Compounds and compositions as inhibitors of cannabinoid receptor 1 activity

Abstract

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).

We claim: 
     
         1 . A compound of Formula I: 
       
         
           
           
               
               
           
         
         in which: 
         Y 1  is selected from N and CR 11 ; 
         Y 2  is selected from N and CR 8 ; 
         Z 1  is selected from S, O, NH, CH—NO 2 , NS(O) 2 NH 2 , NC(O)NH 2 , NS(O) 2 CH 3 , N(OH) and N(CN); or C=Z 1  of Formula I is replaced with CH 2  or S(O) 2 ; 
         Z 2  is selected from O, —CH 2 CHR 1a —, —OCHR 1a —, —CR 1a R 1b  and —NR 1a ; 
         R 1a  is selected from hydrogen, cyano, C 1-6 alkyl, cyano-substituted-C 1-6 alkyl, C 2-6 alkenyl, —X 1 R 12 , —X 1 NR 13 S(O) 2 R 13 , —X 1 OS(O) 2 R 13 , —X 1 NR 13 X 1 OR 13 , —X 1 OR 13 , —X 1 C(O)OR 13 , —X 1 S(O) 2 R 12 , —X 1 S(O) 2 NR 13 C(O)R 13 , —X 1 S(O) 2 R 13 , —X 1 C(O)R 12 , —X 1 NR 13 R 13 , —X 1 S(O) 2 NR 13 R 13 , —X 1 (O)C(O)NR 13 R 13 , —X 1 C(O)NR 12 R 13 , —X 1 NR 13 X 1 C(O)NR 12 , —X 1 NR 13 X 1 C(O)NR 13 R 13 , —X 1 C(O)NR 13 X 1 C(O)OR 13 , —X 1 C(O)NR 13 X 1 NR 13 R 13 , —X 1 C(O)NR 13 X 1 OR 13  and —X 1 C(O)NR 13 R 13 ; wherein R 12  is selected from C 6-10 aryl, C 5-10 heteroaryl, C 3-12 cycloalkyl and C 3-10 heterocycloalkyl; wherein said aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 12  is optionally substituted by 1 to 3 radicals independently selected from hydroxy, bis-hydroxy-C 1-6 alkyl-amino, C 1-6 alkyl-amino, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-carbonyl, C 1-6 alkyl-sulphoxy, C 1-6 alkyl-carboxy, C 1-6 alkyl-sulfonyl, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, C 3-12 cycloalkyl, C 3-10 heterocycloalkyl, C 5-10 heteroaryl and C 6-10 aryl optionally substituted with 1 to 3 halo radicals; wherein said cycloalkyl, heterocycloalkyl, heteroaryl and aryl substituents of R 12  can be further optionally substituted with 1 to 3 C 1-6 alkyl radicals; wherein each R 13  is independently selected from hydrogen, C 1-6 alkyl, hydroxy-C 1-6 alkyl, C 6-10 aryl, C 3-10 heterocycloalkyl; wherein said aryl or heterocycloalkyl of R 13  is optionally substituted with a group selected from C 1-6 alkyl and C 1-6 alkoxy; wherein each X 1  is independently selected from a bond and C 1-4 alkylene; 
         R 1b  is selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; 
         R 2a  is selected from hydrogen, C 1-6 alkyl, halo-substituted-C 1-6 alkyl, C 6-10 aryl, —X 2 NR 14 X 2 NR 14 R 14 , —X 2 NR 14 C(O)X 2 NR 14 C(O)OR 14 , —X 2 NR 14 X 2 R 15 , —X 2 OC(O)NR 14 R 14 , —X 2 OC(O)NR 14 R 15 , —X 2 NR 14 R 14 , —X 2 NR 14 S(O) 2 R 14 , —X 2 NR 14 S(O) 2 R 15 , —X 2 S(O) 0-2 R 15 , —X 2 NR 14 C(O)R 14 , —X 2 NR 14 C(O)R 15 , —X 2 NR 14 C(O)X 2 NR 14 R 14 , —X 2 OSi(R 14 ) 3 , —X 2 OC(O)NR 14 R 15 , —X 2 C(O)OR 14 , —X 2 OR 14 , —X 2 OX 2 R 15 , —X 2 R 15  and —X 2 C(O)R 15 ; wherein each R 14  is independently selected from hydrogen and C 1-6 alkyl; R 15  is selected from cyano, C 6-10 aryl, C 5-10 heteroaryl, C 3-12 cycloalkyl and C 3-10 heterocycloalkyl; wherein said aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 15  is optionally substituted by 1 to 3 radicals independently selected from hydroxy, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkyl-sulphoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, —X 3 NR 16 R 16 , —X 3 ONR 16 R 16 , —X 3 OR 16 , —X 3 S(O) 2 R 16 , —X 3 NR 16 C(O)OR 16 , —X 3 NR 16 S(O) 0-2 R 16 , —X 3 R 16 , —X 3 C(O)OR 16 , —X 3 C(O)NR 16 R 16 , —X 3 OC(O)NR 16 R 16 , —X 3 S(O) 0-2 NR 16 R 16 , —X 3 C(O)R 16 , C 6-10 aryl and C 5-10 heteroaryl; wherein said aryl and heteroaryl substituents of R 15  are optionally substituted with 1 to 3 halo radicals; each X 2  and X 3  are independently selected from a bond and C 1-4 alkylene; and each R 16  is independently selected from hydrogen, C 1-6 alkyl, C 6-10 aryl, C 5-10 heteroaryl, C 3-8 cycloalkyl and C 3-12 heterocycloalkyl; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 16  is optionally substituted by 1 to 3 radicals independently selected from halo, cyano, C 1-6 alkyl, C 1-6 alkyl-carbonyl-amino and C 1-6 alkoxy; 
         R 2b  is selected from hydrogen and C 1-6 alkyl; or R 2a  and R 2b  together with the carbon atom to which R 2a  and R 2b  are attached form carbonyl; 
         R 3 , R 5 , R 6  and R 7  are each independently selected from hydrogen, halo and amino; 
         R 4  is selected from hydrogen, halo, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, hydroxy-substituted-C 1-6 alkyl, hydroxy-substituted-C 1-6 alkoxy, cyano-substituted-C 1-6 alkyl, cyano-substituted-C 1-6 alkoxy, —OX 5 R 4a  and —OX 5 R 4a ; wherein X 5  is selected from a bond and C 1-4 alkylene; R 4a  is selected from C 1-6 alkyl, C 3-8 cycloalkyl, C 6-10 aryl and C 5-10 heteroaryl; wherein any cycloalkyl, aryl or heteroaryl of R 4a  is optionally substituted with 1 to 3 radicals independently selected from halo, cyano, amino, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, hydroxy-substituted-C 1-6 alkyl, hydroxy-substituted-C 1-6 alkoxy, cyano-substituted-C 1-6 alkyl and cyano-substituted-C 1-6 alkoxy; 
         R 8 , R 9 , R 11  and R 12a  are each independently selected from hydrogen, halo, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and halo-substituted-C 1-6 alkoxy; 
         R 10  is selected from halo, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, —X 4 OR 17 , —X 4 S(O) 0-2 R 17  and —X 4 R 17 ; wherein X 4  is selected from a bond and C 1-4 alkylene; and R 17  is selected from C 6-10 aryl and C 5-10 hetyeroaryl; wherein R 17  is optionally substituted with 1 to 3 halo radicals; or a pharmaceutically acceptable salt thereof. 
       
     
     
         2 . The compound of  claim 1  in which R 1a  is selected from cyano, methyl-carbonyl-amino-sulfonyl-ethyl, pyrrolidin-2-onyl-ethyl, imidazolyl-ethyl, oxazolidin-2-only-ethyl, 1-pyrazolyl-ethyl, cyano-methyl, 4′-(4-chlorophenoxy)phenyl, 1,3-dioxanyl-ethyl, allyl, phenyl, pyrazinyl, piperazinyl-sulfonyl-ethyl, azetidinyl-sulfonyl-ethyl, morpholino-sulfonyl-ethyl, pyrrolidinyl-sulfonyl-ethyl, pyrrolidinyl-propyl, pyrrolidinyl-ethyl, piperazinyl-propyl, piperidinyl-sulfonyl-ethyl, pyridazinyl, (5-(4-methoxyphenyl)-1,2,4-oxadiazol-3-yl)methyl, isoxazolyl, piperidinyl-carbonyl-methyl, 3-(N,N-bis(4-methoxyphenyl)sulfamoyl)propyl, methyl-phenyl-sulfonyl, cyanomethyl, 2-oxo-2-(piperidin-1-ylamino)ethyl, propyl-amino-carbonyl-methyl, 2-(carboxymethylamino)-2-oxoethyl), bis-hydroxyethyl-amino-sulfonyl-ethyl, carboxy-methyl-amino-carbonyl-methyl, amino-carbonyl-ethyl, amino-sulfonyl-ethyl, amino-sulfonyl-propyl, methyl-amino-ethyl, piperidinyl-ethyl, piperazinyl-ethyl, methyl-sulfonyl-ethyl, carboxy-methyl, tetrazole-methyl, benzyl, 1,2,4-oxadiazole, 1,2,4-oxadiazole-methyl, 1,2,4-oxadiazole-ethyl, isoxazole-methyl, 2-(2-hydroxyethylamino)-2-oxoethyl, dimethylamino-ethyl-amino-carbonyl-methyl, hydroxyl-ethyl, methoxy-ethyl, hydroxyl-ethyl-amino-ethyl, morpholino-ethyl, methyl-piperazinyl-ethyl, 2-(carbamoyloxy)ethyl, methyl-sulfonyl-oxy-ethyl, morpholino-carbonyl-methyl, methyl-sulfonyl-piperazinyl-ethyl, 2-morpholinoethyl, amino-ethyl, 2-(3,3-dimethylureido)ethyl, morpholino-carbonyl-amino-ethyl, methyl-sulfonyl-amino-ethyl, pyridinyl-methyl, hydroxyl-propyl, 2-(2,6-dimethylmorpholino)ethyl, 2-(2-methylmorpholino)ethyl, methyl-sulfonyl-propyl and morpholino-propyl; wherein said ring systems of R 1a  are optionally substituted with 1 to 3 radicals independently selected from halo, trifluoromethyl, methyl, bis-hydroxy-ethyl-amino, t-butyl, t-butoxy-carbonyl, hydroxy, methyl-sulfonyl, amino-sulfonyl, diethyl-amino, morpholino, cyclohexyl, pyridinyl, piperidinyl, pyrrolidinyl, piperazinyl optionally substituted with ethyl or methyl-sulfonyl, methoxy-carbonyl and methoxy; and R 1b  is selected from hydrogen and allyl. 
     
