Antiviral compositions

Abstract

This invention provides virucidally-enhanced alcoholic compositions. The compositions include at least about 50 wt. % of a C 1-6 alcohol, one or more enhancers selected from the group consisting of cationic oligomers and polymers, chaotropic agents, and mixtures thereof. When the alcoholic composition comprises at least one cationic oligomer or polymer, the composition further includes at least one additional enhancer selected from the group consisting of zinc compounds and copper compounds. The virucidal composition exhibits an efficacy against acid stable non-enveloped viruses that is higher than the efficacy of the same composition but not comprising the enhancers.

What is claimed is: 
     
         1 . A virucidally-enhanced alcoholic composition comprising:
 at least 50 wt. % of a C 1-6  alcohol, based upon the total weight of the alcoholic composition,   an efficacy-enhancing amount of one or more enhancers selected from the group consisting of cationic oligomers and polymers, chaotropic agents, and mixtures thereof,   with the proviso that when the alcoholic composition comprises at least one cationic oligomer or polymer, the composition further comprises at least one additional enhancer selected from the group consisting of zinc compounds and copper compounds,   wherein said chaotropic agent is selected from the group consisting of urea, thiourea, guanidine HCl, guanidine thiocyanate, aminoguanidine HCl, and mixtures thereof, and   wherein said virucidal composition exhibits an efficacy against acid stable non-enveloped viruses that is higher than the efficacy of the same composition but not comprising said enhancers.   
     
     
         2 . The composition of  claim 1 , wherein said virucidal composition exhibits an efficacy against acid stable non-enveloped virus that is at least about 0.5 log reduction higher than the efficacy of the same composition but not comprising said enhancers. 
     
     
         3 . The composition of  claim 1 , wherein said virucidal composition exhibits an efficacy against acid stable non-enveloped virus that is at least about 1 log reduction higher than the efficacy of the same composition but not comprising said enhancers. 
     
     
         4 . The composition of  claim 1 , wherein said cationic oligomer or polymer is selected from the group consisting of cationic polyalkylene imines, cationic ethoxy polyalkylene imines, cationic poly[N-[3-(dialkylammonio)alkyl]N′[3-(alkyleneoxyalkylene dialkylammonio)alkyl]urea dichloride], vinyl caprolactam/VP/dialkylaminoalkyl alkylate copolymers, polyquaternium polymers and mixtures thereof. 
     
     
         5 . The composition of  claim 1 , wherein said cationic oligomer or polymer comprises a polyquaternium selected from the group consisting of polyquaternium-2, polyquaternium-4, polyquaternium-5, polyquaternium-6, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-16, polyquaternium-22, polyquaternium-24, polyquaternium-28, polyquaternium-32, polyquaternium-37, polyquaternium-39, polyquaternium-42, polyquaternium-43, polyquaternium-44, polyquaternium-46, polyquaternium-47, polyquaternium-51, polyquaternium-53, polyquaternium-55, polyquaternium-57, polyquaternium-58, polyquaternium-59, polyquaternium-60, polyquaternium-63, polyquaternium-64, polyquaternium-65, polyquaternium-68, and mixtures thereof. 
     
     
         6 . The composition of  claim 1 , wherein said composition comprises from about 0.2 to about 2 percent by weight of a cationic oligomer or polymer selected from the group consisting of polyquaternium-2, polyquaternium-16, polyquaternium-22, polyquaternium-37, and mixtures thereof, based upon the total weight of the composition. 
     
     
         7 . The composition of  claim 1 , wherein said composition comprises from about 0.25 to about 10 percent by weight of a chaotropic agent. 
     
     
         8 . The composition of  claim 1 , wherein said zinc compound is aluminum zinc oxide, ammonium silver zinc aluminum silicate, ethylene/zinc acrylate copolymer,  lactobacillus /milk/calcium/phosphorus/magnesium/zinc ferment,  lactobacillus /milk/manganese/zinc ferment lysate, luminescent zinc sulfide, magnesium/aluminum/zinc/hydroxide/carbonate, porphyridium/zinc ferment,  saccharomyces /zinc ferment,  saccharomyces /zinc/iron/germanium/copper/magnesium/silicon ferment,  saccharomyces /zinc/magnesium/calcium/germanium/selenium ferment, silicon/titanium/cerium/zinc oxides, sodium zinc cetyl phosphate, sodium zinc histidine dithiooctanamide, zinc acetate, zinc acetylmethionate, zinc adenosine triphosphate, zinc ascorbate, zinc aspartate, zinc borate, zinc borosilicate, zinc carbonate, zinc carbonate hydroxide, zinc cerium oxide, zinc chloride, zinc citrate, zinc coceth sulfate, zinc coco-sulfate, zinc cysteinate, zinc dibutyldithiocarbamate, zinc DNA, zinc formaldehyde sulfoxylate, zinc glucoheptonate, zinc gluconate, zinc glutamate, zinc glycinate, zinc glycyrrhetinate, zinc hexametaphosphate, zinc hydrolyzed collagen, zinc lactate, zinc laurate, zinc magnesium aspartate, zinc myristate, zinc neodecanoate, zinc oxide, zinc palmitate, zinc PCA, zinc pentadecene tricarboxylate, zinc peroxide, zinc phenolsulfonate, zinc picolinate, zinc pyrithione, zinc ricinoleate, zinc rosinate, zinc salicylate, zinc silicates, zinc stearate, zinc sulfate, zinc sulfide, zinc thiosalicylate, zinc undecylenate, zinc undecylenoyl hydrolyized wheat protein, and zinc zeolite, or mixture thereof. 
     
