Methods and devices for treatment of vascular defects

Abstract

Devices and methods for treatment of a patient's vasculature with some embodiments configured for delivery with a microcatheter for treatment of the cerebral vasculature of a patient. Some embodiments include thin permeable membranes configured to occlude blood flow therethrough.

What is claimed is: 
     
         1 . A device for treatment of a patient's vasculature, comprising:
 an expandable wire body support structure having:
 a low profile radially constrained state with a first end, a second end, an elongated tubular configuration having a longitudinal axis, elongate flexible wires defining a plurality of openings between wires, and a first transverse dimension suitable for delivery through a microcatheter configured for navigation in cerebral vasculature, and 
 an expanded relaxed state with a substantially spherical or globular configuration having a smooth outer surface and a second transverse dimension substantially greater than the first transverse dimension of the elongated tubular configuration of the radially constrained state; and 
 a porous permeable layer comprising a braided wire occlusive mesh disposed over at least a portion of the expandable wire body support structure at the first end, which is configured to cover an aneurysm opening. 
   
     
     
         2 . The device of  claim 1 , wherein the porous permeable layer covers at least one-third of the expandable wire body support structure when in the expanded relaxed state. 
     
     
         3 . The device of  claim 1 , wherein the total volume of the permeable layer is less than about 5 mm3. 
     
     
         4 . The device of  claim 1 , wherein the total volume of the permeable layer is between 0.5 mm3 and 4 mm3. 
     
     
         5 . The device of  claim 1 , wherein the permeable layer comprises wires having a thickness of less than about 0.40 mm. 
     
     
         6 . The device of  claim 1 , wherein the permeable layer comprises wires having a thickness of about 0.015 mm to about 0.030 mm. 
     
     
         7 . The device of  claim 1 , wherein upon deployment, the device substantially fills an aneurysm such that the braided mesh layer and wire structural layer cover a neck of the aneurysm being treated. 
     
     
         8 . The device of  claim 1 , wherein each elongate flexible wire forms a smooth arc between first end and second ends. 
     
     
         9 . The device of  claim 1 , wherein the porous permeable layer extends from the first end toward the second end of the expandable wire body support structure when in the expanded relaxed state. 
     
     
         10 . The device of  claim 1 , wherein the expandable wire body support structure defines an opening at the second end when the expandable wire body support structure is in the expanded relaxed state.