Batch filtration system for preparation of sterile fluid for renal replacement therapy

Abstract

A first connector of a connector assembly of a sterile batch container can be unsealed. The connector assembly can be attached to a filling port of the sterile batch container and can have a sterile filter arranged between the filling port and the first connector. The first connector can be coupled so as to receive produced purified water. A transmembrane pressure can be monitored across the sterile filter while flowing the purified water through the connector assembly into the sterile batch container so as to provide a sterile fluid stored therein. The connector assembly can be detached from the filling port of the sterile batch container. After the detaching, the sterile batch container can be coupled to the blood treatment system. In response to a change in the transmembrane pressure exceeding a predefined level, an alarm signal can be generated.

1 . (canceled) 
     
     
         2 . A device for preparing replacement fluid for an extracorporeal blood treatment, comprising:
 a replaceable fluid circuit including a sealed pre-sterilized replacement fluid container, which contains a replacement fluid concentrate, and a port that allows diluting water to be added to said replacement fluid concentrate by passing through said port; and   a water treatment plant connectable to said replaceable fluid circuit for supplying water to the port, said water treatment plant having a permanent component including a metering pump and a replaceable module configured to decontaminate water provided to the plant from a source.   
     
     
         3 . The device according to  claim 2 , wherein the replaceable filter module comprises a first stage filter for subjecting the water to a reduction/oxidation process to remove ions, followed by an adsorption filter, followed by stages of strong acid cation and strong base anion filters, followed by a mixed bed deionization filter, followed by a microtubular ultrafilter. 
     
     
         4 . The device according to  claim 3 , further comprising a sensor detecting ion concentration by contact testing of the conductivity of the water, wherein a signal is generated indicating the last allowed batch before replacement of the replaceable module. 
     
     
         5 . The device of  claim 2 , further comprising a microporous filter, the port being configured such that the diluting water to be added to said replacement fluid concentrate passes through said microporous filter.