Composition for Regenerating Hair Follicles Comprising CD36-Expressing Dermal Sheath Cells

Abstract

Provided is a composition for regenerating hair follicles comprising CD36-expressing dermal sheath cells (DSc).

1 . A composition for regenerating hair follicles, comprising CD36-expressing dermal sheath cells (DSc). 
     
     
         2 . The composition for regenerating hair follicles according to  claim 1 , further comprising dermal papilla cells (DPc). 
     
     
         3 . The composition according to  claim 2 , wherein the ratio of the number of CD36 -expressing DSc to the number of DPc is about 10:1 to 1:10. 
     
     
         4 . The composition according to  claim 2  or  3 , wherein the CD36 -expressing DSc and the DPc are both derived from mice or both derived from rats. 
     
     
         5 . The composition according to  claim 2  or  3 , wherein the CD36 expressing DSc and the DPc are heterologous cells, and each of them are derived from mice, rats or humans. 
     
     
         6 . A method for regenerating hair follicles, comprising transplanting the composition according to any of  claims 1  to  5  to a human. 
     
     
         7 . A method. for regenerating hair follicles by transplanting the composition according to any of  claims 1  to  5  to a recipient animal. 
     
     
         8 . The method according to  claim 7 , wherein the recipient animal is an immunosuppressed animal. 
     
     
         9 . The method according to  claim 7  or  8 , wherein the recipient animal is an immunosuppressed animal selected from the group consisting of a nude mouse, SCID mouse and nude rat. 
     
     
         10 . A method for regenerating hair follicles, comprising producing a three-dimensional skin model containing the composition according to any of  claims 2  to  5 . 
     
     
         11 . A chimeric animal imparted with regenerated. hair follicles by transplanting the composition according to any of  claims 1  to  5  to a recipient animal. 
     
     
         12 . The chimeric animal according to  claim 11 , wherein the recipient animal is an immunosuppressed animal. 
     
     
         13 . The chimeric animal according to  claim 11  or  12 , wherein the recipient animal is an immunosuppressed animal selected from the group consisting of a nude mouse, SCID mouse and nude rat. 
     
     
         14 . A three-dimensional skin model imparted with regenerated hair follicles by producing a three-dimensional skin model containing the composition, according to any of  claims 2  to  5 .