US2013273005A1PendingUtilityA1

Methods for treating hcv

Assignee: DELANEY WILLIAM EPriority: Dec 20, 2010Filed: Dec 8, 2011Published: Oct 17, 2013

Est. expiryDec 20, 2030(~4.4 yrs left)· nominal 20-yr term from priority

Inventors:William E. Delaney, Iv John O. Link Hongmei Mo David W. Oldach Adrian S. Ray William J. Watkins Cheng Yong Yang Weidong Zhong

A61P 43/00A61P 31/14A61P 31/12A61K 31/662A61P 1/16A61K 31/675A61K 31/5377A61K 38/05A61K 31/4353A61K 31/4178A61K 31/4184A61K 31/7068A61K 31/40A61K 31/407A61K 31/4025A61K 38/212A61K 31/401A61K 31/501A61K 31/4436A61K 31/7056A61K 31/381A61K 31/4188A61K 45/06A61K 31/706

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Claims

Abstract

This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.

Claims

exact text as granted — not AI-modified

1 . A composition comprising two or more Combination Compounds selected from Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7 and pharmaceutically acceptable salts thereof, provided that Compound 1 and Compound 2 are not the only Combination Compounds in the composition and further provided that Compound 1 and Compound 3 are not the only Combination Compounds in the composition.

2 . The composition of claim 1 which comprises Compound 1 and further comprises a second compound selected from the group consisting of Compound 2, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7.

3 . The composition of claim 2 , wherein the second compound is Compound 4.

4 . The composition of claim 2 , wherein the second compound is Compound 5.

5 . The composition of claim 2 , wherein the second compound is Compound 6.

6 . The composition of claim 1 which comprises Compound 2 and further comprises a second compound selected from the group consisting of Compound 1, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7.

7 . The composition of claim 6 , wherein the second compound is Compound 4.

8 . The composition of claim 1 which comprises Compound 3 and further comprises a second compound selected from the group consisting of Compound 1, Compound 2, Compound 4, Compound 5, Compound 6 and Compound 7.

9 . The composition of claim 8 , wherein the second compound is Compound 1.

10 . The composition of claim 8 , wherein the second compound is Compound 5.

11 . The composition of claim 8 , wherein the second compound is Compound 6.

12 . The composition of claim 1 which comprises Compound 4 and further comprises a second compound selected from the group consisting of Compound 1, Compound 2, Compound 3, Compound 5, Compound 6 and Compound 7.

13 . The composition of claim 12 , wherein the second compound is Compound 1.

14 . The composition of claim 12 , wherein the second compound is Compound 2.

15 . The composition of claim 12 , wherein the second compound is Compound 3.

16 . The composition of claim 12 , wherein the second compound is Compound 6.

17 . The composition of claim 1 which comprises Compound 5 and further comprises a second compound selected from the group consisting of Compound 1, Compound 2, Compound 3, Compound 4, Compound 6 and Compound 7.

18 . The composition of claim 17 , wherein the second compound is Compound 1.

19 . The composition of claim 17 , wherein the second compound is Compound 3.

20 . The composition of claim 17 , wherein the second compound is Compound 6.

21 . The composition of claim 1 which comprises Compound 6 and further comprises a second compound selected from the group consisting of Compound 1, Compound 2, Compound 3, Compound 4, Compound 5 and Compound 7.

22 . The composition of claim 21 , wherein the second compound is Compound 1.

23 . The composition of claim 21 , wherein the second compound is Compound 2.

24 . The composition of claim 21 , wherein the second compound is Compound 3.

25 . The composition of claim 21 , wherein the second compound is Compound 4.

26 . The composition of claim 21 , wherein the second compound is Compound 5.

27 . The composition of claim 1 which comprises Compound 7 and further comprises a second compound selected from the group consisting of Compound 1, Compound 2, Compound 3, Compound 4, Compound 5 and Compound 6.

28 . The composition of claim 1 which comprises Compound 1 and further comprises a second compound and a third compound each selected from the group consisting of Compound 2, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7.

29 . The composition of claim 28 , wherein the second compound is Compound 3.

30 . The composition of claim 28 , wherein the second compound is Compound 4.