     
         3 . The compound of  claim 2  in which R 2a  is selected from (4-(azepan-1-yl-methyl)-1H-1,2,3-triazol-1-yl)methyl, diethyl-amino-pyrrolidinyl-methyl, N,N-methyl-(t-butoxy-carbonyl)-amino-pyrrolidinyl-methyl, (4-(5-cyanopyridin-2-yl)piperazin-1-yl)methyl, 5-cyanopyridinyl-oxy-methyl, (4-(6-methoxypyridin-3-yl)-3-oxopiperazin-1-yl)methyl, (4-(6-methoxypyridin-2-yl)-3-oxopiperazin-1-yl)methyl, (4-(6-methoxypyridin-2-yl)piperazin-1-yl)methyl, 4-t-butoxy-carbonyl-2-oxopiperazin-1-yl)methyl, (4-(4-fluoropyridin-2-yl)piperazin-1-yl)methyl, 5-(1-(tert-butoxycarbonyl)piperidin-4-yl)-2H-tetrazol-2-yl-methyl, 5-(1-(tert-butoxycarbonyl)piperidin-4-yl)-2H-tetrazol-1-yl-methyl, t-butoxy-carbonyl-piperidinyl-methyl, 4-(4-cyanophenyl)-1H-1,2,3-triazol-1-yl, 4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl, 4-((tetrahydrofuran-3-yloxy)methyl)-1H-1,2,3-triazol-1-yl, 5-phenyl-2H-tetrazol-2-yl, 4-oxadiazolyl-piperidinyl-methyl, 4-(benzyloxycarbonyl)-2-oxopiperazin-1-yl, 4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl, 4-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-1,2,3-triazol-1-yl, 4-ethoxy-1H-1,2,3-triazol-1-yl, 4-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-1,2,3-triazol-1-yl, 5-(2-ethoxy-2-oxoethyl)-2H-tetrazol-2-yl, 5-(hydroxy-ethyl)-2H-tetrazol-2-yl, (4-(piperidin-1-ylcarbamoyl)-1H-1,2,3-triazol-1-yl)methyl, 1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-1,2,3-triazol-4-yl, 5-(6-methoxy-pyridin-3-yl)-2H-tetrazol-2-yl-methyl, 5-(pyridin-3-yl)-2H-tetrazol-2-yl-methyl, (3-(tetrahydrofuran-3-yl)isoxazol-5-yl)methyl, 5-(morpholino-ethyl)-2H-tetrazol-2-yl, (4-(ethoxy-carbonyl)-1H-1,2,3-triazol-1-yl)methyl, ethyl-sulfonyl-piperazinyl-methyl, (4-(ethyl-sulfonyl-methyl)-1H-1,2,3-triazol-1-yl)methyl, methyl, methyl-piperazinyl-methyl, dimethyl-aminoethyl-amino-methyl, amino-methyl, methyl-sulfonyl-amino-methyl, methoxy-carbonyl, ethoxy-carbonyl, phenyl, hydroxy-methyl, methoxy-methyl, morpholino-methyl, phenyl-sulfonyl-methyl, dimethyl-amino-carbonyl-piperazinyl-methyl, dimethylamino-sulfonyl-piperazinyl-methyl, piperidinyl-methyl, t-butyl-carbamoyl-methyl, t-butoxy-carbonyl-amino-piperidinyl-methyl, phenyl-sulfonyl-amino-methyl, (4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl, (4-((tetrahydrofuran-2-yl)methyl)piperazin-1-yl)methyl, chloromethyl, morpholino-ethyl-piperazinyl-methyl, t-butoxy-carbonyl-amino-pyrrolidinyl-methyl, thiomorpholinomethyl, amino-pyrrolidinyl-methyl, piperazinyl-methyl, benzyl-amino-methyl, benzyloxy-methyl, 4-fluoro-benzyloxy-methyl, 2,4-difluoro-benzyloxy-methyl, (4-(3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)methyl, dimethyl-amino-methyl, morpholino-ureido-methyl, (4-methyl-sulfonyl-amino-methyl-1H-1,2,3-triazol-1-yl)methyl, morpholino-carbonyl, propargyl-amino-methyl, phenyl-sulfanyl-methyl, pyridinyl-methyl-amino-methyl, (4-(dimethyl-amino-methyl)-1H-1,2,3-triazol-1-yl)methyl, pyrimidinyl-piperazinyl-methyl, phenyl-pyrazonyl-methyl, (2-(tert-butoxycarbonylamino)-3-methylbutanamido)methyl, (2-amino-3-methylbutanamido)methyl, (4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl, (isopropyl-carbamoyloxy)methyl, ((t-butyl)(dimethyl)siloxy)-methyl, imidazoly-propyl-amino-methyl, (3-(2-oxopyrrolidin-1-yl)propylamino)methyl, pyrrolidinyl-ethyl-aminomethyl, pyrrolidinyl-propyl-aminomethyl, (cyclohexyl-carbamoyloxy)methyl, (benzo[d][1,3]dioxol-5-ylcarbamoyloxy)methyl, (1,3-dioxoisoindolin-2-yl)methyl, methyl-carbonyl-amino-methyl, (3-ethylureido)methyl, (tetrahydro-2H-pyran-2-yloxy)methyl, t-butoxy-carbonyl-piperazinyl-methyl, pyridinyl-ethyl-amino-methyl, methyl-carbonyl-piperazinyl-methyl, pyridinyl-piperazinyl-methyl, methoxy-carbonyl-piperazinyl-methyl, ethoxy-carbonyl-piperazinyl-methyl, piperidinyl-methyl-2H-tetrazol-2-yl, 5-chloro-pyridinyl-2-oxy-methyl, 4-phenyl-piperidinyl-methyl, 4-(pyrimidin-2-yl)-piperidinyl-methyl, (5-(pyrazin-2-yl)-2H-tetrazol-2-yl)methyl, (5-(pyridin-2-yl)-2H-tetrazol-2-yl)methyl, (5-(pyridin-2-yl)-1H-tetrazol-1-yl)methyl, 5-(6-methyl-pyridin-3-yl)-1H-tetrazol-1-yl)methyl, (5-(pyrimidin-2-yl)-2H-tetrazol-2-yl)methyl, (4-(pyrazin-2-yl)piperazin-1-yl)methyl, 4-(pyridin-2-yl)-piperidinyl-methyl, 3-t-butoxy-carbonyl-amino-pyrrolidinyl-methyl, (5-(6-chloropyridin-3-yl)-2H-tetrazol-2-yl)methyl, piperidinyl-methyl-1H-1,2,3-triazol-1-yl-methyl, 4-methyl-piperidinyl-methyl-1H-1,2,3-triazol-1-yl-methyl, 4-isopropyl-amino-methyl-1H-1,2,3-triazol-1-yl-methyl, 4-phenyl-1H-imidazol-1-yl, 1H-1,2,3-triazol-1-yl-methyl, 5-(ethoxy-carbonyl)-2H-tetrazol-2-yl, (4-(3,5-dimethylphenyl)-3-oxopiperazin-1-yl)methyl, (5-(imidazo[1,2-a]pyridin-6-yl)-2H-tetrazol-2-yl)methyl, 4-hydroxy-4-phenyl-piperidinyl-methyl, 4-hydroxy-4-(4-chloro-phenyl)-piperidinyl-methyl, (5-methyl-2-oxopyridin-1(2H)-yl)methyl, 4-methyl-pyridinyl-2-oxy-methyl, 4-ethoxy-1H-1,2,3-triazol-1-yl-methyl, morpholino-methyl-1H-1,2,3-triazol-1-yl-methyl, diethyl-amino-ethyl-1H-1,2,3-triazol-1-yl-methyl, piperidinyl-ethyl-1H-1,2,3-triazol-1-yl-methyl, piperidinyl-methyl-1H-1,2,3-triazol-1-yl-methyl, diethyl-amino-ethyl-1H-1,2,3-triazol-1-yl-methyl, isopropyl-ethyl-1H-1,2,3-triazol-1-yl-methyl, (4-((3-methyl-1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl, (4-((4-methyl-1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl, acetamido-phenyl-1H-1,2,3-triazol-1-yl-methyl, acetyl-1H-1,2,3-triazol-1-yl-methyl, cyclohexyl-methyl-1H-1,2,3-triazol-1-yl-methyl, thienyl-1H-1,2,3-triazol-1-yl-methyl, (2-oxo-4-(pyridin-2-yl)piperazin-1-yl)methyl, (4-(2-methoxyphenyl)-1H-1,2,3-triazol-1-yl)methyl, (4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl, (4-(tert-butoxycarbonyl)-1,4-diazepan-1-yl)methyl, ethoxy-carbonyl-piperidinyl-methyl and isobutoxy-carbonyl-piperazinyl-methyl; and R 2b  is selected from hydrogen and methyl; or R 2a  and R 2b  together with the carbon atom to which R 2a  and R 2b  are attached form carbonyl. 
     
     
         4 . The compound of  claim 3  in which R 3 , R 5 , R 6  and R 7  are each independently selected from hydrogen, halo and amino. 
     
     
         5 . The compound of  claim 4  in which R 4  is selected from: hydrogen; trifluoro-methyl; halo; hydroxy; cyano-methoxy; dimethyl-amino-propyl; cyano; cyclopropyl-methoxy; pyrazinyl-oxy optionally substituted with amino; pyridinyl-oxy; pyrimidinyl-oxy; benzoxy; phenoxy optionally substituted with methyl or cyano; ethoxy; tetrazolyl-methoxy optionally substituted with methyl; pyridazinyl-oxy; pyrazinyl-oxy; hydroxy-ethoxy; and methoxy. 
     
     
         6 . The compound of  claim 5  in which R 8 , R 9 , R 11  and R 12a  are each independently selected from hydrogen, halo, trifluoromethyl and methyl. 
     
