Activating agent for peroxisome proliferator activated receptor delta

Abstract

A compound represented by the following general formula (II) or a salt thereof is used as an activator of PPARδ. wherein G a is O, CH 2 or the like; A a is thiazole, oxazole, or thiophene, which can have a substituent such as C 1-8 alkyl, C 1-8 alkoxy, halogen, C 1-8 alkyl substituted with halogen or the like; B a is a C 1-8 alkylene or C 2-8 alkenylene chain; and each of R 1a and R 2a independently is hydrogen, C 1-8 alkyl, C 1-8 alkoxy, halogen, C 1-8 alkyl substituted with halogen or the like.

1 - 35 . (canceled) 
     
     
         36 . 3-[4-[3-[4-Isopropyl-2-[4-(trifluoromethyl)phenyl]thiazol-5-yl]propionyl-methylphenyl]propionic acid or a pharmaceutically acceptable salt thereof. 
     
     
         37 . A medicament which contains the compound of  claim 36  or salt thereof and a pharmaceutically acceptable vehicle. 
     
     
         38 . A method for treatment of a disease mediated by peroxisome proliferator activated receptor delta comprising administering to a patient in need thereof an effective dose of the compound of  claim 36 . 
     
     
         39 . The method of  claim 38 , wherein the disease is hyperlipidemia, dyslipidemia, hyperchlolesterolemia, hypertriglyceridemia, HDL hypocholesterolemia, LDL hypercholesterolemia and/or HLD non-cholesterolemia, VLDL hyperproteinemia, dyslipoproteinemia, apolipoprotein A-I hypoproteinemia, atherosclerosis, disease of arterial sclerosis, disease of cardiovascular systems, cerebrovascular disease, peripheral circulatory disease, metabolic syndrome, syndrome X, obesity, diabetes, hyperglycemia, insulin resistance, impaired glucose tolerance, hyperinsulinism, diabetic complication, cardiac insufficiency, cardiac infarction, cardiomyopathy, hypertension, fatty liver, non-alcoholic fatty hepatitis, thrombus, Alzheimer disease, neurodegenerative disease, demyelinating disease, multiple sclerosis, adrenal leukodystrophy, dermatitis, psoriasis, acne, skin aging, trichosis, inflammation, arthritis, asthma, hypersensitive intestine syndrome, ulcerative colitis, Crohn's disease, pancreatitis, or cancer including colon cancer, large intestine cancer, skin cancer, cancer of the breast, carcinoma of the prostate, ovary cancer, or lung cancer. 
     
     
         40 . The method of  claim 39 , wherein the disease is dyslipidemia, metabolic syndrome, obesity, atherosclerosis, or diabetes.