31 . The composition of claim 28 , wherein the second compound is Compound 5.

32 . The composition of claim 28 , wherein the second compound is Compound 6.

33 . The composition of claim 28 , wherein the second compound is Compound 2 and the third compound is Compound 4.

34 . The composition of claim 28 , wherein the second compound is Compound 3 and the third compound is Compound 4.

35 . The composition of claim 28 , wherein the second compound is Compound 2 and the third compound is Compound 6.

36 . The composition of claim 29 , wherein the second compound is Compound 3 and the third compound is Compound 6.

37 . The composition of claim 28 , wherein the second compound is Compound 4 and the third compound is Compound 6.

38 . The composition of claim 1 which comprises Compound 2 and further comprises a second compound and a third compound each selected from the group consisting of Compound 1, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7.

39 . The composition of claim 38 , wherein the second compound is Compound 4.

40 . The composition of claim 38 , wherein the second compound is Compound 1 and the third compound is Compound 4.

41 . The composition of claim 38 , wherein the second compound is Compound 1 and the third compound is Compound 6.

42 . The composition of claim 38 , wherein the second compound is Compound 4 and the third compound is Compound 6.

43 . The composition of claim 1 which comprises Compound 3 and further comprises a second compound and a third compound each selected from the group consisting of Compound 1, Compound 2, Compound 4, Compound 5, Compound 6 and Compound 7.

44 . The composition of claim 43 , wherein the second compound is Compound 1.

45 . The composition of claim 43 , wherein the second compound is Compound 5.

46 . The composition of claim 43 , wherein the second compound is Compound 6.

47 . The composition of claim 43 , wherein the second compound is Compound 1 and the third compound is Compound 4.

48 . The composition of claim 43 , wherein the second compound is Compound 1 and the third compound is Compound 6.

49 . The composition of claim 43 , wherein the second compound is Compound 4 and the third compound is Compound 6.

50 . The composition of claim 43 , wherein the second compound is Compound 5 and the third compound is Compound 6.

51 . The composition of claim 1 which comprises Compound 4 and further comprises a second compound and a third compound each selected from the group consisting of Compound 1, Compound 2, Compound 3, Compound 5, Compound 6 and Compound 7.

52 . The composition of claim 51 , wherein the second compound is Compound 1.

53 . The composition of claim 51 , wherein the second compound is Compound 2.

54 . The composition of claim 51 , wherein the second compound is Compound 3.

55 . The composition of claim 51 , wherein the second compound is Compound 6.

56 . The composition of claim 51 wherein the second compound is Compound 1 and the third compound is Compound 2.

57 . The composition of claim 51 wherein the second compound is Compound 1 and the third compound is Compound 3.

58 . The composition of claim 51 wherein the second compound is Compound 1 and the third compound is Compound 6.

59 . The composition of claim 51 , wherein the second compound is Compound 2 and the third compound is Compound 6.

60 . The composition of claim 51 , wherein the second compound is Compound 3 and the third compound is Compound 6.

61 . The composition of claim 1 which comprises Compound 5 and further comprises a second compound and a third compound each selected from the group consisting of Compound 1, Compound 2, Compound 3, Compound 4, Compound 6 and Compound 7.

62 . The composition of claim 61 , wherein the second compound is Compound 1.

63 . The composition of claim 61 , wherein the second compound is Compound 3.

64 . The composition of claim 61 , wherein the second compound is Compound 6.

65 . The composition of claim 61 , wherein the second compound is Compound 3 and the third compound is Compound 6.

66 . The composition of claim 1 which comprises Compound 6 and further comprises a second compound and a third compound each selected from the group consisting of Compound 1, Compound 2, Compound 3, Compound 4, Compound 5 and Compound 7.

67 . The composition of claim 66 , wherein the second compound is Compound 1.

68 . The composition of claim 66 , wherein the second compound is Compound 2.

69 . The composition of claim 66 , wherein the second compound is Compound 3.

70 . The composition of claim 66 , wherein the second compound is Compound 4.

71 . The composition of claim 66 , wherein the second compound is Compound 5.

72 . The composition of claim 66 , wherein the second compound is Compound 1 and the third compound is Compound 2.

