Haloaryl substituted aminopurines, compositions thereof,and methods of treatment therewith

Abstract

Provided herein are Aminopurine Compounds having the following structure: wherein R 1 , R 2 and R 3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

What is claimed is: 
     
         1 . A compound having the formula (I): 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, 
         wherein: 
         R 1  is substituted or unsubstituted aryl or substituted or unsubstituted C 3-10 heterocycle; 
         R 2  is substituted or unsubstituted C 3-10 cycloalkyl; and 
         R 3  is aryl substituted with one or more halogens. 
       
     
     
         2 . A compound of  claim 1  wherein R 1  is substituted or unsubstituted aryl. 
     
     
         3 . A compound of  claim 1  wherein R 1  is substituted or unsubstituted C 3-10 heterocycle. 
     
     
         4 . A compound of  claim 1  wherein R 2  is substituted or unsubstituted aryl. 
     
     
         5 . A compound of  claim 1  wherein R 2  is unsubstituted C 3-10 cycloalkyl. 
     
     
         6 . A compound of  claim 1  wherein R 2  is cyclohexyl substituted with one or more hydroxyl or aminocarbonyl, cyano, acylamino, alkanesulfonylamino, tetrazolyl, triazolyl or imidazolyl groups. 
     
     
         7 . A compound of  claim 1  wherein R 2  is unsubstituted cyclopentyl. 
     
     
         8 . A compound of  claim 1  wherein R 3  is fluoro substituted aryl. 
     
     
         9 . A compound of  claim 1  having the formula: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         10 . A compound of  claim 9  having the formula: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         11 . A compound of  claim 9  having the formula: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         12 . A compound of  claim 9  having the formula: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         13 . A pharmaceutical composition comprising a compound of  claim 1  and a pharmaceutically acceptable carrier, excipient or diluent. 
     
     
         14 . The pharmaceutical composition of  claim 13  suitable for oral, parenteral, mucosal, transdermal or topical administration. 
     
     
         15 . A pharmaceutical composition comprising a compound of  claim 9  and a pharmaceutically acceptable carrier, excipient or diluent. 
     
     
         16 . The pharmaceutical composition of  claim 15  suitable for oral, parenteral, mucosal, transdermal or topical administration. 
     
     
         17 . A pharmaceutical composition comprising a compound of  claim 10  and a pharmaceutically acceptable carrier, excipient or diluent. 
     
     
         18 . A pharmaceutical composition comprising a compound of  claim 10  and a pharmaceutically acceptable carrier, excipient or diluent. 
     
     
         19 . A pharmaceutical composition comprising a compound of  claim 11  and a pharmaceutically acceptable carrier, excipient or diluent. 
     
     
         20 . A pharmaceutical composition comprising a compound of  claim 12  and a pharmaceutically acceptable carrier, excipient or diluent.