     
         7 . The compound of  claim 6  in which R 10  is selected from halo, cyano, methoxy, trifluoromethyl, pyridinyl-oxy, benzoyl, phenoxy, benzyl, pyridazinyl-oxy, phenyl-sulfonyl and pyrimidinyl-oxy; wherein said pyridinyl-oxy, phenyl-sulfonyl, phenoxy, benzoyl, benzyl, pyridazinyl-oxy and pyrimidinyl-oxy can be optionally substituted with 1 to 3 halo radicals. 
     
     
         8 . The compound of  claim 1  selected from: 1-[4-(4-Chloro-phenoxy)-phenyl]-5-phenyl-pyrrolidin-2-one; 5-(4-Amino-3-trifluoromethyl-phenyl)-1-[4-(4-chloro-phenoxy)-phenyl]-pyrrolidin-2-one; 1-[4-(4-Chloro-phenoxy)-phenyl]-5-(3-trifluoromethyl-phenyl)-pyrrolidin-2-one; (S)-3-[4-(4-Chloro-phenoxy)-phenyl]-4-(3-trifluoromethyl-phenyl)-oxazolidin-2-one; 5-(2-Amino-3-trifluoromethyl-phenyl)-1-[4-(4-chloro-phenoxy)-phenyl]-pyrrolidin-2-one; 6-(4-Amino-3-trifluoromethyl-phenyl)-1-[4-(4-chloro-phenoxy)-phenyl]-piperidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-tosyl-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (R)-1-(4-(4-chlorophenoxy)phenyl)-5-phenylimidazolidine-2,4-dione; (S)-1-(4-(4-chlorophenoxy)phenyl)-5-phenylimidazolidine-2,4-dione; 1-[4-(4-Chloro-phenoxy)-phenyl]-5-(3-fluoro-5-trifluoromethyl-phenyl)-pyrrolidin-2-one; (S)-3-[4-(4-Chloro-benzoyl)-phenyl]-4-(3-trifluoromethyl-phenyl)-oxazolidin-2-one; (S)-3-(4-Bromo-phenyl)-4-(3-trifluoromethyl-phenyl)-oxazolidin-2-one; (S)-3-[4-(4-Chloro-phenoxy)-phenyl]-4-(3-fluoro-5-trifluoromethyl-phenyl)-oxazolidin-2-one; (S)-3-(4-Benzyl-phenyl)-4-(3-trifluoromethyl-phenyl)-4-oxazolidin-2-one; 1-[4-(4-Chloro-phenoxy)-phenyl]-3-methyl-5-(S)-phenyl-imidazolidine-2,4-dione; 3-[4-(4-chloro-phenoxy)-phenyl]-1-methyl-4-(3-trifluoromethyl-phenyl)-imidazolidin-2-one; ethyl 2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)acetate; (S)-ethyl 2-(3-(4-(4-chlorophenoxy)phenyl)-2,5-dioxo-4-phenylimidazolidin-1-yl)acetate; (R)-1-(4-(4-chlorophenoxy)phenyl)-3-methyl-5-phenylimidazolidine-2,4-dione; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-5-methyl-4-phenyloxazolidin-2-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4,5-diphenyloxazolidin-2-one; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-4,5-diphenyloxazolidin-2-one; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-5-methyl-4-phenyloxazolidin-2-one; (S)-3-(4-(4-chlorophenoxy)phenyl)-5,5-dimethyl-4-phenyloxazolidin-2-one; (4S,5R)-ethyl 3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-phenyloxazolidine-5-carboxylate; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-(trifluoromethyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-5-(hydroxymethyl)-4-phenyloxazolidin-2-one; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-5-(methoxymethyl)-4-phenyloxazolidin-2-one; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-5-((benzyloxy)methyl)-4-phenyloxazolidin-2-one; ((4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-4-phenyl-2-oxooxazolidin-5-yl)methyl isopropylcarbamate; ((4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-4-phenyl-2-oxooxazolidin-5-yl)methyl cyclohexylmethylcarbamate; ((4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-4-phenyl-2-oxooxazolidin-5-yl)methyl benzo[d][1,3]dioxol-5-ylcarbamate; 2-(((4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-phenyl-2-oxooxazolidin-5-yl)methyl)isoindoline-1,3-dione; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-5-(aminomethyl)-4-phenyl-oxazolidin-2-one; N-((4S,5S)-3-(4-(4-chloro-phenoxy)-phenyl)-2-oxo-4-phenyl-oxazolidin-5-ylmethyl)-methanesulfonamide; N-(((4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-phenyloxazolidin-5-yl)methyl)acetamide; 1-(((4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-phenyloxazolidin-5-yl)methyl)-3-ethylurea; (4S,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-(4-chloro-phenoxy)-phenyl)-4-phenyl-oxazolidin-2-one; (4S,5R)-ethyl 3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-2-oxooxazolidine-5-carboxylate; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one; (S)-4-(4-(4-chlorophenoxy)phenyl)-5-(3-fluorophenyl)morpholin-3-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-5-carboxylate; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-phenyl-5-(hydroxymethyl)oxazolidin-2-one; (2R,3S)-ethyl 4-(4-(4-chlorophenoxy)phenyl)-3-(3-(trifluoromethyl)phenyl)-5-oxomorpholine-2-carboxylate; (2S,3S)-ethyl 4-(4-(4-chlorophenoxy)phenyl)-3-(3-(trifluoromethyl)phenyl)-5-oxomorpholine-2-carboxylate; (4S,5R)-5-((benzyloxy)methyl)-4-(3,5-difluorophenyl)-3-(4-methoxyphenyl)oxazolidin-2-one; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-4-(3,5-difluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-5-(hydroxymethyl)-4-(3-hydroxyphenyl)oxazolidin-2-one; (5S,6R)-4-(4-(4-chlorophenoxy)phenyl)-6-((benzyloxy)methyl)-5-(3,5-difluorophenyl)morpholin-3-one; (5S,6R)-4-(4-(4-chlorophenoxy)phenyl)-5-(3,5-difluorophenyl)-6-(hydroxymethyl)morpholin-3-one); (4S,5S)-5-(2-(dimethylamino)ethylamino)methyl)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-methoxyphenyl)oxazolidin-2-one; (4S,5S)-5-((2-(pyrrolidin-1-yl)ethylamino)methyl)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-methoxyphenyl)oxazolidin-2-one: (4S,5S)-5-((3-(pyrrolidin-2-one)-1-yl)propylamino)methyl)-3-(4-(4-chlorophenoxy)phenyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; (4S,5S)-5-((3-(1H-imidazol-1-yl)propylamino)methyl)-3-(4-(4-chlorophenoxy)phenyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; (4S,5S)-5-((3-(pyrrolidin-1-yl)propylamino)methyl)-3-(4-(4-chlorophenoxy)phenyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; (4S,5S)-5-((3-(1H-imidazol-1-yl)propylamino)methyl)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-methoxyphenyl)oxazolidin-2-one; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-4-(3,5-difluorophenyl)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)oxazolidin-2-one; tert-butyl 4-(((4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)piperazine-1-carboxylate; (4S,5S)-5-((3-(pyridin-3-yl)propylamino)methyl)-3-(4-(4-chlorophenoxy)phenyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; (4S,5R)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)oxazolidin-2-one; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-methoxyphenyl)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)oxazolidin-2-one; (4S,5R)-3-(4-(trifluoromethyl)phenyl)-4-(3,5-difluorophenyl)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)oxazolidin-2-one; (4S,5S)-5-((4-acetylpiperazin-1-yl)methyl)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; (4S,5S)-5-((2-(1H-imidazol-5-yl)ethylamino)methyl)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; (4S,5R)-3-(4-chloro-3-methylphenyl)-4-(3,5-difluorophenyl)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)oxazolidin-2-one; (4S,5R)-3-(4-chloro-3-fluorophenyl)-4-(3,5-difluorophenyl)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)oxazolidin-2-one; tert-butyl 4-(((4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-oxooxazolidin-5-yl)methyl)piperazine-1-carboxylate; tert-butyl 4-(((4S,5S)-3-(4-chloro-3-methylphenyl)-4-(3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)piperazine-1-carboxylate; tert-butyl 4-((4S,5S)-3-(4-chloro-3-(trifluoromethyl)phenyl)-4-(3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)piperazine-1-carboxylate; (4S,5R)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)oxazolidin-2-one; (4S,5R)-5-((benzyloxy)methyl)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)oxazolidin-2-one; tert-Butyl 4-(((4S,5S)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)-2-oxooxazolidin-5-yl)methyl)piperazine-1-carboxylate; Methyl 4-(((4S,5S)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)-2-oxooxazolidin-5-yl)methyl)piperazine-1-carboxylate; Ethyl 4-(((4S,5S)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)-2-oxooxazolidin-5-yl)methyl)piperazine-1-carboxylate; isobutyl 4-(((4S,5S)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)-2-oxooxazolidin-5-yl)methyl)piperazine-1-carboxylate; 4-((4S,5R)-4-(3-methoxyphenyl)-2-oxo-5-((tetrahydro-2H-pyran-2-yloxy)methyl)oxazolidin-3-yl)benzonitrile; 4-((4S,5R)-5-(4-fluorobenzyloxy)methyl)-4-(3-(trifluoromethyl)phenyl)-2-oxooxazolidin-3-yl)benzonitrile; (4S,5R)-5-(4-fluorobenzyloxy)methyl)-3-(4-chlorophenyl)-4-(3-fluorophenyl)oxazolidin-2-one; (4S,5R)-5-((4-fluorobenzyloxy)methyl)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)oxazolidin-2-one; (4S,5R)-5-((2,4-difluorobenzyloxy)methyl)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)oxazolidin-2-one; 54(4S,5R)-5((4-methoxybenzyloxy)methyl)-4-(3-(trifluoromethyl)phenyl)-2-oxooxazolidin-3-yl)pyridine-2-carbonitrile; (4S,5R)-3-(5-(4-chlorophenoxy)pyrazin-2-yl)-4-(3-(trifluoromethyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)-5-((4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-5-(4-((dimethylamino)methyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(3-(trifluoromethyl)phenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)-5((4-(pyrimidin-2-yl)piperazin-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)-5-((3-phenyl-1H-pyrazol-1-yl)methyl)oxazolidin-2-one; tert-butyl(R)-1-(((4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-phenyloxazolidin-5-yl)methylcarbamoyl)-2-methylpropylcarbamate; (2R)—N-(((4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-phenyloxazolidin-5-yl)methyl)-2-amino-3-methylbutanamide; (4S,5S)-5-((3-(pyrrolidin-1-yl)propylamino)methyl)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)oxazolidin-2-one; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-5-(hydroxymethyl)-4-(3-methoxyphenyl)oxazolidin-2-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-5((4-methylpiperazin-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-5-(aminomethyl)-4-(3-fluorophenyl)oxazolidin-2-one; ((4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl cyclohexylcarbamate; ((4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl