Long-chain oxyaminopolyol based gelator and gel

Abstract

[PROBLEMS TO BE SOLVED] It is an object of the present invention to provide a gelator containing a long chain oxyaminopolyol capable of forming a gel with a small amount thereof over a liquid property range from acidic to alkaline, and a gel having high environmental suitability, biocompatibility and biodegradability. [MEANS FOR SOLVING THE PROBLEMS] A gelator, characterized by containing a long chain oxyaminopolyol of Formula (I): (where R 1 is a C 12-16 saturated aliphatic group or a C 12-16 unsaturated aliphatic group having one double bond; R 2 is a substituent which an amino acid has; and X is an oxygen atom or NH) and a pharmaceutically acceptable salt thereof; a self-assembly formed by the self-assembly of the gelator; and a gel containing the gelator or the self-assembly, and water, an aqueous solution, a hydrophilic organic solvent or a hydrophilic organic solution, or a hydrophobic organic solvent or a hydrophobic organic solution.

1 . A gel comprising:
 a gelator comprising a long chain oxyaminopolyol of Formula (I):   
       
         
           
           
               
               
           
         
         
           where R 1  is a C 12-16  saturated aliphatic group or a C 12-16  unsaturated aliphatic group having one double bond; R 2  is a hydrogen atom, a C 1-4  alkyl group which optionally has a C 1-2  branched chain, a phenylmethyl group or a —(CH 2 ) n —Y group, where n is a number of 1 to 4; and Y is an amino group, a guanidino group, a —CONH 2  group or a fused heterocycle composed of a 5-membered ring, a 6-membered ring or a 5-membered ring and a 6-membered ring which optionally has 1 to 3 nitrogen atoms; and X is an oxygen atom or a NH group, 
           or a pharmaceutically available salt of the long chain oxyaminopolyol; and 
           water, an aqueous solution, a hydrophilic organic solvent, a hydrophilic organic solution, a hydrophobic organic solvent or a hydrophobic organic solution. 
         
       
     
     
         2 . The gel according to  claim 1 , wherein the hydrophilic organic solvent is at least one selected from a group consisting of methanol, ethanol, 2-propanol, isobutanol, pentanol, hexanol, 1-octanol, isooctanol, acetone, dioxane, glycerin, propylene glycol and ethylene glycol. 
     
     
         3 . The gel according to  claim 1 , wherein the hydrophilic organic solution is a solvent mixture of at least one selected from a group consisting of methanol, ethanol, 2-propanol, isobutanol, pentanol, hexanol, 1-octanol, isooctanol, acetone, dioxane, glycerin, propylene glycol and ethylene glycol and water. 
     
     
         4 . The gel according to  claim 1 , wherein the aqueous solution is an aqueous solution in which there is dissolved an organic acid, or an inorganic acid, or at least one of inorganic salt selected from a group consisting of an inorganic carbonate salt, an inorganic sulfate salt, an inorganic phosphate salt and an inorganic hydrogen phosphate salt, or at least one of organic salt selected from a group consisting of an inorganic acetate salt, an inorganic sulfate salt, an inorganic citrate salt, an organic amine hydrochloride salt and an organic amine acetate salt. 
     
     
         5 . The gel according to  claim 4 , wherein
 the organic acid is at least one of organic acid selected from a group consisting of acetic acid, citric acid, succinic acid, lactic acid, malic acid, maleic acid, fumaric acid and trifluoroacetic acid,   the inorganic acid is at least one of inorganic acid selected from a group consisting of hydrochloric acid, phosphoric acid, carbonic acid, sulfuric acid, nitric acid and boric acid,   the inorganic salt is at least one of inorganic salt selected from a group consisting of calcium carbonate, sodium carbonate, potassium carbonate, sodium sulfate, potassium sulfate, magnesium sulfate, potassium phosphate, sodium phosphate, disodium hydrogen phosphate and sodium dihydrogen phosphate, and   the organic salt is at least one of organic salt selected from a group consisting of sodium acetate, potassium acetate, sodium lactate, potassium lactate, sodium citrate, potassium citrate, ethylenediamine hydrochloride salt, ethylenediamine tetraacetate salt and tris-hydroxymethylaminomethane hydrochloride salt.   
     
     
         6 . The gel according to  claim 1 , wherein the hydrophobic organic solvent is at least one selected from a group consisting of a vegetable oil, an ester and a hydrocarbon. 
     
     
         7 . The gel according to  claim 1 , wherein the hydrophobic organic solution is a solvent mixture of at least one selected from a group consisting of a vegetable oil, an ester and a hydrocarbon and water. 
     
     
         8 . The gel according to  claim 1 , wherein the aqueous solution is an aqueous solution selected from a group consisting of aqueous solutions of pH 2 to 8. 
     
     
         9 . The gel according to  claim 1 , wherein R 2  is a hydrogen atom, a methyl group, an isopropyl group, a sec-butyl group, an isobutyl group or a phenylmethyl group. 
     
     
         10 . The gel according to  claim 1 , wherein R 1  is a C 14-16  saturated aliphatic group. 
     
     
         11 . The gel according to  claim 1 , wherein R 1  is a palmityl group. 
     
     
         12 . A gel comprising:
 a self-assembly formed by self-assembly of a gelator comprising a long chain oxyaminopolyol of Formula (I):   
       
         
           
           
               
               
           
         
         where R 1  is a C 12-16  saturated aliphatic group or a C 12-16  unsaturated aliphatic group having one double bond; R 2  is a hydrogen atom, a C 1-4  alkyl group which optionally has a C 1-2  branched chain, a phenylmethyl group or a —(CH 2 ) n —Y group where n is a number of 1 to 4; and Y is an amino group, a guanidino group, a —CONH 2  group or a fused heterocycle composed of a 5-membered ring, a 6-membered ring or a 5-membered ring and a 6-membered ring which optionally has 1 to 3 nitrogen atoms; and X is an oxygen atom or a NH group, 
         or a pharmaceutically available salt of the long chain oxyaminopolyol; and 
         water, an aqueous solution, a hydrophilic organic solvent, a hydrophilic organic solution, a hydrophobic organic solvent or a hydrophobic organic solution.