 , wherein the surface-active agent comprises at least one non-ionic surface-active agent having an HLB of less than 9 and at least one non-ionic surface-active agent having HLB of equal or more than 9. 
     
     
         10 . The foamable composition of  claim 1 , wherein the breakable foam has a specific gravity of less than about 0.12 g/mL. 
     
     
         11 . The foamable composition of  claim 1 , wherein the breakable foam does not immediately collapse upon exposure to body temperature. 
     
     
         12 . The foamable composition of  claim 1 , wherein the propellant is selected from the group consisting of butane, propane, isobutane, and mixtures of any two or more thereof. 
     
     
         13 . The foamable composition of  claim 2 , wherein the polymeric additive comprises a gelling agent selected from the group consisting of locust bean gum, sodium alginate, sodium caseinate, egg albumin, gelatin agar, carrageenin gum, xanthan gum, quince seed extract, tragacanth gum, guar gum, starch, chemically modified starches, cellulose ethers, hydroxyethyl cellulose, methyl cellulose, carboxymethyl cellulose, hydroxy propylmethyl cellulose, hydroxypropyl guar gum, soluble starch, cationic celluloses, cationic guars, carboxyvinyl polymers, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylic acid polymers, polymethacrylic acid polymers, polyvinyl acetate polymers, polyvinyl chloride polymers, polyvinylidene chloride polymers, acrylic acid/ethyl acrylate copolymers, crosslinked copolymers of acrylic acid and C10-C30 alkyl acrylate, carboxyvinyl polymers, carbopols, and mixtures of any two or more thereof. 
     
     
         14 . The foamable composition of  claim 1  wherein the organic carrier comprises two or more of:
 a) a hydrophobic organic carrier comprising an oil; 
 b) an emollient selected from the group consisting of hexylene glycol, propylene glycol, isostearic acid derivatives, isopropyl palmitate, isopropyl isostearate, isopropyl myristate, ethyl acetate, butyl acetate, methyl propionate, capric/caprylic triglycerides, octyl myristate, dodecyl-myristate, diisopropyl adipate, diisopropyl dimerate, maleated soybean oil, octyl palmitate, cetyl lactate, cetyl ricinoleate, tocopheryl acetate, acetylated lanolin alcohol, cetyl acetate, phenyl trimethicone, glyceryl oleate, tocopheryl linoleate, wheat germ glycerides, arachidyl propionate, myristyl lactate, decyl oleate, propylene glycol ricinoleate, isopropyl lanolate, pentaerythrityl tetrastearate, neopentylglycol dicaprylate/dicaprate, isononyl isononanoate, isotridecyl isononanoate, myristyl myristate, triisocetyl citrate, octyl dodecanol, sucrose esters of fatty acids, octyl hydroxystearate, and mixtures of any two or more thereof; 
 iii. a polar solvent selected from the group consisting of a polyol, glycerol, propylene glycol, hexylene glycol, diethylene glycol, a propylene glycol n-alkanols, a terpene, a di-terpene, a tri-terpene, a terpen-ol, limonene, menthol, dioxolane, ethylene glycol, a glycol, a sulfoxide, dimethylsulfoxide, dimethylformanide, methyl dodecyl sulfoxide, dimethylacetamide, monooleate of ethoxylated glycerides, 1-dodecylazacycloheptan-2-one, 2-(n-nonyl)-1,3-dioxolane, a polyethylene glycol, PEG 200, PEG 300, PEG 400, PEG 600, PEG 4000, PEG 6000, PEG 10000, and mixtures of any two or more thereof. 
 
     
     
         15 . The foamable composition of  claim 1 , wherein the carrier comprises a microemulsion. 
     
     
         16 . The foamable composition of  claim 14 , wherein the emollient comprises diisopropyl adipate. 
     
     
         17 . The foamable composition of  claim 14 , wherein the oil comprises mineral oil. 
     
     
         18 . The foamable composition of  claim 8 , wherein the surface-active agent comprises a polyoxyethylene alkyl ether. 
     
     
         19 . The foamable composition of  claim 6 , wherein the retinoid comprises tazarotene. 
     
     
         20 . The foamable composition of  claim 1 , wherein the carrier is free of short-chain monohydric alcohols having up to 5 carbon atoms in their carbon chain. 
     
     
         21 . The foamable composition of  claim 1 , wherein the water is present in the foamable composition at 25-95% by weight of the carrier composition. 
     
     
         22 . A foamable composition comprising a carrier composition and a propellant, the carrier composition comprising:
 a) a hydrating combination comprising:
 i. about 6% to about 70% by weight of the carrier composition of an organic carrier comprising a hydrophobic organic carrier, an emollient, and a polar solvent; and 
 ii. about 0.01% to about 5% by weight of the carrier composition of a film forming agent and/or a polymeric agent; 
   b) about 0.1% to about 5% by weight of the carrier composition of a surface-active agent, wherein the surface-active agent is a non-ionic surface-active agent or a mixture of a non-ionic surface-active agent and an ionic surface-active agent in a ratio of 6:1 or greater than about 6:1 by weight, and;   c) an active agent; and   d) water;   wherein the propellant comprises about 3% to about 25% by weight of the carrier composition of a liquefied or compressed gas propellant, and   wherein upon release from a container, the foamable composition forms a breakable foam which when applied to skin can elevate skin hydration by about 20% to about 45%.   
     
     
         23 . The foamable composition of  claim 22 , wherein the hydrophobic organic carrier and the emollient are in a ratio of 2:8 to 8:2 by weight.