Methods and compositions for treating proliferative diseases

Abstract

The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents, or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle composition based on a metronomic dosing regime.

What is claimed is: 
     
         1 . A method of treating a proliferative disease in an individual, comprising administering to the individual an effective amount of a composition comprising nanoparticles comprising a thiocolchicine or a derivative thereof and a carrier protein. 
     
     
         2 . The method according to  claim 1  wherein the proliferative disease is cancer. 
     
     
         3 . The method according to  claim 2 , wherein the cancer is breast cancer. 
     
     
         4 . The method according to  claim 2 , wherein the cancer is ovarian cancer. 
     
     
         5 . The method according to  claim 1 , wherein the thiocolchicine or a derivative thereof is a dimeric thiocolchicine. 
     
     
         6 . The method according to  claim 1 , wherein the dimeric thiocolchicine is IDN 5404, IDN5808, or IDN5801. 
     
     
         7 . The method according to  claim 6 , wherein the dimeric thiocolchicine is IDN5404. 
     
     
         8 . The method according to  claim 1 , wherein the thiocolchicine or a derivative thereof is administered intravenously. 
     
     
         9 . The method according to  claim 1 , wherein the carrier protein is albumin. 
     
     
         10 . The method according to  claim 9 , wherein the albumin is human serum albumin. 
     
     
         11 . The method according to  claim 1 , wherein the average diameter of the nanoparticles in the composition is no greater than about 200 nm. 
     
     
         12 . The method according to  claim 1 , wherein the individual is human. 
     
     
         13 . A method of treating cancer in an individual, comprising administering to the individual an effective amount of a composition comprising nanoparticles comprising rapamycin and a carrier protein. 
     
     
         14 . The method according to  claim 13 , wherein the cancer is colon cancer. 
     
     
         15 . The method according to  claim 13 , wherein the rapamycin is administered intravenously. 
     
     
         16 . A method of treating a proliferative disease in an individual, comprising administering to the individual an effective amount of a composition comprising nanoparticles comprising 17-AAG and a carrier protein.