US2013195995A1PendingUtilityA1
Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide
Est. expiryOct 4, 2019(expired)· nominal 20-yr term from priority
Inventors:Hampar L. Karagoezian
A61P 31/04A61P 31/10A61P 27/04A61P 31/12A61P 31/00A61P 27/02A61K 9/0014A61K 33/22A61K 33/40A61L 12/10A61P 17/02A61P 17/06A61P 17/00A01N 59/00A61K 33/14A61K 31/728A61K 9/0048A61K 33/20A61K 33/00A61L 12/124
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Claims
Abstract
An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.
Claims
exact text as granted — not AI-modified1 . An anti-microbial preservative for use in an ophthalmic product, the preservative comprising from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound, wherein the preservative does not contain chlorine dioxide prior to application to the eye of an individual, and wherein the preservative is at a pH range between about 6.0 and about 8.8.
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77 . The preservative of claim 1 wherein the chlorite compound is a metal chlorite.
78 . The preservative of claim 77 wherein the metal is sodium.
79 . The preservative of claim 77 wherein the metal is selected from the group consisting of potassium, calcium, and magnesium.
80 . The preservative of claim 1 wherein the peroxy compound is hydrogen peroxide.
81 . The preservative of claim 1 wherein the ophthalmic product is an artificial tear solution.
82 . The preservative of claim 1 wherein the ophthalmic product is a contact lens disinfecting solution.
83 . The preservative of claim 1 wherein the ophthalmic product is a contact lens cleaning solution.
84 . The preservative of claim 83 wherein the cleaning solution is directly applied to a contact lens in place on an eye of a living being.
85 . An anti-microbial ophthalmic composition for direct application onto an eye of a living being, the composition composing from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound wherein the composition does not contain chlorine dioxide prior to application to the eye, and wherein the composition is at a pH range between about 6.0 and 8.8.
86 . The antimicrobial ophthalmic composition of claim 85 wherein the chlorite compound is a mend chlorite.
87 . The antimicrobial ophthalmic composition of claim 86 wherein the metal is sodium.
88 . The antimicrobial ophthalmic composition of claim 86 wherein the metal is selected from the group consisting of potassium, calcium, sod magnesium.
89 . The antimicrobial ophthalmic composition of claim 85 wherein the peroxy compound is hydrogen peroxide.
90 . The antimicrobial ophthalmic composition of claim 85 additionally comprising a lubricant chosen from the group consisting of non-ionic polymeric lubricants, anionic polymeric lubricants, and combinations thereof.
91 . The antimicrobial ophthalmic composition of claim 90 additionally comprising a block polymer based surfactant.
92 . The antimicrobial ophthalmic composition of claim 90 wherein the ophthalmic composition additionally comprises:
lubricant
0.05 wt. % to 0.3 wt. %;
boric acid
0.15 wt. % to 0.3 wt. %;
sodium chloride
0.50 wt. % to 0.8 wt. %;
surfactant
0.05 wt. % to 0.3 wt. %;
HCl or NaOH
to adjust pH; and
purified water
Q.S. to volume.
93 . The antimicrobial ophthalmic composition of claim 92 additionally comprising from about 0.001 wt. % to about 0.50 wt. % of sodium hyaluronate.
94 . The antimicrobial ophthalmic composition of claim 90 wherein the ophthalmic composition additionally comprises:
lubricant
0.05 wt. % to 0.30 wt. %;
sodium phosphate monobasic
0.10 wt. % to 0.25 wt. %;
sodium phosphate dibasic
0.10 wt. % to 0.40 wt. %;
sodium chloride
0.50 wt. % to 0.80 wt. %;
surfactant
0.05 wt. % to 0.30 wt. %;
HCl or NaOH
to adjust pH; and
purified water
Q.S. to volume.
95 . The antimicrobial ophthalmic composition of claim 94 additionally comprising from about 0.001 wt. % to about 9.50 wt. % sodium hyaluronate.
96 . The antimicrobial ophthalmic composition of claim 85 wherein the composition is applied onto an eye for treating dryness of the eye.
97 . The antimicrobial ophthalmic composition of claim 85 wherein the composition is applied onto an eye for treating an infection of an eye.
98 . The antimicrobial ophthalmic composition of claim 97 wherein the infection is caused by bacterial keratitis.
99 . The antimicrobial ophthalmic composition of claim 97 wherein the infection is caused by a virus.
100 . The antimicrobial ophthalmic composition of claim 97 wherein the infection is caused by a fungus.
101 . The antimicrobial ophthalmic composition of claim 85 wherein the composition is applied onto an eye for cleansing a contact lens in place on the eye.Join the waitlist — get patent alerts
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