Compositions comprising amino acids for prevention and/or treatment of renal disorders

Abstract

Composition comprising leucine, isoleucine, valine, threonine and lysine for use in prophylactic and/or therapeutic treatment of renal disorders in a subject, preferably an elderly subject.

1 . Composition comprising leucine, isoleucine, valine, threonine and lysine for use in prevention and/or treatment of renal disorder in a subject, preferably an elderly subject. 
     
     
         2 . Composition according to  claim 1 , wherein the renal disorder is selected among: chronic kidney disease, end-stage renal disease, renal failure, diabetic nephropaty, glomerulonephritis, hydronephrosis, interstitial nephritis, nephritic syndrome. 
     
     
         3 . Composition according to  claim 1 , wherein the composition is suitable for oral administration. 
     
     
         4 . Composition according to  claim 1 , wherein the composition is suitable for chronic administration over a long period of time. 
     
     
         5 . Composition according to  claim 1 , wherein
 the leucine:isoleucine molar ratio is comprised in the range of 1:0.2-0.7, preferably between 1:0.4-0.6, and/or   the leucine:valine molar ratio is comprised in the range of 1:0.2-0.8, preferably between 1:0.4-0.7.   
     
     
         6 . Composition according to  claim 1 , wherein
 the leucine:threonine molar ratio is comprised in the range of 1:0.15-0.50, preferably between 1:0.20-0.45, and/or   the leucine:lysine molar ratio is comprised in the range of 1:0.15-0.60, preferably between 1:0.30-0.55.   
     
     
         7 . Composition according to  claim 1 , wherein the leucine:isoleucine:valine weight ratio is substantially equivalent to 2:1:1. 
     
     
         8 . Composition according to  claim 1 , wherein for an overall amount of leucine, isoleucine and valine equivalent to a mole, then threonine and lysine are in an overall molar ratio with respect to leucine, isoleucine and valine comprised between 0.10 and 0.50 (1:0.10-0.50), preferably between 0.25 and 0.45 (1:0.25-0.45). 
     
     
         9 . Composition according to  claim 1 , wherein said composition further comprises at least one of the following amino acids: histidine, phenylalanine, methionine, tryptophan, tyrosine, cysteine, cystine. 
     
     
         10 . Composition according to  claim 9 , wherein for an overall amount of leucine, isoleucine, valine, threonine and lysine equivalent to a mole, then histidine, phenylalanine, methionine and tryptophan are in an overall molar ratio with respect to leucine, isoleucine, valine, threonine and lysine comprised between 0.02 and 0.25 (1:0.02-0.25), preferably between 0.05 and 0.15 (1:0.05-0.15). 
     
     
         11 . Composition according to  claim 9 , wherein said composition comprises methionine and cystine and/or cysteine, the methionine:cystine and/or cysteine molar ratio being comprised in the range 1:1-3.5. 
     
     
         12 . Composition according to  claim 9 , wherein said composition comprises phenylalanine and tyrosine, the phenylalanine:tyrosine molar ratio being comprised in the range 1:0.15-0.5, preferably 1:0.2-0.35. 
     
     
         13 . Composition according to  claim 1 , wherein said composition is free of arginine. 
     
     
         14 . Composition according to  claim 1 , wherein said composition is free of serine, proline, glycine, alanine, glutamic acid. 
     
     
         15 . Composition for preventing and/or treating renal disorders in a subject, particularly but not exclusively an elderly subject, the composition comprising the following main active ingredients:
 the branched amino acid leucine in combination with at least one of, preferably both, the branched chain amino acids isoleucine and valine, and   at least one of, preferably both, the essential amino acids threonine and lysine.