73 . The composition of claim 66 , wherein the second compound is Compound 1 and the third compound is Compound 3.

74 . The composition of claim 66 , wherein the second compound is Compound 1 and the third compound is Compound 4.

75 . The composition of claim 66 , wherein the second compound is Compound 2 and the third compound is Compound 4.

76 . The composition of claim 66 , wherein the second compound is Compound 3 and the third compound is Compound 4.

77 . The composition of claim 66 , wherein the second compound is Compound 3 and the third compound is Compound 5.

78 . The composition of claim 1 which comprises Compound 1 and further comprises a second compound, a third compound and a fourth compound each selected from the group consisting of Compound 2, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7.

79 . The composition of claim 78 , wherein the second compound is Compound 3.

80 . The composition of claim 78 , wherein the second compound is Compound 4.

81 . The composition of claim 78 , wherein the second compound is Compound 5.

82 . The composition of claim 78 , wherein the second compound is Compound 6.

83 . The composition of claim 78 , wherein the second compound is Compound 2 and the third compound is Compound 4.

84 . The composition of claim 78 , wherein the second compound is Compound 3 and the third compound is Compound 4.

85 . The composition of claim 78 , wherein the second compound is Compound 2 and the third compound is Compound 6.

86 . The composition of claim 78 , wherein the second compound is Compound 3 and the third compound is Compound 6.

87 . The composition of claim 78 , wherein the second compound is Compound 4 and the third compound is Compound 6.

88 . The composition of claim 1 which comprises Compound 2 and further comprises a second compound, a third compound and a fourth compound each selected from the group consisting of Compound 1, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7.

89 . The composition of claim 88 , wherein the second compound is Compound 4.

90 . The composition of claim 88 , wherein the second compound is Compound 1 and the third compound is Compound 4.

91 . The composition of claim 88 , wherein the second compound is Compound 1 and the third compound is Compound 6.

92 . The composition of claim 88 , wherein the second compound is Compound 4 and the third compound is Compound 6.

93 . The composition of claim 1 which comprises Compound 3 and further comprises a second compound, a third compound and a fourth compound each selected from the group consisting of Compound 1, Compound 2, Compound 4, Compound 5, Compound 6 and Compound 7.

94 . The composition of claim 93 , wherein the second compound is Compound 1.

95 . The composition of claim 93 , wherein the second compound is Compound 5.

96 . The composition of claim 93 , wherein the second compound is Compound 6.

97 . The composition of claim 93 , wherein the second compound is Compound 1 and the third compound is Compound 4.

98 . The composition of claim 93 , wherein the second compound is Compound 1 and the third compound is Compound 6.

99 . The composition of claim 93 , wherein the second compound is Compound 4 and the third compound is Compound 6.

100 . The composition of claim 93 , wherein the second compound is Compound 5 and the third compound is Compound 6.

101 . The composition of claim 1 which comprises Compound 4 and further comprises a second compound, a third compound and a fourth compound each selected from the group consisting of Compound 1, Compound 2, Compound 3, Compound 5, Compound 6 and Compound 7.

102 . The composition of claim 101 , wherein the second compound is Compound 1.

103 . The composition of claim 101 , wherein the second compound is Compound 2.

104 . The composition of claim 101 , wherein the second compound is Compound 3.

105 . The composition of claim 101 , wherein the second compound is Compound 6.

106 . The composition of claim 101 , wherein the second compound is Compound 1 and the third compound is Compound 2.

107 . The composition of claim 101 , wherein the second compound is Compound 1 and the third compound is Compound 3.

108 . The composition of claim 101 , wherein the second compound is Compound 1 and the third compound is Compound 6.

109 . The composition of claim 101 , wherein the second compound is Compound 2 and the third compound is Compound 6.

110 . The composition of claim 101 , wherein the second compound is Compound 3 and the third compound is Compound 6.

111 . The composition of claim 1 which comprises Compound 5 and further comprises a second compound, a third compound and a fourth compound each selected from the group consisting of Compound 1, Compound 2, Compound 3, Compound 4, Compound 6 and Compound 7.

112 . The composition of claim 111 , wherein the second compound is Compound 1.

113 . The composition of claim 111 , wherein the second compound is Compound 3.

