Compounds and Mixtures Influencing Inflammatory States

Abstract

Suggested is a compound of the formula (X) or any salt of a compound of the formula (X) or any mixture containing or consisting of two or more different compounds of the formula (X), two or more different salts of compounds of the formula (X) or one or more different compounds of the formula (X) and one or more different salts of compounds of the formula (X), wherein for R1, R2 and R3 independently of one another in every compound of the formula (X) the following applies: R1 means hydrogen or methyl, R2 means an organic residue with 5 carbon atoms and one oxygen atom or none and R3 means an organic residue with 10 carbon atoms and one or more oxygen atoms, or R1 and R2 together with the carbon atoms in positions 4 and 5 and the oxygen atom bound to the carbon atom in position 4 form a ring and comprise 5 carbon atoms and one oxygen atom or none, and R3 means an organic residue with 10 carbon atoms and one or more oxygen atoms, for use in a method for the prophylaxis and/or treatment of inflammation.

1 - 30 . (canceled) 
     
     
         31 . A compound of the formula (X) 
       
         
           
           
               
               
           
         
         or any salt of a compound of the formula (X) or any mixture containing or consisting of two or more different compounds of the formula (X), two or more different salts of compounds of the formula (X) or one or more different compounds of the formula (X) and one or more different salts of compounds of the formula (X), wherein for 
         R1, R2 and R3 independently of one another in every compound of the formula (X) the following applies: 
         R1 is hydrogen or methyl, 
         R2 is an organic residue with 5 carbon atoms and one oxygen atom or none and 
         R3 is an organic residue with 10 carbon atoms and one or more oxygen atoms, 
         or 
         R1 and R2 together with the carbon atoms in positions 4 and 5 and the oxygen atom bound to the carbon atom in position 4 form a ring and comprise 5 carbon atoms and one oxygen atom or none, and 
         R3 is an organic residue with 10 carbon atoms and one or more oxygen atoms. 
       
     
     
         32 . The compound, salt or mixture according to  claim 31 , wherein for the groups R1, R2 and R3 in the compound of the formula (X) or independently of one another in one, several or all, preferably all, compound(s) of the formula (X) the following applies:
 R3 is   
       
         
           
           
               
               
           
         
          wherein the dotted line which links the carbon atoms designated as B and C denotes a single bond or a double bond is present between these carbon atoms, and the dotted line which links the carbon atoms designated as E and G means an individual double bond, which is positioned either between the carbon atoms designated as F and G or between the carbon atoms designated as E and F, 
         R7 for the case where the double bond is positioned between the carbon atoms designated as E and F, is a hydroxy group or, for the case where the double bond is positioned between the carbon atoms designated as F and G, is absent, 
         R5 and R6 is a hydrogen atom and a hydroxy group or together are an oxygen atom, the dashed line marks the bond which links R3 with the carbon atom in position 3; 
         R1 is hydrogen or methyl and 
         R2 is 
       
       
         
           
           
               
               
           
         
          wherein R4 is hydrogen or a hydroxy group and the dashed line marks the bond which links R2 with the carbon atom in position 5 
         or 
         R1 and R2 together is 
       
       
         
           
           
               
               
           
         
          wherein the dashed line (a) marks the bond which links the tertiary carbon atom with the oxygen atom bound to the carbon atom in position 4 and the dashed line (b) marks the bond which links the secondary carbon atom with the carbon atom in position 5. 
       
     
     
         33 . The compound, salt or mixture of  claim 31 , wherein one, several or all compound(s) of the formula (X) is selected or are each selected independently of one another from the group consisting of the following compounds (1) to (10): 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
         34 . The mixture of  claim 31 , containing or consisting of two or more different compounds of the formula (X), preferably of two, three, four, five, six, seven, eight, nine or ten different compounds of the formula (X). 
     
     
         35 . The mixture of  claim 33 , containing or consisting of two or more different compounds of the formula (X) selected from the group consisting of the compounds (1) to (10). 
     
     
         36 . A Mixture comprising a compound of the formula (X) or a salt of the formula (X) to  claim 31 , additionally comprising a hydroxyflavone of the formula (Y) 
       
         
           
           
               
               
           
         
         or a salt of a hydroxyflavone of the formula (Y) or a mixture containing or consisting of two or more different hydroxyflavones of the formula (Y), two or more different salts of hydroxyflavones of the formula (Y) or one or more different hydroxyflavones of the formula (Y) and one or more different salts of hydroxyflavones of the formula (Y), wherein for Q1, Q2, Q3, Q4, Q5, Q6, Q7, Q8 and Q9 independently of one another in each hydroxyflavone of the formula (Y) the following applies: Q1 to Q9 independently of one another is hydrogen atoms, hydroxy groups, methyl, ethyl, 1-propyl, methoxy, ethoxy, 1-propyloxy or 2-propyloxy groups, with the proviso that at least one of the residues Q1 to Q9 represents a hydroxy group. 
       
     
     
         37 . The mixture of  claim 36 , wherein the following applies: Q2, Q4, Q5, Q8 and Q9 represent hydrogen atoms, Q1, Q3 and Q6 independently of one another are hydrogen atoms, hydroxy or methoxy groups, with the proviso that at least one of the residues Q1 and Q3 represents a hydroxy group and Q7 represents a hydroxy group. 
     
