Compounds and Method for Modulating Inflammatory Reactions

Abstract

The present invention relates to compounds and methods for modulating, reducing or inhibiting, inflammatory reactions in a patient. Particularly, inflammatory reactions that are targeted by the present invention are cell migration, secretion of toxic products and proteolysis at a site of inflammation. Reduction of inflammation manifestations and reactions occurs by using an anti-S100 polynucleotide or polypeptide inhibitor or antagonist, which is essentially targeted against S100A8, S100A9 or S100A12, alone or in combination with other inhibitors of chemokines or immune modulating products.

What is claimed is: 
     
         1 . A method for the treatment of an inflammatory reaction in a human suffering therefrom comprising administering to said human an inflammatory reaction treatment effective amount of an antibody or a fragment thereof directed against S100A8 protein, S100A9 or a combination thereof. 
     
     
         2 . The method of  claim 1 , wherein said inflammatory reaction is selected from the group consisting of arthritis, chronic polyarthritis, rheumatoid arthritis, gout, asthma, psoriasis, paraneoplastic syndrome, tumor-induced inflammatory diseases, turbid effusions, collagenosis, postinfectious arthritis, seronegative spondylarthritis, vasculitis, sarcoidosis, arthrosis, Crohn's disease, ulcerative colitis, tuberculosis, cell chemotaxis, cell migration, cell recruitement, proteolysis, oxidative burst, radical oxidation, acute myeloid leukemia, chronic myeloid leukemia or acute lymphoid leukemia and graft rejection. 
     
     
         3 . The method of  claim 1 , wherein said inflammatory reaction is selected from the group consisting of rheumatoid arthritis, Crohn's disease, ulcerative colitis, and tuberculosis. 
     
     
         4 . The method of  claim 1 , wherein said inflammatory reaction is selected from the group consisting of rheumatoid arthritis and Crohn's disease. 
     
     
         5 . The method of  claim 1 , wherein said administration is performed by intravenous, oral, intranasal, subcutaneous, topical, or intraperitoneal administration.