Peptide II

Abstract

There is provided an MHC class II peptide epitope from 5T4 antigen. In particular, there is provided a peptide epitope of 5T4 which comprises one of the following: (i) the minimal epitope from the amino acid sequence shown as SEQ ID No. 2; (ii) the minimal epitope from the amino acid sequence shown as SEQ ID No. 3; (iii) a minimal epitope from the region 281-420 of 5T4. There is also provided a vaccine comprising such a peptide (or precursor thereof) and its use to treat and/or prevent a disease, in particular a cancerous disease.

1 . An isolated peptide consisting of the amino acid sequence of SEQ ID NO: 3. 
     
     
         2 . (canceled) 
     
     
         3 . A polyepitope string comprising two or more peptides, wherein each of the peptides consists of the amino acid sequence of SEQ ID NO: 3. 
     
     
         4 . A composition comprising the isolated peptide according to  claim 1  in association with a cell penetrator. 
     
     
         5 . A composition comprising the polyepitope string according to  claim 3  in association with a cell penetrator. 
     
     
         6 . An isolated nucleic acid sequence encoding a peptide, wherein said peptide has an amino acid sequence consisting of the amino acid sequence of SEQ ID NO: 3. 
     
     
         7 . An isolated nucleic acid sequence encoding a polyepitope string comprising two or more peptides, wherein each of the consists of the amino acid sequence of SEQ ID NO: 3. 
     
     
         8 . A cell pulsed with the isolated peptide according to  claim 1 . 
     
     
         9 . An antigen presenting cell according to  claim 8 . 
     
     
         10 - 21 . (canceled) 
     
     
         22 . A composition comprising an isolated peptide consisting of the amino acid sequence of SEQ ID NO: 3 that is bound to an adjuvant.