Nutritional Composition for the Stimulation of Muscle Protein Synthesis

Abstract

The invention relates to the use of an anabolic amino acid derivative stimulus acting in combination with vitamin D for the manufacture of a medicament or nutritional composition for the prevention and/or treatment of a loss of any one of muscle mass, muscle strength, muscle function, and physical function, or any combination thereof, in a mammal.

1 . Method for preventing or treating a loss of any one of muscle mass, muscle strength, muscle function, and physical function, or any combination thereof, in an adult mammal, comprising administering to the adult mammal a medicament or nutritional composition, comprising an anabolic amino acid derivative stimulus acting in combination with vitamin D, which anabolic amino acid derivative comprises L-leucine in a free form. 
     
     
         2 . Method for preventing or treating a loss of any one of muscle mass, muscle strength, muscle function, and physical function, or any combination thereof, in an adult mammal, comprising administering to the adult mammal a medicament or nutritional composition comprising as mutually active components:
 an anabolic amino acid derivative stimulus, which anabolic amino acid derivative stimulus comprises L-leucine in a free form; and   vitamin D in an amount of 800 IU or more per daily dosage.   
     
     
         3 . Method according to  claim 1 , wherein the total L-leucine comprises at least 20 weight % of L-leucine in a free form, relative to the total amount of leucine. 
     
     
         4 . Method according to  claim 1 , wherein the anabolic amino acid derivative stimulus is provided in a daily dosage of 0.5 to 10 g. 
     
     
         5 . Method according to  claim 1 , wherein leucine is provided in a daily dosage of 1 to 10 g. 
     
     
         6 . (canceled) 
     
     
         7 . (canceled) 
     
     
         8 . Method according to  claim 1 , wherein the amount of vitamin D is 1,000 IU or more per daily dosage but not so high that it causes toxicity in the subject to whom it is administered. 
     
     
         9 . Method according to  claim 1 , wherein the composition further comprises a source of proteinaceous matter. 
     
     
         10 . Method according to  claim 1 , wherein the composition comprises leucine, valine and isoleucine in a leucine:valine:isoleucine ratio of about 1.7-3:1:1. 
     
     
         11 . (canceled) 
     
     
         12 . Method according to  claim 1 , wherein the composition is a nutritional composition, further comprising at least one of a fat source, a digestible carbohydrate source, a dietary fibre source and a micronutrient source. 
     
     
         13 . Method according to  claim 1 , wherein the composition is provided as a liquid, powder, spoonable, or solid composition. 
     
     
         14 . Method according to  claim 1 , wherein the composition is a low-caloric composition, the energy of which does not exceed 100 kcal/ml. 
     
     
         15 . Method according to  claim 1 , wherein the adult mammal is an elderly human. 
     
     
         16 . Method according to  claim 1  for the treatment or prevention of a disorder or symptom selected from the group consisting of sarcopenia, insufficient muscle protein synthesis, muscle degradation, muscle proteolysis, muscle atrophy, muscle dystrophy, muscle catabolism, muscle wasting, loss of muscle strength, loss of physical capacity and loss of physical performance. 
     
     
         17 . Method according to  claim 1  for the treatment or prevention of muscle decline and/or loss of muscle mass in a subject during or following body weight maintenance, during or following energy restriction, during or following bed rest or during recovery following physical trauma. 
     
     
         18 . Method according to  claim 17  wherein the subject is suffering from overweight or obesity, said subject following a weight loss program, an energy restriction program and/or an exercise program. 
     
     
         19 . A liquid or spoonable nutritional composition comprising:
 i. not more than about 100 kcal of energy per 100 ml of liquid or spoonable nutritional composition,   ii. at least about 10 g proteinaceous matter per 100 ml of liquid or spoonable nutritional composition, comprising at least about 80 weight % of whey protein, relative to the total proteinaceous matter,   iii. at least about 1 g leucine per 100 ml of liquid or spoonable nutritional composition, of which at least about 20 weight % is in a free form, relative to the total amount of leucine,   iv. at least about 400 IU of vitamin D per 100 ml of liquid or spoonable nutritional composition, and   v. a source of fat and source of digestible carbohydrates.   
     
     
         20 . A solid nutritional composition comprising:
 i. less than about 500 kcal of energy per 100 g of dry weight,   ii. at least about 49 g proteinaceous matter per 100 g of dry weight of comprising at least about 80 weight % of whey protein, relative to the total proteinaceous matter,   iii. at least about 5 g leucine per 100 g of dry weight of which at least about 20 weight % is in a free form, relative to the total leucine,   iv. at least about 50 μg of vitamin D per 100 g of dry weight, and   v. a source of fat and a source of digestible carbohydrates.   
     
     
         21 . Method according to  claim 2 , wherein the anabolic amino acid derivate stimulus is L-leucine, wherein total L-leucine comprises at least 20 weight % of L-leucine in a free form, relative to the total amount of leucine. 
     
     
         22 . Method according to  claim 2 , wherein the anabolic amino acid derivate stimulus is provided in a daily dosage of 0.5 to 10 g. 
     
     
         23 . Method according to  claim 2 , wherein leucine is provided in a daily dosage of 1 to 10 g. 
     
     
         24 . Method according to  claim 2 , wherein the amount of Vitamin D is 1,000 IU or more per daily dosage but not so high that it causes toxicity in the subject to whom it is administered. 
     
     
         25 . Method according to  claim 2 , wherein the composition further comprises a source of proteinaceous matter. 
     
     
         26 . Method according to  claim 2 , wherein the composition comprises leucine, valine, and isoleucine in a leucine:valine:isoleucine ratio of about 1.7-3:1:1. 
     
     
         27 . Method according to  claim 2 , wherein the composition is a nutritional composition, further comprising at least one of a fat source, a digestible carbohydrate source, a dietary fibre source, and a micronutrient source. 
     
     
         28 . Method according to  claim 2 , wherein the composition is provided as a liquid, powder, spoonable, or solid composition. 
     
     
         29 . Method according to  claim 2 , wherein the composition is a low-caloric composition, the energy of which does not exceed 100 kcal/ml. 
     
     
         30 . Method according to  claim 2 , wherein the adult mammal is an elderly human. 
     
     
         31 . Method according to  claim 2 , for the treatment or prevention of a disorder or symptom selected from the group of sarcopenia, insufficient muscle protein synthesis, muscle degradation, muscle proteolysis, muscle atrophy, muscle dystrophy, muscle catabolism, muscle wasting, loss of muscle strength, loss of physical capacity and loss of physical performance. 
     
     
         32 . Method according to  claim 2 , for the treatment or prevention of muscle decline and/or loss of muscle mass in a subject during or following body weight maintenance, during or following energy restriction, during or following bed rest or during recovery following physical trauma. 
     
     
         33 . Method according to  claim 32 , wherein the subject is suffering from overweight or obesity, said subject following a weight loss program, an energy restriction program and/or exercise program. 
     
     
         34 . Method according to  claim 1  wherein the composition further comprises whey. 
     
     
         35 . Method according to  claim 2 , wherein the composition further comprises whey.