isopropylcarbamate; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-5-((benzyloxy)methyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-5-((dimethylamino)methyl)-4-(3-fluorophenyl)oxazolidin-2-one; N-(((4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)morpholine-4-carboxamide; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-5-(morpholine-4-carbonyl)-4-phenyl-oxazolidin-2-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-5-((prop-2-ynylamino)methyl)oxazolidin-2-one; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-5-((phenylthio)methyl)oxazolidin-2-one; (4S,5S)-3-[4-(4-Chloro-phenoxy)-phenyl]-4-(3-fluoro-phenyl)-5-{[(pyridin-3-ylmethyl)-amino]-methyl}-oxazolidin-2-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-methoxyphenyl)-5((4-methylpiperazin-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-[4-(4-Chloro-phenoxy)-phenyl]-4-(3,5-difluoro-phenyl)-5-morpholin-4-ylmethyl-oxazolidin-2-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3,5-difluorophenyl)-5((4-methylpiperazin-1-yl)methyl)oxazolidin-2-one; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-5-((phenylsulfonyl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-5-((4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-5((4-((tetrahydrofuran-2-yl)methyl)piperazin-1-yl)methyl)oxazolidin-2-one; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-5-(chloromethyl)-4-(3-fluorophenyl)oxazolidin-2-one; (4S,5R)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)oxazolidin-2-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-5-((4-(2-morpholinoethyl)piperazin-1-yl)methyl)oxazolidin-2-one; (4S,5R)-4-(3,5-difluorophenyl)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)-3-p-tolyloxazolidin-2-one; (4S,5R)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one; (4S,5R)-5-((benzyloxy)methyl)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-(morpholin-4-ylmethyl)oxazolidin-2-one; (4S,5S)-5-((3-(1H-imidazol-1-yl)propylamino)methyl)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; tert-butyl(R)-1-(((4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)pyrrolidin-3-ylcarbamate; tert-butyl 4-(((4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)piperazine-1-carboxylate; (4S,5R)-3-(4-(trifluoromethyl)phenyl)-4-(3-fluorophenyl)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)oxazolidin-2-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-5-(thiomorpholinomethyl)oxazolidin-2-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-5-(R)-3-aminopyrrolidin-1-yl)methyl)-4-(3-fluorophenyl)oxazolidin-2-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-5-((piperazin-1-yl)methyl)oxazolidin-2-one; (4S,5S)-5-((benzylamino)methyl)-3-(4-(trifluoromethyl)phenyl)-4-(3-fluorophenyl)oxazolidin-2-one; (4S,5R)-3-(4-chlorophenyl)-4-(2,3-difluorophenyl)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)oxazolidin-2-one; (4S,5R)-5-((benzyloxy)methyl)-3-(4-chloro-3-fluorophenyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; 4-(((4S,5S)-3-(3,4-dichlorophenyl)-4-(3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)-N,N-dimethylpiperazine-1-carboxamide; 4-(((4S,5S)-3-(4-trifluoromethylphenyl)-4-(3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)-N,N-dimethylpiperazine-1-sulfamide; (4S,5S)-3-(4-(trifluoromethyl)phenyl)-4-(3-fluorophenyl)-5-((piperidin-1-yl)methyl)oxazolidin-2-one; ((4S,5R)-3-(4-chlorophenyl)-4-(3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl tert-butylcarbamate; (4S,5R)-5-((benzyloxy)methyl)-3-(4-(trifluoromethyl)phenyl)-4-(3-fluorophenyl)oxazolidin-2-one; tert-butyl 1-(((4S,5S)-3-(4-chlorophenyl)-4-(3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)piperidin-4-ylcarbamate; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-(trifluoromethyl)phenyl)-5-((4-((tetrahydrofuran-2-yl)methyl)piperazin-1-yl)methyl)oxazolidin-2-one; (4S,5R)-3-(4-chlorophenyl)-4-(3-fluoro-5-(trifluoromethyl)phenyl)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)oxazolidin-2-one; ((4S,5R)-3-(4-chlorophenyl)-4-(3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl cyclohexylcarbamate; N-(((4S,5S)-3-(4-chlorophenyl)-4-(3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)benzenesulfonamide; 4-((4S,5R)-5-((benzyloxy)methyl)-4-(3-fluorophenyl)-2-oxooxazolidin-3-yl)benzonitrile; (4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluoro-5-(trifluoromethyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one; (4S,5R)-5-(4-fluorobenzyloxy)methyl)-3-(4-(trifluoromethyl)phenyl)-4-(3-fluorophenyl)oxazolidin-2-one; Ethyl 4-(((4S,5S)-3-(4-chlorophenyl)-4-(3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)piperazine-1-carboxylate; (4S,5R)-5((4-methylbenyzyloxy)methyl)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)oxazolidin-2-one; (4S,5S)-3-(5-(4-chlorophenoxy)pyrazin-2-yl)-4-(3-(trifluoromethyl)phenyl)-5-(morpholinomethyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)-5-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; Ethyl 1-(((4S,5S)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazole-4-carboxylate; (4S,5S)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)-5-((4-(3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; N-((1-(((4S,5S)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)methansulfonamide; (S)-2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)acetonitrile; 3-(4-(4-chlorophenoxy)phenyl)-1-(4-(trifluoromethyl)benzyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 3-[4-(4-Chloro-phenoxy)-phenyl]-1-(3,5-dimethyl-isoxazol-4-ylmethyl)-4-(3-trifluoromethyl-phenyl)-imidazolidin-2-one; (S)-3-[4-(6-Chloro-pyridazin-3-yloxy)-phenyl]-4-(3-trifluoromethyl-phenyl)-oxazolidin-2-one; (S)-3-(4-(5-chloropyridin-2-yloxy)phenyl)-4-(3-(trifluoromethyl)-phenyl)oxazolidin-2-one; (S)-1-[4-(4-Chloro-phenoxy)-phenyl]-5-(3-trifluoromethyl-phenyl)-imidazolidin-2-one; (R)-1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-[6-(4-Chloro-phenoxy)-pyridin-3-yl]-4-(3-trifluoromethyl-phenyl)-oxazolidin-2-one; (S)-3-(4-(4-chlorophenoxy)phenyl)-1-(4-methoxybenzyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-[5-(4-Chloro-phenoxy)-pyrazin-2-yl]-4-(3-trifluoromethyl-phenyl)-oxazolidin-2-one; (S)-1-(6-(4-chlorophenoxy)pyridin-3-yl)-5-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-1-(5-(4-chlorophenoxy)pyrazin-2-yl)-5-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-[6-(4-Chloro-phenoxy)-pyridin-3-yl]-1-(4-methoxy-benzyl)-4-(3-trifluoromethyl-phenyl)-imidazolidin-2-one; (S)-3-[5-(4-Chloro-phenoxy)-pyrazin-2-yl]-1-(4-methoxy-benzyl)-4-(3-trifluoromethyl-phenyl)-imidazolidin-2-one; (S)-1,3-Bis-[4-(4-chloro-phenoxy)-phenyl]-4-(3-trifluoromethyl-phenyl)-imidazolidin-2-ylidene-cyanamide; (S)-3-[5-(4-Chloro-phenoxy)-pyrazin-2-yl]-1-(4-methoxy-benzyl)-4-(3-trifluoromethyl-phenyl)-imidazolidin-2-ylidene-cyanamide; (S)-2-(3-(5-(4-chlorophenoxy)pyrazin-2-yl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)ethanesulfonamide; (S)-3-[4-(4-Chloro-phenoxy)-phenyl]-1-(2-methanesulfonyl-ethyl)-4-(3-trifluoromethyl-phenyl)-imidazolidin-2-one; (S)-2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)ethanesulfonamide; 2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)acetic acid; 1-((1H-tetrazol-5-yl)methyl)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)-N-propylacetamide; 2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)-N-(piperidin-1-yl)acetamide; 2-(2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)-imidazolidin-1-yl)acetamido)acetic acid; 2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)-N-(2-hydroxyethyl)acetamide; 2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)-N-(2-(dimethylamino)ethyl)acetamide; 3-(4-(4-chlorophenoxy)phenyl)-1-(2-hydroxyethyl)-4-(3-(trifluoromethyl)phenyl)-imidazolidin-2-one; 1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)phenyl)imidazolidin-2-imine; 1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)phenyl)imidazolidine-2-thione; 2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)ethyl methanesulfonate; 1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)phenyl)imidazolidin-2-one oxime; 3-(4-(4-chlorophenoxy)phenyl)-1-(2-methoxyethyl)-4-(3-(trifluoromethyl)phenyl)-imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(2-(2-hydroxyethylamino)ethyl)-4-(3-(trifluoromethyl)-phenyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(2-morpholinoethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(2-(4-methylpiperazin-1-yl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)ethyl carbamate; 3-(4-(4-chlorophenoxy)phenyl)-1-(2-(methylamino)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(2-(piperidin-1-yl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(2-(piperazin-1-yl)ethyl)-4-(3-(trifluoromethyl)phenyl)-imidazolidin-2-one; (4R,5S)-methyl 1-(4-(4-chlorophenoxy)phenyl)-2-oxo-5-phenylimidazolidine-4-carboxylate; 1-(4-chlorobenzyl)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 1-benzyl-3-(4-(4-chlorophenoxy)phenyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(3-methoxybenzyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(2-methoxybenzyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(4-methoxyphenyl)-4-(3-(trifluoromethyl)phenyl)-imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(2-morpholino-2-oxoethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(2-(4-(methylsulfonyl)piperazin-1-yl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(2-((2S,6R)-2,6-dimethylmorpholino)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 1-(2-aminoethyl)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 3-(2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)ethyl)-1,1-dimethylurea; N-(2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)ethyl)morpholine-4-carboxamide; N-(2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)ethyl)methanesulfonamide; 3-(4-(4-chlorophenoxy)phenyl)-1-(pyridin-2-ylmethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(pyridin-3-ylmethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(pyridin-4-ylmethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)—N-(3-(4-(4-chlorophenoxy)phenyl)-1-tosyl-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-ylidene)cyanamide; (S)-3-(4-(4-chlorophenoxy)phenyl)-1-(3-hydroxypropyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)—N-(1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)phenyl)imidazolidin-2-ylidene)cyanamide; (R)—N-(1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)phenyl)imidazolidin-2-ylidene)cyanamide; 