     
         9 . The composition of  claim 1 , wherein said copper compound is copper sulfate, copper citrate, copper oxylate, copper usnate, copper acetate, copper chloride, copper carbonate, alanine/histidine/lysine polypeptide copper HCl, bis(tripeptide-1) copper acetate, chlorophyllin-copper complex, copper acetylmethionate, copper acetyl tyrosinate methylsilano, copper adenosine triphosphate, copper aspartate, copper chlorophyll, copper DNA, copper gluconate, copper PCA, copper PCA methylsilanol, copper picolinate, copper powder, copper sulfate, copper tripeptide-1, disodium EDTA-copper,  saccharomyces /copper ferment,  saccharomyces /copper ferment lysate filtrate,  saccharomyces /zinc/iron/germanium/copper/magnesium/silicon ferment, and silver copper zeolite, or a mixture thereof. 
     
     
         10 . The composition of  claim 1 , wherein said composition comprises from about 0.0001 to about 0.8 percent by weight of a copper or zinc compound. 
     
     
         11 . The composition of  claim 1 , where the composition comprises from about 50 to about 98 wt. % ethanol, from about 0.02 to about 20 wt. % cationic oligomer or polymer, and from about 0.0001 to about 0.8 wt. % copper or zinc compound, all based upon the total weight of the alcoholic composition. 
     
     
         12 . The composition of  claim 1 , where the composition comprises from about 50 to about 98 wt. % ethanol, from about 0.02 to about 20 wt. % polyquaternium-37, and from about 0.0001 to about 0.8 wt. % copper gluconate, all based upon the total weight of the alcoholic composition. 
     
     
         13 . A virucidally-enhanced alcoholic composition comprising:
 at least 50 wt. % of a C 1-6  alcohol, based upon the total weight of the alcoholic composition,   an efficacy-enhancing amount of one or more cationic oligomers and polymers, and   at least one zinc or copper compound,   wherein said virucidal composition exhibits an efficacy against acid stable non-enveloped viruses that is higher than the efficacy of the same composition but not comprising said cationic oligomer or polymer and said zinc or copper compound.   
     
     
         14 . The composition of  claim 13 , wherein said virucidal composition exhibits an efficacy against acid stable non-enveloped virus that is at least about 0.5 log reduction higher than the efficacy of the same composition but not comprising said enhancers. 
     
     
         15 . The composition of  claim 13 , wherein said virucidal composition exhibits an efficacy against acid stable non-enveloped virus that is at least about 1 log reduction higher than the efficacy of the same composition but not comprising said cationic oligomer or polymer and said copper or zinc compound. 
     
     
         16 . The composition of  claim 13 , wherein said enhancer comprises a cationic oligomer or polymer selected from the group consisting of cationic polyalkylene imines, cationic ethoxy polyalkylene imines, cationic poly[N-[3-(dialkylammonio)alkyl]N′[3-(alkyleneoxyalkylene dialkylammonio)alkyl]urea dichloride], vinyl caprolactam/VP/dialkylaminoalkyl alkylate copolymers, polyquaternium polymers and mixtures thereof. 
     
     
         17 . The composition of  claim 13 , wherein said cationic oligomer or polymer comprises a polyquaternium selected from the group consisting of polyquaternium-2, polyquaternium-4, polyquaternium-5, polyquaternium-6, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-16, polyquaternium-22, polyquaternium-24, polyquaternium-28, polyquaternium-32, polyquaternium-37, polyquaternium-39, polyquaternium-42, polyquaternium-43, polyquaternium-44, polyquaternium-46, polyquaternium-47, polyquaternium-51, polyquaternium-53, polyquaternium-55, polyquaternium-57, polyquaternium-58, polyquaternium-59, polyquaternium-60, polyquaternium-63, polyquaternium-64, polyquaternium-65, polyquaternium-68, and mixtures thereof. 
     
