US2013236891A1PendingUtilityA1

Method and composition for the treatment, prevention, and diagnosis of cancer containing or derived from cancer stem cells

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Assignee: OCHIYA TAKAHIROPriority: Aug 20, 2010Filed: Jan 24, 2011Published: Sep 12, 2013
Est. expiryAug 20, 2030(~4.1 yrs left)· nominal 20-yr term from priority
Inventors:Takahiro Ochiya
C12Q 2600/158C12N 2310/14C12N 15/1137C12Q 2600/118C12N 2310/531G01N 2333/91097A61K 31/7105C12Q 1/6886C12Q 2600/106C12N 2320/32C12Y 204/99018A61P 35/00C12N 2310/3513A61P 43/00A61P 35/04G01N 33/57515G01N 33/575G01N 33/5758
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Claims

Abstract

The invention provides a method and composition for the treatment, prevention, and diagnosis of cancer containing or derived from cancer stem cells.

Claims

exact text as granted — not AI-modified
1 . A pharmaceutical composition comprising an RPN2 inhibitor for the treatment or prevention of cancer containing or derived from cancer stem cells. 
     
     
         2 . The pharmaceutical composition according to  claim 1 , wherein the cancer stem cells carry a mutated p53 gene. 
     
     
         3 . The pharmaceutical composition according to  claim 1  or  2 , wherein the RPN2 inhibitor is an siRNA against the RPN2 gene. 
     
     
         4 . A method for detecting cancer stem cells, comprising determining the presence or level of RPN2 expression. 
     
     
         5 . The method according to  claim 4 , further comprising detecting a mutated p53 gene.

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