US2013217789A1PendingUtilityA1

Biodegradable liquogel and ph sensitive nanocarriers

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Individually held — no corporate assignee on recordPriority: Sep 3, 2010Filed: Sep 2, 2011Published: Aug 22, 2013
Est. expirySep 3, 2030(~4.1 yrs left)· nominal 20-yr term from priority
Inventors:Darlene K. TaylorMelony A. Ochieng
A61K 47/34A61K 9/0024A61K 9/06C08L 101/005A61K 47/551A61K 47/59A61K 31/565A61K 31/4745C08G 83/006
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Claims

Abstract

A delivery system using materials that form a liquogel or nanocarrier are described. The delivery system comprises hyperbranched polyglycerols (HPGs). The delivery system can include a drug or therapeutic agent and this system can be used to administer the drug or therapeutic agent locally. The delivery system provides for controlled release of the drug or therapeutic agent.

Claims

exact text as granted — not AI-modified
1 . A composition comprising HPG macromers, a crosslinker, a biodegradable component and a thermoresponsive component. 
     
     
         2 . The composition according to  claim 1 , wherein the crosslinker is an acrylate group. 
     
     
         3 . The composition according to  claim 1  wherein the biodegradable component is selected from poly(lactic acid), lactide poly(trimethylene carbonate), poly(c-caprolactone), hyaluronic acid, gelatin, peptides and collagen. 
     
     
         4 . The composition according to  claim 1 , wherein the thermoresponsive component is selected from N-alkyl acrylamide or polyethylene glycol. 
     
     
         5 . The composition according to  claim 1 , comprising acrylic acid, poly(lactic acid), N-isopropylacrylamide, and hyperbranched polyglycerol macromer. 
     
     
         6 . The composition according to  claim 5 , further comprising hydroxyethylmethacrylate. 
     
     
         7 . The composition according to  claim 1 , further comprising a drug or therapeutic agent. 
     
     
         8 . The composition according to  claim 1 , comprising up to 17 weight % of hyperbranched polyglycerol. 
     
     
         9 . A composition comprising hyperbranched polyglycerol (HPG), a pH responsive polymer and at least one drug or therapeutic agent. 
     
     
         10 . The composition according to  claim 9 , comprising hyperbranched polyglycerol, tri(ethyleneglycol) divinyl ether and a drug or therapeutic agent. 
     
     
         11 . The composition according to  claim 9 , wherein the pH responsive polymer is selected from hydrazones, orthoesters and acetals. 
     
     
         12 . The composition according to  claim 1 , which is a liquogel or nanocarrier. 
     
     
         13 - 14 . (canceled) 
     
     
         15 . A method of treating a condition or disease or identifying a disease or condition comprising administering a composition according to  claim 1  to a subject in need thereof 
     
     
         16 . The method of  claim 15 , wherein the composition is administered to target tissue. 
     
     
         17 . The method of  claim 15 , wherein the composition is administered by injection.

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