US2013197612A1PendingUtilityA1

Electromagnetic Radiation Therapy

50
Individually held — no corporate assignee on recordPriority: Feb 26, 2010Filed: Feb 8, 2011Published: Aug 1, 2013
Est. expiryFeb 26, 2030(~3.6 yrs left)· nominal 20-yr term from priority
Inventors:Jack W. LasersohnMichael J. Horzewski
A61P 31/12A61P 31/14A61P 31/20A61P 37/04A61P 31/10A61P 33/02A61P 31/16A61P 31/22C07K 14/005A61K 2039/53A61K 2039/545C12N 2760/18422C07K 14/535C12N 2760/18471C12N 2710/24043A61K 2039/552A61K 2039/55522A61K 39/175C12N 2800/22A61K 39/12C12N 2760/18434C12N 2750/14334A61K 48/005A61N 5/0613C12N 7/00A61K 39/205
50
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Claims

Abstract

Apparatuses and methods for the prevention, reduction, or elimination of tissue injury by the application of electromagnetic energy. The apparatuses and methods have application for use in various tissues within diverse regions of the body, including for the prevention, reduction, or elimination of acute kidney injury, kidney failure, and contrast-induced nephropathy.

Claims

exact text as granted — not AI-modified
1 . A method of preventing or treating kidney injury comprising subjecting kidney tissue to electromagnetic radiation in the red-near infrared range for a period of time sufficient to prevent or reduce injury to the kidney. 
     
     
         2 . The method of  claim 1  wherein the electromagnetic energy is laser energy. 
     
     
         3 . The method of  claim 2  wherein the energy has a wavelength of about 635 nm to about 1560 nm. 
     
     
         4 . The method of  claim 1  wherein the electromagnetic energy is light emitting diode energy. 
     
     
         5 . The method of  claim 4  wherein the energy has a wavelength of about 635 nm to about 1560 nm. 
     
     
         6 . The method of  claim 1  wherein the electromagnetic radiation has a power density of at least 0.01 mW/cm 2  at the kidney tissue. 
     
     
         7 . The method of  claim 1  wherein at least a portion of the electromagnetic radiation is delivered prior to the injury to the kidney. 
     
     
         8 . The method of  claim 7  wherein the injury to the kidney is due at least in part to a contrast agent. 
     
     
         9 . The method of  claim 1  wherein at feast a portion of the electromagnetic radiation is delivered during the injury to the kidney. 
     
     
         10 . The method of  claim 9  wherein the injury to the kidney is due at least in part to a contrast agent. 
     
     
         11 . The method of  claim 1  wherein at least a portion of the electromagnetic radiation is delivered after the injury to the kidney. 
     
     
         12 . The method of  claim 11  wherein the injury to the kidney is due at least in part to a contrast agent. 
     
     
         13 . The method of  claim 1  wherein said kidney injury is induced by a pre-renal cause. 
     
     
         14 . The method of  claim 1  wherein said kidney injury is induced by a renal cause. 
     
     
         15 . The method of  claim 1  wherein said kidney injury is induced by a post-renal cause. 
     
     
         16 . The method of  claim 1  wherein a region of the patient's skin is cooled. 
     
     
         17 . The method of  claim 1  wherein the absorption of electromagnetic radiation in at least a portion of the area exposed to the electromagnetic radiation is decreased. 
     
     
         18 . The method of  claim 1  wherein sensing for electromagnetic radiation is conducted concurrently with the delivery of the electromagnetic radiation. 
     
     
         19 . The method of  claim 1  wherein a pharmacologic agent is administered to the patient to enhance reduction or prevention of injury to the kidney. 
     
     
         20 . The method of  claim 19  wherein the pharmacologic agent is selected from the group of angiotensin II, fenoldopam, dopamine, calcium-channel blockers, endothelin antagonists, adenosine, N-acetylcysteine, sodium bicarbonate, and ascorbic acid. 
     
     
         21 . The method of  claim 1  wherein multiple wavelengths of electromagnetic radiation are applied to at least a portion of kidney tissue. 
     
     
         22 . The method of  claim 1  wherein a non-electromagnetic energy is applied concurrently with the electromagnetic radiation to at least a portion of kidney tissue. 
     
     
         23 . Apparatus for preventing or treating kidney injury comprising a source of electromagnetic energy in the red-near infrared range, an applicator adapted to emit and transmit said electromagnetic energy to kidney tissue. 
     
     
         24 . Apparatus for preventing or treating kidney injury comprising a source of electromagnetic energy in the red-near infrared range, a conduit for transmitting said energy and an applicator adapted to emit and transmit said electromagnetic energy to kidney tissue. 
     
     
         25 . The apparatus of  claim 23 , wherein the energy source is a laser. 
     
     
         26 . The apparatus of  claim 23 , wherein the energy has a wavelength of about 635 nm to about 1560 nm. 
     
     
         27 . The apparatus of  claim 23  wherein the energy source is a light emitting diode. 
     
     
         28 . The apparatus of  claim 23 , wherein the energy has a power density of at least 0.01 mW/cm 2  at the kidney tissue. 
     
     
         29 . The apparatus of  claim 23 , wherein the energy is delivered in pulsed mode at a peak power density of at least 0.01 mW/cm 2  at the kidney tissue. 
     
     
         30 . The apparatus of  claim 23 , further comprising an element to measure the temperature near the skin. 
     
     
         31 . The apparatus of  claim 23 , further comprising an element in contact with the skin. The element adapted to reduce thermal changes near the skin. 
     
     
         32 . The apparatus of  claim 23 , further comprising an element adapted to reduce the blood flow near the skin. 
     
     
         33 . The apparatus of  claim 23 , further comprising an element for sensing electromagnetic radiation. 
     
     
         34 . The apparatus of  claim 23 , further comprising an element for sealing the applicator to the patient. 
     
     
         35 . The apparatus of  claim 23 , wherein the applicator is secured to the patient. 
     
     
         36 . The apparatus of  claim 23 , further comprising a controller. 
     
     
         37 . The apparatus of  claim 23 , further comprising two or more applicators adapted to emit and transmit said electromagnetic energy to kidney tissue. 
     
     
         38 . The apparatus of  claim 23 , further comprising at least one applicator capable of transmitting multiple wavelengths of said electromagnetic energy to kidney tissue. 
     
     
         39 . The apparatus of  claim 23 , further comprising at least one acoustic energy source of at least one efficacious energy. 
     
     
         40 . The apparatus of  claim 23 , further comprising at least one magnetic field source of at least one efficacious field strength.

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