Age production inhibitor

Abstract

Disclosed is an AGE production inhibitor or the like, which effectively inhibits the production of an advanced glycation end product (AGE), while having improved biological safety. Specifically disclosed is an AGE production inhibitor or the like, which contains en extract of cherry tree (preferably blossoms or leaves thereof) and/or a processed product of the extract as an active substance. The AGE production inhibitor or the like contains, as an active substance, at least one compound that is selected from among 1-O-(E)-Caffeoyl-β-D-glucopyranoside, 1-O-(E)-Coumaroyl-β-D-glucopyranoside, 1-O-(E)-Cinnamoyl-β-D-glucopyranoside, Kaempferol 3-O-β-D-glucopyranoside, Quercetin 3-O-β-D-glucopyranoside, Kaempferol 3-O-(6″-malony)-β-D-glucopyranoside, and Quercetin 3-O-(6″-malony)-β-D-glucopyranoside.

1 - 26 . (canceled) 
     
     
         27 . The cherry-tree extract of this invention holds all compounds, 1-O-(E)-Caffeoyl-β-D-glucopyranoside, 1-O-(E)-Coumaroyl-β-D-glucopyranoside, 1-O-(E)-Cinnamoyl-β-D-glucopyranoside, Kaempferol 3-O-β-D-glucopyranoside, Quercetin 3-0,3-D-glucopyranoside, Kaempferol 3-O-(6″-malony)-β-D-glucopyranoside, Quercetin 3-O-(6″-malony)-β-D-glucopyranoside and said cherry-tree extract is obtained by a manufacturing method having the following three steps:
 (a) extracting one or both cherry blossom extract and the cherry leaf extract with 20 to 50 wt % hydrous ethanol, 
 (b) absorbing the extract obtained in step (a) by an absorbent, comprising porous synthetic resin, elute the extract in water and remove the eluted extract, and 
 (c) after step (b) further eluting the eluted extract with a lower alcohol content (carbon numbers 1 to 5), and then concentrate the further eluted extract. 
 
     
     
         28 . An AGE production inhibitor comprising cherry-tree extract and/or its processed active substance according to  claim 27 . 
     
     
         29 . An apoptosis inhibitor comprising cherry-tree extract and its processed substance as an active substance, according to  claim 27 , which inhibits fibroblast apoptosis caused by the CML-collagen (Carboxymethyl lysine-collagen) which is an AGE. 
     
     
         30 . An human fibroblast-collagen grating-formulation promoter comprising cherry-tree extract and/or its processed substance as an active substance according to  claim 27 . 
     
     
         31 . An AGE production inhibitor within the fibroblast comprising cherry-tree extract and/or its processed substance as an active substance according to  claim 27 . 
     
     
         32 . An agent, to prevent and cure the diabetic complications, comprising cherry-tree extract and/or its processed substance as an active substance according to  claim 27 . 
     
     
         33 . An agent, to prevent the skin from aging and to improve it, comprising cherry-tree extract and/or its processed substance as an active substance according to  claim 27 .