114 . The composition of claim 111 , wherein the second compound is Compound 6.

115 . The composition of claim 111 , wherein the second compound is Compound 3 and the third compound is Compound 6.

116 . The composition of claim 1 which comprises Compound 6 and further comprises a second compound, a third compound and a fourth compound each selected from the group consisting of Compound 1, Compound 2, Compound 3, Compound 4 and Compound 5.

117 . The composition of claim 116 , wherein the second compound is Compound 1.

118 . The composition of claim 116 , wherein the second compound is Compound 2.

119 . The composition of claim 116 , wherein the second compound is Compound 3.

120 . The composition of claim 116 , wherein the second compound is Compound 4.

121 . The composition of claim 116 , wherein the second compound is Compound 1 and the third compound is Compound 2.

122 . The composition of claim 116 , wherein the second compound is Compound 1 and the third compound is Compound 3.

123 . The composition of claim 116 , wherein the second compound is Compound 1 and the third compound is Compound 4.

124 . The composition of claim 116 , wherein the second compound is Compound 2 and the third compound is Compound 4.

125 . The composition of claim 116 , wherein the second compound is Compound 3 and the third compound is Compound 4.

126 . The composition of claim 116 , wherein the second compound is Compound 3 and the third compound is Compound 5.

127 . The composition of claim 1 which comprises Compound 7 and further comprises a second compound, a third compound and a fourth compound each selected from the group consisting of Compound 1, Compound 2, Compound 3, Compound 4, Compound 5 and Compound 6.

128 . The composition of claim 1 which comprises Compound 1 and further comprises a second compound, a third compound, a fourth compound and a fifth compound each selected from the group consisting of Compound 2, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7.

129 . The composition of claim 128 , wherein the second compound is Compound 2.

130 . The composition of claim 128 , wherein the second compound is Compound 3.

131 . The composition of claim 128 , wherein the second compound is Compound 4.

132 . The composition of claim 128 , wherein the second compound is Compound 5.

133 . The composition of claim 128 , wherein the second compound is Compound 6.

134 . The composition of claim 128 , wherein the second compound is Compound 2 and the third compound is Compound 4.

135 . The composition of claim 128 , wherein the second compound is Compound 3 and the third compound is Compound 4.

136 . The composition of claim 128 , wherein the second compound is Compound 2 and the third compound is Compound 6.

137 . The composition of claim 128 , wherein the second compound is Compound 3 and the third compound is Compound 6.

138 . The composition of claim 128 , wherein the second compound is Compound 4 and the third compound is Compound 6.

139 . The composition of claim 1 which comprises Compound 2 and further comprises a second compound, a third compound, a fourth compound and a fifth compound each selected from the group consisting of Compound 1, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7.

140 . The composition of claim 139 , wherein the second compound is Compound 4.

141 . The composition of claim 139 , wherein the second compound is Compound 1 and the third compound is Compound 4.

142 . The composition of claim 139 , wherein the second compound is Compound 1 and the third compound is Compound 6.

143 . The composition of claim 139 , wherein the second compound is Compound 4 and the third compound is Compound 6.

144 . The composition of claim 1 which comprises Compound 3 and further comprises a second compound, a third compound, a fourth compound and a fifth compound each selected from the group consisting of Compound 1, Compound 2, Compound 4, Compound 5, Compound 6 and Compound 7.

145 . The composition of claim 144 , wherein the second compound is Compound 1.

146 . The composition of claim 144 , wherein the second compound is Compound 5.

147 . The composition of claim 144 , wherein the second compound is Compound 6.

148 . The composition of claim 144 , wherein the second compound is Compound 1 and the third compound is Compound 4.

149 . The composition of claim 144 , wherein the second compound is Compound 1 and the third compound is Compound 6.

150 . The composition of claim 144 , wherein the second compound is Compound 4 and the third compound is Compound 6.

151 . The composition of claim 144 , wherein the second compound is Compound 5 and the third compound is Compound 6.

152 . The composition of claim 1 which comprises Compound 4 and further comprises a second compound, a third compound, a fourth compound and a fifth compound each selected from the group consisting of Compound 1, Compound 2, Compound 3, Compound 5, Compound 6 and Compound 7.

