Device, A Kit And A Method For Treatment Of Disorders In The Heart Rhythm Regulation System

Abstract

A tissue lesion creating device is structured and arranged to be inserted through the vascular system into a body vessel adjacent the heart and to be subsequently subjected to a change of shape in order to penetrate into the heart tissue. The tissue lesion creating device may thus be used for treating disorders to the heart rhythm regulation system. A kit of devices provides a plurality of devices for creating a lesion pattern for treating such disorders.

What is claimed is: 
     
         1 . A tissue cutting device configured for reduction of undesired signal transmission in heart tissue by isolating ectopic sites thereof by cutting said heart tissue,
 wherein the device is structured and arranged to be inserted in a temporary delivery shape through the vascular system into a body vessel adjacent the heart and/or into the heart and to be subsequently subjected to a change of shape via an expanded delivered shape to a further expanded shape, extending at least beyond an outer surface of said tissue, in order to create cutting action configured for cutting said heart tissue and/or said body vessel, wherein the structure is arranged to penetrate by said cutting action through a wall of said vessel into said heart tissue, wherein the device comprises a transversely expandable tubular part having a cross-section, and wherein during said change of shape said cross-section of said tubular part expands such that said tubular part circumferentially penetrates said heart tissue for said reduction.   
     
     
         2 . The tissue cutting device of  claim 1 , wherein the device has an initial elongate shape and wherein the device structure is arranged to change shape from the temporary delivery shape to expand its dimensions in a direction transversally to its elongate direction to the expanded delivered shape and further to the expanded shape. 
     
     
         3 . The tissue cutting device of  claim 1 , wherein the device comprises a shape memory material. 
     
     
         4 . The tissue cutting device of  claim 1 , wherein said tubular part of the device is funnel-shaped. 
     
     
         5 . The tissue cutting device of  claim 1 , wherein said tubular part comprises at least two axially separated tubular portions, which are interconnected by a connecting member. 
     
     
         6 . The tissue cutting device of  claim 5 , wherein said tubular portions are transversely expandable to different degrees. 
     
     
         7 . The tissue cutting device of  claim 1 , wherein an end of the tubular part forms an atrial end, said atrial end being structured and arranged to change shape to extend radially from the tubular part. 
     
     
         8 . The tissue cutting device of  claim 7 , wherein said atrial end comprises a plurality of arches overlapping each other. 
     
     
         9 . The tissue cutting device of  claim 7 , wherein said atrial end, when extending radially from the tubular part, forms an annular flange. 
     
     
         10 . The tissue cutting device of  claim 1 , wherein said device further comprises a cutting arm that is structured and arranged to initially extend axially from the tubular part in order to be inserted into a heart atrium and said cutting arm is structured and arranged to change shape to extend radially from the tubular part. 
     
     
         11 . The tissue cutting device of  claim 10 , wherein the cutting arm has a form comprising at least one closed loop. 
     
     
         12 . The tissue cutting device of  claim 11 , wherein the cutting arm has a form comprising a plurality of closed loops arranged subsequently to each other in a longitudinal direction of the cutting arm. 
     
     
         13 . The tissue cutting device of  claim 10 , wherein the device comprises at least two cutting arms, which are structured and arranged to change shape to extend in different radial directions from the tubular part. 
     
     
         14 . The tissue cutting device of  claim 1 , wherein the tubular part is structured and arranged to be inserted into a coronary sinus. 
     
     
         15 . The tissue cutting device of  claim 14 , wherein the tubular part, in a first state of the device before the device is subjected to a change of shape, strives towards a shape that is curved along its longitudinal direction to fit into the coronary sinus. 
     
     
         16 . The tissue cutting device of  claim 14 , wherein the tubular part has a length corresponding to at least the distance between the two lower pulmonary veins. 
     
     
         17 . The tissue cutting device of  claim 14 , wherein the cross-section of the tubular part is at least partly elliptic. 
     
     
         18 . The tissue cutting device of  claims 14 , wherein said device further comprises a cutting arm that is structured and arranged to initially extend in an axial direction of the tubular part in order to be inserted into the coronary sinus and said cutting arm is structured and arranged to change shape to extend radially from the tubular part. 
     
     
         19 . The tissue cutting device of  claim 1 , wherein an outside surface of the device is provided with sharp edges. 
     
     
         20 . The tissue cutting device of  claim 1 , wherein an outside surface of the device is provided with drugs. 
     
     
         21 . The tissue cutting device of  claim 20 , wherein said drugs include a drug adapted to increase a cutting effect through tissue. 
     
     
         22 . The tissue cutting device of  claim 21 , wherein said drug adapted to increase a cutting effect is selected from the group consisting of alcohol, glutaraldehyde, formaldehyde, and a proteolytic enzyme. 
     
     
         23 . The tissue cutting device of  claim 20 , wherein said drugs include a drug adapted to prohibit a thickening of a wall of the body vessel in which the device is inserted. 
     
     
         24 . The tissue cutting device of  claim 23 , wherein said drug is selected from the gro p consisting of cyclosporin, taxiferol, rapamycin and tacrolimus. 
     
     
         25 . The tissue cutting device of  claim 20 , wherein said drugs are selected from the group consisting of Endothelium Growth Factor, Heparin, amiodarone, sotalol and an antiarrythmic drug. 
     
     
         26 . The tissue cutting device of  claim 1 , wherein said device has a net-like shape formed of closed loops. 
     
     
         27 . The tissue cutting device of  claim 1 , wherein the device is at least partly bioresorbable. 
     
     
         28 . The tissue cutting device of  claim 1 , wherein the device is made of a shape memory polymer, Nitinol, stainless steel, a titanium alloy, or a magnesium alloy.