US2013202699A1PendingUtilityA1

Phosphate binder formulation for simple dosing

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Assignee: STROTHMANN KAIPriority: Oct 13, 2010Filed: Oct 11, 2011Published: Aug 8, 2013
Est. expiryOct 13, 2030(~4.2 yrs left)· nominal 20-yr term from priority
Inventors:Kai StrothmannFriedrich-Wilhelm SchulzeJohannes BartholomaeusEva Fries-SchaffnerAstrid Oppermann
A61K 31/77A61K 9/1617A61K 31/7004A61K 9/0007A61K 31/225A61K 9/1652A61K 33/06A61K 31/19A61K 9/1635A61P 13/12A61K 9/0056A61K 33/10A61K 9/16A61K 9/20A61K 33/14
44
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Claims

Abstract

The invention relates to a pharmaceutical composition in the form of pourable granules or a chewable tablet containing at least one phosphate binding substance and at least one effervescent agent. The composition may be taken orally without adding water.

Claims

exact text as granted — not AI-modified
1 . A pharmaceutical composition in the form of pourable granules or a chewable tablet containing at least one phosphate binding substance and at least one effervescent agent which contains a carbonate and a solid organic edible acid or the acidic salt thereof for use in treatment of renally insufficient patients, where the composition is administered orally without adding water. 
     
     
         2 . The composition according to  claim 1 , characterized in that the carbonate is an alkali or alkaline earth carbonate or an alkali or alkaline earth bicarbonate. 
     
     
         3 . The composition according to  claim 1 , characterized in that the phosphate-binding substance is a calcium salt, a magnesium salt, an ion exchanger polymer, a lanthanum compound or an iron compound. 
     
     
         4 . The composition according to  claim 1 , characterized in that the phosphate binding substance is calcium acetate. 
     
     
         5 . The composition according to  claim 1 , characterized in that the phosphate-binding substance is present in granulated form. 
     
     
         6 . The composition according to  claim 1 , characterized in that the phosphate binding substance is provided with a taste-masking coating. 
     
     
         7 . The composition according to  claim 6 , characterized in that the coating is prepared by a spray coating method in a fluidized bed. 
     
     
         8 . The composition according to  claim 7 , characterized in that the coating is a melt coating. 
     
     
         9 . The composition according to  claim 7 , characterized in that the coating is a spray coating of suspensions and/or solutions. 
     
     
         10 . The composition according to  claim 1 , characterized in that the composition contains magnesium carbonate. 
     
     
         11 . The composition according to  claim 1 , characterized in that the effervescent agent is contained in a coating of the phosphate-binding substance. 
     
     
         12 . The composition according to  claim 1 , characterized in that it contains at least one sugar alcohol. 
     
     
         13 . The composition according to  claim 1 , characterized in that the phosphate-binding substance constitutes 15-80% of the weight of the composition. 
     
     
         14 . The composition according to  claim 1 , characterized in that the effervescent agent constitutes 3-60% of the weight of the composition. 
     
     
         15 . The composition according to  claim 1 , characterized in that the oral cavity is rerinsed with water after oral administration of the composition. 
     
     
         16 . The composition according to  claim 1 , characterized in that it is taken in a dose of 0.5-5 g three or four times daily, preferably with meals. 
     
     
         17 . The composition according to  claim 1 , characterized in that the average particle size of the granules is 100-3500 μm. 
     
     
         18 . A stickpack containing 0.5-4 g of a composition according to  claim 1 . 
     
     
         19 . A pharmaceutical composition in the form of untableted granules containing at least one effervescent agent and containing calcium acetate and magnesium carbonate in a weight ratio of 1:1 to 4:1.

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