153 . The composition of claim 152 , wherein the second compound is Compound 1.

154 . The composition of claim 152 , wherein the second compound is Compound 2.

155 . The composition of claim 152 , wherein the second compound is Compound 3.

156 . The composition of claim 152 , wherein the second compound is Compound 6.

157 . The composition of claim 152 , wherein the second compound is Compound 1 and the third compound is Compound 2.

158 . The composition of claim 152 , wherein the second compound is Compound 1 and the third compound is Compound 3.

159 . The composition of claim 152 , wherein the second compound is Compound 1 and the third compound is Compound 6.

160 . The composition of claim 152 , wherein the second compound is Compound 2 and the third compound is Compound 6.

161 . The composition of claim 152 , wherein the second compound is Compound 3 and the third compound is Compound 6.

162 . The composition of claim 1 which comprises Compound 5 and further comprises a second compound, a third compound, a fourth compound and a fifth compound each selected from the group consisting of Compound 1, Compound 2, Compound 3, Compound 4, Compound 6 and Compound 7.

163 . The method of claim 162 , wherein the second compound is Compound 1.

164 . The method of claim 162 , wherein the second compound is Compound 3.

165 . The method of claim 162 , wherein the second compound is Compound 6.

166 . The composition of claim 162 , wherein the second compound is Compound 3 and the third compound is Compound 6.

167 . The composition of claim 1 which comprises Compound 6 and further comprising a second compound, a third compound, a fourth compound and a fifth compound each selected from the group consisting of Compound 1, Compound 2, Compound 3, Compound 4, Compound 5 and Compound 7.

168 . The composition of claim 167 , wherein the second compound is Compound 1.

169 . The composition of claim 167 , wherein the second compound is Compound 2.

170 . The composition of claim 167 , wherein the second compound is Compound 3.

171 . The composition of claim 167 , wherein the second compound is Compound 4.

172 . The composition of claim 167 , wherein the second compound is Compound 1 and the third compound is Compound 2.

173 . The composition of claim 167 , wherein the second compound is Compound 1 and the third compound is Compound 3.

174 . The composition of claim 167 , wherein the second compound is Compound 1 and the third compound is Compound 4.

175 . The composition of claim 167 , wherein the second compound is Compound 2 and the third compound is Compound 4.

176 . The composition of claim 167 , wherein the second compound is Compound 3 and the third compound is Compound 4.

177 . The composition of claim 167 , wherein the second compound is Compound 3 and the third compound is Compound 5.

178 . The composition of claim 1 which comprises Compound 7 and further comprises a second compound, a third compound, a fourth compound and a fifth compound each selected from the group consisting of Compound 1, Compound 2, Compound 3, Compound 4, Compound 5 and Compound 6.

179 . The composition of claim 1 wherein the composition comprises Compound 1 and Compound 6.

180 . The composition of claim 1 wherein the composition comprises Compound 1, Compound 3 and Compound 6.

181 . The composition of claim 1 wherein the composition comprises Compound 3 and Compound 5.

182 . The composition of claim 1 wherein the composition comprises Compound 3 and Compound 6.

183 . The composition of claim 1 wherein the composition comprises Compound 3, Compound 5 and Compound 6.

184 . The composition of claim 1 which further comprises one or more pharmaceutically acceptable diluents or carriers.

185 . The composition of claim 1 which is formulated as a unit dosage form for once daily administration.

186 . The composition of claim 1 which is formulated for oral administration.

187 . The composition of claim 1 which is formulated as a tablet.

188 . A method of treating an HCV infection in a human, comprising administering two or more Combination Compounds selected from Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7 and pharmaceutically acceptable salts thereof to the human, provided that Compound 1 and Compound 2 are not the only Combination Compounds administered and further provided that Compound 1 and Compound 3 are not the only Combination Compounds administered.

189 . The method of claim 188 wherein a composition as described in claim 1 is administered to the human.

190 . A method for ameliorating one or more symptoms of an HCV infection in a human, comprising administering two or more Combination Compounds selected from Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7 and pharmaceutically acceptable salts thereof to the human, provided that Compound 1 and Compound 2 are not the only Combination Compounds administered and further provided that Compound 1 and Compound 3 are not the only Combination Compounds administered.

