US2013224276A1PendingUtilityA1
Compositions and methods for coating medical implants
Est. expiryMay 24, 2022(expired)· nominal 20-yr term from priority
A61P 43/00A61L 29/085A61L 2300/416A61L 29/16A61L 27/34A61L 2300/404A61L 27/54A61P 31/00
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Claims
Abstract
Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or reducing the incidence of infection associated with the implant.
Claims
exact text as granted — not AI-modified1 - 12 . (canceled)
13 . A composition, comprising a polymer and a fluoropyrimidine, wherein said fluoropyrimidine is present in said composition at a concentration of less than 10 −4 M.
14 . The composition according to claim 13 wherein said fluoropyrimidine is present in said composition at a concentration of less than any one of 10 −5 M, 10 −6 M, or 10 −7 M.
15 . The composition according to claim 13 wherein said polymer is a non-biodegradable polymer.
16 . The composition according to claim 13 wherein said polymer is a polyurethane.
17 . The composition according to claim 13 wherein said polymer is a poly(lactide-co-glycolide).
18 . The composition according to claim 13 wherein said fluoropyrimidine is 5-fluorouracil.
19 . A method for reducing or inhibiting infection associated with a medical implant, comprising the step of introducing into a patient a medical implant which has been covered or coated with a fluoropyrimidine.
20 . The method according to claim 19 wherein said fluoropyrimidine is 5-fluorouracil.
21 . A method for making medical implants, comprising covering or coating a medical implant with a fluoropyrimidine.
22 . The method according to claim 21 wherein said fluoropyrimidine is 5-fluorouracil.
23 . The method according to claim 21 wherein said medical implant covered or coated by dipping or by impregnation.Cited by (0)
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