3-(4-(4-chlorophenoxy)phenyl)-1-(2-((R)-2-methylmorpholino)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(2((S)-2-methylmorpholino)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)—N-(3-(4-(4-chlorophenoxy)phenyl)-1-(2-hydroxyethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-ylidene)cyanamide; (S)-3-(4-(4-chlorophenoxy)phenyl)-1-(3-(methylsulfonyl)propyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; N-(3-(4-(4-chlorophenoxy)phenyl)-1-(2-(methylsulfonyl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-ylidene)cyanamide; 3-(4-(4-chlorophenoxy)phenyl)-1-(3-morpholinopropyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)—N-(3-(4-(4-chlorophenoxy)phenyl)-1-(3-hydroxypropyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-ylidene)cyanamide; N-(3-(4-(4-chlorophenoxy)phenyl)-1-(2-morpholinoethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-ylidene)cyanamide; N-(3-(4-(4-chlorophenoxy)phenyl)-1-(2-((S)-2-methylmorpholino)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-ylidene)cyanamide; N-(3-(4-(4-chlorophenoxy)phenyl)-1-(3-(methylsulfonyl)propyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-ylidene)cyanamide; (R)-1-(4-(4-chlorophenoxy)phenyl)-5-phenylpyrrolidin-2-one; (R)-1-(5-(4-chlorophenoxy)pyrazin-2-yl)-5-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one; (R)-1-(4-(4-chlorophenoxy)phenyl)-5-(3-methoxyphenyl)pyrrolidin-2-one; (R)-1-(5-(4-chlorophenoxy)pyrazin-2-yl)-5-(3-methoxyphenyl)pyrrolidin-2-one; (R)-1-(4-(4-chlorophenylsulfonyl)phenyl)-5-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one; (R)-1-(4-(4-chlorophenylsulfonyl)phenyl)-5-(3-methoxyphenyl)pyrrolidin-2-one; (R)-1-[4-(4-chlorophenoxy)phenyl]-5-[3-(trifluoromethyl)phenyl]pyrrolidin-2-one; (R)-1-(4-(4-chlorophenoxy)phenyl)-2-(3-(trifluoromethyl)phenyl)pyrrolidine; (R)-1-(4-(4-chlorophenoxy)phenyl)-5-(3-hydroxyphenyl)pyrrolidin-2-one; (R)-5-(3-(2-hydroxyethoxy)phenyl)-1-(4-(4-chlorophenoxy)phenyl)pyrrolidin-2-one; (R)-5-(3-(2-hydroxyethoxy)phenyl)-1-(4-(4-chlorophenylsulfonyl)phenyl)pyrrolidin-2-one; (R)-1-(5-(4-chlorophenoxy)pyrazin-2-yl)-5-(3-hydroxyphenyl)pyrrolidin-2-one; (R)-1-(4-(4-chlorophenoxy)phenyl)-5-(3-cyanomethoxyphenyl)pyrrolidin-2-one; (R)-5-(3-(2-hydroxyethoxy)phenyl)-1-(5-(4-chlorophenoxy)pyrazin-2-yl)pyrrolidin-2-one; (3S,5R)-1-(4-(4-chlorophenoxy)phenyl)-3-allyl-5-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one; (3R,5R)-1-(4-(4-chlorophenoxy)phenyl)-3-allyl-5-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one; (R)-1-(4-(4-chlorophenoxy)phenyl)-3,3-diallyl-5-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one; (R)-5-(3-((1-methyl-1H-tetrazol-5-yl)methoxy)phenyl)-1-(4-(4-chlorophenoxy)phenyl)pyrrolidin-2-one; (R)-5-(3-((2-methyl-2H-tetrazol-5-yl)methoxy)phenyl)-1-(4-(4-chlorophenoxy)phenyl)pyrrolidin-2-one; (3R,5R)-1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)phenyl)-3-(2-hydroxyethyl)pyrrolidin-2-one; (3S,5R)-1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)phenyl)-3-(2-hydroxyethyl)pyrrolidin-2-one; (R)-2-(3-(1-(4-(4-chlorophenoxy)phenyl)pyrrolidin-2-yl)phenoxy)ethanol; (3S,5R)-1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)phenyl)-3-(3-hydroxypropyl)pyrrolidin-2-one; (3R,5R)-1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)phenyl)-3-(3-hydroxypropyl)pyrrolidin-2-one; (R)-1-(4-chlorophenyl)-5-(3-methoxyphenyl)pyrrolidin-2-one; (R)-1-(4-chlorophenyl)-5-(3-(pyridazin-3-yloxy)phenyl)pyrrolidin-2-one; (R)-1-(4-chlorophenyl)-5-(3-(pyrazin-2-yloxy)phenyl)pyrrolidin-2-one; (R)-5-(3-(2-hydroxyethoxy)phenyl)-1-(4-chlorophenyl)pyrrolidin-2-one; (3R,5R)-1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)phenyl)-3-(2-(methylsulfonyl)ethyl)pyrrolidin-2-one; (3S,5R)-1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)phenyl)-3-(2-(methylsulfonyl)ethyl)pyrrolidin-2-one; (S)-methyl 5-(4-chlorophenyl)-4-(3-methoxyphenyl)-1,1-dioxo-1,2,5-thiadiazolidine-2-carboxylate; (S)-2-(4-chlorophenyl)-3-(3-methoxyphenyl)-1,1-dioxo-1,2,5-thiadiazolidine; (R)-5-(3-(cyanomethoxy)phenyl)-1-(4-chlorophenyl)pyrrolidin-2-one; (S)-methyl 5-(4-chlorophenyl)-4-(3-hydroxyphenyl)-1,1-dioxo-1,2,5-thiadiazolidine-2-carboxylate; (S)-3-(2-(4-chlorophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-yl)phenol; (S)-2-(4-chlorophenyl)-1,1-dioxo-5-(pyrazin-2-yl)-3-(3-(pyrazin-2-yloxy)phenyl)-1,2,5-thiadiazolidine; (S)-2-(4-chlorophenyl)-1,1-dioxo-3-(3-(pyrazin-2-yloxy)phenyl)-1,2,5-thiadiazolidine; (S)—N,N-bis(4-methoxybenzyl)-3-(5-(4-chlorophenyl)-4-(3-methoxyphenyl)-1,1-dioxo-1,2,5-thiadiazolidin-2-yl)propanesulfamide; (S)-2-(4-chlorophenyl)-1,1-dioxo-5-(3-(methylsulfonyl)propyl)-3-(3-(pyrazin-2-yloxy)phenyl)-1,2,5-thiadiazolidine; (3S,5R)-1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)phenyl)-3-(3-(methylsulfonyl)propyl)pyrrolidin-2-one; (S)-2-(5-(4-chlorophenyl)-4-(3-(cyanomethoxy)phenyl)-1,1,-dioxo-1,2,5-thiadiazolidin-2-yl)acetonitrile; (S)-2-(4-chlorophenyl)-3-(3-methoxyphenyl)-1,1-dioxo-5-(pyrazin-2-yl)-1,2,5-thiadiazolidine; (S)-2-(4-chlorophenyl)-3-(3-methoxyphenyl)-1,1-dioxo-5-(pyridazin-3-yl)-1,2,5-thiadiazolidine; (S)-2-(4-chlorophenyl)-3-(3-methoxyphenyl)-1,1-dioxo-5-phenyl-1,2,5-thiadiazolidine; (S)-2-(5-(4-chlorophenyl)-4-(3-methoxyphenyl)-1,1-dioxo-1,2,5-thiadiazolidin-2-yl)acetonitrile; (S)-2-(4-chlorophenyl)-3-(3-methoxyphenyl)-1,1-dioxo-5-((3,5-dimethylisoxazol-4-yl)methyl)-1,2,5-thiadiazolidine; (S)-methyl 3-((5-(4-chlorophenyl)-4-(3-methoxyphenyl)-1,1-dioxo-1,2,5-thiadiazolidin-2-yl)methyl)isoxazole-5-carboxylate; (S)-3-((5-(4-chlorophenyl)-4-(3-methoxyphenyl)-1,1-dioxo-1,2,5-thiadiazolidin-2-yl)methyl)-1,2,4-oxadiazole; (S)-3-(2-(4-chlorophenyl)-1,1-dioxo-5-phenyl-1,2,5-thiadiazolidin-3-yl)phenol; (S)-3-(5-(4-chlorophenyl)-1,1-dioxo-4-(3-(pyrazin-2-yloxy)phenyl)-1,2,5-thiadiazolidin-2-yl)propane-1-sulfonamide; (S)-2-(4-chlorophenyl)-1,1-dioxo-5-phenyl-3-(3-(pyrazin-2-yloxy)phenyl)-1,2,5-thiadiazolidine; (S)-4-((5-(4-chlorophenyl)-4-(3-(pyrazin-2-yloxy)phenyl)-1,2,5-thiadiazolidin-2-yl)methyl)-3,5-dimethylisoxazole; (S)-2-(4-chlorophenyl)-5-(4-fluorophenyl)-3-(3-methoxyphenyl)-1,1-dioxo-1,2,5-thiadiazolidine; (R)-1-(5-(4-chlorophenoxy)pyrazin-2-yl)-5-(3-(cyanomethoxy)phenyl)pyrrolidin-2-one; (S)-3-(4-chlorophenyl)-4-(3-(pyrazin-2-yloxy)phenyl)oxazolidin-2-one; (S)-methyl 5-(4-(4-chlorophenoxy)phenyl)-4-(3-methoxyphenyl)-1,2,5-thiadiazolidine-1,1-dioxide-2-carboxylate; (S)-2-(4-(4-chlorophenoxy)phenyl)-3-(3-methoxyphenyl)-1,2,5-thiadiazolidine-1,1-dioxide; (S)-4-(3-(m-tolyloxy)phenyl)-3-(4-chlorophenyl)oxazolidin-2-one; (S)-4-(3-(3-cyanophenoxy)phenyl)-3-(4-chlorophenyl)oxazolidin-2-one; (S)-4-(3-(2-chlorophenoxy)phenyl)-3-(4-chlorophenyl)oxazolidin-2-one; (S)-4-(3-(4-methoxyphenoxy)phenyl)-3-(4-chlorophenyl)oxazolidin-2-one: (S)-4-(3-(2-cyanophenoxy)phenyl)-3-(4-chlorophenyl)oxazolidin-2-one; (S)-4-(3-(4-cyanophenoxy)phenyl)-3-(4-chlorophenyl)oxazolidin-2-one; (S)-3-(4-chlorophenyl)-4-(3-(pyridin-2-yloxy)phenyl)oxazolidin-2-one; (S)-3-(4-chlorophenyl)-4-(3-(pyrimidin-2-yloxy)phenyl)oxazolidin-2-one; (S)-3-(4-chlorophenyl)-4-(3-ethoxyphenyl)oxazolidin-2-one; (S)-3-(4-chlorophenyl)-4-(3-isopropoxyphenyl)oxazolidin-2-one; (S)-3-(4-chlorophenyl)-4-(3-(cyclopropylmethoxy)phenyl)oxazolidin-2-one; (S)-4-(3-(3-(dimethylamino)propoxy)phenyl)-3-(4-chlorophenyl)oxazolidin-2-one; (S)-4-(3-(cyanomethoxy)phenyl)-3-(4-chlorophenyl)oxazolidin-2-one; (S)-4-(3-(2-hydroxyethoxy)phenyl)-3-(4-chlorophenyl)oxazolidin-2-one; (S)-3-(4-chlorophenyl)-4-(3-hydroxyphenyl)oxazolidin-2-one; (S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)oxazolidin-2-one; 5-(3-(benzyloxy)phenyl)-1-(4-(4-chlorophenoxy)phenyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-4-(3-(benzyloxy)phenyl)-1-(2-(methylsulfonyl)ethyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-4-(3-hydroxyphenyl)-1-(2-(methylsulfonyl)ethyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(2-(methylsulfonyl)ethyl)-4-(3-(pyridin-2-yloxy)phenyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(2-(methylsulfonyl)ethyl)-4-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-2-one; 4-(3-(2-cyanophenoxy)phenyl)-3-(4-(4-chlorophenoxy)phenyl)-1-(2-(methylsulfonyl)ethyl)imidazolidin-2-one; 5-(3-(benzyloxy)phenyl)-1-(4-chlorophenyl)imidazolidin-2-one; 4-(3-(benzyloxy)phenyl)-3-(4-chlorophenyl)-1-(2-(methylsulfonyl)ethyl)imidazolidin-2-one; 3-(4-chlorophenyl)-4-(3-hydroxyphenyl)-1-(2-(methylsulfonyl)ethyl)imidazolidin-2-one; 3-(4-chlorophenyl)-1-(2-(methylsulfonyl)ethyl)-4-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-2-one; 4-(3-(2-cyanophenoxy)phenyl)-3-(4-chlorophenyl)-1-(2-(methylsulfonyl)ethyl)imidazolidin-2-one; 3-(4-chlorophenyl)-1-(2-(methylsulfonyl)ethyl)-4-(3-(pyrimidin-2-yloxy)phenyl)imidazolidin-2-one; 3-(4-chlorophenyl)-1-(2-(methylsulfonyl)ethyl)-4-(3-(pyridin-2-yloxy)phenyl)imidazolidin-2-one; 3-(4-chlorophenyl)-1-(2-(methylsulfonyl)ethyl)-4-(3-(pyridin-3-yloxy)phenyl)imidazolidin-2-one; 3-(4-chlorophenyl)-1-(2-(methylsulfonyl)ethyl)-4-(3-(pyridin-4-yloxy)phenyl)imidazolidin-2-one; 3-(4-chlorophenyl)-1-(2-(methylsulfonyl)ethyl)-4-(3-(pyridazin-3-yloxy)phenyl)imidazolidin-2-one; 4-(3-(4-methoxyphenoxy)phenyl)-3-(4-chlorophenyl)-1-(2-(methylsulfonyl)ethyl)imidazolidin-2-one; 4-(3-(5-aminopyrazin-2-yloxy)phenyl)-3-(4-chlorophenyl)-1-(2-(methylsulfonyl)ethyl)imidazolidin-2-one; 3-(4-chlorophenyl)-1-(2-(methylsulfonyl)ethyl)-4-(3-(pyrimidin-5-yloxy)phenyl)imidazolidin-2-one; (4S,5S)-1-(3-(4-chlorophenyl)-4-(3-fluoro-5-(trifluoromethyl)phenyl)-2-oxooxazolidin-5-yl)methyl)-N-(piperidin-1-yl)-1H-1,2,3-triazole-4-carboxamide; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-fluorophenyl)-5-(morpholinomethyl)oxazolidin-2-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-5-(morpholinomethyl)-4-(3-(trifluoromethyl)phenyl)oxazolidin-2-one; (4S,5S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-methoxyphenyl)-5-(morpholinomethyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-5-((4-(ethylsulfonylmethyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(3-fluoro-5-(trifluoromethyl)phenyl)oxazolidin-2-one; ethyl 1-(((4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-oxooxazolidin-5-yl)methyl)piperidine-4-carboxylate; tert-butyl 4-(((4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-oxooxazolidin-5-yl)methyl)-1,4-diazepane-1-carboxylate; (4S,5S)-3-(4-chlorophenyl)-5((4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(3-methoxyphenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((4-(2-methoxyphenyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; ethyl 