191 . The method of claim 190 wherein a composition as described in claim 1 is administered to the human.

192 . A method for reducing viral load in a human with HCV, comprising administering two or more Combination Compounds selected from Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7 and pharmaceutically acceptable salts thereof to the human, provided that Compound 1 and Compound 2 are not the only Combination Compounds administered and further provided that Compound 1 and Compound 3 are not the only Combination Compounds administered.

193 . The method of claim 192 wherein a composition as described in claim 1 is administered to the human.

194 . A method for reducing emergence of HCV quasispecies with resistance to coadministered oral antiviral agents in a human, comprising administering two or more Combination Compounds selected from Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7 and pharmaceutically acceptable salts thereof to the human, provided that Compound 1 and Compound 2 are not the only Combination Compounds administered and further provided that Compound 1 and Compound 3 are not the only Combination Compounds administered.

195 . The method of claim 194 wherein a composition as described in claim 1 is administered to the human.

196 . The method of claim 188 further comprising administering an interferon to the human.

197 . The method of claim 188 wherein an interferon is not administered to the human.

198 . The method of claim 188 further comprising administering ribavirin to the human.

199 . The method of claim 188 further comprising administering one or more additional agents selected from ribavirin, an interferon, alpha-glucosidase 1 inhibitors, hepatoprotectants, TLR-7 agonists, cyclophilin inhibitors, HCV viral entry inhibitors, HCV maturation inhibitors, and HCV IRES inhibitors to the human.

200 . The use of two or more Combination Compounds selected from Combination Compounds Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7 and pharmaceutically acceptable salts thereof in medical therapy, provided that Compound 1 and Compound 2 are not the only Combination Compounds selected and further provided that Compound 1 and Compound 3 are not the only Combination Compounds selected.

201 . The use of a composition as described in claim 1 in medical therapy.

202 . The use of two or more Combination Compounds selected from Combination Compounds Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7 and pharmaceutically acceptable salts thereof for the prophylactic or therapeutic treatment of an HCV infection, provided that Compound 1 and Compound 2 are not the only Combination Compounds selected and further provided that Compound 1 and Compound 3 are not the only Combination Compounds selected.

203 . The use of a composition as described in claim 1 for the prophylactic or therapeutic treatment of an HCV infection.

204 . The use of two or more Combination Compounds selected from Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7 and pharmaceutically acceptable salts thereof to prepare a medicament for treating an HCV infection in a human, provided that Compound 1 and Compound 2 are not the only Combination Compounds selected and further provided that Compound 1 and Compound 3 are not the only Combination Compounds selected.

205 . The use of a composition as described in claim 1 to prepare a medicament for treating an HCV infection in a human.

206 . The use of two or more Combination Compounds selected from Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7 and pharmaceutically acceptable salts thereof to prepare a medicament for ameliorating one or more symptoms of an HCV infection in a human, provided that Compound 1 and Compound 2 are not the only Combination Compounds selected and further provided that Compound 1 and Compound 3 are not the only Combination Compounds selected.

207 . The use of a composition as described in claim 1 to prepare a medicament for ameliorating one or more symptoms of an HCV infection in a human.

208 . The use of two or more Combination Compounds selected from Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7 and pharmaceutically acceptable salts thereof to prepare a medicament for reducing viral load in a human, provided that Compound 1 and Compound 2 are not the only Combination Compounds selected and further provided that Compound 1 and Compound 3 are not the only Combination Compounds selected.

209 . The use of a composition as described in claim 1 to prepare a medicament for reducing viral load in a human.

210 . The use of two or more Combination Compounds selected from Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6 and Compound 7 and pharmaceutically acceptable salts thereof to prepare a medicament for reducing emergence of HCV quasispecies with resistance to coadministered oral antiviral agents in a human, provided that Compound 1 and Compound 2 are not the only Combination Compounds selected and further provided that Compound 1 and Compound 3 are not the only Combination Compounds selected.

211 . The use of a composition as described in claim 1 to prepare a medicament for reducing emergence of HCV quasispecies with resistance to coadministered oral antiviral agents in a human.

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