     
         38 . The mixture of  claim 36 , containing one, several or all compounds of the formula (Y) selected from the group consisting of homoeriodictyol, sterubin, eriodictyol, hesperetin, chrysoeriol and luteolin, preferably comprising homoeriodictyol. 
     
     
         39 . The mixture of  claim 36 , wherein the proportion of the total quantity of compounds of the formula (X) and salts of compounds of the formula (X) in the mixture, based on the total weight of the mixture, is 1 to 99 wt. %, 
       and/or
 the proportion of the total quantity of compounds of the formula (Y) and salts of compounds of the formula (Y) in the mixture, based on the total weight of the mixture, is 1 to 99 wt. %. 
 
     
     
         40 . The mixture of  claim 36 , wherein the proportion of the total quantity of compounds of the formula (X), compounds of the formula (Y), salts of compounds of the formula (X) and salts of compounds of the formula (Y) in the mixture, based on the total weight of the mixture, is 0.0001 to 100 wt. %. 
     
     
         41 . The mixture of  claim 36 , wherein the mixture comprises a plant extract or consists thereof, and the proportion of the total quantity of compounds of the formula (X) and salts of compounds of the formula (X) in the mixture, based on the total weight of the mixture, is preferably 0.1 to 100 wt. %. 
     
     
         42 . The mixture of  claim 36 , wherein the plant extract is an extract from  Eriodictyon  ssp. 
     
     
         43 . The mixture of  claim 36 , wherein the ratio of the total quantity of compounds of the formula (X) and salts of compounds of the formula (X) to the total quantity of compounds of the formula (Y) and salts of compounds of the formula (Y) lies in the range from 0.00001:1 to 1:0.00001 based on the weight. 
     
     
         44 . A preparation comprising a compound, a salt or a mixture as defined in  claim 31 , for the prophylaxis and/or treatment of inflammation. in particular of inflammation of the skin. 
     
     
         45 . The preparation of  claim 44 , which is a food or enjoyment preparation, a pharmaceutical preparation, a cosmetic preparation or a dermatological preparation. 
     
     
         46 . The preparation of  claim 44 , additionally containing one or more further components selected from the group consisting of probiotic bacteria, prebiotics, synbiotics, ballast substances, whey proteins, soya proteins, minerals, tocopherols, vanilla, vanilla extracts, omega-3 fatty acids, citrus, apple, grape seed, green tea, rosemary, tarragon, thyme, horseradish and mace extracts, tannins, tomato, melon and rosehip extracts, beta-carotene; aubergines, rhubarb, red onions, red cabbage, black carrot, superfruits, in particular açai, noni, goji, pomegranate, mangosteen, currants, strawberries, aronia, blueberries and/or elderberries, preferably in the form of dried fruit, extracts or fruit preparations; soya isoflavones, nonsteroidal antiinflammatory drugs, antibiotics, budesonide, systemically active steroids, sulfasalazine, azathioprine/6-mercaptopurine, methotrexate, anti-TNF-alpha antibodies, bisabolol, sodium lauryl-sulphate, chlorhexidine, metal fluorides, organic and inorganic fluorides, flavourings, essential oils, cooling active substances, in particular menthol, extracts of pure substances from eucalyptus, thyme, wintergreen, spearmint and peppermint. 
     
     
         47 . The preparation of  claim 44 , for the treatment of animal or human skin which requires a treatment with anti-inflammatory active substances. 
     
     
         48 . A method for the prophylaxis and/or treatment of inflammation comprising administering a compound or salt of formula (X) or mixture according to  claim 31 . 
     
     
         49 . The method of  claim 48  for at least one of
 a) prophylaxis and/or treatment of inflammation of the skin, 
 b) reducing the release of TNF-alpha, 
 c) reducing the release of an interleukin, 
 d) reducing the release of a prostaglandin, or 
 e) reducing the release of interferon-gamma and/or NF-κB. 
 
     
     
         50 . The method of  claim 49 , wherein the method for the prophylaxis and/or treatment of inflammation is or comprises
 (a) a method for the prophylaxis and/or treatment of chronic inflammatory diseases and/or   (b) a method for strengthening damaged or undamaged skin, and/or   (c) a method for reducing tissue damage, and/or   (d) a method for recreating a normal cellular composition in the intestine, and/or   (e) a method for recreating or stabilizing the function of skin.   
     
     
         51 . A process for obtaining the mixture of  claim 36  comprising the following steps:
 (a) extraction of plant material from  Eriodictyon  ssp., preferably from  Eriodictyon califormicum  and/or  Eriodictyon angustifolium , so that a mixture is formed which contains compounds of the formula (X), optionally compounds of the formula (Y) and other extracted compounds, and 
 (b) concentration of extracted compounds of the formula (X) and/or salts of the extracted compounds of the formula (X) and optionally compounds of the formula (Y) and/or salts of the extracted compounds of the formula (Y) in the mixture by partial or complete removal of other extracted compounds and optionally removal of extractants and/or solvents. 
 
     
     
         52 . The process of  claim 51 , wherein the proportion of the total quantity of compounds of the formula (X) and salts of compounds of the formula (X) in the mixture based on the total weight of the mixture is 0.1 to 100 wt. %.