1-(((4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazole-4-carboxylate; (4S,5S)-3-(4-chlorophenyl)-5-((4-(ethylsulfonyl)piperazin-1-yl)methyl)-4-(3-methoxyphenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-5-((4-cyclopentyl-1H-1,2,3-triazol-1-yl)methyl)-4-(3-methoxyphenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-5-(4-(cyclohexylmethyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(3-methoxyphenyl)oxazolidin-2-one; (4S,5S)-5-(4-acetyl-1H-1,2,3-triazol-1-yl)methyl)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-5((4-isopentyl-1H-1,2,3-triazol-1-yl)methyl)-4-(3-methoxyphenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((5-(2-methoxyphenyl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-5-(5-(2-(diethylamino)ethyl)-2H-tetrazol-2-yl)methyl)-4-(3-methoxyphenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((5-(2-(piperidin-1-yl)ethyl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-5((4-((diethylamino)methyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(3-methoxyphenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((4-(piperidin-1-ylmethyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-5-(morpholinomethyl)-4-(3-(pyrazin-2-yloxy)phenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5((4-(morpholinomethyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-5-(4((isopropylamino)methyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(3-methoxyphenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((4-(ethylsulfonyl)piperazin-1-yl)methyl)oxazolidin-2-one; ethyl 4-(((4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)piperazine-1-carboxylate; (4S,5S)-3-(4-chlorophenyl)-5((4-(cyclohexylmethyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5((4-(3-methyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methyl)oxazolidin-2-one; (4S,5S)-5-((4-acetyl-1H-1,2,3-triazol-1-yl)methyl)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidin-1-yl)methyl)oxazolidin-2-one; (4S,5S)-5-((4-(azepan-1-ylmethyl)-1H-1,2,3-triazol-1-yl)methyl)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((4-((4-methylpiperidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5((4-(piperidin-1-ylmethyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; tert-butyl 1-(((4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)pyrrolidin-3-ylcarbamate; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((4-ethoxy-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-5-((5-(6-chloropyridin-3-yl)-2H-tetrazol-2-yl)methyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5((4-phenylpiperidin-1-yl)methyl)oxazolidin-2-one; (4S,5R)-3-(4-chlorophenyl)-5-(5-chloropyridin-2-yloxy)methyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((4-(pyrimidin-2-yl)piperazin-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5((4-(pyridin-2-yl)piperazin-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5((4-(3-methyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((4-(pyrazin-2-yl)piperazin-1-yl)methyl)oxazolidin-2-one; ethyl 4-(((4S,5S)-3-(4-chlorophenyl)-4-(3-ethoxyphenyl)-2-oxooxazolidin-5-yl)methyl)piperazine-1-carboxylate; ethyl 4-(((4S,5S)-3-(4-chlorophenyl)-4-(3-isopropoxyphenyl)-2-oxooxazolidin-5-yl)methyl)piperazine-1-carboxylate; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((5-(pyrimidin-2-yl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((5-(pyrazin-2-yl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((5-(pyridin-2-yl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((5-(pyridin-2-yl)-1H-tetrazol-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((4-hydroxy-4-phenylpiperidin-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-5-((4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)methyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((5-methyl-2-oxopyridin-1(2H)-yl)methyl)oxazolidin-2-one; (4S,5R)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((4-methylpyridin-2-yloxy)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((5-(imidazo[1,2-a]pyridin-6-yl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((3-oxo-4-(pyridin-2-yl)piperazin-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((4-(pyrazin-2-yl)piperazin-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5((4-(3,5-dimethylphenyl)-3-oxopiperazin-1-yl)methyl)oxazolidin-2-one; (S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-(trifluoromethyl)phenyl)-1-(pyrazin-2-yl)imidazolidin-2-one; N-(3-(1-(((4S,5S)-3-(4-chlorophenyl)-4-(3-fluoro-5-(trifluoromethyl)phenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)phenyl)acetamide; (4S,5S)-3-(4-chlorophenyl)-4-(3-fluoro-5-(trifluoromethyl)phenyl)-5-((4-((3-methyl-1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-fluoro-5-(trifluoromethyl)phenyl)-5((4-((5-methyl-1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; ethyl 4-(((4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-oxooxazolidin-5-yl)methyl)piperazine-1-carboxylate; benzyl 1-(((4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-oxooxazolidin-5-yl)methyl)-2-oxopiperidine-4-carboxylate; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5((4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; 4-(1-(((4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)benzonitrile; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5((4-((tetrahydrofuran-3-yloxy)methyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-fluorophenyl)-5-((5-phenyl-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-fluoro-5-(trifluoromethyl)phenyl)-5((4-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-5((4-ethoxy-1H-1,2,3-triazol-1-yl)methyl)-4-(3-methoxyphenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5((4-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5((4-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((5-phenyl-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; ethyl 2-(2-((4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-oxooxazolidin-5-yl)methyl)-2H-tetrazol-5-yl)acetate; (4S,5S)-3-(4-chlorophenyl)-5-((5-(2-hydroxyethyl)-2H-tetrazol-2-yl)methyl)-4-(3-methoxyphenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((5-(2-morpholinoethyl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-5-((1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-4-(3-methoxyphenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((5-(pyridin-3-yl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-5-((3-(tetrahydrofuran-3-yl)isoxazol-5-yl)methyl)-4-(3-methoxyphenyl)oxazolidin-2-one; tert-butyl 4-((4-(((4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)piperidine-1-carboxylate; ethyl 2-(((4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-oxooxazolidin-5-yl)methyl)-2H-tetrazole-5-carboxylate; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((4-phenyl-1H-imidazol-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((4-((tetrahydrofuran-3-yloxy)methyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one; (4S,5S)-5-((1H-1,2,3-triazol-1-yl)methyl)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((5-(pyridin-3-yl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((5-((piperidin-1-yl)methyl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((5-(6-methylpyridin-3-yl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; tert-butyl 4-(2-(((4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)-2H-tetrazol-5-yl)piperidine-1-carboxylate; tert-butyl 4-(1-(((4S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)-1H-tetrazol-5-yl)piperidine-1-carboxylate; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5((4-phenyl-1H-imidazol-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3,5-difluorophenyl)-5-((5-(6-methoxypyridin-3-yl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((4-(pyrimidin-2-yl)piperazin-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((4-(pyridin-2-yl)piperazin-1-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-isopropoxyphenyl)-5-((5-(pyridin-3-yl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-hydroxyphenyl)-5-((5-(pyridin-3-yl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)-5-((5-(6-methoxypyridin-3-yl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((5-(6-methylpyridin-3-yl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-5-((5-(6-methoxypyridin-3-yl)-2H-tetrazol-2-yl)methyl)-4-(3-(trifluoromethoxy)phenyl)oxazolidin-2-one; ethyl 4-(((4S,5S)-3-(4-chlorophenyl)-2-oxo-4-(3-(trifluoromethoxy)phenyl)oxazolidin-5-yl)methyl)piperazine-1-carboxylate; (4S,5S)-3-(4-chlorophenyl)-4-(3-hydroxyphenyl)-5-((5-(6-methylpyridin-3-yl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-isopropoxyphenyl)-5-((5-(6-methylpyridin-3-yl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5-((5-(6-methoxypyridin-3-yl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; 6-(4-(((4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-oxooxazolidin-5-yl)methyl)piperazin-1-yl)pyridine-3-carbonitrile; (4S,5S)-3-(4-chlorophenyl)-4-(3-(2-hydroxyethoxy)phenyl)-5-((5-(6-methoxypyridin-3-yl)-2H-tetrazol-2-yl)methyl)oxazolidin-2-one; (4S,5R)-5-(5-cyanopyridin-2-yloxy)methyl)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)oxazolidin-2-one; 4-((4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-oxooxazolidin-5-yl)methyl)-1-(6-methoxypyridin-3-yl)piperazin-2-one; (4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-5((4-(6-methoxypyridin-2-yl)piperazin-1-yl)methyl)oxazolidin-2-one; 4-((4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-oxooxazolidin-5-yl)methyl)-1-(6-methoxypyridin-2-yl)piperazin-2-one; tert-butyl 4-(((4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-oxooxazolidin-5-yl)methyl)-3-oxopiperazine-1-carboxylate; (4S,5S)-3-(4-chlorophenyl)-5((4-(4-fluoropyridin-2-yl)piperazin-1-yl)methyl)-4-(3-methoxyphenyl)oxazolidin-2-one; ethyl 3-((4S,5S)-3-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-oxooxazolidin-5-yl)propanoate; (4S,5S)-3-(4-chlorophenyl)-5-(3-(diethylamino)pyrrolidin-1-yl)methyl)-4-(3-fluorophenyl)oxazolidin-2-one; tert-butyl 