Polypeptides and Immunizing Compositions Containing Gram Positive Polypeptides and Methods of Use

Abstract

The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.

1 - 50 . (canceled) 
     
     
         51 . An enriched polypeptide having immunogenic activity and a mass fingerprint when digested with trypsin that includes all polypeptide fragments present in a mass fingerprint of a reference polypeptide when digested with trypsin, wherein the reference polypeptide has a molecular weight of 37 kDa as determined by electrophoresis on a sodium dodecyl sulfate-polyacrylamide gel and is expressed by  Staphylococcus aureus  ATCC strain 19636 when incubated in media comprising 2,2′-dipyridyl at a concentration of 1600 μM and not expressed at a detectable level when grown in the media without the 2,2′-dipyridyl.