Hyaluronic acid-collagen matrices for dermal filling and volumizing applications

Abstract

Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

What is claimed is: 
     
         1 . A soft tissue aesthetic product comprising:
 a filler comprising a hydrogel having a form suitable for injecting into mammalian tissue; and   a label comprising instructions to inject the filler into the tissue;   wherein the hydrogel comprises water, and a crosslinked macromolecular matrix comprising:   a hyaluronic acid component; and   a collagen component;   wherein the hyaluronic acid component is crosslinked to the collagen component by a crosslinking component; and   wherein the crosslinking component comprises a plurality of crosslink units, wherein at least a portion of the crosslink units comprise an ester bond or an amide bond.   
     
     
         2 . The product of  claim 1 , wherein the collagen component comprises collagen type I or collagen type III. 
     
     
         3 . The product of  claim 1 , wherein crosslinked macromolecular matrix has a weight ratio of the hyaluronic acid component to the collagen component of about 1 to about 3. 
     
     
         4 . The product of  claim 1 , wherein the hydrogel is in the form of a dermal filler. 
     
     
         5 . The product of  claim 1 , wherein the hydrogel is in the form of a lip filler. 
     
     
         6 . A method of improving an aesthetic quality of soft tissue of a human being comprising:
 injecting a hydrogel composition into a soft tissue of the human being to thereby improve the aesthetic quality of the soft tissue;   wherein the hydrogel composition comprises water, and a crosslinked macromolecular matrix comprising:   a hyaluronic acid component; and   a collagen component;   wherein the hyaluronic acid component is crosslinked to the collagen component by a crosslinking component; and   wherein the crosslinking component comprises a plurality of crosslink units, wherein at least a portion of the crosslink units comprise an ester bond or an amide bond.   
     
     
         7 . The method of  claim 6 , wherein the collagen component comprises collagen type I or collagen type III. 
     
     
         8 . The method of  claim 6 , wherein the hydrogel is in the form of a dermal filler. 
     
     
         9 . The method of  claim 6 , wherein the hydrogel is in the form of a lip filler. 
     
     
         10 . A dermal filler comprising:
 a hydrogel having a form suitable for injecting into mammalian tissue;   wherein the hydrogel comprises water, and a crosslinked macromolecular matrix comprising:   a hyaluronic acid component; and   a collagen component;   wherein the hyaluronic acid component is crosslinked to the collagen component by a crosslinking component; and   wherein the crosslinking component comprises a plurality of crosslink units, wherein at least a portion of the crosslink units comprise an ester bond or an amide bond.   
     
     
         11 . The dermal filler of  claim 10 , wherein the collagen component comprises collagen type I or collagen type III. 
     
     
         12 . The dermal filler of  claim 10 , wherein crosslinked macromolecular matrix has a weight ratio of the hyaluronic acid component to the collagen component of about 1 to about 3. 
     
     
         13 . The dermal filler of  claim 10  wherein the crosslinked macromolecular matrix has a weight ratio of the hyaluronic acid component to the collagen component of about 1 to about 7.