     
         18 . The composition of  claim 13 , wherein said composition comprises from about 0.2 to about 2 percent by weight of a cationic oligomer or polymer selected from the group consisting of polyquaternium-2, polyquaternium-16, polyquaternium-22, polyquaternium-37, and mixtures thereof, based upon the total weight of the composition. 
     
     
         19 . The composition of  claim 13 , wherein said composition further comprises aluminum zinc oxide, ammonium silver zinc aluminum silicate, ethylene/zinc acrylate copolymer,  lactobacillus /milk/calcium/phosphorus/magnesium/zinc ferment,  lactobacillus /milk/manganese/zinc ferment lysate, luminescent zinc sulfide, magnesium/aluminum/zinc/hydroxide/carbonate, porphyridium/zinc ferment,  saccharomyces /zinc ferment,  saccharomyces /zinc/iron/germanium/copper/magnesium/silicon ferment,  saccharomyces /zinc/magnesium/calcium/germanium/selenium ferment, silicon/titanium/cerium/zinc oxides, sodium zinc cetyl phosphate, sodium zinc histidine dithiooctanamide, zinc acetate, zinc acetylmethionate, zinc adenosine triphosphate, zinc ascorbate, zinc aspartate, zinc borate, zinc borosilicate, zinc carbonate, zinc carbonate hydroxide, zinc cerium oxide, zinc chloride, zinc citrate, zinc coceth sulfate, zinc coco-sulfate, zinc cysteinate, zinc dibutyldithiocarbamate, zinc DNA, zinc formaldehyde sulfoxylate, zinc glucoheptonate, zinc gluconate, zinc glutamate, zinc glycinate, zinc glycyrrhetinate, zinc hexametaphosphate, zinc hydrolyzed collagen, zinc lactate, zinc laurate, zinc magnesium aspartate, zinc myristate, zinc neodecanoate, zinc oxide, zinc palmitate, zinc PCA, zinc pentadecene tricarboxylate, zinc peroxide, zinc phenolsulfonate, zinc picolinate, zinc pyrithione, zinc ricinoleate, zinc rosinate, zinc salicylate, zinc silicates, zinc stearate, zinc sulfate, zinc sulfide, zinc thiosalicylate, zinc undecylenate, zinc undecylenoyl hydrolyized wheat protein, and zinc zeolite, or mixture thereof. 
     
     
         20 . The composition of  claim 13 , wherein said composition further comprises copper sulfate, copper citrate, copper oxylate, copper usnate, copper acetate, copper chloride, copper carbonate, alanine/histidine/lysine polypeptide copper HCl, bis(tripeptide-1) copper acetate, chlorophyllin-copper complex, copper acetylmethionate, copper acetyl tyrosinate methylsilano, copper adenosine triphosphate, copper aspartate, copper chlorophyll, copper DNA, copper gluconate, copper PCA, copper PCA methylsilanol, copper picolinate, copper powder, copper sulfate, copper tripeptide-1, disodium EDTA-copper,  saccharomyces /copper ferment,  saccharomyces /copper ferment lysate filtrate,  saccharomyces /zinc/iron/germanium/copper/magnesium/silicon ferment, and silver copper zeolite, or a mixture thereof. 
     
     
         21 . The composition of  claim 13 , wherein said composition further comprises from about 0.0001 to about 0.8 percent by weight of a copper or zinc compound. 
     
     
         22 . The composition of  claim 13 , where the composition comprises from about 50 to about 98 wt. % ethanol, from about 0.02 to about 20 wt. % cationic oligomer or polymer, and from about 0.0001 to about 0.8 wt. % copper or zinc compound, all based upon the total weight of the alcoholic composition. 
     
     
         23 . The composition of  claim 13 , where the composition comprises from about 50 to about 98 wt. % ethanol, from about 0.02 to about 20 wt. % polyquaternium-37, and from about 0.0001 to about 0.8 wt. % copper gluconate, all based upon the total weight of the alcoholic composition. 
     
     
         24 . A virucidally-enhanced alcoholic composition comprising:
 at least 50 wt. % of a C 1-6  alcohol, based upon the total weight of the alcoholic composition,   an efficacy-enhancing amount of one or more chaotropic agents,   wherein said chaotropic agent is selected from the group consisting of urea, thiourea, guanidine HCl, guanidine thiocyanate, aminoguanidine HCl, and mixtures thereof and   wherein said virucidal composition exhibits an efficacy against acid stable non-enveloped viruses that is higher than the efficacy of the same composition but not comprising said chaotropic agent.