Dialysis precursor composition

Abstract

The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water, a sodium containing concentrate, and a bicarbonate containing concentrate into a ready-for-use dialysis solution. Said dialysis acid precursor composition consists of powder components comprising glucose, at least one dry acid and at least one magnesium salt, and optionally potassium salt, and calcium salt. According to the invention said glucose and said at least one magnesium salt, are present as anhydrous components in said dialysis acid precursor composition.

1 . A dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water, a sodium containing concentrate, and a bicarbonate containing concentrate into a ready-for-use dialysis solution, wherein said dialysis acid precursor composition consist of powder components comprising glucose, at least one dry acid and at least one magnesium salt, wherein said glucose and said at least one magnesium salt are present as anhydrous components in said dialysis acid precursor composition and wherein said dialysis acid precursor composition is sealed in a moisture-resistant container with a water vapor transmission rate less than 0.3 g/m 2 /d at 38° C./90% RH. 
     
     
         2 . A dialysis precursor composition according to  claim 1 , wherein said at least one dry acid is selected from the group comprising of lactic acid, citric acid, gluconic acid, glucono-δ-lactone, N-acetyl cystein and α-lipoic acid. 
     
     
         3 . A dialysis precursor composition according to  claim 1 , wherein said at least one magnesium salt in said dialysis acid precursor composition is selected from the group comprising of anhydrous magnesium chloride, magnesium gluconate, magnesium citrate, magnesium lactate, and magnesium α-ketoglutarate. 
     
     
         4 . A dialysis precursor composition according to  claim 1 , wherein said calcium salt in said dialysis acid precursor composition, is at least one selected from the group comprising of calcium chloride dihydrate, calcium chloride monohydrate, anhydrous calcium chloride, calcium gluconate, calcium citrate, calcium lactate, and calcium α-ketoglutarate. 
     
     
         5 . A dialysis precursor composition according to  claim 1 , wherein said water vapor transmission rate is less than 0.2 g/m 2 /d at 38° C./90% RH. 
     
     
         6 . A dialysis precursor composition according to  claim 1 , wherein said water vapor transmission rate is more than 0.1 g/m 2 /d at 38° C./90% RH. 
     
     
         7 . A dialysis precursor composition according to  claim 1 , wherein said dialysis precursor composition is configured to be mixed with a prescribed volume of water within said moisture-resistant container to provide a dialysis acid concentrate solution. 
     
     
         8 . A method of providing a dialysis acid concentrate solution for dilution with water, a sodium containing concentrate, and a bicarbonate containing concentrate to produce a ready-for-use dialysis solution, comprising:
 (a) providing a dialysis precursor composition comprising glucose, at least one dry acid, and at least one magnesium salt, wherein said glucose and said at least one magnesium salt are present as anhydrous components in said dialysis acid precursor composition,   (b) providing said dialysis precursor composition in a sealed, moisture-resistant container with a water vapor transmission rate less than 0.3 g/m 2 /d at 38° C./90% RH, and   (c) adding a prescribed volume of water to said dialysis precursor composition in said container and mixing thereof, thereby providing said dialysis acid concentrate as a solution.   
     
     
         9 . The method according to  claim 8  further comprising using the solution to prepare a dialysis acid concentrate solution. 
     
     
         10 . The method according to  claim 8  wherein the solution is at least one of an infusion solution, a replacement solution, a rinsing solution and a priming solution. 
     
     
         11 . The dialysis precursor composition of  claim 1  wherein the powder components further comprise at least one of a potassium salt and a calcium salt. 
     
     
         12 . A dialysis acid precursor composition product comprising:
 an anhydrous powdered composition including a sodium containing concentrate, a bicarbonate containing concentrate, a dry acid and a magnesium salt, and   a sealed moisture-resistant container housing the anhydrous powdered composition, wherein the container has a water vapor transmission rate less than 0.3 g/m 2 /d at 38° C./90% RH.   
     
     
         13 . The dialysis precursor composition product according to  claim 12 , wherein said dry acid includes at least one of lactic acid, citric acid, gluconic acid, glucono-δ-lactone, N-acetyl cystein and α-lipoic acid. 
     
     
         14 . The dialysis precursor composition product according to  claim 12 , wherein said magnesium salt includes at least one of anhydrous magnesium chloride, magnesium gluconate, magnesium citrate, magnesium lactate, and magnesium α-ketoglutarate. 
     
     
         15 . The dialysis precursor composition product according to  claim 12 , wherein said calcium salt includes at least one of calcium chloride dihydrate, calcium chloride monohydrate, anhydrous calcium chloride, calcium gluconate, calcium citrate, calcium lactate, and calcium α-ketoglutarate. 
     
     
         16 . The dialysis precursor composition product according to  claim 12 , wherein said water vapor transmission rate is less than 0.2 g/m 2 /d at 38° C./90% RH. 
     
     
         17 . The dialysis precursor composition product according to  claim 12 , wherein said water vapor transmission rate is greater than 0.1 g/m 2 /d at 38° C./90% RH. 
     
     
         18 . The dialysis precursor composition product according to  claim 12 , wherein said container is configured to receive water which mixes with the anhydrous powdered composition in the container. 
     
     
         19 . A method comprising:
 forming an anhydrous composition including glucose, a dry acid and a magnesium salt, and   storing the anhydrous composition in moisture free chamber of a sealed, moisture-resistant container with a water vapor transmission rate less than 0.3 g/m 2 /d at 38° C./90% RH.   
     
     
         20 . The method of  claim 19  further comprising adding water to said container and mixing the water and the anhydrous composition to place the composition in a solution. 
     
     
         21 . The method  claim 20  further using the solution to prepare a dialysis acid concentrate solution. 
     
     
         22 . The method according to  claim 20  wherein the solution is at least one of an infusion solution, a replacement solution, a rinsing solution and a priming solution.