1-(((4S,5S)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)-2-oxooxazolidin-5-yl)methyl)pyrrolidin-3-ylmethylcarbamate; (S)-3-(4-chlorophenyl)-1-(5-(4-methoxyphenyl)-1,2,4-oxadiazol-3-yl)methyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(pyridin-3-ylmethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(4-methoxybenzyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-2-(3-(4-chlorophenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)ethanesulfonamide; (S)-3-(4-chlorophenyl)-1-(2-hydroxyethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(3-hydroxypropyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-2-(3-(4-chlorophenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)-N-propylacetamide; (S)-3-(4-chlorophenyl)-1-(2-oxo-2-(piperidin-1-yl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-2-(3-(4-chlorophenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)-N-(piperidin-1-yl)acetamide; (S)-tert-butyl 4-(2-(3-(4-chlorophenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)acetyl)piperazine-1-carboxylate; (S)-3-(4-chlorophenyl)-1-((5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(5-(4-chlorophenyl)oxazol-2-yl)methyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-methyl 3-((3-(4-chlorophenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)methyl)isoxazole-5-carboxylate; (S)-3-(4-chlorophenyl)-1-(2-morpholinoethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(2-(4-hydroxypiperidin-1-yl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(3-morpholinopropyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(2-(4-(methylsulfonyl)piperazin-1-yl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-1-((5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(2-(4-methylpiperazin-1-ylsulfonyl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(2-(piperidin-1-ylsulfonyl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(2-(pyrrolidin-1-ylsulfonyl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(2-(morpholinosulfonyl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(3-(4-chlorophenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)propane-1-sulfonamide; (S)-2-(3-(4-chlorophenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)-N,N-bis(2-hydroxyethyl)ethanesulfonamide; (S)-3-(4-chlorophenyl)-1-((6-morpholinopyridin-3-yl)methyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-((6-(4-ethylpiperazin-1-yl)pyridin-3-yl)methyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(6-(piperidin-1-yl)pyridin-3-yl)methyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(6-(pyrrolidin-1-yl)pyridin-3-yl)methyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-1-((6-(bis(2-hydroxyethyl)amino)pyridin-3-yl)methyl)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(6-(4-(methylsulfonyl)piperazin-1-yl)pyridin-3-yl)methyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(3-(4-(methylsulfonyl)piperazin-1-yl)propyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (4S)-3-(4-chlorophenyl)-1-(3-(3-(diethylamino)pyrrolidin-1-yl)propyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(2-(5-cyclohexyl-1,2,4-oxadiazol-3-yl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-1-(2-(5-tert-butyl-1,2,4-oxadiazol-3-yl)ethyl)-3-(4-chlorophenyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(2-(5-(pyridin-3-yl)-1,2,4-oxadiazol-3-yl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-(4-chlorophenoxy)phenyl)-1-(2-(morpholinosulfonyl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)propane-1-sulfonamide; (S)-3-(4-(4-chlorophenoxy)phenyl)-1-(2-(4-methylpiperazin-1-ylsulfonyl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)-N-(2-hydroxyethyl)ethanesulfonamide; (S)-2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)-N,N-bis(2-hydroxyethyl)ethanesulfonamide; (S)-1-(4-(4-chlorophenoxy)phenyl)-5-(3-methoxyphenyl)imidazolidin-2-one; (S)-1-(4-(4-chlorophenoxy)phenyl)-5-(3-hydroxyphenyl)imidazolidin-2-one; (S)-2-(3-(4-(4-chlorophenoxy)phenyl)-4-(3-methoxyphenyl)-2-oxoimidazolidin-1-yl)ethanesulfonamide; (S)-1-(4-(4-chlorophenoxy)phenyl)-5-(3-(2-hydroxyethoxy)phenyl)imidazolidin-2-one; (S)-2-(3-(4-(4-chlorophenoxy)phenyl)-4-(3-(2-hydroxyethoxy)phenyl)-2-oxoimidazolidin-1-yl)ethanesulfonamide; (S)—N-(2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)ethylsulfonyl)acetamide; (S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-(2-hydroxyethoxy)phenyl)-1-(2-(methylsulfonyl)ethyl)imidazolidin-2-one; tert-butyl 4-((2-((S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-(trifluoromethyl)phenyl)-2-oxoimidazolidin-1-yl)ethyl)sulfonyl)piperazine-1-carboxylate; (S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-(trifluoromethyl)phenyl)-1-(2-((piperazin-1-yl)sulfonyl)ethyl)imidazolidin-2-one; (S)-1-(4-chlorophenyl)-5-(3-(pyridazin-3-yloxy)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-4-(3-(pyridazin-3-yloxy)phenyl)oxazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(2-(morpholinosulfonyl)ethyl)-4-(3-(pyridazin-3-yloxy)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(2-(4-methylpiperazin-1-ylsulfonyl)ethyl)-4-(3-(pyridazin-3-yloxy)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-4-(3-(pyridazin-3-yloxy)phenyl)-1-(2-(pyrrolidin-1-ylsulfonyl)ethyl)imidazolidin-2-one; (S)-2-(3-(4-chlorophenyl)-2-oxo-4-(3-(pyridazin-3-yloxy)phenyl)imidazolidin-1-yl)ethanesulfonamide; (S)-3-(4-chlorophenyl)-4-(3-(2-hydroxyethoxy)phenyl)-1-(2-(methylsulfonyl)ethyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-4-(3-(2-hydroxyethoxy)phenyl)-1-(2-(morpholinosulfonyl)ethyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-4-(3-(2-hydroxyethoxy)phenyl)-1-(2-(4-methylpiperazin-1-ylsulfonyl)ethyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-4-(3-(2-hydroxyethoxy)phenyl)-1-(2-(pyrrolidin-1-ylsulfonyl)ethyl)imidazolidin-2-one; (S)-2-(3-(4-chlorophenyl)-4-(3-(2-hydroxyethoxy)phenyl)-2-oxoimidazolidin-1-yl)ethanesulfonamide; (S)-3-(4-(4-chlorophenoxy)phenyl)-1-(2-(methylsulfonyl)ethyl)-4-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-2-one; (S)-1-(4-(4-chlorophenoxy)phenyl)-5-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-2-one; (S)-2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-1-yl)ethanesulfonamide; (S)-1-(5-(4-chlorophenoxy)pyrazin-2-yl)-5-(3-methoxyphenyl)imidazolidin-2-one; (S)-3-(5-(4-chlorophenoxy)pyrazin-2-yl)-4-(3-methoxyphenyl)-1-(2-(methylsulfonyl)ethyl)imidazolidin-2-one; (S)-1-(2-(azetidin-1-ylsulfonyl)ethyl)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-1-(2-(azetidin-1-ylsulfonyl)ethyl)-3-(4-chlorophenyl)-4-(3-(pyridazin-3-yloxy)phenyl)imidazolidin-2-one; (S)-3-(4-(4-chlorophenoxy)phenyl)-1-(4-(methylsulfonyl)phenyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(4-(methylsulfonyl)phenyl)-4-(3-(pyridazin-3-yloxy)phenyl)imidazolidin-2-one; (S)-4-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)benzenesulfonamide; (S)-4-(3-(4-chlorophenyl)-2-oxo-4-(3-(pyridazin-3-yloxy)phenyl)imidazolidin-1-yl)benzenesulfonamide; (S)-methyl 3-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)propanoate; (S)-3-(4-chlorophenyl)-1-(2-(methylsulfonyl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-3-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)propanamide; (S)—N-(1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)phenyl)imidazolidin-2-ylidene)sulfamide; (S)-3-(4-chlorophenyl)-1-(pyrazin-2-yl)-4-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-2-one; (S)—N-(1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)phenyl)imidazolidin-2-ylidene)methanesulfonamide; (S)-3-(4-chlorophenyl)-1-(2-(methylsulfonyl)ethyl)-4-(3-(pyridin-2-yloxy)phenyl)imidazolidin-2-one; (4S)-3-(4-(4-chlorophenoxy)phenyl)-1-(2-(1-methylpyrrolidin-2-yl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-1-(2-(1,3-dioxan-2-yl)ethyl)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 3-(4-(4-chlorophenoxy)phenyl)-1-(2-(2-oxopyrrolidin-1-yl)ethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 3-(2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)ethyl)oxazolidin-2-one; 1-(2-(1H-pyrazol-1-yl)ethyl)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; 1-(2-(1H-imidazol-1-yl)ethyl)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one; (S)-1-(4-(4-chlorophenoxy)phenyl)-2-(nitromethylene)-5-(3-(trifluoromethyl)phenyl)imidazolidine; (S)—N-(1-(4-chlorophenyl)-5-(3-(trifluoromethyl)phenyl)imidazolidin-2-ylidene)methanesulfonamide; (S)-3-(4-chlorophenyl)-4-(3-(6-methylpyridin-3-yloxy)phenyl)-1-(2-(methylsulfonyl)ethyl)imidazolidin-2-one; (S)-1-(4-chlorophenyl)-5-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-2-one; (S)-1-(1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)phenyl)imidazolidin-2-ylidene)urea; (S)-3-(4-chlorophenyl)-1-(2-(methylsulfonyl)ethyl)-4-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-2-one; (S)-2-(3-(4-chlorophenyl)-2-oxo-4-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-1-yl)ethanesulfonamide; (S)-3-(4-chlorophenyl)-4-(3-(pyrazin-2-yloxy)phenyl)-1-(2-(pyrrolidin-1-ylsulfonyl)ethyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(2-(morpholinosulfonyl)ethyl)-4-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(2-(4-methylpiperazin-1-ylsulfonyl)ethyl)-4-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-2-one; (S)-3-(4-chlorophenyl)-1-(2-(piperazin-1-ylsulfonyl)ethyl)-4-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-2-one; (S)—N-(1-(4-chlorophenyl)-5-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-2-ylidene)methanesulfonamide; (S)—N-(1-(4-chlorophenyl)-5-(3-(2-hydroxyethoxy)phenyl)imidazolidin-2-ylidene)methanesulfonamide; (S)—N-(1-(4-chlorophenyl)-5-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-2-ylidene)sulfamide; (S)—N-(1-(4-chlorophenyl)-5-(3-(pyridazin-3-yloxy)phenyl)imidazolidin-2-ylidene)methanesulfonamide; (S)-1-(2-(1,3-dioxan-2-yl)ethyl)-3-(4-chlorophenyl)-4-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-2-one; (S)-3-(4-(4-chlorophenoxy)phenyl)-4-(3-methoxyphenyl)-1-(2-(methylsulfonyl)ethyl)imidazolidin-2-one; (S)-3-(3-(4-chlorophenyl)-2-oxo-4-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-1-yl)propanamide; (S)—N-(3-(4-(4-chlorophenoxy)phenyl)-1-cyano-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-ylidene)cyanamide; (S)-1-(2-(1H-1,2,4-triazol-3-yl)ethyl)-3-(4-chlorophenyl)-4-(3-(pyrazin-2-yloxy)phenyl)imidazolidin-2-one; (S)-3-(3-(3-(4-chlorophenyl)-1-(2-(methylsulfonyl)ethyl)-2-oxoimidazolidin-4-yl)phenoxy)pyrazine-2-carbonitrile; (S)-3-(4-chlorophenyl)-4-(3-(3-ethylpyrazin-2-yloxy)phenyl)-1-(2-(methylsulfonyl)ethyl)imidazolidin-2-one; and (S)-4-(3-(5-aminopyrazin-2-yloxy)phenyl)-3-(4-chlorophenyl)-1-(2-(methylsulfonyl)ethyl)imidazolidin-2-one. 
     
