US2013189783A1PendingUtilityA1

Methods of modulating angiogenesis via trpv4

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Assignee: CHILDRENS MEDICAL CENTERPriority: Jun 4, 2008Filed: Feb 8, 2013Published: Jul 25, 2013
Est. expiryJun 4, 2028(~1.8 yrs left)· nominal 20-yr term from priority
Inventors:Donald E. IngberCharles K. Thodeti
A61P 9/10A61P 35/00A61P 25/28A61P 27/02A61P 3/04A61K 31/713A61K 45/06A61K 31/70C12N 2310/14A61P 19/02G01N 33/5064C07K 16/2842C12N 15/1138A61P 17/06
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Claims

Abstract

The present invention relates to methods of inhibiting capillary endothelial (CE) cell migration, the formation of CE networks and angiogenesis, and uses thereof for the purpose of treating angiogenesis-related diseases and disorders, particularly when the diseases or disorders are directly related aberrant angiogenesis. Inhibition is achieved by inhibiting TRPV4 activity, such as the levels of TRPV4 expression, calcium influx through TRPV4, and/or the intracellular signaling from TRPV4 via β1 integrin activation.

Claims

exact text as granted — not AI-modified
What is claimed: 
     
         1 . A method for inhibiting endothelial cell migration, the method comprising contacting an endothelial cell with a TRPV4 inhibitor.

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