     
         9 . A method of treating a disease mediated by the Cannabinoid-1 receptor comprising administration of to a patient in need of such treatment of a therapeutically effective amount of a compound of  claim 1 . 
     
     
         10 . The method according to  claim 9  wherein the disease mediated by the Cannabinoid-1 receptor is an eating disorder associated with excessive food intake. 
     
     
         11 . The method according to  claim 10  wherein the eating disorder associated with excessive food intake is selected from obesity, bulimia nervosa, and compulsive eating disorders. 
     
     
         12 . The method according to  claim 11  wherein the eating disorder associated with excessive food intake is obesity. 
     
     
         13 . A method of preventing obesity in a person at risk for obesity comprising administration to said person of about 0.001 mg to about 100 mg per kg of a compound selected from a compound of  claim 1 . 
     
     
         14 . A composition comprising a pharmaceutically acceptable carrier and a compound selected from a compound of  claim 1 . 
     
     
         15 . The use of a compound for the manufacture of a medicament useful for the treatment of a disease mediated by the Cannabinoid-1 receptor in a human patient in need of such treatment, said compound being selected from a compound of  claim 1 . 
     
     
         16 . The use according to  claim 15  wherein the disease mediated by the Cannabinoid-1 receptor is selected from: metabolic disorders as well as conditions associated with metabolic disorders including obesity, bulimia nervosa, compulsive eating disorders, diabetes, arteriosclerosis, hypertension, osteoporosis, polycystic ovary disease, cardiovascular disease, osteoarthritis, dermatological disorders, hypertension, insulin resistance, hypercholesterolemia, hypertriglyceridemia, cholelithiasis and sleep disorders, and hyperlipidemic conditions; or psychiatric disorders such as substance abuse, psychosis, depression, anxiety, stress, epilepsy, mania and schizophrenia; or cognitive disorders such as dementia including Alzheimer's disease, memory deficits, short term memory loss and attention deficit disorders; or neurodegenerative disorders such as Parkinson's Disease, cerebral apoplexy and craniocerebral trauma, hypotension, catabolism in connection with pulmonary dysfunction and ventilator dependency; or cardiac dysfunction including valvular disease, myocardial infarction, cardiac hypertrophy and congestive heart failure); or the overall pulmonary dysfunction, transplant rejection, rheumatoid arthritis, migraine, neuropathy, multiple sclerosis, Guillain-Barre syndrome, the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, inflammatory bowel disease, lupus, graft vs. host disease, T-cell mediated hypersensitivity disease, psoriasis, osteoporosis, asthma, Hashimoto's thyroiditis, Guillain-Barre syndrome, cancer, contact dermatitis, allergic rhinitis, ischemic or reperfusion injury, head trauma and movement disorders. 
     
     
         17 . The use according to  claim 16  wherein the disease mediated by the Cannabinoid-1 receptor is an eating disorder associated with excessive food intake. 
     
     
         18 . The use according to  claim 17 , wherein the eating disorder associated with excessive food intake is selected from obesity, bulimia nervosa, and compulsive eating disorders. 
     
     
         19 . The use according to  claim 18  wherein the eating disorder associated with excessive food intake is obesity. 
     
     
         20 . The use of a compound according to  claim 1  for the manufacture of a medicament for the prevention of obesity in a person at risk therefor. 
     
     
         21 . A process of preparing a compound of  claim 1  with a greater than 80% yield wherein any aryl is bonded directly to a group selected from an amide, a carbamate and a nitrogen containing heterocycle forming a compound of Formula I; which process comprises: reacting an aryl-halide with an amide, a carbamate or a nitrogen containing heterocycle in the presence of a copper catalyst; cesium fluoride; a solvent; at a temperature of less than or equal to 100° C. for less than or equal to 24 hours. 
     
     
         22 . The process of  claim 21  in which the copper catalyst is copper iodide. 
     
     
         23 . The process of  claim 22  in which the solvent is selected from THF, CAN, DMSO, DME, DMF, Dioxane, toluene and EtOAc. 
     
     
         24 . The process of  claim 23  in which the temperature is less than or equal to 75° C. 
     
     
         25 . The process of  claim 24  in which the temperature is less than or equal to 50° C. 
     
     
         26 . The process of  claim 25  in which the temperature is less than or equal to 25° C. 
     
     
         27 . The process of  claim 26  in which the reaction takes between 18 and 24 hours.